what is the main ingredient in trazodone

Precautions

Long-term use of trazodone and alcohol can also lead to abuse and withdrawal. However, patients may find that moderate alcohol consumption while taking trazodone is safe, but Drinking alcohol while taking trazodone can be dangerous.

Can you drink while on trazodone?

Desyrel (trazodone) is an antidepressant and Xanax is a benzodiazepine. Side effects of trazodone and Xanax that are similar include nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, dry mouth, stuffy nose, constipation, and change in sexual interest/ability.

Does trazodone have any benzodiazepine in it?

While much less common, you might also experience the following serious side effects from trazodone:

• Abnormal heart rhythms
• Anemia
• Extrapyramidal symptoms
• Fainting
• Hallucinations
• Heart attack
• Hepatitis (liver inflammation)
• Hypertension (high blood pressure)
• Hypomania
• Mania

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What are the side effects of trazadone?

Trazodone: Trazodone is the generic name for Desyrel and Oleptro. It was primarily developed as an antidepressant. It works by helping to increase the availability of serotonin in the brain. Serotonin is considered a natural mood stabilizer. It is also the chemical that helps with sleeping, eating, reducing depression, and regulating anxiety.

Is Desyrel the same as trazodone?

What is trazodone?

How does trazodone work?

How should I take trazodone?

What other drugs will affect trazodone?

Why is my name on the registry for trazodone?

How long after stopping trazodone can you take MAOI?

What happens if you are allergic to trazodone?

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Is Xanax and trazodone the same?

No. You might experience some of the same side effects while taking alprazolam (Xanax) or trazodone, but the two medications belong to different medication classes. Trazodone is a selective serotonin reuptake inhibitor (SSRI), while alprazolam (Xanax) is a benzodiazepine.

What narcotic is in trazodone?

Trazodone is not a narcotic either. Narcotics are opioids—drugs that relieve pain by blocking the pain receptors in your brain. Trazodone is an antidepressant medication that alters brain chemicals, called neurotransmitters, to help ease depression.

What ingredient in trazodone makes you sleepy?

Trazodone belongs to a class of medications called serotonin modulators. These drugs work by moderating levels of serotonin – a neurotransmitter – in the brain and increasing its availability in the CNS (central nervous system). Because of it's effects on serotonin, trazodone functions well as a sleep aid.

What should you not take with trazodone?

Do not use trazodone with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), tryptophan, St. John's wort, or some pain or migraine medicines (eg, sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®).

Is trazodone a high risk medication?

Trazodone has a boxed warning. This is the most serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous. Drugs used to treat depression, including trazodone, may cause an increase in suicidal thoughts or actions.

What is the most likely side effect of trazodone?

The most common side effects of trazodone are drowsiness, nausea, dizziness, and dry mouth (Zhang, 2014). Trazodone is generally well tolerated and may be less likely than some other antidepressants to cause insomnia, sexual side effects, and anxiety (Shin, 2020).

Who should avoid trazodone?

Trazodone may not be safe for some people to use, especially those who have heart disease, psychiatric illnesses, or are pregnant or breastfeeding. It also shouldn't be used by people under 25 or the elderly. Talk with your doctor about the possible side effects and whether it's safe for you to take trazodone.

Is there an over the counter substitute for trazodone?

Since trazodone is often used to help with sleep problems in people treating depression, over-the-counter sleep aids are available as alternatives. Melatonin is a natural hormone in the body that promotes sleep that is available as a supplement in dosage forms such as tablets, gummies, and liquid.

Is 50 mg of trazodone a lot?

The starting dose is usually 50 mg to 100 mg dose at bedtime. If needed, the dose can be increased to up to 200 mg at bedtime. Those with both depression and sleep problems may need a higher dose in some cases — up to 300 mg at bedtime.

Is trazodone linked to dementia?

Crude results showed that trazodone users were more likely to be diagnosed with dementia earlier (median = 1.7 years; IQR = 0.4–4.7 years) compared with users of other antidepressants (median = 4.3 years; IQR = 1.7–7.8 years).

Is trazodone 50 mg a narcotic?

Trazodone is neither a narcotic nor classified as a controlled substance in the United States. It does require a prescription for its use. It also has some potential for abuse, although the risk is not as high as many other drugs that help with sleep.

How long does it take for trazodone to kick in for sleep?

Since it is a generic drug covered by most insurance plans, trazodone is lower in cost than other medications. Trazodone works quickly as a sleep aid, often taking only 30 minutes to feel the effects.

Is trazodone an opioid or narcotic?

Trazodone Drug Class. Trazodone is considered to be an atypical antidepressant, and as noted, not a narcotic. Narcotics are opioid drugs that include prescription medications as well as illegal substances sold on the black market. Narcotics are classified this way because they have a high potential for addiction.

Is trazodone a benzo or narcotic?

Trazodone is neither a narcotic nor classified as a controlled substance in the U.S., but it does require a prescription and carry risks. Trazodone is a prescription antidepressant medication, and many wonder if it is considered a controlled substance or narcotic in the United States.

Does trazodone have street value?

The average street price of trazodone is $1 to $15 per tablet. Get Help Now! Trazodone is a prescription medication that's FDA-approved for treating depression. It is also prescribed by healthcare providers off-label for the treatment of insomnia.

Is trazodone considered a barbiturate?

No, trazodone is not a barbiturate. It is an antidepressant that treats the chemical imbalance in the brain. It is used to treat anxiety, depression, or a combination of both. Trazodone can also ease symptoms like poor sleep, low mood, and poor concentration.

Trazodone: 7 things you should know - Drugs.com

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 12 Oct 2022), Cerner Multum™ (updated 21 Sep 2022), ASHP (updated 12 Oct 2022 ...

Trazodone Oral: Uses, Side Effects, Interactions, Pictures ... - WebMD

Find patient medical information for trazodone oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Trazodone for Sleep: Everything You Need To Know - WebMD

Trazodone is a medication approved to treat depression, but it’s also often prescribed as a sleep aid. Read on to learn about the risks and benefits of taking trazodone for sleep.

Trazodone Side Effects: Common, Severe, Long Term - Drugs.com

Warning. Oral route (Tablet, Extended Release; Tablet) Antidepressants increased the risk compared to placebo of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder (MDD) and other psychiatric disorders in short-term studies. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in ...

Trazodone Dosage - The Recovery Village Drug and Alcohol Rehab

Trazodone Dosage Information . Trazodone is available as an oral tablet in several dosages. The tablets can be split to get a lower dose when needed; for example, someone may split a 50 mg tab to get a 25 mg dose.

What is trazodone used for?

Indications and Usage for Trazodone. Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults.

What is the USP for Trazodone?

Trazodone hydrochloride tablets, USP are available in the following strengths: 50 mg: White, round, compressed tablet, debossed “PLIVA 433” on one side and scored on the other side. 100 mg: White, round, compressed tablet, debossed “PLIVA 434” on one side and scored on the other side.

How long after stopping trazodone can you take MAOI?

Do not take an MAOI within 2 weeks of stopping Trazodone hydrochloride tablets unless directed to do so by your healthcare provider.

How long does it take for trazodone to peak?

Peak plasma levels occur approximately one hour after dosing when Trazodone hydrochloride is taken on an empty stomach or 2 hours after dosing when taken with food.

Does trazodone prolong QTC?

Trazodone hydrochloride prolongs the QT/QTc interval. The use of Trazodone hydrochloride should be avoided in patients with known QT prolongation or in combination with other drugs that are inhibitors of CYP3A4 (e.g., itraconazole, clarithromycin, voriconazole), or known to prolong QT interval including Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class 3 antiarrhythmics (e.g., amiodarone, sotalol), certain antipsychotic medications (e.g., ziprasidone, chlorpromazine, thioridazine), and certain antibiotics (e.g., gatifloxacin). Concomitant administration of drugs may increase the risk of cardiac arrhythmia [see Drug Interactions ( 7.1 )].

Is trazodone a cardiac arrhythmia?

Clinical studies indicate that Trazodone hydrochloride may be arrhythmogenic in patients with preexisting cardiac disease. Arrhythmias identified include isolated PVCs, ventricular couplets, tachycardia with syncope, and torsade de pointes. Postmarketing events, including torsade de pointes have been reported at doses of 100 mg or less with the immediate-release form of Trazodone hydrochloride. Trazodone hydrochloride should also be avoided in patients with a history of cardiac arrhythmias, as well as other circumstances that may increase the risk of the occurrence of torsade de pointes and/or sudden death, including symptomatic bradycardia, hypokalemia or hypomagnesemia, and the presence of congenital prolongation of the QT interval. Trazodone hydrochloride is not recommended for use during the initial recovery phase of myocardial infarction. Caution should be used when administering Trazodone hydrochloride to patients with cardiac disease and such patients should be closely monitored, since antidepressant drugs (including Trazodone hydrochloride ) may cause cardiac arrhythmias [see Adverse Reactions ( 6.2 )].

Can you reduce trazodone hydrochloride?

Consider reducing Trazodone hydrochloride tablets dose based on tolerability when Trazodone hydrochloride tablets are coadministered with a strong CYP3A4 inhibitor [see Drug Interactions ( 7.1 )].

How many ng/ml is trazodone?

Following oral administration of single doses of 25, 50, or 100 mg of trazodone to healthy, fasted adults in another study, mean peak plasma trazodone concentrations were 490, 860, and 1620 ng/mL, respectively. The areas under the plasma concentration-time curves (AUCs) were 3.44, 5.95, and 11.19 ug-hr/mL, for the 25-, 50-, and 100-mg doses, respectively. Limited crossover data are available comparing AUCs in fasted and nonfasted patients; however, it appears that the presence of food slightly increases the AUC for trazodone.

What is trazodone used for?

Trazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder. Trazodone therapy can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.

How much does trazodone decrease apparent clearance?

Another pharmacokinetic study determined the total body clearance of trazodone to be 5.3 +/- 0.9 L/hr in 8 healthy patients taking a single dose of trazodone.

How much trazodone is given per kg?

The FDA medical review of trazodone reports a volume of distribution of 0.47 to 0.84 L/kg.

How fast does trazodone absorb?

In the fed state in 8 healthy volunteers, the Cmax was measured to be 1.47 +/- 0.16 micrograms/mL, and in the fasted state, was measured at 1.88 +/- 0.42 micrograms/mL. The average Tmax after a single dose of 300 mg was 8 hours. Food may increase absorption by up to 20%.

What is the LD50 of trazodone?

The oral LD50 of trazodone is 690 mg/kg in rats. An overdose of trazodone may result in central nervous system, cardiac, respiratory effects. Signs and symptoms may include dyspnea, bradycardia, hypotension, mental status changes, lack of coordination, and coma, among others. In addition, an overdose may result in priapism, a persistent unrelievable penile tissue erection that may cause permanent damage if not treated promptly. No specific antidote exists for a trazodone overdose. If an overdose occurs, consider the possibility that trazodone may have been combined with other drugs. Contact a poison control center in case of overdose for the most current management guidelines. Dialysis does not accelerate trazodone clearance.

What is the FDA requirement for trazodone?

11.7.1 FDA Requirements. The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including trazodone hydrochloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

How many mg of trazodone is there?

Trazodone is available in the form of 25 mg, 50 mg, 100 mg, 150 mg, and 300 mg tablets for oral ingestion.

What is the metabolite of trazodone?

Trazodone has a minor active metabolite known as meta -chlorophenylpiperazine (mCPP), and this metabolite may contribute to some degree to the pharmacological properties of trazodone. In contrast to trazodone, mCPP is an agonist of various serotonin receptors. It has relatively low affinity for α 1 -adrenergic receptors unlike trazodone, but does high affinity for α 2 -adrenergic receptors and weak affinity for the H 1 receptor. In addition to direct interactions with serotonin receptors, mCPP is a serotonin releasing agent similarly to agents like fenfluramine and MDMA. In contrast to these serotonin releasing agents however, mCPP does not appear to cause long-term serotonin depletion (a property thought to be related to serotonergic neurotoxicity ).

How much trazodone is excreted in urine?

Less than 1% of the drug is excreted in its unchanged form. After an oral dose of trazodone, it was found to be excreted 20% in the urine as TPA and conjugates, 9% as the dihydrodiol metabolite, and less than 1% as unconjugated mCPP. mCPP is glucuronidated and sulfated similarly to other trazodone metabolites.

How long does trazodone stay in your system?

The mean blood elimination half-life of trazodone is biphasic: the first phase's half-life is 3 to 6 hours, and the following phase's half-life is 5 to 9 hours. The elimination half-life of mCPP is 4 to 14 hours and is longer than that of trazodone. Metabolites are conjugated to gluconic acid or glutathione and around 70 to 75% of 14 C-labelled trazodone was found to be excreted in the urine within 72 hours. The remaining drug and its metabolites are excreted in the faeces via biliary elimination. Less than 1% of the drug is excreted in its unchanged form. After an oral dose of trazodone, it was found to be excreted 20% in the urine as TPA and conjugates, 9% as the dihydrodiol metabolite, and less than 1% as unconjugated mCPP. mCPP is glucuronidated and sulfated similarly to other trazodone metabolites.

How long does it take for trazodone to be absorbed?

Trazodone is well- absorbed after oral administration. Its bioavailability is 65 to 80%. Peak blood levels of trazodone occur 1 to 2 hours after ingestion and peak levels of the metabolite mCPP occur after 2 to 4 hours. Absorption is somewhat delayed and enhanced by food.

What enzymes are involved in the metabolism of trazodone?

Trazodone is metabolized by several liver enzym es, including CYP3A4, CYP2D6, and CYP1A2. Its active metabolite meta -chlorophenylpiperazine (mCPP) is known to be formed by CYP3A4 and metabolized by CYP2D6. Inhibition or induction of the aforementioned enzymes by various other substances may alter the metabolism of trazodone and/or mCPP, leading to increased and/or decreased blood concentrations. The enzymes in question are known to be inhibited and induced by many medications, herbs, and foods, and as such, trazodone may interact with these substances. Potent CYP3A4 inhibitors such as clarithromycin, erythromycin, fluvoxamine, grapefruit juice, ketoconazole, and ritonavir may lead to increased concentrations of trazodone and decreased concentrations of mCPP, while CYP3A4 inducers like carbamazepine, enzalutamide, phenytoin, phenobarbital, and St. John's wort may result in decreased trazodone concentrations and increased mCPP concentrations. CYP2D6 inhibitors may result in increased concentrations of both trazodone and mCPP while CYP2D6 inducers may decrease their concentrations. Examples of potent CYP2D6 inhibitors include bupropion, cannabidiol, duloxetine, fluoxetine, paroxetine, quinidine, and ritonavir, while CYP2D6 inducers include dexamethasone, glutethimide, and haloperidol. CYP1A2 inhibitors may increase trazodone concentrations while CYP1A2 inducers may decrease trazodone concentrations. Examples of potent CYP1A2 inhibitors include ethinylestradiol (found in hormonal birth control) fluoroquinolones (e.g., ciprofloxacin ), fluvoxamine, and St. John's wort, while potent CYP1A2 inducers include phenytoin, rifampin, ritonavir, and tobacco .

When was trazodone first used?

Trazodone was developed in Italy, in the 1960s, by Angelini Research Laboratories as a second-generation antidepressant. It was developed according to the mental pain hypothesis, which was postulated from studying patients and which proposes that major depression is associated with a decreased pain threshold. In sharp contrast to most other antidepressants available at the time of its development, trazodone showed minimal effects on muscarinic cholinergic receptors. Trazodone was patented and marketed in many countries all over the world. It was approved by the Food and Drug Administration (FDA) in 1981 and was the first non- tricyclic or MAOI antidepressant approved in the US.

What are the side effects of trazodone?

Some common side effects of trazodone include: sleepiness. dizziness.

What to do if you take too much trazodone?

Drug overdose can be fatal. If you suspect you have taken too much trazodone, call 911 or local emergency services and seek medical attention immediately .

Does trazodone help with insomnia?

Effective treatment for insomnia. A 2017 review of studies of trazodone use for insomnia found the medication was effective for primary and secondary insomnia in low doses.

Is trazodone addictive?

Trazodone is not addictive, and common side effects are dry mouth, drowsiness, dizziness, and lightheadedness. Trazodone may offer benefits in certain conditions such as sleep apnea over other sleep aids. Last medically reviewed on May 24, 2019.

Does trazodone make you sleepy?

Even at lower doses, trazodone can cause you to feel relaxed, tired, and sleepy. It does this by blocking chemicals in the brain that interact with serotonin and other neurotransmitters, such as, 5-HT2A, alpha1 adrenergic receptors, and H1 histamine receptors.

Can trazodone cause breathing problems?

Although rare, trazodone can cause serious reactions. Call 911 or local emergency services if you are experiencing any life-threatening symptoms such as difficulty breathing.

Is trazodone a black box?

FDA Warning about trazodone. Like many anti depressants, trazodone has been issued a “Black Box Warning” by the FDA. Taking trazodone has increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients.

What is the most commonly prescribed antidepressant?

The most commonly prescribed antidepressants are reuptake inhibitors. Reuptake, as described by WebMD, is "the process in which neurotransmitters are naturally reabsorbed back into nerve cells in the brain after they are released to send messages between nerve cells.".

Can you mix trazodone and alcohol?

Absolutely not . Since both alcohol and trazodone affect the central nervous system, the consequences of mixing the two can be deadly. And mixing the medication with drugs of abuse can result in the onset of serotonin syndrome, a potentially lethal adverse drug reaction.

Is trazodone an antidepressant?

Because trazodone doesn’t fall under any of these categories, it’s often referred to as an "atypical antidepressant."

Does trazodone affect the brain?

Trazodone increases natural neurotransmitters in the central nervous system, essentially restoring depleted chemicals in the brain. One of these important neurotransmitters—serotonin—regulates our internal clock for resting and being awake, as well as mood, appetite, digestion, memory, sexual function and desire.

What is trazodone?

Trazodone is an antidepressant that belongs to a group of drugs called serotonin receptor antagonists and reuptake inhibitors ( SARIs). While trazodone is not a true member of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, it does still share many properties of the SSRIs.

How does trazodone work?

Trazodone works by helping to restore the balance of a certain natural chemical (serotonin) in the brain.

How should I take trazodone?

Take trazodone exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

What other drugs will affect trazodone?

Using trazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication , a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Why is my name on the registry for trazodone?

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby.

How long after stopping trazodone can you take MAOI?

After you stop taking trazodone, you must wait at least 14 days before you start taking an MAOI.

What happens if you are allergic to trazodone?

Get emergency medical help if you have signs of an allergic reaction to trazodone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Indications and Usage For Trazodone

Trazodone Dosage and Administration

Dosage Forms and Strengths

Contraindications

Warnings and Precautions

Adverse Reactions

Use in Specific Populations

Drug Abuse and Dependence

Overdosage

Trazodone Description

Overview

Medical uses

Side effects

Overdose

• Trazodone hydrochloride tablets, USP for oral administration contain Trazodone hydrochloride, USP a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist. Trazodone hydrochloride, USP is a triazolopyridine derivative designated as 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4, 3-a]pyridin-3(2 H)-one hydrochloride. It...

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