Full Answer
What is TNK used for?
To date, the only scientifically-proven and FDA-approved treatment for acute stroke is the clot-busting drug, tissue plasminogen activator (tPA). A newer clot-busting drug, tenecteplase (TNK), has chemical properties that make it a potentially safer and more effective drug for treating stroke.
Is tPA and TNK the same thing?
Tenecteplase (TNKase, TNK-tPA or TNK) is a thrombolytic agent derived from the tissue plasminogen activator (tPA).
Is TNK better than tPA?
The EXTEND-IA TNK study showed that TNK (0.25 mg/kg) before thrombectomy was associated with a higher rate of reperfusion and better functional outcome than the standard dose of tPA in AIS patients with an large vessel occlusion (LVO), if treated within 4.5 hours of onset.
What is TNK procedure?
TENECTEPLASE (TEN neck te place) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack.
How much does TNK cost?
The cost for TNKase intravenous powder for injection 50 mg is around $7,305 for a supply of 1 powder for injection, depending on the pharmacy you visit.
When should I give TNK?
Currently, TNK is only given to patients from 0 to 4.5 hours after onset of ischemic stroke symptoms. That may change, however, if data from clinical trials on an extended window or use in other populations are positive.
How fast do you push tenecteplase?
TNKase® (Tenecteplase) is for intravenous administration only. The recommended total dose should not exceed 50 mg and is based upon patient weight. A single bolus dose should be administered over 5 seconds based on patient weight.
What is TNK in cardiology?
Background—Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent.
What is replacing tPA?
Tenecteplase (TNK) is a bioengineered variant of tPA to make it a better lytic by increasing its specificity to fibrin and more resistant to degradation by endogenous enzymes.
How long does TNK stay in system?
Pharmacokinetics. Tenecteplase has an initial half-life of 20 to 24 minutes with a terminal half-life of 90 to 130 minutes with a mean plasma clearance ranging from 99 to 119 mL/min. The initial volume of distribution approximates plasma volume and the major route of elimination is by hepatic metabolism.
How long does tenecteplase take to work?
Tenecteplase can be given by a single bolus injection. This will improve the blood flow through the infarct-related artery in most patients within 90 minutes. The elimination is biphasic with a terminal half-life of approximately two hours.
When is TNKase given?
TNKase® (Tenecteplase) is a single-bolus thrombolytic, or clot-busting agent, approved by the U.S. Food and Drug Administration for use in mortality reduction associated with acute myocardial infarction (AMI). Treatment should be initiated as soon as possible after the onset of AMI symptoms.
What is another name for tPA?
Known by the generic name alteplase and marketed as Activase® (Genentech), tPA is given to patients through an IV in the arm, and it works by dissolving blood clots that block blood flow to the brain.
Is tPA the same as tenecteplase?
Tenecteplase is a type of tPA (tissue-type plasminogen activator) of increasing interest for the thrombolytic treatment of acute ischemic stroke due to advantageous drug characteristics and ease of administration.
Is TNKase a tPA?
TNKase® (Tenecteplase) is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese Hamster Ovary cells).
What is the difference between alteplase and tenecteplase?
Tenecteplase is a modified version of alteplase with several potential advantages over alteplase, such as a longer half-life and higher fibrin specificity. Tenecteplase thrombolysis for acute ischemic stroke.
How is TNKase given?
TNKase is given as an infusion into a vein. A healthcare provider will give you this injection.
What is TNKase?
TNKase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
What should I avoid after receiving TNKase?
Ask your doctor before taking aspirin or ibuprofen ( Motrin, Advil) shortly after you have received TNKase. These medications can increase your risk of bleeding.
What to tell your doctor before TNKase?
If possible before you receive TNKase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure, hemophilia or other bleeding disorder, a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord.
Does TNKase affect medical tests?
TNKase can affect the results of certain medical tests. Tell any doctor who treats you that you are using TNKase.
Can you tell your caregiver about TNKase?
In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received TNKase.
Does TNKase have a daily schedule?
Since TNKase is used as a single dose, it does not have a daily dosing schedule.
