Precautions
Metronidazole is not the same as doxycycline; I'm not at all certain that's an appropriate substitution. Doxycycline is a very inexpensive drug; I don... Read More If i've had a bad reaction to doxycycline previously is it advisable to continue with metronidazole given i'm having the same side effects?
Is metronidazole the same as doxycycline?
Metronidazole is of the nitroimidazole class. It inhibits nucleic acid synthesis by forming nitroso radicals, which disrupt the DNA of microbial cells.
What class of drug is metronidazole?
You should not use Flagyl if you are allergic to metronidazole, secnidazole, or tinidazole, or if:
- you drank alcohol in the past 3 days;
- you consumed foods or medicines that contain propylene glycol in the past 3 days; or
- you took disulfiram ( Antabuse) within the past 14 days.
What does the name metronidazole mean?
Metronidazole is an antibiotic used to treat bacterial vaginosis and trichomonas vaginal infections, and fluconazole is an antifungal used to treat vaginal fungal infections caused by Candida. Brand names for metronidazole include Flagyl and Flagyl ER and a brand name for fluconazole is Diflucan.
Is metronidazole an antifunal?
What is the generic name for metronidazole?
Metronidazole is used to treat a certain type of vaginal infection (bacterial vaginosis) in women who are not pregnant. Metronidazole is an antibiotic that works by stopping the growth of bacteria. Metronidazole is available under the following different brand names: Flagyl, Flagyl ER, and Flagyl IV RTU.
What is another name for metronidazole tablets?
Brand names: Acea, Anabact, Flagyl, Metrogel, Metrosa, Rosiced, Rozex, Vaginyl, Zidoval, Zyomet.
What is metronidazole commonly used to treat?
Metronidazole is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).
Are metronidazole and Flagyl the same thing?
Metronidazole (Flagyl) IR and metronidazole (Flagyl) ER are different forms of the same medication. They work differently in your body. The ER tablet is slowly released into your body and works over time, while the IR tablets and capsules start working in your body right away.
Can I buy metronidazole over the counter?
Metronidazole is a prescription-only medication, and a doctor needs to check if you need to take it before they prescribe it for you. Drug Metronidazole is an antibiotic commonly used to treat bacterial vaginosis, but it can also treat other types of infections such as trichomoniasis.
What is metronidazole tab 500mg used for?
Metronidazole capsules and tablets are used to treat infections of the reproductive system, gastrointestinal (GI) tract, skin, heart, bone, joint, lung, blood, nervous system, and other areas of the body. Metronidazole capsules and tablets are also used to treat sexually transmitted diseases (STDs).
What is the strongest antibiotic for bacterial infection?
Vancomycin, long considered a "drug of last resort," kills by preventing bacteria from building cell walls.
What drugs should not be taken with metronidazole?
Common medications that may interact with metronidazole include:alcohol.anticoagulants, such as warfarin.astemizole.busulfan.cimetidine.disulfiram.lithium.medications that inhibit cytochrome p450 enzymes (CYP2C9 and possibly others), such as phenytoin or phenobarbital.
How many days does it take metronidazole to work?
Metronidazole starts to work 1 to 2 hours after you take it, because it is quickly absorbed, and it reaches its maximum concentration after 20 minutes to 3 hours. But it may take a couple of days before you start to feel better or notice an improvement in your symptoms.
Which is better metronidazole or Flagyl?
Flagyl ER (metronidazole) are all almost identical antimicrobial drugs used to treat bacterial vaginosis (mainly Flagyl ER), trichomonas, amebiasis, and anaerobic bacterial infections.
What antibiotic is similar to metronidazole?
Cefadroxil as an alternative to metronidazole in the treatment of bacterial vaginosis.
Which is better Flagyl or Metrogel?
Conclusion: The most cost-effective treatment for bacterial vaginosis was generic metronidazole. While the use of the more expensive Metrogel Vaginal may be reasonable for patients experiencing side effects of oral metronidazole, most patients should be treated with the less expensive generic metronidazole.
What happens if you drink alcohol with metronidazole?
Drinking alcohol while taking metronidazole is not recommended because the combination of metronidazole and alcohol can cause a reaction (often ref...
How long does it take for metronidazole to work?
Metronidazole starts to work 1 to 2 hours after you take it, because it is quickly absorbed, and it reaches its maximum concentration after 20 minu...
Can metronidazole cause a yeast infection?
About 10% of women report a vaginal yeast infection (vaginal candidiasis) as a side effect of metronidazole treatment. This is because metronidazol...
Does metronidazole treat chlamydia?
Metronidazole does not treat chlamydia and is not a recommended treatment for chlamydia, but it may be given if symptoms of chlamydia persist after...
Can you have sex while taking metronidazole?
If you are taking oral metronidazole or using metronidazole gel for an infection that is linked with sexual activity, such as trichomoniasis, pelvi...
What medications can affect metronidazole?
Many drugs can affect metronidazole, especially: an antidepressant; asthma medication; cancer medicine; heart or blood pressure medication; lithium or other antipsychotic medicine; medicine to treat malaria, HIV, or other infection; or. a blood thinner - warfarin, Coumadin, Jantoven.
How long does metronidazole last?
Metronidazole is usually given for up to 10 days in a row. You may need to repeat this dosage several weeks later.
How long after taking metronidazole can you breastfeed?
You should not breastfeed within 24 hours after using metronidazole. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Metronidazole is not approved for use in children younger than 12 years old, or in girls who have not begun having menstrual periods.
Can you take metronidazole while pregnant?
Do not take metronidazole during the first trimester of pregnancy. This medicine can harm an unborn baby. Tell your doctor if you are pregnant. To make sure this medicine is safe for you, tell your doctor if you have ever had: liver disease; kidney disease (or if you are on dialysis); a heart rhythm disorder;
Can you drink alcohol while taking metronidazole?
While you are taking metronidazole and for 3 days after your last dose: Avoid drinking alcohol or consuming foods or other products that contain alcohol or propylene glycol. Drinking alcohol may cause unpleasant effects such as headaches, nausea, vomiting, stomach cramps, and warmth or tingling under your skin.
Can metronidazole cause cancer?
a blood cell disorder such as anemia (lack of red blood cells) or low white blood cell (WBC) counts; a nerve disorder. In animal studies, metronidazole caused certain types of tumors, some of which were cancerous. However, it is not known whether these effects would occur in humans. Ask your doctor about your risk.
Can metronidazole affect blood levels?
Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tell your doctor about all your current medicines. Many drugs can affect metronidazole, especially: an antidepressant; asthma medication; cancer medicine;
When was metronidazole first used?
Metronidazole began to be commercially used in 1960 in France. It is on the World Health Organization's List of Essential Medicines. It is available in most areas of the world. In 2018, it was the 119th most commonly prescribed medication in the United States, with more than 5 million prescriptions.
Why is metronidazole used in women?
Metronidazole has also been used in women to prevent preterm birth associated with bacterial vaginosis, amongst other risk factors including the presence of cervicovaginal fetal fibronectin (fFN).
How long does metronidazole stay in the body?
The biological half-life in healthy adults is eight hours, in infants during the first two months of their lives about 23 hours, and in premature babies up to 100 hours.
How is metronidazole metabolized?
About 60% of the metronidazole is metabolized by oxidation to the main metabolite hydroxymetronidazole and a carboxylic acid derivative, and by glucuronidation. The metabolites show antibiotic and antiprotozoal activity in vitro.
Why is metronidazole used in veterinary medicine?
Food and Drug Administration (FDA) suggests it only be used when necessary because it has been shown to be carcinogenic in mice and rats, as well as to prevent antimicrobial resistance.
How long does it take for metronidazole to peak?
Oral metronidazole is approximately 80% bioavailable via the gut and peak blood plasma concentrations occur after one to two hours. Food may slow down absorption but does not diminish it. Of the circulating substance, about 20% is bound to plasma proteins.
How is 2-methylidazole prepared?
2-Methylimidazole ( 1) may be prepared via the Debus-Radziszewski imidazole synthesis, or from ethylenediamine and acetic acid, followed by treatment with lime, then Raney nickel. 2-Methylimidazole is nitrated to give 2-methyl-4 (5)-nitroimidazole ( 2 ), which is in turn alkylated with ethylene oxide or 2-chloroethanol to give metronidazole ( 3 ):
Does the strength of metronidazole affect its pricing? For example, do 500-mg tablets cost more than 250-mg tablets?
It’s possible. Depending on your insurance plan and coverage, the price of metronidazole may vary based on the strength your doctor prescribes.
Why are metronidazole gel and cream more expensive than other forms of metronidazole?
Often, metronidazole creams and gels cost more due to their added ingredients and packaging. Creams and gels can only be prescribed as an entire tube or jar. Tablets and capsules usually come in larger containers and are divided up into many prescriptions.
How much does metronidazole cost without insurance?
Metronidazole will likely cost more without insurance than with insurance. Other factors may include the quantity, strength, and the form of metronidazole your doctor prescribes.
What is the purpose of metronidazole?
Metronidazole is used to treat a certain type of vaginal infection ( bacterial vaginosis) in women who are not pregnant. Metronidazole is an antibiotic that works by stopping the growth of bacteria. Metronidazole is available under the following different brand names: Flagyl, Flagyl ER, and Flagyl IV RTU. Dosage of Metronidazole: ...
How many pregnant women have metronidazole?
There are published data from case-control studies, cohort studies, and 2 meta-analyses that included more than 5000 pregnant women who used metronidazole systemically during pregnancy. Many studies included first trimester exposures. One study showed an increased risk of cleft lip, with or without cleft palate, ...
Can you take metronidazole while breastfeeding?
Metronidazole is excreted in human milk; it is not recommended for use while breastfeeding.
Can you drink alcohol while taking Metronidazole?
Avoid alcohol while taking medication and for at least 1 day after discontinuation. Antiandrogen: May cause gynecomastia. Known or previously unrecognized candidiasis may present more prominent symptoms during therapy with Metronidazole Injection and requires treatment with a candicidal agent. Pregnancy and Lactation.
Can you take Flagyl IV RTU?
This medication contains metronidazole. Do not take Flagyl, Flagyl ER, or Flagyl IV RTU if you are allergic to metronidazole or any ingredients contained in this drug. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
How to report metronidazole side effects in Canada?
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking metronidazole, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as tinidazole ); or if you have any other allergies.
Can antibiotics affect birth control?
Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.
What is the trade name for Metronidazole?
Metronidazole is also used in the treament of the dermatological condition rosacea, where it is marketed by Galderma under the trade names Rozex® and MetroGel®. Brand Name (s): Flagyl; MetroCream; MetroGel; MetroGel-Vaginal. CAS nº: 443-48-1. (me-troe-NI-da-zole)
When was metronidazole approved?
Metronidazole was approved by the FDA in 1963. Metronidazole is approved for the treatment of amebic dysentery, amebic liver abscess, trichomoniasis anaerobic infection, bacterial vaginosis, and rosacea. Off-lable, it is also indicated for antibiotic induced pseudo membranous enterocolitis and giardiasis.
How often should I apply metronidazole gel?
The usual treatment of rosacea is by application of metronidazole gel twice daily. The usual dose of the vaginal form of metronidazole gel is one full applicator (containing 37.5mg of metronidazole) intravaginally twice daily for 5 days. It should be applied once in the morning and once in the evening.
What is the MNZ brand?
The reference site for Metronidazole. Metronidazole (MNZ), marketed under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis.
What is the drug used for colon infection?
Metronidazole is also used in treating colon infection caused by a bacteria called C. difficile. However, it is important that you first talk to your doctor about the possible risks of using this drug for your particular condition. Dosage and using this medicine. USAGE.
Is metronidazole a man made drug?
Metronidazole is a man-made drug that is effective against certain bacteria and parasites (protozoa). It is used for treating vaginal infections with protozoa such as Trichomonas vaginalis, ameba, and giardia and also is effective against anaerobic bacterial infections (anaerobic bacteria are a type of bacteria that grow without oxygen).
Can you drink alcohol while taking metronidazole?
Do not, however, take metronidazole without first talking to your doctor if you are pregnant. Furthermore, this medication passes into breast milk and may affect a nursing infant, so do not take this medication without first talking to your doctor. Do not drink alcohol while taking metronidazole.
Overview
Metronidazole is an antibiotic that is used to treat a wide variety of infections.
May Treat: Trichomoniasis · Acute intestinal amebiasis due to Entamoeba histolytica · Lower respiratory infection · Liver abscess amebiasis due to Entamoeba histolytica · Bacteroides liver abscess and more
Brand Names: Flagyl · Metrogel · Noritate · MetroCream · Rosadan and more
Drug Class: Antiprotozoal-Antibacterial 1st Generation 2-methyl-5-nitroimidazole · Dermatological - Rosacea Therapy, Topical · Vaginal Antiprotozoal-Antibacterial - Nitroimidazole Derivatives
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Trichomoniasis · Acute intestinal amebiasis due to Entamoeba histolytica · Lower respiratory infection · Liver abscess amebiasis due to Entamoeba histolytica · Bacteroides liver abscess and more
Brand Names: Flagyl · Metrogel · Noritate · MetroCream · Rosadan and more
Drug Class: Antiprotozoal-Antibacterial 1st Generation 2-methyl-5-nitroimidazole · Dermatological - Rosacea Therapy, Topical · Vaginal Antiprotozoal-Antibacterial - Nitroimidazole Derivatives
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Avoid intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
- Use sunscreen
- For gel with applicator products : If available, read the patient package insert. Read instructions carefully. Insert into the vagina as directed. Avoid alcohol during therapy & 24 hrs after. Usually used at bedtime. Avoid alcohol in drinks, foods, and medicines. Refrain from intercourse during therapy. Call doctor if you are not better in 5 days.
- For lotion products : For external use only. Wash hands before and after using. Clean and dry skin, then use a thin layer on area. Keep away from eyes. Avoid sun lamps/prolonged direct sun. Call doctor if you are not better in 3 weeks. Ask doctor before use in other conditions. Follow directions on best place to keep drug supply.
- Use sunscreen
- For gel with applicator products : If available, read the patient package insert. Read instructions carefully. Insert into the vagina as directed. Avoid alcohol during therapy & 24 hrs after. Usually used at bedtime. Avoid alcohol in drinks, foods, and medicines. Refrain from intercourse during therapy. Call doctor if you are not better in 5 days.
- For lotion products : For external use only. Wash hands before and after using. Clean and dry skin, then use a thin layer on area. Keep away from eyes. Avoid sun lamps/prolonged direct sun. Call doctor if you are not better in 3 weeks. Ask doctor before use in other conditions. Follow directions on best place to keep drug supply.
- For tablet products : Avoid alcohol during and for 3 days after therapy. Take with food or milk to lessen stomach upset. Take with meals at evenly spaced intervals. May make you dizzy. Use caution when driving. Success is dependent on completing therapy course. May darken urine while taking this drug. Review all drugs you are taking with your doctor.
Brand name
Medical uses
Adverse effects
Drug interactions
Pharmacology
In India, it is sold under the brand name Metrogyl and Flagyl. In Bangladesh, it is available as Amodis, Amotrex, Dirozyl, Filmet, Flagyl, Flamyd, Metra, Metrodol, Metryl, etc. In Pakistan, it is sold under the brand name of Flagyl and Metrozine.
History
Metronidazole is primarily used to treat: bacterial vaginosis, pelvic inflammatory disease (along with other antibacterials like ceftriaxone), pseudomembranous colitis, aspiration pneumonia, rosacea (topical), fungating wounds (topical), intra-abdominal infections, lung abscess, periodontitis, amoebiasis, oral infections, giardiasis, trichomoniasis, and infections caused by susceptible anaerobic org…
Synthesis
Common adverse drug reactions (≥1% of those treated with the drug) associated with systemic metronidazole therapy include: nausea, diarrhea, weight loss, abdominal pain, vomiting, headache, dizziness, and metallic taste in the mouth. Intravenous administration is commonly associated with thrombophlebitis. Infrequent adverse effects include: hypersensitivity reactions (rash, itch, flushing, fever), headache, dizziness, vomiting, glossitis, stomatitis, dark urine, and paraesthesia. …