what is zofran odt 4mg

Precautions

Zofran has its own warning, though, at least for higher dosages that were once for nausea and vomiting associated with chemotherapy. This followed a study that found that a single 32-milligram dose might affect the heart's rhythm, leading to QT interval prolongation.

How much Zofran is too much?

Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Zofran may be used for purposes not listed in this medication guide. You should not use Zofran if you are also using apomorphine (Apokyn).

What is Zofran 4 mg used for?

How often can you take Zofran 4mg ODT? Adults typically take one 8-mg tablet or rapidly disintegrating tablet or 10 mL of liquid twice a day. For patients ages 12 and older, the dosage is the same as for adults. For those ages 4 to 11, patients should take a 4-mg tablet or rapidly disintegrating tablet or 5 mL of liquid three times per day.

How often can you take Zofran?

What is Zofran (ondansetron) used for?

• Prevention of nausea and vomiting due to cancer medications (chemotherapy)
• Prevention of nausea and vomiting due to radiation therapy
• Prevention of nausea and vomiting after surgery

What is Zofran used to treat?

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Is Zofran a narcotic?

Is Zofran (ondansetron) a narcotic? No, Zofran (ondansetron) is not a narcotic, instead it belongs to a class of medication called 5-HT3 (serotonin) receptor antagonist.

What is the difference between Zofran and Zofran ODT?

ZOFRAN ODT Tablets are a freeze-dried, orally administered formulation of ondansetron which rapidly disintegrates on the tongue and does not require water to aid dissolution or swallowing. Each 5 mL of ZOFRAN Oral Solution contains 5 mg of ondansetron HCl dihydrate equivalent to 4 mg of ondansetron.

How long does Zofran ODT take to work?

Ondansetron is an anti-sickness medicine. It will start to work within 1-2 hours. The most common side-effects are a headache, constipation, and feeling flushed.

Does Zofran make you sleepy?

Yes, ondansetron (Zofran) might make you feel sleepy or tired. Ondansetron injection for the treatment of post-operative nausea and vomiting has been reported to cause drowsiness or sedation in 8% of patients vs. 7% of those using a placebo (an inactive treatment).

What does ODT mean on a prescription?

Orally disintegrating tablets (ODTs) provide an alternative to overcome these challenges. They resemble a traditional tablet, but have one important difference: they disintegrate rapidly in the mouth, and therefore do not need to be swallowed.

Is Zofran used for anxiety?

Conclusions: Ondansetron has been shown to be an effective treatment for early-onset alcoholism. Ondansetron's ability to improve symptoms of depression, anxiety, and hostility among EOA may make an additional contribution to its therapeutic effect.

Is Zofran good for stomach pain?

Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.

When should you not take Zofran?

Who should not take Zofran?low amount of magnesium in the blood.low amount of potassium in the blood.extrapyramidal disease, a type of movement disorder.neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion.serotonin syndrome, a type of disorder with high serotonin levels.More items...

Does Zofran help with stomach bug?

Ondansetron is a highly potent antiemetic drug that is effective in preventing chemotherapy-and radiation-induced nausea and vomiting with a very low risk of adverse effects. Recently, ondansetron has been used to control vomiting related to acute gastroenteritis.

Why was Zofran taken off the market?

FDA Drug Safety Communications & Zofran Recall In 2012, the 32 mg intravenous dose of Zofran was pulled from the market due to concerns that it could trigger QT interval prolongation, a heart rhythm disorder that could lead to an abnormal and potentially fatal heart rhythm called Torsades de Pointes.

Can you take Zofran on an empty stomach?

Ondansetron can be taken with or without food. The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully. Take the ondansetron regular tablet with a full glass of water.

How long does 4mg Zofran last?

A: Zofran (ondansetron) lasts about eight hours. It begins to work quickly and reaches peak concentration in about two hours. To prevent nausea, the dose is usually repeated eight hours after the first one.

Is ondansetron ODT the same as Zofran?

Ondansetron is available under the following different brand names: Zofran, Zofran ODT, and Zuplenz.

Is ODT and SL the same?

ODTs are different to conventional sublingual and buccal tablets, which are absorbed directly through the oral mucosa. sensitive to moisture and are not appropriate for placing into Dosage Administration Aids (e.g. Webster packs, dosette boxes).

Are Zofran and ondansetron the same thing?

Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy and surgery.

Is Zofran or ondansetron better?

Ondansetron has an average rating of 7.7 out of 10 from a total of 449 ratings on Drugs.com. 72% of reviewers reported a positive effect, while 19% reported a negative effect. Zofran has an average rating of 8.0 out of 10 from a total of 215 ratings on Drugs.com.

What Is Zofran ODT?

Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain.

What Are the Side Effects of Zofran ODT?

This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

What Other Medications Interact With Zofran ODT?

When taken with Zofran ODT, several medications may increase your risk of developing serotonin syndrome. Along with Zofran ODT, if you are taking a medicine that increases serotonin levels in the body, your doctor may need to choose a different treatment or monitor you more closely.

What to do if you miss Zofran?

In that case, skip your missed dose and take your Zofran ODT at your regularly scheduled time.

How to store Zofran ODT?

Store the Zofran ODT bottle or foil blister pack at room temperature or in the refrigerator. Be sure to keep your medication out of reach of children and pets.

What is the name of the drug that is similar to Zofran?

Two drugs that most closely resemble Zofran ODT are Anzemet (dolasetron) and the generic drug granisetron (the brand-name Kytril has been discontinued in the United States). These drugs also work by blocking the effects of serotonin in the body. 6

How long does it take for Zofran to work?

Zofran begins to work within 30 minutes of taking it and reaches peak blood levels within one to two hours. 2

What is a Zofran tablet?

ZOFRAN tablets are oval, film-coated tablets engraved with “Zofran” on one side and are available in the following strengths:

What is the active ingredient in Zofran?

The active ingredient in ZOFRAN tablets and ZOFRAN oral solution is ondansetron hydrochloride as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT 3 receptor type. Chemically it is (±) 1, 2, 3, 9-tetrahydro-9-methyl-3- [ (2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one, monohydrochloride, dihydrate. It has the following structural formula:

How much ondansetron is in a bottle?

a clear, colorless to light yellow liquid with a characteristic strawberry odor, contains 5 mg of ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron per 5 mL in amber glass bottles of 50 mL with child-resistant closures (NDC 0078-0677-22).

What are the adverse reactions to Zofran?

The most common adverse reactions (greater than or equal to 2%) reported in patients receiving ZOFRAN and concurrent radiotherapy were similar to those reported in patients receiving ZOFRAN and concurrent chemotherapy and were headache, constipation, and diarrhea.

How long does it take to take 8 mg of chemo?

Dosage Regimen. Moderately Emetogenic Cancer Chemotherapy. 12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose. Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy.

When to remove Zofran ODT?

Instruct patients not to remove Zofran ODT orally disintegrating tablets from the blister until just prior to dosing.

Where is Ondansetron absorbed?

Ondansetron is absorbed from the gastrointestinal tract and undergoes some first-pass metabolism. Mean bioavailability in healthy subjects, following administration of a single 8-mg tablet, is approximately 56%.

How long before radiation can you take ondansetron?

To prevent nausea from radiation treatment, take this medication 1 to 2 hours before the start of your treatment. To prevent nausea after surgery, take ondansetron 1 hour before the start of surgery. This medication may be taken with or without food. However, your doctor may tell you not to eat before chemotherapy, radiation, or surgery.

How does Ondansetron work?

This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment ( chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. Ondansetron works by blocking one of the body's natural substances (serotonin) that causes vomiting.

Can Ondansetron cause heart problems?

Ondansetron may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

Can you take Ondansetron if you are allergic to it?

Before taking ondansetron, tell your doctor or pharmacist if you are allergic to it; or to other anti- nausea serotonin blockers (e.g., granisetron ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Can Ondansetron cause QT prolongation?

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using ondansetron, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Are you currently using Zofran ODT 8 Mg Disintegrating Tablet?

This survey is being conducted by the WebMD marketing sciences department.

What is 4 mg of Zofran?

4 mg (ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron), are white, oval, film-coated tablets engraved with “Zofran” on one side and “4” on the other in bottles of 30 tablets (NDC 0078-0675-15).

What is the Zofran tablet?

ZOFRAN tablets are oval, film-coated tablets engraved with “Zofran” on one side and are available in the following strengths: 4 mg - white tablet with “4” engraved on the other side. 8 mg - yellow tablet with “8” engraved on the other side.

What is the active ingredient in Zofran?

The active ingredient in ZOFRAN tablets and ZOFRAN oral solution is ondansetron hydrochloride as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT 3 receptor type.

How long does it take to take 8 mg of chemo?

Dosage Regimen. Moderately Emetogenic Cancer Chemotherapy. 12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose. Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy.

When to remove Zofran ODT?

Instruct patients not to remove ZOFRAN ODT orally disintegrating tablets from the blister until just prior to dosing.

What are the adverse reactions to Zofran?

The most common adverse reactions (greater than or equal to 2%) reported in patients receiving ZOFRAN and concurrent radiotherapy were similar to those reported in patients receiving ZOFRAN and concurrent chemotherapy and were headache, constipation, and diarrhea.

Is Ondansetron a white powder?

Ondansetron hydrochloride dihydrate is a white to off-white powder that is soluble in water and normal saline. The active ingredient in ZOFRAN ODT orally disintegrating tablets is ondansetron base, the racemic form of ondansetron, and a selective blocking agent of the serotonin 5- HT 3 receptor type.

What is Ondansetron used for?

A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Antiemetics are drugs that reduce nausea and vomiting.

What is the best medicine to take for a seizure?

Anti-seizure drugs, such as phenytoin or carbamazepine. Your doctor may switch you from ondansetron to a different drug if needed.

How long after chemo can you take 8 mg?

Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 8 mg given 30 minutes before chemotherapy. Four and eight hours after the first dose, your child can take another 8 mg. For 1–2 days after chemotherapy, they can take 8 mg three times per day.

Does Ondansetron cause coma?

Serotonin syndrome warning: Ondansetron raises your risk of a life-threatening condition called serotonin syndrome. This syndrome occurs when the chemical serotonin builds up too much in your body. A high level of serotonin can cause agitation, delirium (confused thinking) and hallucinations (seeing or hearing things that aren’t real). It can also cause sweating, rapid heartbeat, muscle stiffness, tremor, seizures, jerky muscle movements, and coma. Call your doctor right away if you have any of these symptoms. This condition can result from using ondansetron alone. However, it’s more likely to occur when you’re also taking another drug that affects serotonin levels.

Is Ondansetron a generic drug?

Ondansetron orally disintegrating tablet is available as a brand-name drug and as a generic drug. Brand name: Zofran ODT.

Can you take Ondansetron with phenylketonuria?

This amino acid can cause dangerous effects in people with a condition called phenylketonuria. Don’t take the orally disintegrating tablet if you have phenylketonuria.

Can Ondansetron cause drowsiness?

Ondansetron orally disintegrating tablet may cause drowsiness. It can also cause other side effects.

What is Zofran used for?

Zofran (ondansetron) is used to prevent nausea and vomiting caused by cancer medications (chemotherapy), radiation therapy, or surgery. It's available in different forms which can be helpful if you're unable to swallow or keep things down.

What is the ingredient in Zofran?

Risk factors: People who have phenylketonuria (a disorder that makes people unable to break down and get rid of phenylalanine) The dissolvable tablet of Zofran (ondansetron) contains an ingredient called phenylalanine.

What are the side effects of Zofran (ondansetron)?

With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.

How much does Zofran (ondansetron) cost?

Zofran (ondansetron) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.

How does Zofran work?

Zofran (ondansetron) is an antiemetic that works by blocking the actions of serotonin in the body that can trigger nausea and vomiting.

How long does Zofran last?

The effects of Zofran (ondansetron) can last anywhere between 8 to 12 hours.

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What is Ondansetron used for?

Ondansetron orally disintegrating tablets are indicated for the prevention of nausea and vomiting associated with: highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m2. initial and repeat courses of moderately emetogenic cancer chemotherapy.

Can you push Ondansetron?

Do not attempt to push ondansetron oral ly disintegrating tablets through the foil backing. With dry hands, remove the tablet from the bottle or PEEL BACK the foil backing of 1 blister and GENTLY remove the tablet. IMMEDIATELY place the ondansetron orally disintegrating tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary.

Indications and Usage For Zofran Odt

Zofran Odt Dosage and Administration

Dosage Forms and Strengths

Contraindications

Warnings and Precautions

Adverse Reactions

Drug Interactions

• ZOFRAN tablets are oval, film-coated tablets engraved with “Zofran” on one side and are available in the following strengths: • 1. 4 mg – white tablet with “4” engraved on the other side. • 1. 8 mg – yellow tablet with “8” engraved on the other side. Zofran ODT orally disintegrating tablets are white, round, and plano-convex tablets available in th...

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Use in Specific Populations

Drug Abuse and Dependence

Overdosage