Precautions
Zafirlukast (Accolate) is used to help control the symptoms of asthma and improve lung function. It doesn't replace your rescue inhaler ( albuterol (ProAir, Ventolin, Proventil)) when you're having an asthma attack, and you need to take it regularly twice a day. What is zafirlukast (Accolate)?
What is zafirlukast used for?
These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms. Zafirlukast is used for chronic treatment of asthma, and to prevent asthma attacks in adults and children as young as 5 years old. Do not give zafirlukast to a child younger than 5 years without a doctor's advice.
What are the side effects of zafirlukast for asthma?
Additionally, taking aspirin, fluconazole, theophylline, or erythromycin can alter the effects of zafirlukast. What are the side effects of zafirlukast? The most common side effects include headaches, infections, nausea, diarrhea, and insomnia.
Can you take zafirlukast with fluconazole?
Zafirlukast (Accolate) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value.
Is there a generic version of Accolate (zafirlukast)?
Is zafirlukast the same as Singulair?
#5: Accolate (Zafirlukast) Accolate is an alternative to Singulair for asthma and allergies. Like Singulair, it's a prescription-only LTRA except that the active ingredient is different (zafirlukast rather than montelukast). Estimated Cost (Without Insurance): Accolate tends to be cheaper than Singulair.
What type of drug is zafirlukast?
Zafirlukast is used to prevent asthma symptoms. Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of certain natural substances that cause swelling and tightening of the airways.
Is zafirlukast a control or rescue medication?
How does Accolate (zafirlukast) work? Accolate is a preventive drug. It is not a rescue medication and does not provide immediate relief of acute symptoms.
What is zafirlukast prescribed for?
Zafirlukast is used to prevent asthma attacks. It is not used to relieve an attack that has already started. For relief of an asthma attack that has already started, you should use an inhaled medicine that works quickly.
Is zafirlukast the same as montelukast?
Singulair (montelukast) Although it's less effective than inhaled steroid medications for controlling asthma, Accolate (zafirlukast) has less side effects. Makes it easier to breathe. Singulair (montelukast) has fewer side effects but doesn't work as well as some inhaled medications for asthma and allergies.
What is montelukast and zafirlukast?
Montelukast and zafirlukast are leukotriene receptor antagonists. They block the effects of leukotrienes. Zileuton is a leukotriene synthesis inhibitor. It prevents the body from making leukotrienes.
Is zafirlukast still available in the US?
Zafirlukast is an oral prescription tablet used for the long-term management of asthma. Accolate, the brand version of zafirlukast, is no longer available in the United States.
Does zafirlukast cause weight gain?
Weight gain is not a common side effect of zafirlukast (Accolate). Sometimes, people might have stomach issues, like diarrhea or nausea, when they start this medication, but they typically don't gain weight.
What are the side effects of zafirlukast?
Common side effects may include:nausea, diarrhea, stomach pain;headache; or.cold symptoms such as stuffy nose, sneezing, sore throat.
Is zafirlukast an anti inflammatory?
Zafirlukast produced significant effects on BAL cell counts and appeared to decrease the activation of alveolar macrophages purified from BAL fluid. These preliminary results suggest that zafirlukast does have anti-inflammatory properties.
Can you take Benadryl with zafirlukast?
Interactions between your drugs No interactions were found between Benadryl and zafirlukast.
What is Accolate generic name?
GENERIC NAME: ZAFIRLUKAST - ORAL (ZA-fir-LOO-kast)
Before Taking This Medicine
You should not use this medicine if you are allergic to zafirlukast, or if you have liver disease (including cirrhosis).To make sure zafirlukast is...
How Should I Take Zafirlukast?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.Zafirlukast...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Zafirlukast Dosing Information
Usual Adult Dose for Asthma -- Maintenance:-20 mg orally twice a day, 1 hour before or 2 hours after mealsComments:-A dose of 20 mg twice daily was...
What Other Drugs Will Affect Zafirlukast?
Other drugs may interact with zafirlukast, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your...
Zafirlukast Dosage Guide + Max Dose, Adjustments - Drugs.com
No. Zafirlukast (Accolate) works differently by blocking leukotrienes. Leukotrienes cause inflammation in your airways and more mucus secretion in...
Zafirlukast (Oral Route) Description and Brand Names - Mayo Clinic
Zafirlukast (Accolate) is considered a maintenance medication. It works to help your body in the long-term and will take time to reach its full eff...
Is zafirlukast (Accolate) the same as an antihistamine?
Insomnia or trouble sleeping is not a common side effect. Usually, zafirlukast (Accolate) is well tolerated. However, some people have reported ins...
How long does it take for zafirlukast (Accolate) to start working?
Zafirlukast (Accolate) doesn't cause withdrawal symptoms, or bothersome side effects that might occur if you stop the medication suddenly. Even tho...
Will zafirlukast (Accolate) affect my sleep?
Weight gain is not a common side effect of zafirlukast (Accolate). Sometimes, people might have stomach issues, like diarrhea or nausea, when they...
What happens if I stop taking zafirlukast (Accolate)? Will it cause withdrawal symptoms?
Will I gain weight while on zafirlukast (Accolate)?
What is Zafirlukast used for?
Uses. Zafirlukast is used to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma. Controlling symptoms of asthma helps you maintain your normal activities and cuts down on time lost from work or school.This medication must be used regularly to be effective.
How to report side effects of Zafirlukast?
You may report side effects to Health Canada at 1-866-234-2345. Before taking zafirlukast, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Can Zafirlukast cause allergies?
Before taking zafirlukast, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Does Zafirlukast slow down the removal of other medications?
Other medications can affect the removal of zafirlukast from your body, which may affect how zafirlukast works. An example is erythromycin, among others. This medication can slow down the removal of other medications from your body, which may affect how they work. An example is warfarin, among others.
What is Zafirlukast used for?
It helps by stopping inflammatory cells, called leukotrienes, from constricting (closing) your airways and from producing mucus in your lungs.
Can elderly people take Zafirlukast?
Appropriate studies performed to date have not demonstrated geriatric- specific problems that would limit the usefulness of zafir lukast in the elderly . However, elderly patients are more likely to have lower respiratory tract infections and unwanted side effects, which may require caution and an adjustment in the dose for elderly patients receiving zafirlukast.
Does Zafirlukast interact with other medications?
Zafirlukast (Accolate) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Can Zafirlukast cause liver failure?
LIVER DAMAGE. Some people taking zafirlukast (Accolate) have had liver failure, which can be dangerous. If you have abdominal pain, nausea, tiredness, yellowing of your skin or whites of the eyes, dark stool, flu-like symptoms, or loss of appetite, talk to your healthcare provider right away.
Is Zafirlukast safe for children?
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of zafirlukast in children. However, safety and efficacy have not been established in children younger than 5 years of age.
Does Zafirlukast cause insomnia?
Insomnia or trouble sleeping is not a common side effect. Usually, zafirlukast (Accolate) is well tolerated. However, some people have reported insomnia while taking zafirlukast (Accolate). If you have any issues with sleep or any changes in your mood while on this medication, let you provider know as soon as possible.
Can Zafirlukast be used for asthma?
Zafirlukast is used to help control the symptoms of asthma and improve lung function. However, this medicine should not be used to relieve an asthma attack that has already started.
What are the side effects of Zafirlukast?
The most common side effects of Zafirlukast in people 12 years and older include: · headache. · infection. · nausea. · diarrhea.
How long does Zafirlukast last?
In other studies, the mean plasma half-life of Zafirlukast ranged from approximately 8 to 16 hours in both normal subjects and patients with asthma.
Does Zafirlukast cause liver failure?
right upper quadrant abdominal pain, nausea, fatigue, lethargy, pruritus, jaundice, flu-like symptoms, and anorexia). Liver failure resulting in liver transplantation and death has occurred in patients taking Zafirlukast (see WARNINGS, Hepatotoxicity and ADVERSE REACTIONS).
Does Zafirlukast increase prothrombin time?
Coadministration of Zafirlukast with warfarin results in a clinically significant increase in prothrombin time (PT). Patients on oral warfarin anticoagulant therapy and Zafirlukast should have their prothrombin times monitored closely and anticoagulant dose adjusted accordingly (see PRECAUTIONS, Drug Interactions).
Does Zafirlukast have a gender?
Gender:The pharmacokinetics of Zafirlukast are similar in males and females. Weight-adjusted apparent oral clearance does not differ due to gender. Race: No differences in the pharmacokinetics of Zafirlukast due to race have been observed. Elderly: The apparent oral clearance of Zafirlukast decreases with age.
Does Zafirlukast inhibit CYP3A4?
Additional in vitro studies utilizing human liver microsomes show that Zafirlukast inhibits the cytochrome P450 CYP3A4 and CYP2C9 isoenzymes at concentrations close to the clinically achieved total plasma concentrations (see Drug Interactions).
Is Zafirlukast a plasma protein?
Zafirlukast is more than 99% bound to plasma proteins, predominantly albumin. The degree of binding was independent of concentration in the clinically relevant range. The apparent steady-state volume of distribution (Vss/F) is approximately 70 L, suggesting moderate distribution into tissues.
What Is Zafirlukast?
Zafirlukast is an oral prescription tablet used for the long-term management of asthma .
What Is Zafirlukast Used For?
The Food and Drug Administration approved zafirlukast for long-term prevention of asthma symptoms in adults and children aged 5 years and older. 2
What Are the Side Effects of Zafirlukast?
This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Dosage: How Much Zafirlukast Should I Take?
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Precautions
It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
What Other Medications Interact With Zafirlukast?
Zafirlukast has several medication interactions. If you take a medication that interacts with zafirlukast, your healthcare provider might adjust the doses or monitor for side effects.
What Medications Are Similar?
There are many medications prescribed for the treatment of asthma with a variety of different mechanisms. 1 Some medications are prescribed as part of combination therapy.
What is Zafirlukast used for?
Expand Section. Zafirlukast is used to prevent asthma symptoms. Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of certain natural substances that cause swelling and tightening of the airways.
What are the side effects of Zafirlukast?
yellowing of the skin or eyes. flu-like symptoms. rash. swelling of the eyes, face, lips, tongue, or throat. difficulty breathing or swallowing . hoarseness. pain, burning, numbness, or tingling in the hands or feet. Zafirlukast may cause other side effects.
What to tell your doctor before taking Zafirlukast?
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
How often should I take Zafirlukast?
Zafirlukast comes as a tablet to take by mouth. It is usually taken two times a day, 1 hour before or 2 hours after meals. Try to take zafirlukast at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Does Zafirlukast help with asthma?
Zafirlukast may help control asthma symptoms, but it does not cure asthma. Continue to take zafirlukast even if you feel well. Do not stop taking zafirlukast without talking to your doctor.
Can you take Zafirlukast more often?
Take zafirlukast exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Do not use zafirlukast to treat a sudden attack of asthma symptoms. Your doctor will prescribe a short-acting inhaler to use during attacks. Talk to your doctor about how to treat symptoms of a sudden asthma attack.
Can you get pregnant while taking Zafirlukast?
Your doctor may need to change the doses of your medications or monitor you more carefully for side effects. tell your doctor if you have or have ever had liver disease. tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking zafirlukast, call your doctor.
What is Zafirlukast used for?
Zafirlukast is an oral leukotriene receptor antagonist used for treating asthma. Leukotrienes are a group of chemicals manufactured in the body from arachidonic acid. Release of leukotrienes within the body, for example, by allergic reactions, promotes inflammation in many diseases such as asthma, a disease in which inflammation occurs in the lungs.
How long does Zafirlukast work?
For the treatment of asthma, it starts working only after 3 to 14 days of therapy.
Is Zafirlukast a hay fever medicine?
Zafirlukast (Accolate) is a drug prescribed for the treatment of chronic asthma, preventing exercise-induced asthma, and the symptoms of allergic rhinitis (hay fever). It is not prescribed for acute asthma attacks.
Does Zafirlukast interact with warfarin?
Thus far, data in humans are very limited. In one small study, zafirlukast was shown to interact with warfarin ( Coumadin, Jantoven ), resulting in increased "thinning" of blood and a decreased ability of blood to clot. This can increase the risk of bleeding.
Does Zafirlukast block leukotriene?
Zafirlukast blocks the binding of leukotriene types D4 (LTD4), and E4 (LTE4) and the promotion of inflammation. Accolate is the brand name for zafirlukast. Zafirlukast is available in generic form. You need a prescription for zafirlukast.
Ways to save on your Zafirlukast prescription
You may find that filling a 90-day supply will reduce your total cost for this prescription. As an added bonus, you'll make fewer trips to the pharmacy, saving you time and money.
Price history for 60 tablets of zafirlukast 20mg
GoodRx‘s cash prices are based on multiple sources, including published price lists, purchases, claims records, and data provided by pharmacies. Most of our discount and coupon prices are based on contracts between a pharmacy (or pharmacy purchasing group) and a Pharmacy Benefit Manager (PBM), who provides prices to us.
warnings
You should not use zafirlukast if you are allergic to it, or if you have liver disease (including cirrhosis).
Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives, blisters, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat.
Pregnancy & Breastfeeding
It is not known if zafirlukast will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Dosage Guidelines & Tips
Use Zafirlukast (Accolate) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Zafirlukast Description
Zafirlukast is used to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma.
May Treat: Maintenance therapy for asthma
Brand Names: Accolate
Drug Class: Asthma Therapy - Leukotriene Receptor Antagonists
Availability: Prescription Required
Pregnancy: Consult your doctor
Lactation: Consult a doctor before using
- If available, read the patient package insert
- Take on empty stomach 1hr prior or 2 hr after meals
- Will not stop an acute asthma attack
- If available, read the patient package insert
- Take on empty stomach 1hr prior or 2 hr after meals
- Will not stop an acute asthma attack
- Use daily
- Take doses regularly, even when feeling well
- Call MD if new abdominal pain/yellowing eyes/skin
- Call MD immediately for any mental/mood changes
- Tell Dr. if using rescue inhaler more & more often
- Lab tests may be ordered to monitor therapy
Zafirlukast - Clinical Pharmacology
Indications and Usage For Zafirlukast
Contraindications
Precautions
Adverse Reactions
- Mechanism of Action: Zafirlukast is a selective and competitive receptor antagonist of leukotriene D4 and E4 (LTD4 and LTE4), components of slow-reacting substance of anaphylaxis (SRSA). Cysteinyl leukotriene production and receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle constriction, and altered ce…
Overdosage
- Zafirlukast is indicated for the prophylaxis and chronic treatment of asthma in adults and children 5 years of age and older.
Zafirlukast Dosage and Administration
- Zafirlukast is contraindicated in patients who are hypersensitive to Zafirlukast or any of its inactive ingredients. Zafirlukast is contraindicated in patients with hepatic impairment including hepatic cirrhosis. Hepatotoxicity: Cases of life-threatening hepatic failure have been reported in patients treated with Zafirlukast. Cases of liver injury without other attributable cause have bee…
How Is Zafirlukast Supplied
- Information for Patients
Patients should be told that a rare side effect of Zafirlukast is hepatic dysfunction, and to contact their physician immediately if they experience symptoms of hepatic dysfunction (eg. right upper quadrant abdominal pain, nausea, fatigue, lethargy, pruritus, jaundice, flu-like symptoms, and an… - Eosinophilic Conditions:
In rare cases, patients with asthma on Zafirlukast may present with systemic eosinophilia, eosinophilic pneumonia, or clinical features of vasculitis consistent with Churg-Strauss syndrome, a condition which is often treated with systemic steroid therapy. Physicians should be alert to e…
Patient Information
- Adults and Children 12 years of age and older The safety database for Zafirlukast consists of more than 4000 healthy volunteers and patients who received Zafirlukast, of which 1723 were asthmatics enrolled in trials of 13 weeks duration or longer. A total of 671 patients received Zafirlukast for 1 year or longer. The majority of the patients were 18 years of age or older; howev…