Precautions
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What is the most common side effect of donepezil?
The most common adverse events were diarrhea, muscle cramps, fatigue, nausea, vomiting, anorexia and insomnia.
Why is donepezil taken at night?
The drug is also available in 5 mg and 10 mg orally disintegrating tablets. The package insert recommends that donepezil be administered in the evening just before retiring. Nighttime administration was suggested to prevent the patient from experiencing the side effects during the day.
What are the side effects of taking donepezil?
What side effects can this medication cause?nausea.vomiting.diarrhea.loss of appetite.weight loss.frequent urination.difficulty controlling urination.muscle cramps.More items...•
How long should a dementia patient take donepezil?
Donepezil (5 and 10 mg) is an agent with a simple once-daily dosage schedule which improves cognition and global clinical function in the short (up to 24 weeks) and long term (up to about 1 year) in patients with mild to moderate Alzheimer's disease.
What happens when you stop taking donepezil?
Terminating treatment, especially abruptly, is not without consequences for the patient. It has been reported that intense hallucinations can occur after sudden donepezil withdrawal [2]. One published study has suggested that discontinuation of treatment with donepezil may bring withdrawal symptoms [3].
Is 10 mg of donepezil a lot?
For mild to moderate Alzheimer's disease: Adults—5 milligrams (mg) taken at bedtime. Your doctor may increase your dose as needed. However, the dose usually is not more than 10 mg per day.
What are the 3 foods that fight memory loss?
What are the foods that fight memory loss? Berries, fish, and leafy green vegetables are 3 of the best foods that fight memory loss. There's a mountain of evidence showing they support and protect brain health.
Can donepezil harm you?
People who take donepezil can experience adverse effects such as nausea, vomiting, diarrhea, urine leakage (incontinence), vivid dreams, slowed heart rate, drowsiness, and weakness. These can pose health hazards for patients who already might not be eating well, have cardiovascular problems, or are at risk for falls.
What medicines should not be taken with donepezil?
Do not take this medicine with any of the following medications:certain medicines for fungal infections like itraconazole, fluconazole, posaconazole, and voriconazole.cisapride.dextromethorphan; quinidine.dronedarone.pimozide.quinidine.thioridazine.
Is donepezil worth taking?
Donepezil is more effective than placebo and is well tolerated in improving the major symptoms of this disease. Improvements are usually modest, although stabilization of cognitive and functional symptoms with donepezil can also be considered an important clinical outcome. Donepezil may lessen caregiver burden.
Does donepezil slow down dementia?
Acetylcholinesterase inhibitors, such as donepezil, work by preventing acetylcholine from being broken down. This may improve the symptoms of dementia.
When should you stop donepezil?
These medications should be stopped if the desired effects—stabilizing cognitive and functional status—are not perceived within a reasonable time, such as 12 weeks. In some cases, stopping cholinesterase inhibitor therapy may cause negative effects on cognition and neuropsychiatric symptoms.
Should I take donepezil at night or in the morning?
It's best to take your donepezil at bedtime. This is because you may feel dizzy after you take it. If donepezil gives you bad dreams or makes it hard to sleep, you can take it in the morning instead.
Does donepezil help you sleep?
Conclusions: Donepezil treatment enhanced REM sleep and reduced slow frequencies of REM sleep EEG, suggesting a possible action upon REM sleep-related cholinergic neurons in patients with Alzheimer disease.
Does donepezil make you sleepy?
Donepezil oral tablet doesn't cause drowsiness, but it can cause other side effects.
Does donepezil keep you awake?
Cholinesterase inhibitors, such as donepezil, can improve cognitive and behavioral symptoms in people with Alzheimer's but also can cause insomnia. If the person with dementia is taking these kinds of medications, talk to the doctor.
How should I take donepezil?from drugs.com
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What happens if I overdose?from drugs.com
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking donepezil?from drugs.com
Avoid driving or hazardous activity until you know how donepezil will affect you. Your reactions could be impaired.
What other drugs will affect donepezil?from drugs.com
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen ( Advil, Motrin ), naproxen ( Aleve ), celecoxib ( Celebrex ), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with donepezil may increase your risk of stomach ulcer.
How long does donepezil suspension last?from en.wikipedia.org
Although occurrence of seizures is rare, people who have a predisposition to seizures should be treated with caution. If daily donepezil has suspended for 7 days or less, restarting at the same dose is recommended, while if the suspension lasts longer than 7 days, retitrate from 5 mg daily is suggested.
What is Donepezil used for?from drugs.com
Donepezil is used to help improve mental function in people with Alzheimer's disease.
When did donepezil come out?from en.wikipedia.org
As of 2011, Aricept was the world's best-selling Alzheimer's disease treatment. The first generic donepezil became available in November 2010 with the USFDA approval of a formulation prepared by Ranbaxy Labs.
What is the ingredient in donepezil?from alzheimersdisease.net
Donepezil hydrochloride is the active ingredient in Aricept, and is a reversible inhibitor of acetylcholinesterase. 2
How should I take donepezil?from drugs.com
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What should I avoid while taking donepezil?from drugs.com
Avoid driving or hazardous activity until you know how donepezil will affect you. Your reactions could be impaired.
What other drugs will affect donepezil?from drugs.com
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen ( Advil, Motrin ), naproxen ( Aleve ), celecoxib ( Celebrex ), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with donepezil may increase your risk of stomach ulcer.
What happens if I overdose?from drugs.com
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I know about storage and disposal of this medication?from medlineplus.gov
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
How much do you take donepezil for Alzheimer's?from drugs.com
The effectiveness of Donepezil hydrochloride in the treatment of patients with moderate to severe Alzheimer’s disease was established in studies employing doses of 10 mg/day and 23 mg/day. Results of a controlled clinical trial in moderate to severe Alzheimer’s Disease that compared Donepezil hydrochloride 23 mg once daily to 10 mg once daily suggest that a 23 mg dose of Donepezil hydrochloride provided additional benefit.#N#Swedish 6 Month Study (10 mg/day)#N#The effectiveness of Donepezil hydrochloride as a treatment for severe Alzheimer's disease is demonstrated by the results of a randomized, double-blind, placebo-controlled clinical study conducted in Sweden (6 month study) in patients with probable or possible Alzheimer's disease diagnosed by NINCDS-ADRDA and DSM-IV criteria, MMSE: range of 1 to 10. Two hundred and forty eight (248) patients with severe Alzheimer's disease were randomized to Donepezil hydrochloride or placebo. For patients randomized to Donepezil hydrochloride, treatment was initiated at 5 mg once daily for 28 days and then increased to 10 mg once daily. At the end of the 6 month treatment period, 90.5% of the Donepezil hydrochloride treated patients were receiving the 10 mg/day dose. The mean age of patients was 84.9 years, with a range of 59 to 99. Approximately 77% of patients were women, and 23% were men. Almost all patients were Caucasian. Probable Alzheimer's disease was diagnosed in the majority of the patients (83.6% of Donepezil hydrochloride treated patients and 84.2% of placebo treated patients).
What are some things I need to know or do while I take Donepezil Tablets?from drugs.com
Tell all of your health care providers that you take this medicine (donepezil tablets). This includes your doctors, nurses, pharmacists, and dentists.
How should I take donepezil?from drugs.com
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
How is this medicine (Donepezil Tablets) best taken?from drugs.com
Use this medicine (donepezil tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What happens if I overdose?from drugs.com
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking donepezil?from drugs.com
Avoid driving or hazardous activity until you know how donepezil will affect you. Your reactions could be impaired.
What other drugs will affect donepezil?from drugs.com
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen ( Advil, Motrin ), naproxen ( Aleve ), celecoxib ( Celebrex ), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with donepezil may increase your risk of stomach ulcer.
What should I know about storage and disposal of this medication?from medlineplus.gov
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
How is donepezil metabolized?from go.drugbank.com
Donepezil is metabolized by first pass metabolism in the liver, primarily by CYP3A4, in addition to CYP2D6. After this, O-dealkylation, hydroxylation, N-oxidation, hydrolysis, and O-glucuronidation occur, producing various metabolites with similar half-lives to the unchanged parent drug. A study of the pharmacokinetics of radiolabeled donepezil demonstrated that about 53% of plasma radioactivity appeared as donepezil in the unchanged form, and 11% was identified as the metabolite 6-O-desmethyl donepezil, which exerts similar potency inhibition of the acetylcholinesterase enzyme. 8, 19 This drug is heavily metabolized to four primary metabolites, two of which are considered pharmacologically active, as well as to multiple inactive and unidentified metabolites. 19
What is Donepezil used for?from go.drugbank.com
Summary. Donepezil is an acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
How long does it take for donepezil to be absorbed?from go.drugbank.com
Donepezil is slowly absorbed via the gastrointestinal tract after oral administration. Tmax is 3 to 4 hours with a bioavailability of 100% and steady-state concentrations are attained within 15 to 21 days of administration. 8 The Tmax in one pharmacokinetic study determined a Tmax of 4.1 ± 1.5 hours. 6 The Cmax of 5 mg donepezil tablets is estimated to be 8.34 ng/mL, according to the Canadian monograph. 23 The AUC of 5 mg donepezil tablets has been determined to be 221.90-225.36 ng.hr/mL. 23
How long does donepezil suspension last?from en.wikipedia.org
Although occurrence of seizures is rare, people who have a predisposition to seizures should be treated with caution. If daily donepezil has suspended for 7 days or less, restarting at the same dose is recommended, while if the suspension lasts longer than 7 days, retitrate from 5 mg daily is suggested.
How long does donepezil last?from go.drugbank.com
The average elimination half-life of donepezil is about 70 hours according to the results of various studies and the FDA label for donepezil. 8, 19. One pharmacokinetic study determined the average terminal half-life to be 81.5±22.0 h 6
When did donepezil come out?from en.wikipedia.org
As of 2011, Aricept was the world's best-selling Alzheimer's disease treatment. The first generic donepezil became available in November 2010 with the USFDA approval of a formulation prepared by Ranbaxy Labs.
When was Aricept developed?from en.wikipedia.org
10 mg Aricept pill. Research leading to the development of donepezil began in 1983 at Eisai, and in 1996, Eisai received approval from the United States Food and Drug Administration (USFDA) for donepezil under the brand Aricept, which it co-marketed with Pfizer. The team at Eisai was led by Hachiro Sugimoto.
What are some things I need to know or do while I take Donepezil Tablets?from drugs.com
Tell all of your health care providers that you take this medicine (donepezil tablets). This includes your doctors, nurses, pharmacists, and dentists.
How should I take donepezil?from drugs.com
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
How is this medicine (Donepezil Tablets) best taken?from drugs.com
Use this medicine (donepezil tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What happens if I overdose?from drugs.com
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking donepezil?from drugs.com
Avoid driving or hazardous activity until you know how donepezil will affect you. Your reactions could be impaired.
What other drugs will affect donepezil?from drugs.com
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen ( Advil, Motrin ), naproxen ( Aleve ), celecoxib ( Celebrex ), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with donepezil may increase your risk of stomach ulcer.
How much do you take donepezil for Alzheimer's?from drugs.com
The effectiveness of Donepezil hydrochloride in the treatment of patients with moderate to severe Alzheimer’s disease was established in studies employing doses of 10 mg/day and 23 mg/day. Results of a controlled clinical trial in moderate to severe Alzheimer’s Disease that compared Donepezil hydrochloride 23 mg once daily to 10 mg once daily suggest that a 23 mg dose of Donepezil hydrochloride provided additional benefit.#N#Swedish 6 Month Study (10 mg/day)#N#The effectiveness of Donepezil hydrochloride as a treatment for severe Alzheimer's disease is demonstrated by the results of a randomized, double-blind, placebo-controlled clinical study conducted in Sweden (6 month study) in patients with probable or possible Alzheimer's disease diagnosed by NINCDS-ADRDA and DSM-IV criteria, MMSE: range of 1 to 10. Two hundred and forty eight (248) patients with severe Alzheimer's disease were randomized to Donepezil hydrochloride or placebo. For patients randomized to Donepezil hydrochloride, treatment was initiated at 5 mg once daily for 28 days and then increased to 10 mg once daily. At the end of the 6 month treatment period, 90.5% of the Donepezil hydrochloride treated patients were receiving the 10 mg/day dose. The mean age of patients was 84.9 years, with a range of 59 to 99. Approximately 77% of patients were women, and 23% were men. Almost all patients were Caucasian. Probable Alzheimer's disease was diagnosed in the majority of the patients (83.6% of Donepezil hydrochloride treated patients and 84.2% of placebo treated patients).
Does stopping Aricept cause side effects? When and how can you stop taking the drug?from medicalnewstoday.com
The manufacturer of Aricept recommends that you do not stop taking the drug on your own.
What is Aricept?from drugs.com
Aricept (donepezil) improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah SEET il KOE leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning.
How should I take donepezil?from drugs.com
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What happens if I overdose?from drugs.com
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking donepezil?from drugs.com
Avoid driving or hazardous activity until you know how donepezil will affect you. Your reactions could be impaired.
What other drugs will affect donepezil?from drugs.com
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen ( Advil, Motrin ), naproxen ( Aleve ), celecoxib ( Celebrex ), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with donepezil may increase your risk of stomach ulcer.
What should I know about storage and disposal of this medication?from medlineplus.gov
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
How should I take donepezil?from drugs.com
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What happens if I overdose?from drugs.com
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking donepezil?from drugs.com
Avoid driving or hazardous activity until you know how donepezil will affect you. Your reactions could be impaired.
What other drugs will affect donepezil?from drugs.com
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen ( Advil, Motrin ), naproxen ( Aleve ), celecoxib ( Celebrex ), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with donepezil may increase your risk of stomach ulcer.
What should I know about storage and disposal of this medication?from medlineplus.gov
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
How long does donepezil suspension last?from en.wikipedia.org
Although occurrence of seizures is rare, people who have a predisposition to seizures should be treated with caution. If daily donepezil has suspended for 7 days or less, restarting at the same dose is recommended, while if the suspension lasts longer than 7 days, retitrate from 5 mg daily is suggested.
What is Donepezil used for?from drugs.com
Donepezil is used to help improve mental function in people with Alzheimer's disease.
