Precautions
What kind of infections does Zosyn treat?
- a bacterial infection
- presumed infection in neutropenic patient with fever
- bacterial pneumonia caused by Haemophilus influenzae
- pneumonia caused by bacteria
- nosocomial bacterial pneumonia
- hospital-acquired pneumonia from Staphylococcus bacteria
- cystic fibrosis and infection from Pseudomonas bacteria
- appendicitis caused by Escherichia coli bacteria
What conditions does Zosyn treat?
Zithromax Z – PAK is used to treat middle ear infection (otitis media), tonsillitis, laryngitis, bronchitis, pneumonia, sinusitis, and sexually transmitted infectious diseases (STDs) such as nongonococcal urethritis and cervicitis.
What STD is Zithromax used to treat?
Zithromax is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases.
What is the drug Zithromax used to treat?
How much does zosyn cost? The cost for Zosyn intravenous powder for injection (2 g-0.25 g) is around $81 for a supply of 10 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How much does Zosyn cost?
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What kind of infections does ZOSYN treat?
ZOSYN is indicated in adults for the treatment of uncomplicated and complicated skin and skin structure infections, including cellulitis, cutaneous abscesses and ischemic/diabetic foot infections caused by beta-lactamase producing isolates of Staphylococcus aureus.
Is ZOSYN a strong antibiotic?
Yes. Zosyn (piperacillin / tazobactam) is a broad spectrum antibiotic, which means that it works against many types of bacteria. This is why it is often used for people who are very sick or have serious infections.
How long can you take ZOSYN?
The usual total daily dose of ZOSYN for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). The usual duration of ZOSYN treatment is from 7 to 10 days.
Who should not take ZOSYN?
ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors.
Is zosyn hard on the liver?
Piperacillin-tazobactam has been linked with idiosyncratic liver injury, including cases of DRESS and cholestatic liver injury that can be prolonged and even fatal.
What are the side effects of zosyn?
Nausea, constipation, diarrhea, headache, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
Does zosyn affect the kidneys?
If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn. Precautions section stating that combined use of these two drugs may be associated with an increased incidence of acute kidney injury.
Can zosyn cause liver damage?
Most cases of liver injury related to piperacillin are linked to the combination of piperacillin with the beta-lactamase inhibitor tazobactam (Zosyn and generics), which is more commonly used than piperacillin alone. Likelihood score: B (known rare cause of clinically apparent liver injury).
How many times a day is zosyn given?
The usual total daily dosage of ZOSYN for adult patients with indications other than nosocomial pneumonia is 3.375 g every six hours [totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam)], to be administered by intravenous infusion over 30 minutes. The usual duration of ZOSYN treatment is from 7 to 10 days.
How do you know if zosyn is working?
Your doctor will check your or your child's progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.
How long does IV zosyn stay in your system?
Following single or multiple ZOSYN doses to healthy subjects, the plasma half-life of piperacillin and of tazobactam ranged from 0.7 to 1.2 hours and was unaffected by dose or duration of infusion.
Is zosyn expensive?
The cost for Zosyn intravenous solution (2 g-0.25 g/50 mL) is around $394 for a supply of 1200 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans....Intravenous Solution.QuantityPer unitPrice1200 (12 x 100 milliliters)$0.28$330.16
How do you know if Zosyn is working?
Your doctor will check your or your child's progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.
How long does IV Zosyn stay in your system?
Following single or multiple ZOSYN doses to healthy subjects, the plasma half-life of piperacillin and of tazobactam ranged from 0.7 to 1.2 hours and was unaffected by dose or duration of infusion.
Why is Zosyn 4 hours?
Studies published in the medical literature support the concept that extending the infusion time of P-TZ to 4 hours maximizes the pharmacodynamic activity.
Can Zosyn cause liver damage?
Most cases of liver injury related to piperacillin are linked to the combination of piperacillin with the beta-lactamase inhibitor tazobactam (Zosyn and generics), which is more commonly used than piperacillin alone. Likelihood score: B (known rare cause of clinically apparent liver injury).
What is a Zosyn?
ZOSYN is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a beta-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.
How much tazobactam is removed from hemodialysis?
Peritoneal dialysis removes approximately 6% and 21% of the piperacillin and tazobactam doses, respectively, with up to 16% of the tazobactam dose removed as the tazobactam metabolite. For dosage recommendations for patients undergoing hemodialysis [see DOSAGE AND ADMINISTRATION ].
How long does tazobactam last in plasma?
Following single or multiple ZOSYN doses to healthy subjects, the plasma half-life of piperacillin and of tazobactam ranged from 0.7 to 1.2 hours and was unaffected by dose or duration of infusion.
What is the chemical structure of tazobactam?
The chemical structure of tazobactam sodium is: ZOSYN (piperacillin and tazobactam) for Injection, is a white to off-white sterile, cryodesiccated powder consisting of piperacillin and tazobactam as their sodium salts packaged in glass vials.
How much tazobactam is in a Zosyn vial?
Each ZOSYN 2.25 g vial provides piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. Each ZOSYN 3.375 g vial provides piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam.
What is a Zosyn injection?
ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam so dium for intravenous administration.
Where is piperacillin found in the body?
Piperacillin and tazobactam are widely distributed into tissues and body fluids including intestinal mucosa, gallbladder, lung, female reproductive tissues (uterus, ovary, and fallopian tube), interstitial fluid, and bile. Mean tissue concentrations are generally 50% to 100% of those in plasma.
What are some things I need to know or do while I take Zosyn?
Tell all of your health care providers that you take Zosyn. This includes your doctors, nurses, pharmacists, and dentists.
What are the side effects of Zosyn that I need to call my doctor about immediately?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
What are some other side effects of Zosyn?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
How do I store and/or throw out Zosyn?
If you need to store Zosyn at home, talk with your doctor, nurse, or pharmacist about how to store it.
What are the symptoms of an allergic reaction?
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
How old do you have to be to take Zosyn?
If you are 65 or older , use Zosyn with care. You could have more side effects.
What are the signs of kidney problems?
Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
What are the side effects of Zosyn (piperacillin / tazobactam)?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
What is Zosyn a combination of?
Zosyn (piperacillin / tazobactam) is a combination of 2 antibiotic medications, piperacillin and tazobactam. Piperacillin is an antibiotic that kills bacteria by preventing them from making their own protective covering.
How long does it take for Zosyn to work?
Zosyn (piperacillin / tazobactam) will start working right away to fight the infection in your body. You should start to feel better within 2 days, but be sure to finish all of your medication even if you feel like you don't need it anymore. If you are feeling worse after 2 days, check back with your healthcare provider because the Zosyn (piperacillin / tazobactam) might not be working well against the bacteria that's causing the infection.
What to know before taking Zosyn?
Before using Zosyn (piperacillin / tazobactam), tell your provider if you have kidney problems, have a history of seizures, or follow a low-sodium diet. You will need to have more frequent blood tests while using this medication.
What does it mean when you have a rash on your face?
Tell your provider or get medical help right away if you get a rash, itchy skin, trouble breathing, or swelling in your face and mouth. This can be a sign of an allergic reaction.
Can you take Zosyn if you are allergic to cephalosporins?
Before taking Zosyn (piperacillin / tazobactam) tell your provider if you are allergic to penicillins, cephalosporins, or any other antibiotics - serious allergic reactions can happen if you have a history of allergies to these medications.
Is Zosyn a penicillin?
Zosyn (piperacillin / tazobactam) contains piperacillin, which is a penicillin-type antibiotic. It works against some of the same bacteria that regular penicillin does, as well as many others because it is combined with tazobactam. If you're allergic to penicillin, you'll want to be careful about taking Zosyn (piperacillin / tazobactam) since there is a risk that it will cause your body to have a similar allergic reaction as it did with penicillin.
What is Zosyn used for?
Zosyn is a combination of penicillin and beta-lactamase inhibitors used for the treatment of bacterial infections in many different parts of the body.
What to know before taking Zosyn?
Before using Zosyn, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.
How to check for unwanted effects?
Unwanted effects can be screened using blood tests. Call your healthcare professional immediately if your symptoms do not improve or if they become worse.
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Can you take a drug to treat diarrhea?
Check with your healthcare professional before you take any drug to treat diarrhea since these drugs may make the diarrhea worse or make it last longer.
Is piperacillin safe for children?
Studies in children have not demonstrated any pediatric-specific problems that would limit the utility of piperacillin and ta zobactam combination while safety and efficacy have not been established in children younger than 2 months of age. Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the utility of piperacillin and tazobactam combination.
Can a doctor give you Zosyn?
Proper usage of Zosyn requires strict adherence to your doctor’s orders. A trained healthcare professional will be the only one to give you this drug.
What is standardized susceptibility test?
Standardized susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of the test procedures.1,2,3,4 Standard piperacillin/tazobactam powder should provide the following ranges of values noted in Table 3. Quality control microorganisms are specific strains of microorganisms with intrinsic biological properties relating to resistance mechanisms and their genetic expression within the microorganism; the specific strains used for microbiological quality control are not clinically significant.
What is a bulk vale?
The PHARMACY BULK VIAL is a container of sterile preparation which contains many single doses for parenteral use. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion.
What temperature should a frozen container be thawed at?
Thaw frozen container at room temperature 20°C to 25°C [68°F to 77°F] or under refrigeration (2°C to 8°C [36°F to 46°F]). DO NOT FORCE THAW BY IMMERSION IN WATER
What is Zosyn 2040?
ZOSYN (piperacillin and tazobactam injection) in Galaxy® Containers (PL 2040 Plastic) is a sterile injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration.
What is USP in a zosyn?
ZOSYN (piperacillin and tazobactam for injection, USP) is indicated for the treatment of patients with moderate to severe infections caused by piperacillin-resistant, piperacillin/tazobactamsusceptible, β-lactamase producing strains of the designated microorganisms in the specified conditions listed below:
How many patients were treated with Zosyn?
During the initial clinical investigations, 2621 patients worldwide were treated with ZOSYN (piperacillin and tazobactam for injection, USP) in phase 3 trials. In the key North American clinical trials (n=830 patients), 90% of the adverse events reported were mild to moderate in severity and transient in nature. However, in 3.2% of the patients treated worldwide, ZOSYN was discontinued because of adverse events primarily involving the skin (1.3%), including rash and pruritus; the gastrointestinal system (0.9%), including diarrhea, nausea, and vomiting; and allergic reactions (0.5%).
What is USP in medicine?
ZOSYN (piperacillin and tazobactam for injection, USP) is an injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the βlactamase inhibitor tazobactam sodium for intravenous administration.
What are the uses for piperacillin/tazobactam sodium injection?
The combination of piperacillin and tazobactam (Zosyn) is used to treat a variety of bacterial infections, including:
Is piperacillin/tazobactam sodium injection safe to take if I'm pregnant or breastfeeding?
No evidence of fetal harm has been reported from use of piperacillin/tazobactam, piperacillin alone, and tazobactam alone in mice and rats (animal studies). Piperacillin/tazobactam is known to cross the placenta. Piperacillin/tazobactam is approved for the treatment of postpartum infections. As with all medications, piperacillin/tazobactam should be used cautiously in pregnancy. Potential benefits of treatment should be weighed against any potential risk to the fetus. Piperacillin and tazobactam is classified as FDA pregnancy risk category C.
How cold should tazobactam be stored?
Piperacillin and tazobactam vials should be stored at controlled room temperature, between 20 C to 25 C (68 F to 77 F), before reconstitution.
What is the effect of tazobactam on piperacillin?
Piperacillin is an extended-spectrum penicillin antibiotic, but it can be destroyed by an enzyme produced by bacteria called beta lactamase. Tazobactam inhibits beta lactamase and prevents the destruction of piperacillin. Therefore, tazobactam is given with piperacillin to enhance the activity of piperacillin in eradicating bacterial infections. ...
What is a Zosyn injection?
What is piperacillin/tazobactam sodium injection, and how does it work (mechanism of action)? Zosyn is an injectable combination of two antibiotics, piperacillin and tazobactam, with broad spectrum activity against an extended range of bacterial species. Piperacillin is an extended-spectrum penicillin antibiotic, ...
What is Zosyn used for?
Piperacillin and tazobactam (Zosyn) is a combination of two antibiotics prescribed to treat a variety of bacterial infections such as pneumonia, appendicitis, pelvic inflammatory disease, E. coli infection, cellulitis, and postpartum endometriosis. Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking this medication.
How does piperacillin kill bacteria?
Piperacillin kills bacteria by inhibiting the synthesis of bacterial cell walls. It binds preferentially to specific penicillin-binding proteins (PBPs) located inside bacterial cell walls. PBPs vary among bacterial species, and thus susceptibility to piperacillin depends on the ability of piperacillin to bind to each species' specific PBPs. ...
