Seminomatous tumors are the germ cell tumors composed of cells that resemble primordial germ cells or early gonocytes whereas nonseminomatous tumors are the masses that contain undifferentiated embryonic stem cells that can differentiate among different cell lines. Seminomas have differentiated cells, but nonseminomas have undifferentiated cells.
What is the difference between nonseminoma and seminal tumor?
Accordingly, seminomas have differentiated cells, unlike the nonseminomas that are composed of undifferentiated cells that have the potential to differentiate along any cell lineage. This can be considered as the key difference between these tumors. 1. Overview and Key Difference
What is the difference between germ cell tumors and nonseminomatous tumors?
Summary - Seminoma vs Nonseminoma Seminomatous tumors are the germ cell tumors composed of cells that resemble primordial germ cells or early gonocytes whereas nonseminomatous tumors are the masses that contain undifferentiated embryonic stem cells that can differentiate among different cell lines.
What is the pathophysiology of nonseminomatous tumors?
Nonseminomatous tumors contain undifferentiated embryonic stem cells that can differentiate among different cell lines.
What are the different types of seminoma?
Subtypes of seminoma include: Spermatocytic seminoma: tend to occur in older men and has an excellent prognosis Seminomas can secrete human chorionic gonadotropin (HCG) but do not secrete other tumor markers (see the section on tumor markers for more details).
What are the 2 types of testicular cancer?
The most common type of testis cancer is a germ cell tumor. There are two main types of GCT: seminoma and nonseminomatous germ cell tumors (NSGCT). Both seminoma and NSGCT occur at about the same rate, and men can have seminoma, NSGCT or a combination of both.
What is a seminoma?
(SEH-mih-NOH-muh) A type of cancer that begins in germ cells in males. Germ cells are cells that form sperm in males or eggs in females. Seminomas occur most often in the testicle, but they may also occur in other areas of the body, such as the brain, chest, or abdomen. Seminomas tend to grow and spread slowly.
Is non seminoma worse than seminoma?
Seminomas tend to grow and spread more slowly than non-seminomas. The 2 main sub-types of these tumors are classical (or typical) seminomas and spermatocytic seminomas.
What is the difference between seminomas and Nonseminomas quizlet?
Seminomas Occur in 30 - 60 year olds and are slow growing. Nonseminomas Occur in late teens to early 40s and are more aggressive and resistant to radiation.
Is a seminoma benign or malignant?
Seminoma is a malignant germ cell tumor that involves most commonly the testicle or less frequently the mediastinum, the retroperitoneum, or other extra-gonadal sites. They are common among men ages 15-34 years old.
Where does seminoma metastasize?
Metastatic spread of seminoma predominantly occurs via the lymphatic drainage pathways to the retroperitoneal lymph nodes with 84–94% developing in para-aortic lymph nodes.
How fast does non seminoma grow?
The median lymph node growth rate for patients with seminoma was 1.35 mm/month (range 0.62-4.56) and for patients with non-seminoma 2.99 mm/month (range 0.77-7.06); the difference in growth rates was statistically significant (P=0.029).
Is non seminoma curable?
Stage I non-seminomas Nearly all of these cancers can be cured, but the treatment is different from that of seminomas. As with seminomas, the initial treatment is surgery to remove the testicle and tumor (called radical inguinal orchiectomy). The other treatment choices will depend on the stage.
Does seminoma spread fast?
The 2 most common types of testicular cancer are: Seminomas. These tumors tend to grow and spread slower than most other testicular cancers.
What Tumour marker is raised in seminoma?
Testicular Lactate Dehydrogenase (LDH) LDH is expressed on chromosome 12p, which is often amplified in testis cancer cells. LDH is less specific for testis cancer than HCG or AFP. However, elevated LDH levels are correlated to high tumor burden in seminoma and recurrence in NSGCT.
Can you still father a child after seminoma?
You have surgery to remove the testicle. This doesn't usually affect your ability to have children.
What is the most common testicular malignancy?
The most common type of testicular cancer is germ cell testicular cancer, which accounts for around 95% of all cases. Germ cells are a type of cell that the body uses to create sperm.
What is the cause of seminoma?
Testicular seminoma originates in the germinal epithelium of the seminiferous tubules. The disease is thought to result from the proliferation of immature spermatogonia.
What are symptoms of seminoma?
SymptomsA feeling of heaviness in the scrotum.Pain or discomfort in a testicle or the scrotum.A dull ache in the abdomen or groin.The build-up of fluid in the scrotum.Breast tenderness and growth (due to the secretion of the hormone estrogen by the tumor)Lower back pain (if the tumor has spread to nearby lymph nodes)
Is seminoma curable?
Stage I seminomas These cancers can be cured in nearly all patients. Surgery is done first to remove the testicle and spermatic cord (called a radical inguinal orchiectomy).
What is the prognosis of seminoma?
Good prognosis means that the seminoma has spread only to the lymph nodes or the lungs. It has not spread anywhere else. Intermediate prognosis means that the seminoma has spread beyond the lung or lymph nodes. It has spread to other parts of the body, such as the brain or liver.
Where does seminoma occur?
Usually metastasis: Seminoma can occur in testes or the mediastinum as the primary tumor, it is classified as one of the germ cell tumors. If there is regional paraaorti ... Read More
How long does it take for a seminoma to regenerate?
More info: If u got chemo, it may take a few years to regenerate sperm. Also, seminoma is often treated with radiation but they likely shielded your left testis. ... Read More
What is the difference between a hernia and testicle cancer?
Pathology: Hernia is benign happened secondary to abdominal muscle weakness while testicular cancer is malignant growth.
What percentage of testicle tumors are germ cells?
Different tumors: Over 90% of testis tumors are germ cell tumors which are seminoma, non-seminoma or mixed depending on the type of malignant cell. Classic seminoma i ... Read More
Does non seminoma testicular cancer made up of embryonic and yolk sac spread and where to?
Can spread: Can spread to any part of the body including the brain ; need full body scan to eval.
Which type of seminoma tends to spread more slowly?
Seminomas tend to grow and spread more slowly than NSGCT, although some seminomas can grow very rapidly. Subtypes of seminoma include: Classic seminoma: 95 percent of seminomas are classic. Spermatocytic seminoma: tend to occur in older men and has an excellent prognosis.
What percentage of testicle tumors are stromal?
Stromal Tumors. Tumors can also develop from the supportive tissues around the germ cells in the testicle. These tumors are rare, making up less than 5 percent of testis cancers, and have an excellent prognosis if surgically resected. There are two types of stromal tumors:
What are the different types of testicular cancer?
Types of Testicular Cancer. Testicular Cancer. The most common type of testis cancer is a germ cell tumor. There are two main types of GCT: seminoma and nonseminomatous germ cell tumors (NSGCT). Both seminoma and NSGCT occur at about the same rate, and men can have seminoma, NSGCT or a combination of both. There are several differences between ...
Is teratoma a mixed NSGCT?
Teratoma: most often appear as a mixed NSGCT; usually grow locally but can appear in retroperitoneal lymph nodes. Teratoma is chemotherapy- and radiation-resistant and best treated with surgical removal.
Can a seminoma be treated with chemotherapy?
If seminoma spreads from the testicle, it is most often and best treated with chemotherapy and/or radiation. Surgery can be performed in some cases.
What is the difference between a seminoma and a nonseminoma?
Seminomatous tumors are the germ cell tumors composed of cells that resemble primordial germ cells or early gonocytes whereas nonseminomatous tumors are the masses that contain undifferentiated em bryonic stem cells that can differentiate among different cell lines. Seminomas have differentiated cells, but nonseminomas have undifferentiated cells. This can be taken as the key difference between these tumors.
Can a yolk sac tumor be life threatening?
This is the commonest testicular tumor in infants and children who are below 3 years of age. Although there is a very good prognosis in the above age group, yolk sac tumors in adults can be life threatening. Histologically these tumors are nonencapsulated and have a mucinous appearance. Papillary structures can also be seldom found within them.
Is choriocarcinoma a nodule?
They do not give rise to an enlargement of the testicles and will be presented as a palpable nodule. There are two cell types in these tumors as syncytiotrophoblasts and cytotrophoblasts.
