Precautions
Losartan/hydrochlorothiazide is a prescription drug that's used to treat high blood pressure (hypertension). It’s also used to reduce stroke risk. It comes only as an oral tablet. It's available ...
What does losartan stand for?
What Is Losartan, and How Is It Abused? Losartan medication, also known by the brand name Cozaar, is an antihypertensive in the angiotensin II receptor agonists class. The medication results in blood vessels not constricting, and its action allows for more even blood flow and lowered blood pressure.
What is losartan used for, and how is it abused?
Vitals
- Losartan is a prescription medication used to lower blood pressure.
- Because of the way losartan works in the kidneys, it also affects the amount of potassium in your body.
- In people with high blood pressure and normal kidney function, a high potassium diet may not be a problem while taking losartan. ...
What is losartan use for. what is losartan use for?
- Olmesartan was approved in 2002 as brand-name Benicar, but is now available as a cheaper generic.
- Olmesartan is available in convenient combination tablets: olmesartan/HCTZ and olmesartan/amlodipine/HCTZ.
- Olmesartan is better than losartan at lowering blood pressure and generally provides good 24-hour coverage.
What does the name losartan mean?
What losartan means?
Definition of losartan : an antihypertensive drug that is taken orally in the form of its potassium salt C22H22ClKN6O and blocks the action of the physiologically active form of angiotensin The onset of the hypotensive effect of losartan appears to be more gradual than that associated with ACE inhibitors …— Theodore L.
Is losartan a good blood pressure medication?
Losartan (Cozaar) is a medication used to lower blood pressure. It can also help protect the kidneys, so it is a good first-line option for people with both hypertension and diabetes.
What is losartan drugs used for?
Losartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries.
What are the most common side effects of losartan?
Commonly reported side effects of losartan include: asthenia, chest pain, diarrhea, fatigue, and hypoglycemia. Other side effects include: hyperkalemia, hypotension, and orthostatic hypotension.
Does losartan affect sleep?
It has been reported that losartan, an angiotensin II receptor blocker, alters the circadian rhythm of melatonin secretion and significantly reduces melatonin production.
What happens if I stop taking losartan?
Do not stop taking losartan without talking to your doctor. Stopping it suddenly can cause your blood pressure to increase quickly. This raises your risk of a heart attack or stroke.
Can losartan cause kidney problems?
There is a risk of acute kidney failure developing in people taking losartan.
What is normal blood pressure by age?
Table 5.1: Estimated Blood Pressure Ranges (mm Hg)AgeSystolic RangeDiastolic RangeAdolescent (14–18 years)90–12050–80Adult (19–40 years)95–13560–80Adult (41–60 years)110–14570–90Older adult (61 and older)95–14570–904 more rows
Which is the best medicine for high blood pressure?
In terms of prescriptions written, here are the top 4 high blood pressure medications,the ACE inhibitor lisinopril (Prinivil, Zestril) tops the list,followed by amlodipine besylate (Norvasc),a calcium channel blocker, and.generic hydrochlorothiazide (HCTZ).
What foods should I avoid while taking losartan?
Potential Negative Interaction Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (including Noni juice) should be avoided by those taking losartan, unless directed otherwise by their doctor.
How quickly does losartan lower blood pressure?
How long does it take to work? Losartan starts to reduce high blood pressure after about 1 hour but it may take 3 to 6 weeks to fully take effect.
What is the safest blood pressure medicine?
Methyldopa, which works to lower blood pressure through the central nervous system, has the lowest risk of harming the mother and developing fetus. Other possible safe options include labetalol, beta-blockers, and diuretics.
What is the best high blood pressure medicine?
The two classes of medication are both recommended as "first-line" treatments for high blood pressure: angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). ACE inhibitors have been around longer and studied more extensively, so doctors prescribe them more often.
Is it better to take losartan at night or morning?
Take losartan tablets once a day. Your doctor may suggest that you take your first dose before bedtime, because it can make you feel dizzy. After your first dose, you can take losartan at any time of day.
What should I avoid while taking losartan?
Potential Negative Interaction Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (including Noni juice) should be avoided by those taking losartan, unless directed otherwise by their doctor.
Before Taking This Medicine
You should not use losartan if you are allergic to it.If you have diabetes, do not use losartan together with any medication that contains aliskire...
How Should I Take Losartan?
Take losartan exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Losartan Dosing Information
Usual Adult Dose of Losartan for Diabetic Nephropathy:Initial dose: 50 mg orally once a day.Maintenance dose: 25 to 100 mg orally in 1 to 2 divided...
What Other Drugs Will Affect Losartan?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with losartan, especially: 1. a diuretic or "...
What is Losartan used for?
Losartan is used for hypertension, including in people with left ventricular hypertrophy (enlarged heart muscle), and kidney dysfunction among type II diabetics. It may also delay progression of diabetic nephropathy.
What is the name of the salt in Losartan?
Losartan is generally marketed as the (basic) potassium salt of the aromatized negatively charged tetrazole, called "losartan potassium".
How long does losartan stay in your system?
The terminal elimination half lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively.
How is Losartan absorbed?
Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5- carboxylic acid metabolite, designated as EXP3174. About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT 1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT 1 receptors than losartan. In addition, the binding to the target enzyme is pH-sensitive, and the negatively-charged tetrazole ring, which is similar in size to the negative carboxylic acid derivative, may contribute to the activity of the drug.
How long does it take for Losartan to work?
It is taken by mouth. It may be used alone or in addition to other blood pressure medication. Up to six weeks may be required for the full effects to occur.
What companies are recalling losartan?
Between November 2018, and September 2019, the FDA announced multiple recalls of tablets containing losartan by Sandoz, Torrent Pharmaceuticals, Hetero Labs, Camber Pharmaceuticals, Legacy Pharmaceutical Packaging, Teva Pharmaceuticals, Vivimed Life Sciences, and Macleods Pharmaceutical Limited due to detection of one of the possible carcinogens N-nitrosodiethylamine, N-methylnitrosobutyric acid, or N-nitroso-N-methyl-4-aminobutyric acid in the active pharmaceutical ingredient (API).
What is the name of the medication that is used to treat high blood pressure?
Losartan. Losartan, sold under the trade name Cozaar among others, is a medication mainly used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.
Overview
Losartan is used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes. It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart.
May Treat: Hypertension · Chronic heart failure · Diabetic nephropathy · Hypertension with left ventricular hypertrophy
Brand Names: Cozaar
Drug Class: Angiotensin II Receptor Blockers (ARBs)
Availability: Prescription Required
Pregnancy: Do not use. This medication may be harmful to an unborn child.
May Treat: Hypertension · Chronic heart failure · Diabetic nephropathy · Hypertension with left ventricular hypertrophy
Brand Names: Cozaar
Drug Class: Angiotensin II Receptor Blockers (ARBs)
Availability: Prescription Required
Pregnancy: Do not use. This medication may be harmful to an unborn child.
Lactation: Consult a doctor before using
Driving: May cause drowsiness or dizziness. Use caution
- If available, read the patient package insert
- Do not take if pregnant contact your doctor
- May make you dizzy. Use caution when driving.
- If available, read the patient package insert
- Do not take if pregnant contact your doctor
- May make you dizzy. Use caution when driving.
- Be careful not to stand up too quickly
- Tell Dr. of slow pulse. Avoid potassium salt.
- Check warnings on OTC medications.
- Review all drugs you are taking with your doctor
- It is important to check blood pressure regularly.
Chemistry
Medical uses
Adverse effects
Mechanism of action
Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It is taken by mouth. It may be used alone or in addition to other blood pressure medication. Up to six weeks may be required for the full effects to occur.
Pharmacokinetics
Losartan potassium is chemically described as 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-metahnol monopotassium salt. Its empirical formula is C22H23CIKN6O, and its molecular weight is 422.9.
Losartan is generally marketed as the (basic) potassium salt of the aromatized negatively charged tetrazole, called "losartan potassium". The molecule has an extended biphenyl group w…
History
Losartan is used for hypertension, including in people with left ventricular hypertrophy (enlarged heart muscle), and kidney dysfunction among type II diabetics. It may also delay progression of diabetic nephropathy. It is a suitable pharmacological agent for the reduction of renal disease progression in patients with type 2 diabetes, hypertension, and microalbuminuria (>30 mg/24 hours) or proteinuria (>900 mg/24 hours).
Research
The most common adverse effects for losartan in adults are upper respiratory infections, dizziness, and back pain. People with type 2 diabetes and kidney disease may experience diarrhea, fatigue, low blood pressure, low blood glucose, elevated potassium, chest pain, or allergic reaction. Losartan should not be taken by people who are diabetic and taking aliskiren. Anemia may occur, due to inhibition of the renin–angiotensin system. As with other angiotensin receptor blockers, l…