What is aminophylline used for?
What other information should I know? Why is this medication prescribed? Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe.
What is the brand name for aminophylline systemic?
Brand names: Truphylline, Phyllocontin. Drug class(es): methylxanthines. Aminophylline systemic is used in the treatment of: Apnea of Prematurity. Asthma, acute.
What are the multi-ingredient medications containing aminophylline?
Multi-ingredient medications containing aminophylline: 1 aminophylline/amobarbital/ephedrine systemic. Brand names: Asthmacon. Drug class (es): antiasthmatic combinations. 2 aminophylline/ephedrine/guaifenesin/phenobarbital systemic. 3 aminophylline/ephedrine/phenobarbital/potassium iodide systemic. 4 aminophylline/guaifenesin systemic.
Is aminophylline the same as ethylenediamine?
Aminophylline is the ethylenediamine salt of theophylline. After ingestion, theophylline is released from aminophylline, and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen.
Is aminophylline a corticosteroid?
Aminophylline is an adjunct to beta2-agonists and corticosteroids in treating reversible bronchoconstriction caused by asthma and chronic lung conditions. However, the drug demonstrates a narrow therapeutic index, and even with regular monitoring, it can lead to adverse effects.
What's another name for aminophylline?
Theophylline is available under the following different brand names: Theo 24, Theochron, Elixophyllin, aminophylline, and Uniphyl.
Is aminophylline a beta agonist?
Beta2-agonist and aminophylline drugs are used for the treatment of asthma and work by opening the airways to help people breathe more easily. Both drugs can be given intravenously (IV) (directly through a vein).
What drugs interact with aminophylline?
The therapeutic efficacy of Alprazolam can be decreased when used in combination with Aminophylline. The risk or severity of seizure can be increased when Aminophylline is combined with Amifampridine. The metabolism of Aminophylline can be increased when combined with Aminoglutethimide.
What is a common side effect of aminophylline?
increased or rapid heart rate. irregular heartbeat. seizures. skin rash.
What is the drug aminophylline used for?
Aminophylline injection is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases in a hospital setting.
What are the 4 bronchodilators?
Types of bronchodilatorbeta-2 agonists, such as salbutamol, salmeterol, formoterol and vilanterol.anticholinergics, such as ipratropium and tiotropium.theophylline.
What are the 2 types of bronchodilators?
There are two main types of bronchodilators: long-acting and short-acting. Both types have a role in treating common lung diseases, such as asthma and COPD....Common long-acting bronchodilators include:salmeterol (Serevent)formoterol (Perforomist)aclidinium (Tudorza)tiotropium (Spiriva)umeclidinium (Incruse)
What is the mode of action of aminophylline?
Mechanism of Action: Aminophylline is a complex of theophylline and ethylenediamine and is given for its theophylline activity to relax smooth muscle and to relieve bronchial spasm. Theophylline is a smooth muscle relaxant and it relaxes the smooth muscle of the bronchial airways.
Who should not take aminophylline?
Kidney disease in infants younger than 3 months of age or. Liver disease (e.g., cirrhosis, hepatitis) or. Pulmonary edema (lung condition) or. Shock (serious condition with very little blood flow in the body)—Use with caution.
Does aminophylline make you sleepy?
In some cases, AMINOPHYLLINE may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
How long does aminophylline stay in your system?
It comes into effect immediately after being administered. Aminophylline majorly contains theophylline. Theophylline medication, once taken, starts working within 30 minutes. Aminophylline lasts for 4 to 6 hours in the body.
Is aminophylline still used?
IV aminophylline was previously a frequent therapy used to manage acute exacerbations of COPD and asthma but now sees much less frequent use, as it is far less effective than nebulized beta2-agonists. The currently recommended loading dose is 6 to 7 mg/kg administered intravenously over 20 to 30 minutes.
What is the brand name of salbutamol?
Salbutamol inhaler Brand names: Ventolin, Airomir, Asmalal, Easyhaler, Pulvinal, Salamol, Easi-Breathe, Salbulin.
What is the other name for amiodarone?
Amiodarone oral tablet is a prescription drug that's available as the brand-name drug Pacerone.
What is the trade name of epinephrine?
Epinephrine (medication)Clinical dataTrade namesEpiPen, Adrenaclick, othersOther namesEpinephrine, adrenaline, adrenalinAHFS/Drugs.comMonographMedlinePlusa60300239 more rows
What Is The Most Important Information I Should Know About aminophylline?
Do not crush or chew any extended-release formulation of aminophylline. Swallow the medication whole. It is specially formulated to release slowly...
Who Should Not Take aminophylline?
Before taking this medication, tell your doctor if you have 1. a stomach ulcer; 2. seizures or epilepsy; 3. high blood pressure, a heart condition,...
How Should I Take aminophylline?
Take aminophylline exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take t...
What Happens If I Overdose?
Seek emergency medical attention.Symptoms of an aminophylline overdose include nausea, vomiting, headache, insomnia, tremor (shaking hands or twitc...
What Should I Avoid While Taking aminophylline?
Use caution when driving, operating machinery, or performing other hazardous activities. Aminophylline may cause dizziness or drowsiness. If you ex...
Aminophylline Side Effects
If you experience any of the following serious side effects, stop taking aminophylline and seek emergency medical attention: 1. an allergic reactio...
Aminophylline Dosing Information
Usual Adult Dose for Asthma -- Acute:IV: (all dosages based on aminophylline-patient not receiving aminophylline or theophylline}Loading dose: 6 mg...
What Other Drugs Will Affect aminophylline?
Aminophylline interacts with many other drugs. Tell your doctor and pharmacist about all other medications that you are taking, including herbal re...
What Do I Need to Tell My Doctor Before I Take aminophylline?
1. If you have an allergy to aminophylline or any other part of aminophylline. 2. If you are allergic to any drugs like this one, any other drugs,...
What Are Some Things I Need to Know Or Do While I Take aminophylline?
1. Tell all of your health care providers that you take aminophylline. This includes your doctors, nurses, pharmacists, and dentists. 2. This medic...
How Is This Medicine (Aminophylline) Best Taken?
Use aminophylline as ordered by your doctor. Read all information given to you. Follow all instructions closely. 1. It is given as an infusion into...
What Are Some Side Effects That I Need to Call My Doctor About Right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor o...
What Are Some Other Side Effects of aminophylline?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help i...
How Do I Store and/or Throw Out aminophylline?
1. If you need to store aminophylline at home, talk with your doctor, nurse, or pharmacist about how to store it.
How is this medicine (Aminophylline) best taken?
Use aminophylline as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What are some things I need to know or do while I take Aminophylline?
Tell all of your health care providers that you take aminophylline. This includes your doctors, nurses, pharmacists, and dentists.
What do I need to tell my doctor BEFORE I take Aminophylline?
If you have an allergy to aminophylline or any other part of aminophylline.
What are some other side effects of Aminophylline?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
How do I store and/or throw out Aminophylline?
If you need to store aminophylline at home, talk with your doctor, nurse, or pharmacist about how to store it.
What to do if you are 60 and taking aminophylline?
If you are 60 or older, use aminophylline with care . You could have more side effects. Use with care in children. Talk with the doctor.
What to do if you overdose on aminophylline?
If you have any questions about aminophylline, please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away.
What is aminophylline?
Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.
What is the FDA requirement for aminophylline?
11.7.1 FDA Requirements. The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including aminophylline, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
What is the effect of adenosine antagonist on CD4 lymphocytes?
Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation.
What is the highest concentration of theophylline?
IV theophylline produces the highest and most rapid serum theophylline concentration. Following a single IV dose of theophylline (as aminophylline) of about 5 mg/kg over 30 minutes to healthy adults, mean peak serum theophylline concentrations of about 10 ug/mL are reached.
What is the ratio of aminophylline to ethylenediamine?
Aminophylline is a mixture comprising of theophylline and ethylenediamine in a 2:1 ratio. It has a role as a bronchodilator agent and a cardiotonic drug. It contains a theophylline and an ethylenediamine. Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio.
Is theophylline a corticosteroid?
/HUMAN EXPOSURE STUDIES/ ... Theophyl line has been recognized as an important drug for not only asthma but also corticosteroid-insensitive chronic obstructive pulmonary disease ( COPD). To clarify the role of theophylline in hypercapnic ventilatory responses in humans, we analyzed the effects of aminophylline administered at the usual clinical therapeutic doses on ventilation and augmentation of respiratory muscle contractility in room air and under 3 conditions of hypercapnia. We performed electromyography (EMG) of the parasternal intercostal muscle (PARA) and transversus abdominis muscle (TA) in 7 healthy subjects and recorded both ventilatory parameters and EMG data in room air and under 3 conditions of hypercapnia before (control) and during aminophylline administration. Before aminophylline administration (control), hypercapnic stimulation elicited ventilatory augmentation in a hypercapnia intensity-dependent manner. Ventilatory parameters (tidal volume, frequency of respiration, and minute ventilation) showed significant increases from lower PaCO2 levels during aminophylline administration when compared with the corresponding values before aminophylline administration. EMG activity of both PARA and TA increased significantly at each level of hypercapnia, and those augmentations were shown from lower PaCO2 levels during aminophylline administration. Aminophylline administered at the usual clinical therapeutic dose increases ventilation and EMG activity of both inspiratory and expiratory muscles during hypercapnia in healthy humans.
Does aminophylline cause twitching?
Theophyllines may also produce transiently increased urinary frequency, dehydration, twitching of fingers and hands, tachypnea, and elevated serum AST (SGOT) concentrations. Hypersensitivity reactions characterized by urticaria, generalized pruritus, and angioedema have been reported with aminophylline administration.
What is Aminophylline?
Aminophylline is a 2 to 1 ratio drug combination of theophylline and ethylenediamine. To alleviate symptoms of reversible airway obstruction due to asthma or other chronic lung disorders such as chronic bronchitis and emphysema, it is FDA approved. It is also used in preterm infants to avoid apnea..
How much aminophylline is needed for slow intravenous administration?
Injection of aminophylline by B.P. For slow intravenous administration, 250mg/10ml is intended. The solution can be injected very slowly or infused with either 5 percent dextrose or 0.9 percent sodium chloride injection in a limited amount.
What to do if you are allergic to aminophylline?
If you are allergic to aminophylline or some other medicine, notify your doctor and pharmacist.
Does aminophylline cause side effects?
Side effects can be caused by Aminophylline. If any of these symptoms are serious or do not go away, tell your doctor.
Can you get pregnant while taking aminophylline?
If you are pregnant, are trying to become pregnant, or are breast-feeding, tell your doctor. Give your doctor a call if you get pregnant while taking aminophylline.
Does aminophylline cure asthma?
Aminophylline controls but does not cure, the effects of asthma and other lung diseases. Even if you are not well, continue taking aminophylline. Without consulting your doctor, do not quit taking aminophylline.
What is the mechanism of action of aminophylline?
Aminophylline's mechanism of action is not entirely understood. Upon entering the body, aminophylline releases theop hylline, which is responsible for the bronchodilatory effects. There are various proposals for the molecular mechanism for theophylline, but not all of them take place at clinically effective concentrations. Theophylline works in three distinct ways:
How long does it take to load aminophylline?
This dose is for patients who have not taken aminophylline in the past 24 hours.
What is the ratio of aminophylline to ethylenediamine?
Aminophylline is a drug combination of theophylline and ethylenediamine in a ratio of 2 to 1.
How long after oral aminophylline can you breastfeed?
Breastfeeding Avoid breastfeeding for 2 hours after intravenous or 4 hours after an oral aminophylline product to reduce the dose received by the breastfed infant. [20]
How old do you have to be to get a dose adjustment for theophylline?
Renal Impairment: No dose adjustments are needed for renal impairment in adults or children older than three months. However, in infants younger than three months, a large amount of theophylline is excreted in the urine, requiring a dose adjustment.
What drugs induce CYP450?
CYP450 enzyme induction by drugs like phenobarbital, carbamazepine
Does theophylline inhibit phosphodiesterase?
Theophylline causes non-selective inhibition of type III and types IV isoenzymes of phosphodiesterase, which leads to increased tissue cyclic adenine monophosphate (cAMP) and cyclic 3′,5′ guanosine monophosphate concentrations, resulting in smooth muscle relaxation in lungs and pulmonary vessels, diuresis, CNS and cardiac stimulation. The bronchodilatory effect is not maximal at therapeutically effective dosages.[5] Inhibition of type IV isoenzyme is responsible for inhibiting the release of mediators from the alveolar macrophages but requires much higher serum concentrations. [6]
What is aminophylline?
Aminophylline is a complex of theophylline and ethylenediamine. Theophylline crosses the placenta. Refer to Theophylline monograph for additional information.
What are the two actions of Theophylline?
Pharmacology. Theophylline has two distinct actions; smooth muscle relaxation (ie, bronchodilation) and suppression of the response of the airways to stimuli (ie, non-bronchodilator prophylactic effects).
When should theophylline levels be monitored?
Theophylline levels: Serum theophylline levels should be monitored after initiation of therapy and prior to making dose increases; in the presence of signs or symptoms of toxicity; or when a new illness, worsening of a present illness, or change in patient’s treatment regimen that may alter theophylline clearance (eg, fever > 102°F or sustained for 24 hours or more, hepatitis, or drugs that are added or discontinued); changes in fluid balance; electrolyte concentrations, acid-base balance during prolonged therapy.
When does theophylline clearance decrease?
Significant reduction in theophylline clearance has been reported in women on the 20th day of the menstrual cycle and during the third trimester of pregnancy.
What percentage of albumin is theophylline?
Theophylline: ~40%, primarily to albumin; decreased in neonates (due to a greater percentage of fetal albumin), hepatic cirrhosis, acidemia (uncorrected), elderly, third trimester of pregnancy.
Is aminophylline a good medicine for asthma?
Note: All dosages expressed as aminophylline; use ideal body weight (theophylline distributes poorly into body fat) to calculate dose; individualize dose based on steady-state serum concentrations. Theophylline dose is ~79% of aminophylline dose. The treatment of asthma exacerbations with aminophylline is not supported or recommended by current clinical practice guidelines (GINA 2020; NAEPP 2007). The treatment of acute COPD exacerbations with aminophylline is not recommended by current clinical practice guidelines (Global Initiative for COPD Guidelines 2018).
Can aminophylline be used for cardiac stress testing?
Based on the American Society of Nuclear Cardiology (ASNC) Guidelines for Nuclear Cardiology Procedures, aminophylline given for the reversal of adenosine-, dipyridamole-, or regadenoson-induced adverse reactions (eg, angina, hypotension) during nuclear cardiac stress testing is effective and recommended in this setting. Use of aminophylline with adenosine-induced adverse reactions specifically is usually not warranted due to adenosine's short half-life (adverse reactions will usually stop within seconds of stopping adenosine). In the setting of aminophylline shortage, theophylline or caffeine may be used as alternatives to reverse regadenoson or dipyridamole. In addition, to reduce aminophylline use overall, adenosine or dobutamine can be used as alternative pharmacologic testing agents, if appropriate, since aminophylline reversal is not typically required [Singleton 2018].
What is aminophylline?
Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment ...
What is the mechanism of action of aminophylline?
Mechanism of action. Aminophylline is the ethylenediamine salt of theophylline. After ingestion, theophylline is released from aminophylline , and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen.
What is the name of the bronchodilator that is used for the treatment of bronchospas?
Aminophylline. Aminophylline is a bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
Can aminophylline be combined with abametapir?
The serum concentration of Aminophylline can be increased when it is combined with Abametapir. Abatacept. The metabolism of Aminophylline can be increased when combined with Abatacept. Abiraterone. The serum concentration of Aminophylline can be increased when it is combined with Abiraterone.
Is Aminophylline discontinued?
Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.
Which drug increases the excretion rate of aminophylline?
Liothyronine. Liothyronine may increase the excretion rate of Aminophylline which could result in a lower serum level and potentially a reduction in efficacy. Liotrix. Liotrix may increase the excretion rate of Aminophylline which could result in a lower serum level and potentially a reduction in efficacy.
Does porcine increase aminophylline?
Thyroid, porcine may increase the excretion rate of Aminophylline which could result in a lower serum level and potentially a reduction in efficacy. Thyrotropin alfa. Thyrotropin alfa may increase the excretion rate of Aminophylline which could result in a lower serum level and potentially a reduction in efficacy.
What is aminophylline?
Aminophylline is a bronchodilator that is used with other medications to treat sudden worsening of the symptoms of asthma, bronchitis, or emphysema.
What other drugs will affect aminophylline?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
What should I avoid while receiving aminophylline?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Can you smoke aminophylline?
a serious infection called sepsis. Tell your doctor if you smoke or have recently stopped smoking. Smoking can affect your aminophylline dose needs. It is not known whether this medicine will harm an unborn baby.
Can you tell a doctor you received aminophylline?
In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received aminophylline.
Can aminophylline harm a baby?
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant. Aminophylline can pass into breast milk and may cause fussiness or other side effects in the nursing baby. Tell your doctor if you are breast-feeding.
Product (s) containing aminophylline
Brand names: Phyllocontin, Truphylline Drug class (es): methylxanthines Aminophylline systemic is used in the treatment of:
Further information
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