The primary mode of action of bismuth subsalicylate, the active ingredient of Pepto-Bismol, is as an antimicrobial agent. Bismuth subsalicylate disassociates in gastric acid to form bismuth salts, such as bismuth oxychloride.
Does Pepto Bismol really work?
When you have nausea due to overindulgence in food or drink, Pepto Bismol can provide you relief fast.* Pepto is clinically proven to be effective on upper gastrointestinal symptoms, like nausea after eating.
What is a substitute for Pepto Bismol?
What is a substitute for Pepto Bismol? Pepto-Bismol (bismuth subsalicylate) Over-the-counter. 7 alternatives. Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) Over-the-counter. Imodium (loperamide) Over-the-counter.
How does Pepto Bismol affect me?
Salicylism has been reported in patients who chronically ingest bismuth subsalicylate (the active ingredient contained in Pepto-Bismol) Common complaints include vertigo, diminished hearing, lethargy, CNS dysfunction, confusion, tinnitus, vomiting, and abdominal pain.
What are the contraindications for Pepto Bismol?
- Ringing in the ears
- Diarrhea that lasts for more than two days
- Severe vomiting
- High fever
- Any signs of an allergic reaction
What is the mechanism of action of bismuth?
Mechanism of action Stimulation of absorption of fluids and electrolytes by the intestinal wall (antisecretory action) As a salicylate, reducing inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H synthase 1/2.
What is the action of Pepto-Bismol?
Pepto-Bismol is thought to treat diarrhea by: increasing the amount of fluid your intestines absorb. reducing inflammation and overactivity of your intestines. preventing your body's release of a chemical called prostaglandin that causes inflammation.
What is the mechanism of action for over the counter bismuth subsalicylate?
Bismuth subsalicylate is in a class of medications called antidiarrheal agents. It works by decreasing the flow of fluids and electrolytes into the bowel, reduces inflammation within the intestine, and may kill the organisms that can cause diarrhea.
How does Pepto work in the stomach?
Pepto-bismol works by coating the walls of the gastrointestinal tract, forming protection against stomach acid. It can act as an antacid, which can help in reducing the symptoms associated with upset stomach, heartburn and indigestion.
How does Pepto-Bismol work for nausea?
It soothes your discomfort as the active ingredient in Pepto binds with toxins and provides a protective coating layer in the upper gastrointestinal tract to help you feel better fast from nausea due to overindulgence in food or drink.
Is Pepto-Bismol an acid base or neutral?
Bismuth Subsalicylate is a drug which is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. Bismuth Subsalicylate is an extremely weak basic (essentially neutral) compound (based on its pKa).
Is bismuth an antacid?
Bismuth subsalicylate is an antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. Bismuth subsalicylate is an antacid and anti-diarrheal agent.
What are the side effects of Pepto-Bismol?
Pepto-Bismol can cause you to have a black or darkened tongue. This is a harmless side effect. Common side effects include: constipation; or....Pepto-Bismol side effectschanges in behavior with nausea and vomiting;hearing loss or ringing in your ears;diarrhea lasting longer than 2 days; or.worsened stomach symptoms.
How effective is bismuth subsalicylate?
Bismuth subsalicylate has shown modest efilcacy in treating traveler's diarrhea and acute and chronic diarrhea in children, and it is effective prophylactically for traveler's diarrhea.
Does Pepto-Bismol stop you from pooping?
Aside from dark-colored stools and a black tongue, another possible side effect of Pepto Bismol is constipation. Be sure to stop taking Pepto Bismol and get medical care if you experience: nausea and vomiting.
Why does Pepto-Bismol make your poop black?
Medicines With Bismuth Drugs for upset stomach like bismuth subsalicylate (Pepto-Bismol and Kaopectate) contain bismuth to calm your belly. Bismuth can turn your tongue and poop black. This symptom is harmless. It should go away once you stop taking the medicine.
Does Pepto help poop?
The active ingredients of Pepto Bismol are thought to have the following actions within the body: Increasing the amount of fluid that is absorbed in the intestines, therefore firming up stool. Reducing inflammation. Calming intestinal spasms.
Before Taking This Medicine
This medication should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Subsalicy...
How Should I Take Pepto-Bismol?
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.Do no...
What Happens If I Miss A Dose?
Since Pepto-Bismol is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soo...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include increased thirst, anxiety, muscle spa...
What Should I Avoid While Taking Pepto-Bismol?
Ask your doctor or pharmacist before taking other antacids or diarrhea medications together with Pepto-Bismol.
Pepto-Bismol Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue...
What Other Drugs Will Affect Pepto-Bismol?
Ask a doctor or pharmacist if it is safe for you to use Pepto-Bismol if you are also using any of the following drugs: 1. a blood thinner such as w...
What are the side effects of Pepto Bismol?
Common side effects include: constipation; or. dark colored stools. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Pepto-Bismol side effects (more detail)
How long does it take to get diarrhea from Pepto Bismol?
Do not take more than 8 doses in one day (24 hours). Call your doctor if you still have diarrhea after 2 days of using Pepto-Bismol. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Pepto-Bismol.
Can you take Pepto Bismol for a stomach ulcer?
You should not use Pepto-Bismol for a stomach ulcer unless your ulcer is caused by H. pylori and your doctor has prescribed Pepto-Bismol as part of modified bismuth-containing quadruple therapy (mBCQT). Do not give this medicine to a child or teenager with a fever, flu symptoms, or chickenpox.
What is bismuth subsalicylate used for?
Bismuth subsalicylate is used as an antacid and antidiarrheal, and to treat some other gastrointestinal symptoms , such as nausea . The means by which this occurs is still not well documented. It is thought to be some combination of the following:
What is the formula for pink bismuth?
Bismuth subsalicylate has the empirical chemical formula of C 7 H 5 BiO 4, and it is a colloidal substance obtained by hydrolysis of bismuth salicylate (Bi (C 6 H 4 (OH)CO 2) 3 ).
When did bismuth salts start being used?
While bismuth salts were in use in Europe by the late 1700s, the combination of bismuth subsalicylate and zinc salts for astringency with salol (phenyl salicilate) appears to have begun in the US in the early 1900s as a remedy for life-threatening diarrhea in infants with cholera.
Is Bismuth a generic?
A generic version of Pepto-Bismol, back view. As a derivative of salicylic acid, bismuth subsalicylate displays anti-inflammatory and bactericidal action. It also acts as an antacid .
Is bismuth sulfide a salicylic acid?
Long-term use (greater than six weeks) may lead to accumulation and toxicity. Some of the risks of salicylism can apply to the use of bismuth subsalicylate.
Is bismuth oxychloride a bactericidal agent?
Bismuth oxychloride and bismuth hydroxide are both believed to have bactericidal effects, as is salicylic acid for enterotoxigenic E. coli a common cause of " traveler's diarrhea .". Organobismuth compounds have historically been used in growth media for selective isolation of microorganisms.
Can you take bismuth subsalicylate in breast milk?
For the same reason, it is typically recommended that nursing mothers not use medication containing bismuth subsalicylate because small amounts of the medication are excreted in human breast milk, and these pose a theoretical risk of Reye's syndrome to nursing children.
Overview
Mechanism of action
Bismuth subsalicylate is used as an antacid and antidiarrheal, and to treat some other gastrointestinal symptoms, such as nausea. The means by which this occurs is still not well documented. It is thought to be some combination of the following:
• Stimulation of absorption of fluids and electrolytes by the intestinal wall (antisecretory action)
• As a salicylate, reducing inflammation/irritation of stomach and intestinal lining through inhibition o…
Medical uses
As a derivative of salicylic acid, bismuth subsalicylate displays anti-inflammatory and bactericidal action. It also acts as an antacid.
Adverse effects
There are some adverse effects. It can cause a black tongue and black stools in some users of the drug when it combines with trace amounts of sulfur in saliva and the colon to form bismuth sulfide. Bismuth sulfide is a highly insoluble black salt, and the discoloration seen is temporary and harmless.
Long-term use (greater than six weeks) may lead to accumulation and toxicity. Some of the risk…
Drug interactions
There is an increased risk of bleeding when using bismuth subsalicylate and anticoagulation therapy, like Coumadin (Warfarin)
Structure
Despite its common usage and commercial significance, the exact structure of the pharmaceutical long remained undetermined, but was revealed, through the use of advanced electron crystallography techniques, to be a layered coordination polymer with the formula BiO(C7H5O3). In the structure, both the carboxylate and phenol groups of the salicylate coordinate towards the bismut…
History
While bismuth salts were in use in Europe by the late 1700s, the combination of bismuth subsalicylate and zinc salts for astringency with salol (phenyl salicylate) appears to have begun in the US in the early 1900s as a remedy for life-threatening diarrhea in infants with cholera. At first sold directly to physicians, it was first marketed as Bismosal in 1918.
External links
• Andrews PC, Deacon GB, Forsyth CM, Junk PC, Kumar I, Maguire M (August 2006). "Towards a structural understanding of the anti-ulcer and anti-gastritis drug bismuth subsalicylate". Angewandte Chemie. 45 (34): 5638–42. doi:10.1002/anie.200600469. PMID 16865763.