Precautions
Stadol, or butorphanol tartrate, is a synthetically-derived opioid that treats pain and comes in injectable form and as a nasal spray. The spray, intravenous and intramuscular shots are used as pre-operative and pre-anesthetic medicine, and for pain relief during child labor.
Is Stadol an opioid?
Stadol Nasal Spray is my miracle medication. It is a narcotic nasal spray. You should only use one spray at a time ( mine usually take two), but if you get any hallucinigenic effects, you are taking too much. It is marvelous taken right at the beginning of a migraine. You should go to sleep as soon as you can and sleep as long as you can.
Is Stadol nasal spray a narcotic?
Stadol is the brand name of a pain reliever developed and sold by the Bristol Myers Squibb pharmaceutical company. It is now discontinued. However, the drug is still available in the US under the generic name of butorphanol as well as in other countries under different brand names.
Is Stadol still available?
Tramadol is considered to have fewer potential risks and complications when compared to other strong pain medications. It is often prescribed for patients who have had adverse reactions to other pain medications. However, serious side effects and risks still exist. See Opioid Medication Potential Risks and Complications. References
Is tramadol a risky pain medication?
What are some side effects that I need to call my doctor about right away?
What are some other side effects of Stadol?
What do I need to tell my doctor BEFORE I take Stadol?
How is this medicine (Stadol) best taken?
How do I store and/or throw out Stadol?
What are the side effects of benzodiazepines?
How to avoid passing out from stadol?
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About this website
What class of drug is Stadol?
Stadol belongs to a class of drugs called Opioid Analgesics; Analgesics, Opioid Partial Agonist.
How does Stadol make you feel?
Stadol can cause the mother to have respiratory depression, dizziness, and dysphoria (a state of feeling unwell and unhappy).
Is Stadol a controlled substance?
Stadol nasal spray is a Class IV federally controlled substance. There have been many reports of patients abusing this agent. It should only be prescribed with caution in most patients due to its addictive potential.
What class of drug is butorphanol?
It belongs to the group of medicines called narcotic analgesics (pain medicines). Butorphanol acts on the central nervous system (CNS) to relieve pain.
Is Stadol a morphine?
Stadol (butorphanol tartrate) is a narcotic pain reliever, similar to morphine used to treat moderate to severe pain. Stadol is also used as part of anesthesia for surgery, or during early labor (if childbirth is expected to be more than 4 hours away).
Can butorphanol be abused?
Butorphanol Tartrate Injection contains butorphanol, a substance with a high potential for abuse similar to other opioids including fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, oxymorphone, and tapentadol.
How long does a shot of Stadol last?
After intramuscular administration, pain relief onset occurred at 30 minutes or less, and peak effect occurred between 30 minutes and 1 hour. The duration of action of Stadol Injection was 3–4 hours when defined as the time necessary for pain intensity to return to pretreatment level or the time to retreatment.
Is butorphanol legal?
Butorphanol is a morphinan-type synthetic agonist–antagonist opioid analgesic developed by Bristol-Myers....Butorphanol.Clinical dataLegal statusAU : S8 (Controlled drug) CA : Schedule IV UK : Controlled Drug US : Schedule IVPharmacokinetic data34 more rows
What narcotic is a nasal spray?
Butorphanol tartrate nasal spray is an opioid narcotic pain reliever that is used for the relief of pain when the use of an opioid pain medication is appropriate. Butorphanol tartrate nasal spray comes in the form of a nasal spray. One spray of butorphanol tartrate nasal spray is quickly absorbed in the nasal passages.
Does Stadol cause hallucinations?
Abnormal dreams, agitation, dysphoria, hallucinations, hostility, withdrawal symptoms, and depression have been reported in less than 1% of patients.
How long does a shot of Stadol last?
After intramuscular administration, pain relief onset occurred at 30 minutes or less, and peak effect occurred between 30 minutes and 1 hour. The duration of action of Stadol Injection was 3–4 hours when defined as the time necessary for pain intensity to return to pretreatment level or the time to retreatment.
How long does Stadol last during labor?
Intravenous (IV): A dose of 1-2 mg is given every three to four hours through a small, plastic, strawlike tube in your vein, which delivers the medicine directly into your blood. Medication through an IV begins to work quickly within a few minutes, and the relief lasts up to four hours.
What is the best pain relief during labor?
Epidural anaesthesia. Epidural injections are the most effective pain relief available. They are used for vaginal births and also for caesarean sections, because they allow the mother to stay awake and alert during the baby's birth.
Stadol Side Effects: Common, Severe, Long Term - Drugs.com
Stadol Side Effects. Generic name: butorphanol Medically reviewed by Drugs.com. Last updated on Jun 20, 2022. Consumer; Professional; Note: This document contains side effect information about butorphanol. Some of the dosage forms listed on this page may not apply to the brand name Stadol.. For the Consumer
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Find everything you need to know about Stadol (Butorphanol (Injection)), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Stadol (Butorphanol ...
Side Effects of Stadol (Butorphanol Tartrate), Warnings, Uses - RxList
What Is Stadol? Stadol (butorphanol tartrate) is a narcotic pain reliever, similar to morphine used to treat moderate to severe pain. Stadol is also used as part of anesthesia for surgery, or during early labor (if childbirth is expected to be more than 4 hours away). The brand name Stadol is no longer manufactured and can only be found in generic form.
Stadol NS Nasal: Uses, Side Effects, Interactions, Pictures ... - WebMD
Find patient medical information for Stadol NS nasal on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
How long does it take for butorphanol to work?
Onset of analgesia is within a few minutes for intravenous administration, within 15 minutes for intramuscular injection, and within 15 minutes for the nasal spray doses.
What is a stadol nasal spray?
Stadol (butorphanol tartrate) Injection and Stadol NS (butorphanol tartrate) Nasal Spray are indicated for the management of pain when the use of an opioid analgesic is appropriate.
What is the n-octanol/aqueous buffer partition coefficient of butorphano?
Butorphanol tartrate is a white crystalline substance. The dose is expressed as the tartrate salt. One milligram of the salt is equivalent to 0.68 mg of the free base. The n-octanol/aqueous buffer partition coefficient of butorphanol is 180:1 at pH 7.5.
How is butorphanol eliminated?
Elimination occurs by urine and fecal excretion. When 3 H labelled butorphanol is administered to normal subjects, most (70–80%) of the dose is recovered in the urine, while approximately 15% is recovered in the feces. About 5% of the dose is recovered in the urine as butorphanol.
Why is it important to monitor butorphanol?
Proper patient selection, dose and prescribing limitations, appropriate directions for use, and frequent monitoring are important to minimize the risk of abuse and physical dependence with butorphanol tartrate. Special care should be exercised in administering butorphanol to patients with a history of drug abuse or to patients receiving the drug on a continuous basis for an extended period.
How long does butorphanol affect you?
Effects such as drowsiness or dizziness can appear, usually within the first hour after dosing. These effects may persist for varying periods of time after dosing. Patients who have taken butorphanol should not drive or operate dangerous machinery for at least 1 hour and until the effects of the drug are no longer present.
What are the symptoms of butorphanol overdose?
The most serious symptoms are hypoventilation, cardiovascular insufficiency, coma, and death. Butorphanol overdose may be associated with ingestion of multiple drugs (see ADVERSE REACTIONS: Postmarketing Experience ).
How long does it take for butorphanol to work?
Onset of analgesia is within a few minutes for intravenous administration, within 15 minutes for intramuscular injection, and within 15 minutes for the nasal spray doses.
What is butorphanol nasal spray?
Butorphanol tartrate nasal spray is an opioid narcotic pain reliever that is used for the relief of pain when the use of an opioid pain medication is appropriate. Butorphanol tartrate nasal spray comes in the form of a nasal spray. One spray of butorphanol tartrate nasal spray is quickly absorbed in the nasal passages.
How long does butorphanol affect you?
Opioid analgesics, including butorphanol, impair the mental or physical abilities required for the performance of potentially dangerous tasks such as driving a car or operating machinery. Effects such as drowsiness or dizziness can appear, usually within the first hour after dosing. These effects may persist for varying periods of time after dosing. Patients who have taken butorphanol should not drive or operate dangerous machinery for at least 1 hour and until the effects of the drug are no longer present.
What are the symptoms of butorphanol overdose?
The most serious symptoms are hypoventilation, cardiovascular insufficiency, coma, and death.
How long does it take to take butorphanol tartrate nasal spray?
In patients with hepatic or renal impairment, the initial dose sequence of butorphanol tartrate nasal spray should be limited to 1 mg followed, if needed, by 1 mg in 90 to 120 minutes. The repeat dose sequence in these patients should be determined by the patient’s response rather than at fixed times but will generally be at intervals of no less than at 6 hours (see CLINICAL PHARMACOLOGY : Pharmacokinetics And Individualization Of Dosagesection ).
How many patients were in the premarketing trial of butorphanol?
A total of 2446 patients were studied in premarketing clinical trials of butorphanol. Approximately half received butorphanol tartrate injection with the remainder receiving butorphanol tartrate nasal spray. In nearly all cases the type and incidence of side effects with butorphanol by any route were those commonly observed with opioid analgesics.
What is butorphanol tartrate?
Butorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The chemical name is (-)-17- (cyclobutylmethyl)morphinan-3,14-diol D- (-)-tartrate (1:1) salt. The molecular formula is C 21 H 29 NO 2 •C 4 H 6 O 6, which corresponds to a molecular weight of 477.6 and the following structural formula:
What is an agent that suppresses cough?
Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents .)
Does butorphanol cause liver damage?
Therapy with butorphanol has not been linked to serum enzyme elevations during therapy or to instances of idiosyncratic, clinically apparent liver injury. It is generally given for short periods of time for acute pain only and experience with prolonged use is limited.
Is butorphanol a narcotic?
Butorphanol is a synthetic opioid which is used as a nasal spray for treatment of migraine headaches and parenterally as a narcotic analgesic for moderate-to-severe pain or as an adjunct to general anesthesia. Butorphanol has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.
How is butorphanol given?
Intravenous (IV): A dose of 1-2 mg is given every three to four hours through a small, plastic, strawlike tube in your vein, which deliver s the medicine directly into your blood .
What pain medication is used during labor?
Doctors use different types of pain medication during labor and delivery. Butorphanol, also called Stadol, is one option. 1 Here’s what you need to know about the effectiveness and safety of butorphanol during childbirth.
What is the best way to relieve pain during labor?
A narcotic analgesic can relieve moderate to severe pain during labor. It can make you feel more comfortable by:
How long does it take for IM to work?
Medication through an IM injection begins to work in about 10 to 15 minutes, and the relief lasts for up to four hours. 1 .
Why do you take methadone?
You are taking methadone or another opioid antagonist to combat addiction.
What to do if you have too much pain during labor?
You need delivery assistance with forceps or a vacuum extractor.
Is butorphanol an opioid?
Butorphanol is a narcotic analgesic medication and an opioid agonist-antagonist. 2 Doctors may prescribe this medication to treat migraine headaches, relieve pain after surgery, or help with the pain during labor.
What is butorphanol used for?
Theoretically it offers an advantage over traditional opiates such as morphine and meperidine in the treatment of moderate pain. Butorphanol has been used as a preoperative sedative and analgesic, as a supplement to balanced anesthesia, and for suppression of postanesthesia shaking. Other recognized uses include obstetric analgesia during labor and relief of moderate postpartum pain. In addition, butorphanol has been used effectively for conscious sedation. Its lack of euphoric effects may be useful in emergency medicine for clinical populations prone to drug-seeking behavior. Butorphanol has been used more recently for epidural analgesia or for intravenous patient-controlled analgesia when allergies to opiates exist. Since butorphanol is not a controlled substance, its use can reduce administrative liability for abuse and can lower the number of distribution records associated with Schedule II narcotics.
Is butorphanol a sedative?
Butorphanol has been used as a preoperative sedative and analgesic, as a supplement to balanced anesthesia, and for suppression of postanesthesia shaking. Other recognized uses include obstetric analgesia during labor and relief of moderate postpartum pain.
Is butorphanol a euphoric drug?
Its lack of euphoric effects may be useful in emergency medicine for clinical populations prone to drug-seeking behavior. Bu torphanol has been used more recently for epidural analgesia or for intravenous patient-controlled analgesia when allergies to opiates exist.
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Pain Management
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome.
Muscle Pain (Myofascial Pain Syndrome)
Muscle pain (myofascial pain syndrome) is muscle pain in the body's soft tissues due to injury or strain. Symptoms include muscle pain with tender points and fatigue. Treatment usually involves physical therapy, massage therapy, or trigger point injection.
Neuropathic Pain
Neuropathic pain is a chronic condition that leads to ongoing pain symptoms. Patients can be predisposed to developing neuropathic pain who have conditions such as diabetes, cancer, stroke, HIV, vitamin deficiencies, shingles, and multiple sclerosis. Patient history and nerve testing are used to diagnose neuropathic pain.
Pain Relief Options for Childbirth
Women experience and tolerate pain differently. For some pregnant women, focused breathing is all they need to get through labor and childbirth; but for others, numbing of the pain is desired. There are a number of different medications a woman can take during labor and childbirth.
Are you currently using Stadol NS Spray, Non-Aerosol?
This survey is being conducted by the WebMD marketing sciences department.
What medications can affect butorphanol?
Examples include azole antifungals (such as ketoconazole ), macrolide antibiotics (such as erythromycin ), HIV medications (such as ritonavir ), rifamycins (such as rifabutin, rifampin ), certain drugs used to treat seizures (such as carbamazepine, phenytoin), among others.
How to use nasal spray?
This medication is a nasal spray. Have your doctor or pharmacist show the proper way to use the nasal spray. For best results, blow your nose gently before using. Follow the patient instruction leaflet for priming the pump before first use. If the spray has not been used in 48 hours, you may need to prime the pump again before use.
How to stop constipation from a syringe?
If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.
What to do if someone overdoses on naloxone?
Overdose. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, give them naloxone if available, then call 911. If the person is awake and has no symptoms, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222.
What to do if your pain doesn't get better?
Tell your doctor if your pain does not get better or if it gets worse.
Can you take a drowsy pill with alcohol?
The risk for severe breathing problems is higher when you start this medication and after a dose increase, or if you use the wrong dose/strength. Using this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death. Also, other medications can affect the removal ...
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
What are some other side effects of Stadol?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
What do I need to tell my doctor BEFORE I take Stadol?
Tell your doctor about the allergy and what signs you had.
How is this medicine (Stadol) best taken?
Use Stadol (butorphanol injection solution) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
How do I store and/or throw out Stadol?
If you need to store Stadol (butorphanol injection solution) at home, talk with your doctor, nurse, or pharmacist about how to store it.
What are the side effects of benzodiazepines?
This includes slow or troubled breathing and death. Benzodiazepines include drugs like alprazolam, diazepam, and lorazepam.
How to avoid passing out from stadol?
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
Stadol Description
This medication is used to treat moderate to severe pain, including pain from surgery, muscle pain, and migraine headaches.
Status: Discontinued
May Treat: General anesthesia adjunct · Labor pain · Pain · Sedation as adjunct to anesthesia
Alternate Brand Names: Stadol NS
Drug Class: Analgesic Opioid Partial-Mixed Agonists
Availability: Prescription Required
Status: Discontinued
May Treat: General anesthesia adjunct · Labor pain · Pain · Sedation as adjunct to anesthesia
Alternate Brand Names: Stadol NS
Drug Class: Analgesic Opioid Partial-Mixed Agonists
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Avoid intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
Addiction: Risk of abuse and addiction. Use only as directed
- Important to read patient package insert& med guide
- Discuss risks/benefits if woman of childbearing age
- Know how to use before taking.
- Important to read patient package insert& med guide
- Discuss risks/benefits if woman of childbearing age
- Know how to use before taking.
- May make you drowsy or dizzy. Drive with caution
- Avoid alcohol/other drugs that make you sleepy
- Call Dr before increasing dose or frequency.
- Taking a larger dose may cause breathing problems.
- May be habit forming
Stadol - Clinical Pharmacology
Indications and Usage For Stadol
Contraindications
Warnings
Precautions
- General Pharmacology and Mechanism of Action
Butorphanol is a mixed agonist-antagonist with low intrinsic activity at receptors of the µ-opioid type (morphine-like). It is also an agonist at κ-opioid receptors. Its interactions with these receptors in the central nervous system apparently mediate most of its pharmacologic effects, i… - Pharmacodynamics
The analgesic effect of butorphanol is influenced by the route of administration. Onset of analgesia is within a few minutes for intravenous administration, within 15 minutes for intramuscular injection, and within 15 minutes for the nasal spray doses. Peak analgesic activit…
Adverse Reactions
- Stadol (butorphanol tartrate) Injection and Stadol NS (butorphanol tartrate) Nasal Spray are indicated for the management of pain when the use of an opioid analgesic is appropriate. Stadol Injection is also indicated as a preoperative or preanesthetic medication, as a supplement to balanced anesthesia, and for the relief of pain during labor.
Drug Abuse and Dependence
- Stadol Injection and Stadol NS are contraindicated in patients hypersensitive to butorphanol tartrate or the preservative benzethonium chloride in Stadol NS or Stadol Injection in the multi-dose vial.
Overdosage
- Patients Dependent on Narcotics
Because of its opioid antagonist properties, butorphanol is not recommended for use in patients dependent on narcotics. Such patients should have an adequate period of withdrawal from opioid drugs prior to beginning butorphanol therapy. In patients taking opioid analgesics chronically, bu… - Drug Abuse and Dependence
Drug Abuse—Butorphanol tartrate, by all routes of administration, has been associated with episodes of abuse. Of the cases received, there were more reports of abuse with the nasal spray formulation than with the injectable formulation. Physical Dependence, Tolerance, and Withdraw…
Stadol Dosage and Administration
- General
Hypotension associated with syncope during the first hour of dosing with Stadol NS has been reported rarely, particularly in patients with past history of similar reactions to opioid analgesics. Therefore, patients should be advised to avoid activities with potential risks. - Head Injury and Increased Intracranial Pressure
As with other opioids, the use of butorphanol in patients with head injury may be associated with carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, drug-induced miosis, and alterations in mental state that would obscure the interpretation of the clinical cours…
What It Is
- Clinical Trial Experience
A total of 2446 patients were studied in premarketing clinical trials of butorphanol. Approximately half received Stadol Injection with the remainder receiving Stadol NS. In nearly all cases the type and incidence of side effects with butorphanol by any route were those commonly observed wit… - Postmarketing Experience
Postmarketing experience with Stadol NS and Stadol Injection has shown an adverse event profile similar to that seen during the premarketing evaluation of butorphanol by all routes of administration. Adverse experiences that were associated with the use of Stadol NS or Stadol In…
How It Works
- Stadol (butorphanol tartrate) Injection and Stadol NS (butorphanol tartrate) Nasal Spray are listed in Schedule IV of the Controlled Substances Act (CSA). Proper patient selection, dose and prescribing limitations, appropriate directions for use, and frequent monitoring are important to minimize the risk of abuse and physical dependence with butorphanol tartrate. Special care sho…
Side Effects
- Clinical Manifestations
The clinical manifestations of butorphanol overdose are those of opioid drugs in general. Consequences of overdose vary with the amount of butorphanol ingested and individual response to the effects of opiates. The most serious symptoms are hypoventilation, cardiovascular insuffi… - Treatment
The management of suspected butorphanol overdosage includes maintenance of adequate ventilation, peripheral perfusion, normal body temperature, and protection of the airway. Patients should be under continuous observation with adequate serial measures of mental state, respons…
Safety
- Factors to be considered in determining the dose are age, body weight, physical status, underlying pathological condition, use of other drugs, type of anesthesia to be used, and surgical procedure involved. Use in the elderly, in patients with hepatic or renal disease, or in labor requires extra caution (see PRECAUTIONS and CLINICAL PHARMACOLOGY: Individualization of Dosage). The …
Complications
- Stadol is the brand name of a pain reliever developed and sold by the Bristol Myers Squibb pharmaceutical company. It is now discontinued. However, the drug is still available in the US under the generic name of butorphanol as well as in other countries under different brand names. Butorphanol is a narcotic analgesic medication and an opioid agonis...
Choosing to Use Pain Medication
- A narcotic analgesic can relieve moderate to severe pain during labor. It can make you feel more comfortable by: 1. Calming anxiety. 2. Helping the body relax. 3. Relieving the intense pain of contractions. 4. Making you sleepy so you can rest between contractions. This type of pain reliever can help to lessen the pain, but it does not block it completely. So, it allows you to feel e…
Breastfeeding
- During labor, the goal is to relieve the pain without putting you at risk for harm or severe side effects. Studies show that butorphanol is a safe, low cost, and effective medication for pain relief during labor. However, like all medications, side effects are possible. They can affect both you and your baby.