Reboxetine, sold under the brand name Edronax among others, is a drug of the norepinephrine reuptake inhibitor (NRI
Norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor or Noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor, is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine and epinephrine by blocking the action of the norepinephrine transporter. This in turn leads to increased extracellular concentrations of norepinephrine and epinephrine and therefore can increase in adren…
Pfizer
Pfizer Inc. is an American multinational pharmaceutical corporation headquartered in New York City, with its research headquarters in Groton, Connecticut. It is one of the world's largest pharmaceutical companies. It is listed on the New York Stock Exchange, and its shares have been …
How does reboxetine work?
Reboxetine is an antidepressant that works by increasing the amount of serotonin in the brain. Serotonin plays a key role in emotion, mood, and sleep. Reboxetine belongs to a group called selective norepinephrine reuptake inhibitors (SNRIs). Some antidepressants only affect one neurotransmitter. But the SNRI type affects both.
Is reboxetine safe for the elderly?
Reboxetine, a novel selective noradrenaline reuptake inhibitor, is well tolerated by adults and the elderly during short- and long-term treatment for depression. Adrenergic Uptake Inhibitors / adverse effects
Can reboxetine be used for anxiety and depression?
The FDA has approved reboxetine for the treatment of depression. It is also used to treat anxiety, as it helps some people with that condition as well. Reboxetine has been approved by the FDA to treat the major depressive disorder (MDD) and generalized anxiety disorder (GAD). Those with depression tend to have low levels of serotonin.
Is reboxetine (Edronax) available in the US?
While it's never been available in the US, it's created a lot of controversy abroad. What is Reboxetine (Edronax)? Reboxetine is one of the most controversial drugs and a mystery to the scientific community. Starting with the basics, reboxetine is a type of antidepressant known as a selective noradrenaline reuptake inhibitor (NARI).
Is reboxetine a strong antidepressant?
Clinical studies show reboxetine to be highly effective for the treatment of major depression. Reboxetine is more effective than placebo and comparable in efficacy to tricyclic antidepressants and selective serotonin reuptake inhibitors.
Is reboxetine good for anxiety?
Compared with placebo, reboxetine treatment improved the specific symptoms of agitation and anxiety, and, after the first week of treatment, was not associated with an increased risk of insomnia-related side effects.
What type of drug is reboxetine?
Reboxetine is one of the most controversial drugs and a mystery to the scientific community. Starting with the basics, reboxetine is a type of antidepressant known as a selective noradrenaline reuptake inhibitor (NARI).
How does reboxetine make you feel?
Dry mouth, insomnia, increased sweating and constipation are among the most commonly reported side effects. In both double-blind and open studies, reboxetine has been shown to be effective and well tolerated in the treatment of depression in elderly patients.
Is reboxetine a sedating?
Chronic administration of reboxetine at therapeutic doses causes autonomic dysfunction and subjective sedation but does not impair cognitive and psychomotor abilities in healthy humans.
Does reboxetine cause weight loss?
We report a case of significant weight loss experienced by a 44-year-old Caucasian woman treated with reboxetine. She was treated with this drug at 12 mg daily for a total duration of 11 months. During the corresponding period her body mass index (BMI) decreased from a baseline of 21.4 kg m−2 to a low of 16.8 kg m−2.
How long does it take for reboxetine to work?
Reboxetine is prescribed to treat depression. It may take a week or two after starting the tablets before you start to feel the benefit.
What are the side effects of reboxetine?
The adverse effects of reboxetine include dry mouth, constipation, insomnia, dizziness and tachycardia. ECG changes appear in 15% of elderly patients taking reboxetine. Hypotension can occur, but is less likely than in patients taking imipramine.
What is the safest antidepressant?
Among the newer antidepressants, bupropion and venlafaxine were associated with the highest case fatality rates. In addition, among SSRIs, citalopram and fluvoxamine appeared to be related to higher mortality rates in overdose, whereas fluoxetine and sertraline were the safest [188].
Is reboxetine a stimulant?
Reboxetine is a non-stimulant drug without a risk of abuse that can be prescribed for adolescents.
How long does it take Edronax to work?
Some of your symptoms may improve after two weeks but it may take four to six weeks for you to start to feel the full benefit of Edronax. You may need to take Edronax for several months or longer. Continue taking your medicine for as long as your doctor tells you.
Which antidepressants are best for anxiety?
SSRIs and SNRIs are often the first-line treatment for anxiety. Common SSRI brands are Celexa, Lexapro, Luvox, Paxil, and Zoloft, and common SNRI brands are Pristiq, Cymbalta, and Effexor XR. Pros: They are effective for a lot of people and they have a solid safety profile.
How long does it take for reboxetine to work?
Reboxetine is prescribed to treat depression. It may take a week or two after starting the tablets before you start to feel the benefit.
Is reboxetine a stimulant?
Reboxetine is a non-stimulant drug without a risk of abuse that can be prescribed for adolescents.
Does norepinephrine help anxiety?
Norepinephrine is responsible for how the person reacts to stress and anxiety and is associated with the fight-or-flight response. SNRIs work to influence both serotonin and norepinephrine by preventing a person's brain cells from rapidly absorbing these neurotransmitters.
What is the brand name of Reboxetine?
Edronax is the brand name of reboxetine in every English-speaking country that has approved it for clinical use. Brand names include (where † denotes a product that is no longer marketed):
How many chiral centers does reboxetine have?
Reboxetine has two chiral centers. Thus, four stereoisomers may exist, the ( R, R )-, ( S, S )-, ( R, S )-, and ( S, R )-isomers. The active ingredient of reboxetine is a racemic mixture of two enantiomers, the ( R, R )- (–)- and ( S, S )- (+)-isomer.
When was reboxetine first used?
Reboxetine was discovered at Farmitalia-Carlo Erba and was first published in 1984 ; Farmitalia did the first clinical studies. Farmitalia was acquired by Pharmacia in 1993, and Pharmacia in turn was acquired by Pfizer in 2003. It was first approved in Europe in 1997 and was provisionally approved by the FDA in 1999.
What is the name of the drug that is used for depression?
Reboxetine. Reboxetine, sold under the brand name Edronax among others, is a drug of the norepinephrine reuptake inhibitor (NRI) class, marketed as an antidepressant by Pfizer for use in the treatment of major depression, although it has also been used off-label for panic disorder and attention deficit hyperactivity disorder (ADHD).
Does reboxetine interact with fluoxetine?
It weakly inhibits CYP2D6 and CYP3A4. Reboxetine is an intermediate-level inhibitor of P-glycoprotein, which gives it the potential to interact with ciclosporin, tacrolimus, paroxetine, sertraline, quinidine, fluoxetine, fluvoxamine.
Is reboxetine a low risk medication?
Reboxetine is considered a relatively low-risk antidepressant in overdose. The symptoms are as follows:
Is reboxetine contraindicated for glaucoma?
Reboxetine is contraindicated in narrow-angle glaucoma, cardiovascular disease, epilepsy, bipolar disorder, urinary retention, prostatic hypertrophy, patients concomitantly on MAOIs and those hypersensitive to reboxetine or any of its excipients.
Content
Reboxetine is a 4th generation antidepressant drug. Its mechanism of action involves the selective reuptake of norepinephrine, that is, it is an ISRN (Selective Noradrenaline Reuptake Inhibitor).
Reboxetine: general characteristics
Reboxetine is an antidepressant drug, specifically an SNRI (Selective noradrenaline reuptake inhibitor).
Indications and Contraindications
Regarding its indications, reboxetine it is indicated for the acute treatment of major depressive disorders (and other depressive disorders) and for the maintenance of clinical improvement in patients who have responded to treatment initially.
Tradenames
Reboxetine is marketed in drugs under different brand names: Davedax, Edronax, Norebox and Solvex.
4th generation antidepressants
As we have seen, reboxetine is considered a 4th generation antidepressant, together with other SNRIs and together with dual antidepressants, that is, drugs that inhibit the reuptake of both serotonin and norepinephrine (SSRI).
Side effects
The main side effects that reboxetine can produce are: abdominal pain, headaches, and decreased appetite (They are the most frequent). Others such as nausea, vomiting, constipation, dry mouth and drowsiness may also appear.
Precautions
On the other hand, some antidepressants such as reboxetine have produced seizures in clinical trials Therefore, great caution should also be exercised in the case of patients with a history of seizure disorders. Drug treatment should be stopped if the person has seizures at any time.
What is paroxetine?
Paroxetine is an antidepressant that belongs to group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders.
What other drugs will affect paroxetine?
Using paroxetine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
What is Brisdelle used for?
The Brisdelle brand of paroxetine is used to treat hot flashes related to menopause. Brisdelle is not for treating any other conditions.
How to contact the poison help line?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of paroxetine can be fatal.
How old do you have to be to take proxetine?
Paroxetine is not approved for use by anyone younger than 18 years old.
How long after MAO injection can you take paroxetine?
Do not use paroxetine within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
What are the symptoms of serotonin syndrome?
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
What is edronax used for?
Edronax is used for acute treatment of major depression and for maintaining the improvement of your symptoms when you initially respond to treatment with reboxetine. 2.
What is the active ingredient in Edronax?
The active substance in Edronax is reboxetine which belongs to a group of medicines called antidepressants. Edronax is used for acute treatment of major depression and for maintaining the improvement of your symptoms when you initially respond to treatment with reboxetine.
What is the drug used to treat migraines?
Drugs called ergotamines and used to treat migraines or Parkinson’s disease
What to do if you forget to take Edronax?
If you forget to take Edronax, take the next dose at the usual time Do not take a double dose to make up for a forgotten dose.
Where is Edronax approved?
This medicine is approved under the name Edronax in Belgium, Denmark, Finland, Ireland, Italy, Luxembourg, Portugal, Great Britain, Germany, and Austria. It is also approved in Spain under the name Norebox.
What is the phenomenon of cold hands and feet?
Cold hands and feet, Raynaud’s phenomenon (poor blood circulation in the extremities usually in the toes and fingers but can also affect the nose and ears, the skin becomes pale, cold, and numb),
What are the withdrawal symptoms of Edronax?
There are a few reports of withdrawal symptoms that include headaches, dizziness, nervousness, and nausea when patients have discontinued treatment with Edronax.
Overview
Reboxetine, sold under the brand name Edronax among others, is a drug of the norepinephrine reuptake inhibitor (NRI) class, marketed as an antidepressant by Pfizer for use in the treatment of major depression, although it has also been used off-label for panic disorder and attention deficit hyperactivity disorder (ADHD). It is approved for use in many countries worldwide, but has not been …
Medical uses
There has been much debate as to whether reboxetine is more efficacious than placebo in the treatment of depression. According to a 2009 meta-analysis of 12 second-generation antidepressants, reboxetine was no more effective than placebo, and was "significantly less" effective, and less acceptable, than the other drugs in treating the acute-phase of adults with unipolar major depression.
Contraindications
Reboxetine is contraindicated in narrow-angle glaucoma, cardiovascular disease, epilepsy, bipolar disorder, urinary retention, prostatic hypertrophy, patients concomitantly on MAOIs and those hypersensitive to reboxetine or any of its excipients.
Adverse effects
Very common (>10% incidence) adverse effects include insomnia, dizziness, dry mouth, constipation, nausea, and excessive sweating.
Common (1–10%) adverse effects include loss of appetite, agitation, anxiety, headache, restlessness, tingling sensations, distorted sense of taste, difficulty with seeing near or far (problems with accommodation), fast heart beat, heart palpitations, relaxing of blood vessels lea…
Overdose
Reboxetine is considered a relatively low-risk antidepressant in overdose. The symptoms are as follows:
• Sweating
• Tachycardia
• Changes in blood pressure
Interactions
Because of its reliance on CYP3A4, reboxetine O-desethylation is markedly inhibited by papaverine and ketoconazole. It weakly inhibits CYP2D6 and CYP3A4. Reboxetine is an intermediate-level inhibitor of P-glycoprotein, which gives it the potential to interact with ciclosporin, tacrolimus, paroxetine, sertraline, quinidine, fluoxetine, fluvoxamine.
Pharmacology
Reboxetine is a fairly selective norepinephrine reuptake inhibitor (NRI), with approximately 20-fold selectivity for the norepinephrine transporter (NET) over the serotonin transporter (SERT). Despite this selectivity, reboxetine does slightly inhibit the reuptake of serotonin at therapeutic doses. It does not interact with or inhibit the dopamine transporter (DAT).
Reboxetine has been found to inhibit both brain and cardiac GIRKs, a characteristic it shares wit…
Chemistry
Reboxetine has two chiral centers. Thus, four stereoisomers may exist, the (R,R)-, (S,S)-, (R,S)-, and (S,R)-isomers. The active ingredient of reboxetine is a racemic mixture of two enantiomers, the (R,R)-(–)- and (S,S)-(+)-isomer.