Precautions
Tapazole prevents the thyroid gland from producing too much thyroid hormone. Tapazole is used to treat hyperthyroidism (overactive thyroid). It is also used before thyroid surgery or radioactive iodine treatment.
What does tapazole do to the thyroid?
Indications and Usage for Tapazole. Tapazole is indicated: In patients with Graves' disease with hyperthyroidism or toxic multinodular goiter for whom surgery or radioactive iodine therapy is not an appropriate treatment option. To ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy.
What is tapazole used for in the treatment of Graves disease?
Indications and Usage for Tapazole. Tapazole is indicated: In patients with Graves' disease with hyperthyroidism or toxic multinodular goiter for whom surgery or radioactive iodine therapy is not an appropriate treatment option.
What are the indications for tapazole?
Tapazole 1 DESCRIPTION. TAPAZOLE ® (Methimazole Tablets, USP) (1-methylimidazole-2-thiol) is a white,... 2 INDICATIONS. In patients with Graves' disease with hyperthyroidism or toxic multinodular goiter... 3 DOSAGE AND ADMINISTRATION. TAPAZOLE is administered orally. 4 HOW SUPPLIED. The 5-mg tablets are round, white to off-white,...
What is tapazole 5mg?
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What are the side effects of taking Tapazole?
Common side effects may include:nausea, vomiting, upset stomach;headache, dizziness, drowsiness;numbness or tingly feeling;rash, itching, skin discoloration;muscle or joint pain;hair loss; or.decreased sense of taste.
What does methimazole do to your body?
Methimazole is used to treat hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone. It is also used before thyroid surgery or radioactive iodine treatment. Methimazole is an antithyroid medicine. It works by making it harder for the body to make thyroid hormone.
How long can you stay on Tapazole?
“Long-term, low-dose methimazole treatment for 60-120 months is a safe and effective treatment for Graves hyperthyroidism and is accompanied by much higher remission rates than the usual 18-24 months of methimazole treatment,” he summarized.
What is the best time to take Tapazole?
Food in your stomach may change the amount of methimazole that is able to enter the bloodstream. To make sure that you always get the same effects, try to take methimazole at the same time in relation to meals every day. That is, always take it with meals or always take it on an empty stomach.
How does methimazole make you feel?
Feeling sleepy. Headache. Muscle or joint pain. Hair loss.
What happens when you stop taking methimazole?
Recap. Skipping or stopping your antithyroid medication or thyroid hormone replacement will lead to undesirable and possibly dangerous effects. Not taking your medication also increases your risk of fatal conditions like myxedema coma if you are hypothyroid, and thyroid storm if you are hyperthyroid.
What foods should be avoided with hyperthyroidism?
A person with hyperthyroidism should avoid eating excessive amounts of iodine-rich foods, such as:iodized salt.fish and shellfish.seaweed or kelp.dairy products.iodine supplements.food products containing red dye.egg yolks.blackstrap molasses.More items...•
Does Graves disease ever go away?
Graves' disease is a lifelong (chronic) condition. However, treatments can keep your thyroid hormone levels in check. Medical care may even make the disease temporarily go away (remission).
What are the long term side effects of methimazole?
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Abnormal loss of hair.changes in skin coloring.difficulty in moving.heartburn.joint pain or swelling.loss of taste.muscle pain, cramps, or stiffness.More items...•
Does Tapazole cause weight gain?
Undergoing treatment for hyperthyroidism can cause excessive weight gain. Maintaining a healthy diet and staying active will aid in weight loss while you take Tapazole.
How quickly does Tapazole work?
Pharmacist tips for methimazole (Tapazole) Methimazole (Tapazole) is usually taken 3 times a day at first, but eventually you will just take it once a day. It may take a few weeks to months before you see your symptoms getting better.
What supplements should not be taken with thyroid medication?
Yes. Calcium supplements — or antacids containing calcium — can interfere with the absorption of thyroid hormone replacement medications, such as synthetic thyroid hormones levothyroxine (Synthroid, Unithroid, others) and liothyronine (Cytomel), as well as thyroid extract supplements.
Does everyone gain weight on methimazole?
During the first six months, experiencing consistent weight gain is most common, followed by a drop-off during treatment for their thyroid disease. However, most patients experienced some degree of weight change for more than 24 months after therapy.
How long does it take methimazole to work?
Results: Within 3 weeks, 40.2% of patients responded to 10 mg of methimazole and 77.5% responded within 6 weeks.
Does methimazole weaken immune system?
However, a slight reduction of PHA-induced IL-2 receptor expression was observed. Although the hypothesis of an effect of MMI on some specialized T cell functions cannot be ruled out, it is likely that the supposed "immunosuppressive" effect of the drug does not concern primarily the T lymphocyte.
Does methimazole cure hyperthyroidism?
Methimazole — Methimazole is usually preferred over propylthiouracil because it reverses hyperthyroidism more quickly and has fewer side effects. Methimazole requires an average of six weeks to lower T4 levels to normal and is often given before radioactive iodine treatment. Methimazole can be taken once per day.
How to take tapazole?
How to use Tapazole. Take this medication by mouth with or without food as directed by your doctor, usually 1 to 3 times a day. Dosage is based on your medical condition and response to treatment. For children, the dosage is also based on their weight. Take this medication exactly as directed.
How to report methimazole side effects in Canada?
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions. Before taking methimazole, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
What is tapazole used for?
What is Tapazole and how is it used? Tapazole is a prescription medicine used to treat the symptoms of Hyperthyroidism (overactive thyroid) and Graves Disease. Tapazole may be used alone or with other medications. Tapazole belongs to a class of drugs called Antithyroid Agents.
How to report side effects of tapazole?
These are not all the possible side effects of Tapazole. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What are the less frequent events of methimazole?
Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression. No information is available on the median lethal dose of the drug or the concentration of methimazole in biologic fluids associated with toxicity and/or death.
Where is methimazole metabolized?
Methimazole is readily absorbed in the gastrointestinal tract, metabolized in the liver, and excreted in the urine.
Can methimazole be used during pregnancy?
Because methimazole crosses placental membranes and can induce goiter and cretinism in the developing fetus, hyperthyroidism should be closely monitored in pregnant women and treatment adjusted such that a sufficient, but not excessive, dose be given during pregnancy. In many pregnant women, the thyroid dysfunction diminishes as the pregnancy proceeds; consequently, a reduction of dosage may be possible. In some instances, anti-thyroid therapy can be discontinued several weeks or months before delivery.
Does methimazole cause thyroid problems?
Because methimazole may cause hypo prothrombinemia and bleeding, prothrombin time should be monitored during therapy with the drug, especially before surgical procedures. Thyroid function tests should be monitored periodically during therapy. Once clinical evidence of hyperthyroidism has resolved, the finding of a rising serum TSH indicates that a lower maintenance dose of TAPAZOLE should be employed.
Does tapazole cause liver failure?
Liver Toxicity. Although there have been reports of hepatotoxicity (including acute liver failure) associated with TAPAZOLE, the risk of hepatotoxicity appears to be less with methimazole than with propylthiouracil , especially in the pediatric population.
What are the less frequent events of methimazole?
Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression. No information is available on the median lethal dose of the drug or the concentration of methimazole in biologic fluids associated with toxicity and/or death.
Where is methimazole metabolized?
Methimazole is readily absorbed in the gastrointestinal tract, metabolized in the liver, and excreted in the urine.
When to switch from propylthiouracil to methimazole?
Given the potential maternal adverse effects of propylthiouracil (e.g., hepatotoxicity), it may be preferable to switch from propylthiouracil to methimazole for the second and third trimesters.
Does methimazole inhibit thyroid hormones?
Methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. The drug does not inactivate existing thyroxine and tri-iodothyronine that are stored in the thyroid or circulating in the blood nor does it interfere with the effectiveness of thyroid hormones given by mouth or by injection. ...
Is methimazole safe for sore throat?
General. Patients who receive methimazole should be under close surveillance and should be cautioned to report immediately any evidence of illness, particularly sore throat, skin eruptions, fever, headache, or general malaise.
Is methimazole soluble in water?
Methimazole (1-methylimidazole-2-thiol) is a white, crystalline substance that is freely soluble in water. It differs chemically from the drugs of the thiouracil series primarily because it has a 5- instead of a 6-membered ring.
Can tapazole cause thyroid problems?
Tapazole can cause hypothyroidism necessitating routine monitoring of TSH and free T4 levels with adjustments in dosing to maintain a euthyroid state. Because the drug readily crosses placental membranes, methimazole can cause fetal goiter and cretinism when administered to a pregnant woman. For this reason, it is important that a sufficient, but not excessive, dose be given during pregnancy (see PRECAUTIONS, Pregnancy ).
Tapazole Description
Methimazole is used to treat overactive thyroid (hyperthyroidism).
May Treat: Hyperthyroidism
Drug Class: Antithyroid Agents, Thionamides - Imidazole Derivatives
Availability: Prescription sometimes needed
Pregnancy: Consult your doctor. This medication may be harmful to an unborn child.
Lactation: Consult a doctor before using
May Treat: Hyperthyroidism
Drug Class: Antithyroid Agents, Thionamides - Imidazole Derivatives
Availability: Prescription sometimes needed
Pregnancy: Consult your doctor. This medication may be harmful to an unborn child.
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
Manufacturer: ELI LILLY & CO. · MONARCH PHRM · PFIZER US PHARM
- Tell doctor if you think you are pregnant
- Take at the same time(s) daily as directed
- Call MD if new abdominal pain/yellowing eyes/skin
- Tell doctor if you think you are pregnant
- Take at the same time(s) daily as directed
- Call MD if new abdominal pain/yellowing eyes/skin
- Call MD now for fever, chills, cough or fatigue.
- Do not increase dose or frequency or prolong use.
- Lab tests may be ordered to monitor therapy
- Call doctor if you are not getting better
- Review all drugs you are taking with your doctor
Tapazole - Clinical Pharmacology
Indications and Usage For Tapazole
Contraindications
Warnings
Precautions
- Methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. The drug does not inactivate existing thyroxine and tri-iodothyronine that are stored in the thyroid or circulating in the blood nor does it interfere with the effectiveness of thyroid hormones given by mouth or by injection. Methimazol...
Adverse Reactions
- Tapazole is indicated: 1. In patients with Graves' disease with hyperthyroidism or toxic multinodular goiter for whom surgery or radioactive iodine therapy is not an appropriate treatment option. 2. To ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy.
Overdosage
- Tapazole is contraindicated in the presence of hypersensitivity to the drug or any of the other product components.
Tapazole Dosage and Administration
- First Trimester Use of Methimazole and Congenital Malformations
Methimazole crosses the placental membranes and can cause fetal harm, when administered in the first trimester of pregnancy. Rare instances of congenital defects, including aplasia cutis, craniofacial malformations (facial dysmorphism; choanal atresia), gastrointestinal malformatio… - Agranulocytosis
Agranulocytosis is potentially a life-threatening adverse reaction of Tapazole therapy. Patients should be instructed to immediately report to their physicians any symptoms suggestive of agranulocytosis, such as fever or sore throat. Leukopenia, thrombocytopenia, and aplastic anem…
How Is Tapazole Supplied
- General
Patients who receive methimazole should be under close surveillance and should be cautioned to report immediately any evidence of illness, particularly sore throat, skin eruptions, fever, headache, or general malaise. In such cases, white-blood-cell and differential counts should be … - Information for Patients
Patients should be advised that if they become pregnant or intend to become pregnant while taking an antithyroid drug, they should contact their physician immediately about their therapy. Inform patients that cases of vasculitis resulting in severe complications have occurred with Ta…