Precautions
What kind of infections does Zosyn treat?
- a bacterial infection
- presumed infection in neutropenic patient with fever
- bacterial pneumonia caused by Haemophilus influenzae
- pneumonia caused by bacteria
- nosocomial bacterial pneumonia
- hospital-acquired pneumonia from Staphylococcus bacteria
- cystic fibrosis and infection from Pseudomonas bacteria
- appendicitis caused by Escherichia coli bacteria
What conditions does Zosyn treat?
Zithromax Z – PAK is used to treat middle ear infection (otitis media), tonsillitis, laryngitis, bronchitis, pneumonia, sinusitis, and sexually transmitted infectious diseases (STDs) such as nongonococcal urethritis and cervicitis.
What STD is Zithromax used to treat?
Zithromax is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases.
What is the drug Zithromax used to treat?
How much does zosyn cost? The cost for Zosyn intravenous powder for injection (2 g-0.25 g) is around $81 for a supply of 10 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How much does Zosyn cost?
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What kind of infections does Zosyn treat?
What Conditions does Zosyn Vial Treat?a bacterial infection.presumed infection in neutropenic patient with fever.bacterial pneumonia caused by Haemophilus influenzae.pneumonia caused by bacteria.nosocomial bacterial pneumonia.hospital-acquired pneumonia from Staphylococcus bacteria.More items...
How quickly does Zosyn work?
How long does it take Zosyn (piperacillin / tazobactam) to work? Zosyn (piperacillin / tazobactam) will start working right away to fight the infection in your body. You should start to feel better within 2 days, but be sure to finish all of your medication even if you feel like you don't need it anymore.
What bacteria does Zosyn cover?
Piperacillin/tazobactam (Zosyn) This antibiotic has activity against many Gram-positive, Gram-negative, and anaerobic pathogens. It covers Streptococci, Staphylococci (but not methicillin-resistant S. aureus [MRSA]), Hemophilus, Moraxella, Enterobacteriaceae, and Pseudomonas aeruginosa.
How long should Zosyn be given?
ZOSYN should be administered by intravenous infusion over 30 minutes. The usual total daily dose of ZOSYN for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). The usual duration of ZOSYN treatment is from 7 to 10 days.
Does Zosyn make you tired?
SIDE EFFECTS: Swelling, redness, pain, and soreness at the injection site may occur. Dizziness, trouble sleeping, nausea, vomiting, diarrhea, and headache may also occur.
How do you know if Zosyn is working?
Your doctor will check your or your child's progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.
Can Zosyn cause kidney failure?
If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn. Precautions section stating that combined use of these two drugs may be associated with an increased incidence of acute kidney injury.
What is the best antibiotic for sepsis?
The majority of broad-spectrum agents administered for sepsis have activity against Gram-positive organisms such as methicillin-susceptible Staphylococcus aureus, or MSSA, and Streptococcal species. This includes the antibiotics piperacillin/tazobactam, ceftriaxone, cefepime, meropenem, and imipenem/cilastatin.
Why do you give Zosyn over 4 hours?
As discussed previously, studies have demonstrated that infusing P-TZ over 4 hours can lead to optimization of antimicrobial efficacy.
Can ZOSYN be given at home?
Treats bacterial infections. Zosyn (piperacillin-tazobactam) is only available as an injectable, so it's usually only given in the hospital. You can take Zosyn (piperacillin-tazobactam) at home, but it has to be stored in the fridge and used every 6 hours.
Does ZOSYN cover E coli?
Susceptible bacteria include: Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus. Aerobic and facultative gram-negative microorganisms: Acinetobacter baumannii, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Can ZOSYN be used for UTI?
Zosyn (piperacillin and tazobactam for injection) is a combination of two antibiotics used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia.
Why is Zosyn 4 hours?
Studies published in the medical literature support the concept that extending the infusion time of P-TZ to 4 hours maximizes the pharmacodynamic activity.
Is piperacillin a strong antibiotic?
Overall, piperacillin is a more potent ,B-Iactam antibiotic than are the carboxypenicillins, and it has a broader antimicrobial spectrum than do the aminopenicillins [3,4] .
What does Zosyn not cover?
Comparison of the 3 broadest spectrum beta-lactams: Cefepime, Zosyn, and Carbapenems (non-Ertapenem) have activity against both Gram positive (MSSA, Strep) and Gram negative including Pseudomonas. They do NOT cover: MRSA, VRE, Atypicals, among others.
How long does piperacillin stay in your system?
Following single or multiple doses of Piperacillin/Tazobactam to healthy subjects, the plasma half-life of piperacillin and tazobactam ranged from 0.7 to 1.2 hours and was unaffected by dose or duration of infusion.
Before Taking This Medicine
You should not use Zosyn if you are allergic to: 1. piperacillin or any other penicillin antibiotic (amoxicillin, ampicillin, Augmentin, dicloxacil...
What Happens If I Miss A Dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to m...
What Should I Avoid While Using Zosyn?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. D...
What Other Drugs Will Affect Zosyn?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may in...
Is Zosyn (piperacillin / tazobactam) a broad spectrum antibiotic?
Yes. Zosyn (piperacillin / tazobactam) is a broad spectrum antibiotic, which means that it works against many types of bacteria. This is why it is...
How long does it take Zosyn (piperacillin / tazobactam) to work?
Zosyn (piperacillin / tazobactam) will start working right away to fight the infection in your body. You should start to feel better within 2 days,...
Is Zosyn (piperacillin / tazobactam) bad for the kidneys?
Zosyn (piperacillin / tazobactam) can cause kidney damage, but this usually happens to people who are very sick and in the hospital or those who al...
Will Zosyn (piperacillin / tazobactam) cover MRSA?
No. Zosyn (piperacillin / tazobactam) will not treat infections caused by MRSA (methicillin-resistant Staphylococcus aureus). MRSA is a bacteria th...
Is Zosyn (piperacillin / tazobactam) a penicillin?
Zosyn (piperacillin / tazobactam) contains piperacillin, which is a penicillin-type antibiotic. It works against some of the same bacteria that reg...
What is Zosyn used for?
Zosyn is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a β-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below .
Why was Zosyn discontinued?
However, in 3.2% of the patients treated worldwide, Zosyn was discontinued because of adverse events primarily involving the skin (1.3%), including rash and pruritus; the gastrointestin al system (0.9%) , including diarrhea, nausea, and vomiting; and allergic reactions (0.5%).
How much sodium is in Zosyn?
Zosyn contains a total of 2.84 mEq (65 mg) of Na + (sodium) per gram of piperacillin in the combination product. This should be considered when treating patients requiring restricted salt intake. Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics.
How much tazobactam is in Zosyn?
Each Zosyn 2.25 g vial provides piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. Each Zosyn 3.375 g vial provides piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam.
How long does Zosyn take to infuse?
Zosyn should be administered by intravenous infusion over 30 minutes.
Can you take Zosyn and Aminoglycosides separately?
Zosyn and aminoglycosides should be reconstituted, diluted, and administered separately when concomitant therapy with aminoglycosides is indicated [ see Drug Interactions (7.1) ].
Can Zosyn be taken with renal impairment?
In patients with renal impairment (creatinine clearance ≤ 40 mL/min) and dialysis patients ( hemodialysis and CAPD), the intravenous dose of Zosyn should be reduced to the degree of actual renal function impairment. The recommended daily doses of Zosyn for patients with renal impairment are as follows:
What is Zosyn a combination of?
Zosyn (piperacillin / tazobactam) is a combination of 2 antibiotic medications, piperacillin and tazobactam. Piperacillin is an antibiotic that kills bacteria by preventing them from making their own protective covering.
What to know before taking Zosyn?
Before using Zosyn (piperacillin / tazobactam), tell your provider if you have kidney problems, have a history of seizures, or follow a low-sodium diet. You will need to have more frequent blood tests while using this medication.
What are the side effects of Zosyn (piperacillin / tazobactam)?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
How long does it take for Zosyn to work?
Zosyn (piperacillin / tazobactam) will start working right away to fight the infection in your body. You should start to feel better within 2 days, but be sure to finish all of your medication even if you feel like you don't need it anymore. If you are feeling worse after 2 days, check back with your healthcare provider because the Zosyn (piperacillin / tazobactam) might not be working well against the bacteria that's causing the infection.
Is Zosyn a penicillin?
Zosyn (piperacillin / tazobactam) contains piperacillin, which is a penicillin-type antibiotic. It works against some of the same bacteria that regular penicillin does, as well as many others because it is combined with tazobactam. If you're allergic to penicillin, you'll want to be careful about taking Zosyn (piperacillin / tazobactam) since there is a risk that it will cause your body to have a similar allergic reaction as it did with penicillin.
Can Zosyn be used for MRSA?
No. Zosyn (piperacillin / tazobactam) will not treat infections caused by MRSA (methicillin-resistant Staphylococcus aureus ). MRSA is a bacteria that is resistant to multiple antibiotics, so only a small handful of medications can treat it.
Can you give yourself Zosyn at home?
Before using Zosyn (piperacillin / tazobactam) at home, speak with your provider to learn about the proper way to give yourself a dose.
What is a Zosyn?
ZOSYN is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a beta-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.
What is a Zosyn injection?
ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam so dium for intravenous administration.
How long does tazobactam last in plasma?
Following single or multiple ZOSYN doses to healthy subjects, the plasma half-life of piperacillin and of tazobactam ranged from 0.7 to 1.2 hours and was unaffected by dose or duration of infusion.
How much tazobactam is in a Zosyn vial?
Each ZOSYN 2.25 g vial provides piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. Each ZOSYN 3.375 g vial provides piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam.
Can you take probenecid with Zosyn?
Probenecid should not be co-administered with ZOSYN unless the benefit outweighs the risk.
Is tazobactam a protein?
Both piperacillin and tazobactam are approximately 30% bound to plasma proteins. The protein binding of either piperacillin or tazobactam is unaffected by the presence of the other compound. Protein binding of the tazobactam metabolite is negligible.
What are some things I need to know or do while I take Zosyn?
Tell all of your health care providers that you take Zosyn. This includes your doctors, nurses, pharmacists, and dentists.
What are some other side effects of Zosyn?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
What are the side effects of Zosyn that I need to call my doctor about immediately?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
How do I store and/or throw out Zosyn?
If you need to store Zosyn at home, talk with your doctor, nurse, or pharmacist about how to store it.
How old do you have to be to take Zosyn?
If you are 65 or older , use Zosyn with care. You could have more side effects.
Does Zosyn affect lab results?
This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Zosyn.
Who to talk to about Zosyn?
Check with your pharmacist. If you have any questions about Zosyn, please talk with your doctor, nurse, pharmacist, or other health care provider.
How to use Zosyn Vial
This medication is given by injection into a vein as directed by your doctor, usually every 6 hours. It should be injected slowly over at least 30 minutes. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on age and weight.
Are you currently using Zosyn Vial?
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How long does Zosyn last?
Stability of ZOSYN in an ambulatory intravenous infusion pump has been demonstrated for a period of 12 hours at room temperature. Each dose was reconstituted and diluted to a volume of 37.5 mL or 25 mL. One-day supplies of dosing solution were aseptically transferred into the medication reservoir (I.V. bags or cartridge). The reservoir was fitted to a preprogrammed ambulatory intravenous infusion pump per the manufacturer's instructions. Stability of ZOSYN is not affected when administered using an ambulatory intravenous infusion pump.
How long does it take to administer Zosyn?
ZOSYN should be administered by intravenous infusion over 30 minutes.
How long does ZOSYN stay in the refrigerator?
bags have demonstrated chemical stability (potency, pH of reconstituted solution and clarity of solution) for up to 24 hours at room temperature and up to one week at refrigerated temperature. ZOSYN contains no preservatives. Appropriate consideration of aseptic technique should be used.
How long to infuse Zosyn?
Administer by infusion over a period of at least 30 minutes. During the infusion it is desirable to discontinue the primary infusion solution.
How much tazobactam to reconstitute?
Reconstitute the pharmacy bulk vial with exactly 152 mL of a compatible reconstitution diluent, listed below, to a concentration of 200 mg/mL of piperacillin and 25 mg/mL of tazobactam. Shake well until dissolved. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to and during administration whenever solution and container permit.
Can you take Zosyn and Aminoglycosides separately?
ZOSYN and aminoglycosides should be reconstituted, diluted, and administered separately when concomitant therapy with aminoglycosides is indicated [ see Drug Interactions (7.1) ].
Can you mix Zosyn with other drugs?
ZOSYN should not be mixed with other drugs in a syringe or infusion bottle since compatibility has not been established. ZOSYN is not chemically stable in solutions that contain only sodium bicarbonate and solutions that significantly alter the pH. ZOSYN should not be added to blood products or albumin hydrolysates.
What is Zosyn used for?
Zosyn (piperacillin and tazobactam) is a combination of two antibiotics prescribed to treat a variety of bacterial infections such as pneumonia, appendicitis, pelvic inflammatory disease, E. coli cellulitis, and postpartum endometriosis. Piperacillin is an extended-spectrum penicillin antibiotic, but it can be destroyed by an enzyme produced by ...
What is Levaquin? What is Zosyn?
Levaquin (levofloxacin) is an antibiotic used to treat bacterial infections of the sinuses, skin, lungs, ears, airways, bones, and joints; urinary infections; prostatitis; infectious diarrhea caused by E. coli, Campylobacter jejuni, and Shigella; obstetric infections, including mastitis (infection of the breast); inhalational anthrax exposure; and to prevent and treat plague caused by Yersinia pestis. Levaquin stops multiplication of bacteria by preventing the reproduction and repair of their genetic material, DNA. It is in a class of antibiotics called fluoroquinolones that includes ciprofloxacin ( Cipro ), norfloxacin ( Noroxin ), ofloxacin (Floxin), trovafloxacin ( Trovan ), and lomefloxacin (Maxaquin).
What is the purpose of Levaquin?
Summary. Levaquin (levofloxacin) and Zosyn (piperacillin and tazobactam) are antibiotics used to treat bacterial infections. Levaquin is used to treat bacterial infections of the sinuses, skin, lungs, ears, airways, bones, and joints; urinary infections; prostatitis; infectious diarrhea caused by E.
How does Levaquin work?
Levaquin stops multiplication of bacteria by preventing the reproduction and repair of their genetic material, DNA. It is in a class of antibiotics called fluoroquinolones that includes ciprofloxacin ( Cipro ), norfloxacin ( Noroxin ), ofloxacin (Floxin), trovafloxacin ( Trovan ), and lomefloxacin (Maxaquin). ...