Precautions
Sep 01, 2020 · Zosyn is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe uterine infections. Zosyn is sometimes given together with other antibiotics. Warnings You should not use Zosyn if you have ever had an allergic reaction to certain antibiotics (especially a penicillin antibiotic).
How does Zosyn work in the body?
Zosyn (piperacillin / tazobactam) is a combination antibiotic medication used to treat a wide variety of bacterial infections. It's only available in injection form, so it's usually given in the hospital. COMMON BRANDS Zosyn DRUG CLASS Penicillin antibiotic / Beta-lactamase inhibitor CONTROLLED SUBSTANCE CLASSIFICATION Not a controlled medication
What conditions does Zosyn treat?
Zosyn Vial - Uses, Side Effects, and More Uses Piperacillin /tazobactam is used to treat a wide variety of bacterial infections. It is a penicillin antibiotic. It works by stopping the growth of...
Is Zosyn a broad spectrum antibiotic?
Dec 02, 2020 · What is Zosyn and how is it used? Zosyn is a combination antibiotic used to treat a variety of infections, including: Intra-Abdominal Infections, Skin And Skin Structure Infections, Female Pelvic Infections, Community-Acquired Pneumonia, and; Nosocomial Pneumonia; What are side effects of Zosyn? Common side effects associated with Zosyn may include: diarrhea,
Is Zosyn a penicillin?
What is zosyn used for? Piperacillin and tazobactam are penicillin antibiotics that fight bacteria in the body. Zosyn is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe vaginal infections. Click to see full answer. In this manner, what are side effects of zosyn?
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What is zosyn used for? Piperacillin and tazobactam is a combination penicillin antibiotic that is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe uterine infections.
What kind of bacteria does Zosyn treat?
Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus. Aerobic and facultative gram-negative microorganisms: Acinetobacter baumannii, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Why do you give Zosyn?
Zosyn contains a combination of piperacillin and tazobactam. Piperacillin and tazobactam are penicillin antibiotics that fight bacteria in the body. Zosyn is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe uterine infections.Sep 1, 2020
How long does it take Zosyn to work?
How long does it take Zosyn (piperacillin / tazobactam) to work? Zosyn (piperacillin / tazobactam) will start working right away to fight the infection in your body. You should start to feel better within 2 days, but be sure to finish all of your medication even if you feel like you don't need it anymore.
Is Zosyn used to treat sepsis?
Broad-spectrum agents, such as piperacillin-tazobactam (Zosyn) and vancomycin, are commonly used for empirical antibiotic coverage in suspected early sepsis and critically ill patients.Jan 23, 2017
Is Zosyn good for pneumonia?
Initial presumptive treatment of patients with nosocomial pneumonia should start with ZOSYN at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam). The recommended duration of ZOSYN treatment for nosocomial pneumonia is 7 to 14 days.
Is Zosyn hard on the kidneys?
If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn. Precautions section stating that combined use of these two drugs may be associated with an increased incidence of acute kidney injury.May 5, 2017
What is the side effects of Zosyn?
Nausea, constipation, diarrhea, headache, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
How do you know if Zosyn is working?
Your doctor will check your or your child's progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.Jul 2, 2021
Before Taking This Medicine
You should not use Zosyn if you are allergic to: 1. piperacillin or any other penicillin antibiotic (amoxicillin, ampicillin, Augmentin, dicloxacil...
What Happens If I Miss A Dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to m...
What Should I Avoid While Using Zosyn?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. D...
What Other Drugs Will Affect Zosyn?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may in...
Is Zosyn (piperacillin / tazobactam) a broad spectrum antibiotic?
Yes. Zosyn (piperacillin / tazobactam) is a broad spectrum antibiotic, which means that it works against many types of bacteria. This is why it is...
How long does it take Zosyn (piperacillin / tazobactam) to work?
Zosyn (piperacillin / tazobactam) will start working right away to fight the infection in your body. You should start to feel better within 2 days,...
Is Zosyn (piperacillin / tazobactam) bad for the kidneys?
Zosyn (piperacillin / tazobactam) can cause kidney damage, but this usually happens to people who are very sick and in the hospital or those who al...
Will Zosyn (piperacillin / tazobactam) cover MRSA?
No. Zosyn (piperacillin / tazobactam) will not treat infections caused by MRSA (methicillin-resistant Staphylococcus aureus). MRSA is a bacteria th...
Is Zosyn (piperacillin / tazobactam) a penicillin?
Zosyn (piperacillin / tazobactam) contains piperacillin, which is a penicillin-type antibiotic. It works against some of the same bacteria that reg...
What is Zosyn a combination of?
Zosyn (piperacillin / tazobactam) is a combination of 2 antibiotic medications, piperacillin and tazobactam. Piperacillin is an antibiotic that kills bacteria by preventing them from making their own protective covering.
What is the difference between tazobactam and piperacillin?
Piperacillin is an antibiotic that kills bacteria by preventing them from making their own protective covering. Tazobactam, a beta-lactamase inhibitor, helps in blocking enzymes that can often lead to antibiotic resistance.
Can Zosyn cause blisters?
In some rare cases, people have developed really bad, potentially life-threatening skin reactions after starting Zosyn (piperacillin / tazobactam). These are types of allergic rashes that are painful and create blisters all over the body. Get medical help right away if you notice a new rash, have a rash and a fever, unexplained blisters, or new sores inside your mouth.
Can Zosyn cause diarrhea?
Like all antibiotics, Zosyn (piperacillin / tazobactam) can cause diarrhea because it gets rid of the good bacteria in your gut. In rare cases, this diarrhea is caused by a bacteria called Clostridioides difficile (commonly called C. diff) that is usually kept under control by your gut bacteria.
Can medicine cause side effects?
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
What to do if you miss a dose of a sulfate sulfate?
It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up. Storage. Consult the product instructions or your pharmacist for storage details.
How to store medical supplies?
Learn how to store and discard medical supplies safely. If you are using the frozen pre-mixed solution, thaw the container at room temperature or in the refrigerator. If the bag is thawed in the refrigerator, let it sit at room temperature for at least 1 hour before using.
Where to report side effects?
You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions.
What are the symptoms of an allergic reaction?
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever that doesn't go away, new or worsening lymph node swelling, rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing.
Is First Databank copyrighted?
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
Can drug interactions change your medication?
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
Why is Zosyn used?
To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZOSYN and other antibacterial drugs, ZOSYN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
What is a Zosyn?
ZOSYN is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a beta-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.
What is a Zosyn injection?
ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam so dium for intravenous administration.
Can you take Zosyn and Aminoglycosides separately?
ZOSYN and aminoglycosides should be reconstituted, diluted, and administered separately when concomitant therapy with aminoglycosides is indicated [see DRUG INTERACTIONS ].
Can you take probenecid with Zosyn?
Probenecid should not be co-administered with ZOSYN unless the benefit outweighs the risk.
What is the name of the bacteria that causes peritonitis?
Appendicitis (complicated by rupture or abscess) and peritonitis caused by beta-lactamase producing isolates of Escherichia coli or the following members of the Bacteroides fragilis group: B. fragilis, B. ovatus, B. thetaiotaomicron, or B. vulgatus. The individual members of this group were studied in fewer than 10 cases.
Should coagulation parameters be tested more frequently?
Coagulation parameters should be tested more frequently and monitored regularly during simultaneous administration of high doses of heparin, oral anticoagulants, or other drugs that may affect the blood coagulation system or the thrombocyte function [see WARNINGS AND PRECAUTIONS ].
What is USP in a zosyn?
ZOSYN (piperacillin and tazobactam for injection, USP) is indicated for the treatment of patients with moderate to severe infections caused by piperacillin-resistant, piperacillin/tazobactamsusceptible, β-lactamase producing strains of the designated microorganisms in the specified conditions listed below:
How many patients were treated with Zosyn?
During the initial clinical investigations, 2621 patients worldwide were treated with ZOSYN (piperacillin and tazobactam for injection, USP) in phase 3 trials. In the key North American clinical trials (n=830 patients), 90% of the adverse events reported were mild to moderate in severity and transient in nature. However, in 3.2% of the patients treated worldwide, ZOSYN was discontinued because of adverse events primarily involving the skin (1.3%), including rash and pruritus; the gastrointestinal system (0.9%), including diarrhea, nausea, and vomiting; and allergic reactions (0.5%).
What is USP in medicine?
ZOSYN (piperacillin and tazobactam for injection, USP) is an injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the βlactamase inhibitor tazobactam sodium for intravenous administration.
How much ZOSYN should I take for nosocomial pneumonia?
Initial presumptive treatment of patients with nosocomial pneumonia should start with ZOSYN at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam). Treatment with the aminoglycoside should be continued in patients from whom Pseudomonas aeruginosa is isolated. If Pseudomonas aeruginosa is not isolated, the aminoglycoside may be discontinued at the discretion of the treating physician.
Can -lactam cause bleeding?
Bleeding manifestations have occurred in some patients receiving β-lactam antibiotics, including piperacillin. These reactions have sometimes been associated with abnormalities of coagulation tests such as clotting time, platelet aggregation and prothrombin time, and are more likely to occur in patients with renal failure. If bleeding manifestations occur, ZOSYN (piperacillin and tazobactam for injection, USP) should be discontinued and appropriate therapy instituted.
What is Zosyn 2040?
ZOSYN (piperacillin and tazobactam injection) in Galaxy® Containers (PL 2040 Plastic) is a sterile injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration.
Can Zosyn be used for viral infections?
Patients should be counseled that antibacterial drugs, including ZOSYN, should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When ZOSYN is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by ZOSYN or other antibacterial drugs in the future.
What is Zosyn used for?
Piperacillin and tazobactam (Zosyn) is a combination of two antibiotics prescribed to treat a variety of bacterial infections such as pneumonia, appendicitis, pelvic inflammatory disease, E. coli infection, cellulitis, and postpartum endometriosis. Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking this medication.
What is a Zosyn injection?
What is piperacillin/tazobactam sodium injection, and how does it work (mechanism of action)? Zosyn is an injectable combination of two antibiotics, piperacillin and tazobactam, with broad spectrum activity against an extended range of bacterial species. Piperacillin is an extended-spectrum penicillin antibiotic, ...
How does piperacillin kill bacteria?
Piperacillin kills bacteria by inhibiting the synthesis of bacterial cell walls. It binds preferentially to specific penicillin-binding proteins (PBPs) located inside bacterial cell walls. PBPs vary among bacterial species, and thus susceptibility to piperacillin depends on the ability of piperacillin to bind to each species' specific PBPs. ...
Is piperacillin gram positive or negative?
In-vitro studies of piperacillin and tazobactam have shown that the combination has activity against a variety of gram-positive and gram-negative aerobic and anaerobic bacteria. Susceptible bacteria include: Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus.
Does piperacillin cross the placenta?
Piperacillin/tazobactam is known to cross the placenta. Piperacillin/tazobactam is approved for the treatment of postpartum infections.
Is tazobactam safe for pregnancy?
As with all medications, piperacillin/tazobactam should be used cautiously in pregnancy. Potential benefits of treatment should be weighed against any potential risk to the fetus. Piperacillin and tazobactam is classified as FDA pregnancy risk category C. Piperacillin is excreted into human milk in small amounts.
Does tazobactam inhibit lactamase?
Tazobactam inhibits beta lactamase and prevents the destruction of piperacillin. Therefore, tazobactam is given with piperacillin to enhance the activity of piperacillin in eradicating bacterial infections. Piperacillin kills bacteria by inhibiting the synthesis of bacterial cell walls.
