What is Reteplase (Retavase)?
Please help improve this article by introducing citations to additional sources. Reteplase, trade names include Retavase, is a thrombolytic drug, used to treat heart attacks by breaking up the clots that cause them.
What are the side effects of reteplase?
Reteplase side effects. easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection); bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
How is Reteplase administered?
Reteplase can be administered as a bolus dose (nonweight-based) rather than an infusion, which promotes rapid and safe administration.
What is the role of as reteplase in the treatment of thrombosis?
As reteplase is able to penetrate inside the thrombi, an enhanced fibrinolytic activity will be achieved → rapid reperfusion → low incidence of bleeding. ^ Mohammadi E, Seyedhosseini-Ghaheh H, Mahnam K, Jahanian-Najafabadi A, Mir Mohammad Sadeghi H (2019).
When should reteplase be given?
Usual Adult Dose for Myocardial Infarction 10 units administered over 2 minutes as an IV bolus as soon as possible after the onset of acute myocardial infarction (AMI) symptoms, followed 30 minutes later by a second 10 unit IV bolus injection also administered over 2 minutes.
What are the side effects of reteplase?
What Are Side Effects of Retavase?nausea,vomiting,fever,injection site bleeding,blood in the urine,bloody or tarry stools,stomach pain, or.vomiting blood or vomit that looks like coffee grounds.
Is reteplase a blood thinner?
Reteplase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
What drug category is reteplase?
Retavase belongs to a class of drugs called Thrombolytics.
What is the difference between alteplase and reteplase?
Reteplase is a second-generation nonglycosylated deletion mutant of alteplase. Reteplase is less fibrin specific than alteplase but has a longer half-life (18 minutes) that enables administration by double-bolus IV injection.
Can reteplase be used in stroke?
Both as FDA-approved methods, recombinant tissue plasminogen activator (rt-PA, Alteplase) has been used to treat acute ischemic stroke (AIS) while recombinant plasminogen activator (rPA, Reteplase) has been especially used to treat acute myocardial infarction (AMI) in adults [11,12].
When should you not give heparin?
You should not use heparin if you have uncontrolled bleeding or a severe lack of platelets in your blood, or if you have ever had low platelets caused by using heparin or pentosan polysulfate. Do not use heparin injection to flush (clean out) an intravenous (IV) catheter, or fatal bleeding could result.
How is reteplase made?
Reteplase comprises the C-terminal kringle-2 and serine protease domains of tPA that lacks valine-4 through the glutamate-175 residue [Figure 1]. Its total molecular weight is 39 kDa and it has nine disulfide bonds in its structure.
Which thrombolytic is best?
Alteplase (rt-PA) is still the most commonly used thrombolytic agent in pulmonary embolism. The approved dose for PTE is infusion of 100 mg in 2 hours. This dose is known to cause major bleeding complications (primarily cerebral hemorrhage), especially in older patients.
What is the mechanism of action of reteplase?
Reteplase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.
How do you infuse reteplase?
As soon as possible after the onset of STEMI, administer 10 units intravenously over 2 minutes. Administer a second dose of 10 units 30 minutes after the first dose. Reconstitute RETAVASE immediately before administration. Reconstitute RETAVASE only with the supplied Sterile Water for Injection.
How do you pronounce reteplase?
Pronunciation(Received Pronunciation) IPA: /ˈɹiː.təp.leɪz/(General American) IPA: /ˈɹi.təˌpleɪs/
When should you not give heparin?
You should not use heparin if you have uncontrolled bleeding or a severe lack of platelets in your blood, or if you have ever had low platelets caused by using heparin or pentosan polysulfate. Do not use heparin injection to flush (clean out) an intravenous (IV) catheter, or fatal bleeding could result.
Which thrombolytic is best?
Alteplase (rt-PA) is still the most commonly used thrombolytic agent in pulmonary embolism. The approved dose for PTE is infusion of 100 mg in 2 hours. This dose is known to cause major bleeding complications (primarily cerebral hemorrhage), especially in older patients.
What thrombolytic drug is more likely to cause an allergic reaction?
Allergic reactions to thrombolytic agents can occur, but are most commonly seen with administration of streptokinase.
What drugs are used in thrombolytic therapy?
The most commonly used clot-busting drugs -- also known as thrombolytic agents -- include:Eminase (anistreplase)Retavase (reteplase)Streptase (streptokinase, kabikinase)t-PA (class of drugs that includes Activase)TNKase (tenecteplase)Abbokinase, Kinlytic (rokinase)
What is reteplase (Retavase)?
Reteplase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
What should I discuss with my healthcare provider before I receive reteplase (Retavase)?
You should not be treated with reteplase if you are allergic to it, or if you have:
What should I avoid after receiving reteplase (Retavase)?
Ask your doctor before taking aspirin or ibuprofen ( Motrin, Advil) shortly after you have received reteplase. These medications can increase your risk of bleeding.
What happens if I miss a dose (Retavase)?
Because you will receive reteplase in a clinical setting, you are not likely to miss a dose.
What is reteplase used for?
Reteplase, trade names include Retavase, is a thrombolytic drug, used to treat heart attacks by breaking up the clots that cause them. Reteplase is a recombinant non-glycosylated form of human tissue plasminogen activator, which has been modified to contain 357 of the 527 amino acids of the original protein.
How long does reteplase last?
Reteplase is similar to recombinant human tissue plasminogen activator ( alteplase ), but the modifications give reteplase a longer half-life of 13–16 minutes. Reteplase also binds fibrin with lower affinity than alteplase, improving its ability to penetrate into clots.
Does reteplase penetrate thrombi?
As reteplase is able to penetrate inside the thrombi, an enhanced fibrinolytic activity will be achieved → rapid reperfusion → low incidence of bleeding.
What is reteplase used for?
About Reteplase. Reteplase is used in the treatment of heart attacks and improving heart functions. It is a thrombolytic drug, or a type of tissue plasminogen activator that works by breaking up bood clots responsible for the heart problems.
Which domain binds to clots rich with fibrin?
Reteplase Through the fibronectin finger-like domain and the Kringle 2 domain Reteplase binds to clots rich with fibrin. After this plasmin is formed as the protease domain then cleaves the Arg/Val bond in plasminogen. The fibrin matrix of the thrombus is thus degenerated, and exerts its thrombolytic action.
Does Reteplase cause numbness?
The reported side effects of Reteplase are sudden headache, vision problems, chest pain, sudden cough, change in heart rate, sudden weakness or numbness in the body, confusion, allergic reactions like rashes, swelling of throat, tongue, face or lips. You should see a doctor immediately if you encounter any of these conditions.
Does Lybrate take responsibility for any medication?
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
Is Retefast safe for pregnant women?
Retefast 18mg injection may be unsafe to use during pregnancy . Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Can you take Reteplase while pregnant?
You should consult a doctor before taking Reteplase if you have kidney, heart or liver disease, infection, stomach ulcers, are on blood thinners. It should also be avoided if you are pregnant , plan on becoming pregnant, or are breastfeeding, or if you are on some medicines or supplements.
What is reteplase used for?
Reteplase is used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack (acute myocardial infarction). Reteplase may also be used for purposes not listed in this medication guide.
How to use Reteplase?
Use Reteplase (Retavase) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
What to tell your doctor before reteplase?
If possible before you receive reteplase, tell your doctor if you have ever had: a major surgery, medical trauma, or injury; bleeding in your brain, stomach, intestines, or urinary tract; a stroke; or. high blood pressure. In an emergency, you may not be able to tell caregivers about your health conditions.
How to contact a doctor about Reteplase?
If you think you or someone else may have overdosed on: Reteplase (Retavase) , call your doctor or the Poison Control center. (800) 222-1222.
Can reteplase affect your test results?
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using reteplase.
Can you take ibuprofen after reteplase?
Ask your doctor before taking aspirin or ibuprofen (Motrin, Advil) shortly after you have received reteplase. These medications can increase your risk of bleeding.
Can you take reteplase if you are allergic to it?
You should not be treated with reteplase if you are allergic to it, or if you have: active bleeding inside your body; a bleeding or blood clotting disorder such as hemophilia; a brain tumor or blood vessel disorder; a brain aneurysm (dilated blood vessel); severe uncontrolled high blood pressure; a history of stroke; or.
What Is Reteplase and How Does It Work?
Reteplase is a prescription medication used for the treatment of acute myocardial infarction.
What Other Drugs Interact with Reteplase?
If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.
What is reteplase used for?
Retavase (reteplase) is a thrombolytic drug used to dissolve blood clots used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack.
What is retavase tpa?
Retavase® (Reteplase) is a non-glycosylated deletion mutein of tissue plasminogen activator ( tPA ), containing the kringle 2 and the protease domains of human tPA. Retavase® contains 355 of the 527 amino acids of native tPA (amino acids 1-3 and 176-527). Retavase® is produced by recombinant DNA technology in E. coli. The protein is isolated as inactive inclusion bodies from E. coli, converted into its active form by an in vitro folding process and purified by chromatographic separation. The molecular weight of Reteplase is 39,571 daltons.
How to remove a reconstitution spike?
Open the package containing the reconstitution spike. Remove the protective cap from the luer lock port of the reconstitution spike and remove the protective cap on the end of the sterile 10 mL pre- filled syringe. Remove the protective flip-cap from one vial of RETAVASE.
What is the pH of Retavase?
Following reconstitution, the pH is 6.0 ± 0.3. Retavase® is supplied as a 10.4 unit vial to ensure sufficient drug for administration of each 10 unit injection. Each single-use vial contains:
How is retavase produced?
Retavase® is produced by recombinant DNA technology in E. coli. The protein is isolated as inactive inclusion bodies from E. coli, converted into its active form by an in vitro folding process and purified by chromatographic separation. The molecular weight of Reteplase is 39,571 daltons.
How much sterile water to inject into a retavate?
Transfer the 10 mL of Sterile Water for Injection through the reconstitution spike into the vial of RETAVASE.
Can you reconstitute a retivase?
Reconstitute RETAVASE only with the supplied Sterile Water for Injection. Slight foaming upon reconstitution may occur; if necessary allow the vial to stand undisturbed for several minutes to allow dissipation of any large bubbles. Prior to administration, inspect the product for particulate matter and discoloration.
What is Retavase?
Retavase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
Can Retavase affect your test results?
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Retavase.
