What is the function of the blood testis barrier Quizlet?
The presence of the blood-testis barrier allows Sertoli cells to control the environment in which germ cells (i.e., spermatocytes, spermatids, and sperm) develop. It also prevents toxins from entering the seminiferous tubules, protecting the germ cells as they develop.
What happens when the blood–testes barrier is breached?
When the blood–testes barrier is breached, and sperm enters the bloodstream, the immune system mounts an autoimmune response against the sperm, since the immune system has not been tolerized against the unique sperm antigens that are only expressed by these cells. The anti-sperm antibodies generated by...
What is the function of the blood barrier in the gut?
The barrier also protects the germ cells from blood-borne noxious agents, prevents antigenic products of germ cell maturation from entering the circulation and generating an autoimmune response, and may help establish an osmotic gradient that facilitates movement of fluid into the tubular lumen.
What does the blood-testis-barrier protect the sperm from?
The blood-testis-barrier protects it from the immune system. It also prevents certain proteins specific for the function of the spermatozoa from entering the bloodstream, which might also set off an immune response.
What is the function of the blood-testis barrier quizlet?
What is the function of the blood testes barrier? THe immune system developed prior to sperm being present in the body, the purpose of the blood testis barrier formed by sertoli cells is to prevent the immune system from coming into contact with the sperm and inducing an immune reaction.
What is the function of the blood-testis barrier Mcq?
It is the barrier between blood vessels and seminiferous tubules. It is one of the tightest blood-tissue barriers. It divides seminiferous tubules into basal and adluminal compartments.
What is the function of the blood-testis barrier CH 27?
Tight junctions between these sustentacular cells create the blood–testis barrier, which keeps bloodborne substances from reaching the germ cells and, at the same time, keeps surface antigens on developing germ cells from escaping into the bloodstream and prompting an autoimmune response.
What are the 3 functions of the testes?
The Testis has following three functions. First, it produces spermatozoa, the male gametes. Second, it synthesizes testosterone, the principal male sex hormone. Third, it participates with the hypothalamus-pituitary unit in regulating reproductive function.
What is the function of the blood-testis barrier to prevent activation of the immune system of the male against the developing sperm?
As a result of the blood testis barrier, nutrients and leukocytes cannot move between the Sertoli cells into the seminiferous tubules, thereby protecting developing spermatogenetic cells from exposure to cells and antibodies of the immune system.
Why is the blood testes barrier necessary in the male?
The barrier also protects the germ cells from blood-borne noxious agents, prevents antigenic products of germ cell maturation from entering the circulation and generating an autoimmune response, and may help establish an osmotic gradient that facilitates movement of fluid into the tubular lumen.
What is blood epididymis barrier?
The blood-epididymis barrier (BEB) is a critical structure for male fertility. It enables the development of a specific luminal environment that allows spermatozoa to acquire both the ability to swim and fertilize an ovum.
What is the function of testis Class 8?
They are responsible for producing the male sex hormone, testosterone. They are responsible for producing sperms (male reproductive cells).
What is the function of BBB?
The BBB ensures that anything passing from blood to brain has to pass through the cytoplasm of the endothelial cells, and not between them. This gives the endothelial cells the ability to accept, reject, or modify anything trying to get to the nerve cells. Endothelial cells are much more selective than the clefts between them. They exclude antibodies, other blood-borne proteins, toxins, and so forth, while allowing such vital materials as water, glucose, amino acids, electrolytes, oxygen, and carbon dioxide to pass through.
What are the gaps between blood capillaries called?
The gaps are called intercellular clefts (see the third label from the top).
What cells are sealed off in the brain?
In the brain, however—for the extra protection of the vital and irreplaceable neurons—these clefts are sealed off. Certain supporting cells of the developing brain called astrocytes (green cell below) send out long tentacles that touch the blood capillaries with their perivascular feet. They secrete a signal that makes the endothelial cells grow closer together and form tight junctions (see bottom label above).
What does the BBB look like?
As for what the BBB looks like, this requires special microscopic imaging techniques. With the aid of fluorescent tissue-specific dyes, the image below shows blood capillaries (the black channels) and the blood-brain barrier (fluorescent green) separating the blood (not seen) from the surrounding brain tissue cells (red).
Why do babies have fetal alcohol syndrome?
Alcohol, caffeine, nicotine, anesthetics, and other materials not natural to the body can also get through, which is why some babies are born with fetal alcohol syndrome and other drug addictions. Metastasizing cancer cells have a way of breaking down the blood-brain barrier so they can invade the brain tissue.
Why do we need a blood barrier?
Both the brain and the testes have a blood - organ - barrier. Just as the blood-brain-barrier keeps toxins out of the brain , presumably the blood-testis-barrier keeps toxins from damaging the integrity of the genetic code used for reproduction. Also, when the primary spermatocyte undergoes meiosis, to form the spermatozoa, it becomes genetically different from the body’s normal cells, which could cause it to be attacked by the immune system. The blood-testis-barrier protects it from the immune system. It also prevents certain proteins specific for the function of the spermatozoa from entering the bloodstream, which might also set off an immune response.
Why are drugs so addictive?
What makes certain drugs so addictive is partly related to their chemical structure that allows them to cross that barrier.
