What is the boiling point of acetanilide?
Molar mass: 135.166 g·mol −1 Odor: Odorless Density: 1.219 g/cm 3: Melting point: 113–115 °C (235–239 °F; 386–388 K) Boiling point: 304 °C (579 °F; 577 K) What are pure crystals of acetanilide used for?
What is the temperature of autoignition for acetanilide?
autoignition temp. 304 °C (lit.) 113-115 °C (lit.) Looking for similar products? Visit Product Comparison Guide Acetanilide belongs to a class of compounds which are the active components of drugs exhibiting analgesic and antipyretic properties.
Is acetanilide toxic?
In 1948, Julius Axelrod and Bernard Brodie discovered that acetanilide is much more toxic in these applications than other drugs, causing methemoglobinemia and ultimately doing damage to the liver and kidneys. As such, acetanilide has largely been replaced by less toxic drugs, in particular acetaminophen,...
What is the use of acetanilide in purepure?
Pure crystals are plate shaped and colorless to white. Acetanilide is used as an inhibitor of hydrogen peroxide decomposition and is used to stabilize cellulose ester varnishes. It has also found uses in the intermediation in rubber accelerator synthesis, dyes and dye intermediate synthesis, and camphor synthesis.
What is the melting point for acetanilide?
237.7°F (114.3°C)Acetanilide / Melting point
What is the literature melting point of benzoic acid?
121-123 °CBenzoic acid melting point standard, 121-123 °C is useful as a melting point calibration standard while defining the purity of pharmaceutical chemicals.
What is the boiling point of acetanilide?
579.2°F (304°C)Acetanilide / Boiling point
What is Colour obtained acetanilide and its melting point?
Acetanilide is a white organic solid compound used primarily in organic synthesis....Observations:Colour of the crystalsColourless crystalsMelting point114oC1 more row
What is the literature melting point of naphthalene?
The substance crystallizes in lustrous white plates, melting at 80.1° C (176.2° F) and boiling at 218° C (424° F). It is almost insoluble in water. Naphthalene is highly volatile and has a characteristic odour; it has been used as moth repellent.
What is the literary melting point?
Identification. As a compound's melting point is a physical constant, it can be used to support the identity of an unknown solid. The melting point can be looked up in a reference book (this value would then be called the "literature melting point"), and compared to the experimental melting point.
What is the melting point of water?
32°F (0°C)Water / Melting pointPure water transitions between the solid and liquid states at 32°F (0°C) at sea level. This temperature is referred to as the melting point when rising temperatures are causing ice to melt and change state from a solid to a liquid (water).
Does acetanilide dissolve in water?
WaterBenzeneEthanolAcetoneDiethyl etherAcetanilide/Soluble in
Is acetanilide a salt?
ACETANILIDE is an amide. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts.
How do you identify acetanilide?
Appearance: It is a white solid with a flaky appearance. Odor: This is an odorless compound. Solubility: Acetanilide is a little soluble in water. It is also soluble in diethyl ether, ethanol, benzene and acetone.
Do impurities lower melting point?
The presence of even a small amount of impurity will lower a compound's melting point by a few degrees and broaden the melting point temperature range. Because the impurity causes defects in the crystalline lattice, it is easier to overcome the intermolecular interactions between the molecules.
What is used of acetanilide?
acetanilide, synthetic organic compound introduced in therapy in 1886 as a fever-reducing drug. Its effectiveness in relieving pain was discovered soon thereafter, and it was used as an alternative to aspirin for many years in treating such common complaints as headache, menstrual cramps, and rheumatism.
What is the melting point range of benzoic acid reported in the literature 2 points provide a reference for your data?
For example, pure benzoic acid has a melting point range of 121-123 °C. If benzoic were contaminated with an impurity, the melting point range might decrease and broaden to 117-120 °C.
How do you determine the melting point of benzoic acid?
Procedure to determine the melting point of Benzoic Acid: Take a capillary tube and by heating one end close the end of the tube. Hold the closed end of the capillary tube between your finger and thumb as shown in figure (a) above. Dip the open end of the capillary tube in the finely powdered Benzoic acid.
What is the melting point of impure benzoic acid?
119.9-121.0 °CCONCLUSIONS: The melting point of the impure benzoic acid was 119.9-121.0 °C and the pure was 119.8-120.4 °C. The final/experimental melting point of benzoic acid was 119.3- 120.5 °C.
What is the literature melting point range of 9 Fluorenone?
80-83 °Cmp. 80-83 °C (lit.)
What is acetanilide used for?
Acetanilide is used as an inhibitor of hydrogen peroxide decomposition and is used to stabilize cellulose ester varnishes. It has also found uses in the intermediation in rubber accelerator synthesis, dyes and dye intermediate synthesis, and camphor synthesis. Acetanilide is used for the production of 4-acetamidobenzenesulfonyl chloride, a key intermediate for the manufacture of the sulfa drugs.
Is acetanilide a drug?
Acetanilide was the first aniline derivative found to possess analgesic as well as antipyretic properties, and was quickly introduced into medical practice under the names of Antifebrin by A. Cahn and P. Hepp in 1886. But its (apparent) unacceptable toxic effects, the most alarming being cyanosis due to methemoglobinemia and ultimately liver and kidney damage, prompted the search for supposedly less toxic aniline derivatives such as phenacetin. After several conflicting results over the ensuing fifty years, it was established in 1948 that acetanilide was mostly metabolized to paracetamol (acetaminophen) in the human body, and that it was this metabolite that was responsible for the analgesic and antipyretic properties. The observed methemoglobinemia after acetanilide administration was ascribed to the small proportion of acetanilide that is hydrolyzed to aniline in the body. Acetanilide is no longer used as a drug in its own right, although the success of its metabolite – paracetamol (acetaminophen) – is well known (although it is itself toxic in excessive amounts ).
Is paracetamol safer than acetaminophen?
^ The presence of aniline as an impurity in 19th century batches of acetanilide drugs cannot be ruled out. In this sense as well, paracetamol (acetamino phen) is safer than acetanilide, as (1) the corresponding impurity would be 4-aminophenol, which is less toxic than aniline; and (2) in vivo hydrolysis of the amide group in paracetamol appears to be negligible.
General description
Acetanilide belongs to a class of compounds which are the active components of drugs exhibiting analgesic and antipyretic properties.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAA7127 in the slot below. This is an example certificate only and may not be the lot that you receive.
Overview
Acetanilide is an odourless solid chemical of leaf or flake-like appearance. It is also known as N-phenylacetamide, acetanil, or acetanilid, and was formerly known by the trade name Antifebrin.
Preparation and properties
Acetanilide can be produced by reacting acetic anhydride with aniline:
C6H5NH2 + (CH3CO)2O → C6H5NHCOCH3 + CH3COOH
The preparation used to be a traditional experiment in introductory organic chemistry lab classes, but it has now been widely replaced by the preparation of either paracetamol or aspirin, both of which teach the same practical techniques (especially recrystallization of the product) but which …
Applications
Acetanilide is used as an inhibitor of hydrogen peroxide decomposition and is used to stabilize cellulose ester varnishes. It has also found uses in the intermediation in rubber accelerator synthesis, dyes and dye intermediate synthesis, and camphor synthesis. Acetanilide is used for the production of 4-acetamidobenzenesulfonyl chloride, a key intermediate for the manufacture of the sulfa drugs.
See also
• Nitroacetanilide
External links
"Making an old pain and fever medication" by NileRed. YouTube. May 21, 2017.