What is the mechanism of action for digoxin?
Mechanism of action Digoxin binds to and inhibits the sodium/potassium-ATPase (sodium pump) within the plasma membrane of cardiac myocytes. This inhibition increases the intracellular sodium content which in turn increases the intracellular calcium content which leads to increased cardiac contractility.
Is Digoxin Immune Fab the same as digoxin?
Digoxin immune fab or digoxin-specific antibody is an antidote for overdose of digoxin. It is made from immunoglobulin fragments from sheep that have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA).
How does digoxin-specific antibody fragments work?
Digoxin acts via inhibition of Na⁺/K⁺ ATPase. It has a narrow therapeutic index. Digoxin has 60-80% bioavailability, a mean plasma half-life of 40 h and a volume of distribution (Vd) of 5-10 L/kg and low protein binding (20%). A 40-mg vial of digoxin-Fab (DigiFab) binds 0.5 mg digoxin.
When do you take digoxin immune fab?
Digoxin immune Fab is indicated for the treatment of life threatening digoxin toxicity in patients with manifestations of severe toxicity. It is NOT indicated for mild cases of digoxin toxicity or in cases of elevated serum digoxin concentrations in the absence of signs and symptoms of digoxin toxicity.
Does Digibind increase digoxin levels?
The total serum digoxin level increased significantly after initiation of Digibind therapy and peaked at 125 ng/mL, but the free serum digoxin level immediately decreased to nontoxic levels immediately after initiation of Fab therapy.
What is the antidote for digoxin?
Digoxin-specific antibody antigen-binding fragments (DSFab), brand name Digibind or Digifab, are an effective antidote that directly binds digoxin. DSFab is indicated for life-threatening toxicity including: Ventricular arrhythmias.
What is digoxin antibody?
Digoxin-specific antibody (Fab) fragments are the definitive treatment for patients with severe digitalis poisoning. Prior to the advent of digoxin-specific antibodies, treatment for cardiac glycoside toxicity was largely supportive [1]. In 1976, antibody fragments were first used successfully to treat patients [2].
Which enzyme is used in assay of digoxin for antigen binding?
5 The assay is based on competition between drug in the sample and drug labled with recombinant glucose-6-phosphate dehydrogenase (rG6PDH) for antibody binding sites. Enzyme activity decreases upon binding to the antibody, so the drug concentration in the sample can be measured in terms of enzyme activity.
What happens in digoxin toxicity?
Digoxin toxicity can emerge during long-term therapy as well as after an overdose. It can occur even when the serum digoxin concentration is within the therapeutic range. Toxicity causes anorexia, nausea, vomiting and neurological symptoms. It can also trigger fatal arrhythmias.
What is Digibind an antidote for?
Digibind is indicated for the treatment of potentially life-threatening digoxin intoxication. The manifestations of life-threatening digoxin toxicity include ventricular arrhythmias such as ventricular tachycardia or ventricular fibrillation or profound and progressive bradyarrhythmias not responsive to atropine.
Which are therapeutic effects of digoxin?
Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate.
When do you check digoxin after Digifab?
Consider the serum digoxin level in the context of the patient's clinical presentation; a reliable serum digoxin level must be obtained at steady state (ie, obtained ≥ 6 hours after ingestion). The serum digoxin level may be misleadingly high if obtained < 6 hours after ingestion.
Is Digibind and DigiFab the same thing?
Although Digibind and DigiFab are equivalent in their digoxin-binding activity, the antigens used to produce these Fabs are different.
What is Digibind used for?
Digibind is indicated for the treatment of potentially life-threatening digoxin intoxication. The manifestations of life-threatening digoxin toxicity include ventricular arrhythmias such as ventricular tachycardia or ventricular fibrillation or profound and progressive bradyarrhythmias not responsive to atropine.
What is digoxin used for?
Digoxin: a medicine used to treat irregular heartbeats - NHS.
What is DigiFab used for?
Digoxin immune fab is a medication used in the management and treatment of digoxin toxicity. Most toxicity cases are seen in patients with a past medical history of atrial fibrillation and underlying heart failure.