what type of antibiotic is aztreonam

Precautions

Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics, the monobactams. Aztreonam is selectively active against Gram-negative aerobic bacteria and inactive against Gram-positive bacteria. Thus, in vitro, aztreonam is inhibitory at low concentrations (MIC90 l …

What class of antibiotics does aztreonam belong to?

Aztreonam is used to treat severe infections of the blood, urinary tract, lungs, skin, stomach, or female reproductive organs. Aztreonam may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package.

What is aztreonam prescribed for?

Does aztreonam cover gram-negative organisms? Yes. Does aztreonam cover anaerobes? No. Imipenem, meropenem, and ertapenem are _____ carbapenems. Do carbapenems cover staph? Yes. Do carbapenems cover s. pyogenes? Yes. Do carbapenems cover s. pneumoniae? yes.

Does aztreonam cover anaerobes?

Aztreonam (Azactam) is a monobactam that binds to penicillin binding proteins (PBP) and interferes with cell wall synthesis for sensitive bacteria. Has a high affinity for PBP-3. Has an inhaled formulation (brand name Cayston) Has activity against Gram negative bacteria ONLY, like Pseudomonas aeruginosa. Beware bacterial resistance to aztreonam.

Is aztreonam a penicillin?

How long does it take for aztreonam to be in your system?

What is USP aztreonam?

What is aztreonam used for?

How long does it take for a Pseudomonas aeruginosa to produce?

What to do if you are allergic to Aztreonam?

How much arginine is in a 2 gram vial of aquous solution?

How much arginine is in a gram of azoteonam?

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Is aztreonam a penicillin?

Pharmacology of Specific Drug Groups Aztreonam is a monocyclic β-lactam (monobactam) lacking the thiazolidine ring of penicillin (see Fig.

Is aztreonam a carbapenem?

Carbapenems and Monobactams: Imipenem, Meropenem, and Aztreonam. Imipenem and meropenem, members of the carbapenem class of β-lactam antibiotics, are among the most broadly active antibiotics available for systemic use in humans.

Is aztreonam a broad spectrum antibiotic?

It has a broad spectrum of activity against gram-negative bacteria but has no activity against gram-positive or anaerobic bacteria. Aztreonam readily penetrates the outer membrane of gram-negative bacteria.

Is aztreonam a strong antibiotic?

Aztreonam has strong activity against susceptible Gram-negative bacteria, including Pseudomonas aeruginosa. It is resistant to some beta-lactamases, but is inactivated by extended-spectrum beta-lactamases. It has no useful activity against Gram-positive bacteria or anaerobes.

Which antibiotics are carbapenems?

WHAT ARE NAMES OF CARBAPENEMS?Doribax.Doripenem.Ertapenem.Imipenem/cilastatin.Imipenem/cilastatin/relebactam.Invanz.Meropenem.Meropenem/vaborbactam.More items...

What organisms does aztreonam cover?

Aztreonam is selectively active against Gram-negative aerobic bacteria and inactive against Gram-positive bacteria.

What are the adverse effects associated with aztreonam use?

Side EffectsDiarrhea, nausea, vomiting, dizziness, headache, blurred vision, or redness/discomfort/pain/swelling at the injection site may occur. ... Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.More items...

What are the contraindications of aztreonam?

The following conditions are contraindicated with this drug....Conditions:diarrhea from an infection with Clostridium difficile bacteria.liver problems.decreased kidney function.

What is the generic name for aztreonam?

Aztreonam (Azactam) is used for the treatment of a variety of infections caused by certain bacteria called Gram-negative bacteria.

When should aztreonam be used?

Aztreonam injection is used to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary tract, blood, skin, gynecological, and abdominal (stomach area) infections, that are caused by bacteria.

Does aztreonam cover UTI?

Aztreonam has been demonstrated to be a valuable tool in the therapy of many types of nosoconiial urinary tract infections. It has considerable potential as therapy for resistant infections and as a prophylactic agent against postoperative urinary tract infection.

Does aztreonam cover MRSA?

MRSA infections are staphylococcal infections that are resistant to beta-lactam antibiotics including: penicillin, ampicillin, amoxicillin, amoxicillin/clavulanate, methicillin, oxacillin, dicloxacillin, nafcillin, cephalosporins, carbapenems (e.g., imipenem), and the monobactams (e.g., aztreonam).

Is aztreonam a monobactam?

Aztreonam is the only monobactam currently approved by the FDA. Aztreonam is a synthetic monocyclic β-lactam, the core structure of which was originally isolated from Chromobacterium violaceum (Fig. 22-2). It has high affinity for PBP3 of gram-negative bacteria, causing their filamentation, bacterial lysis, and death.

What is the difference between a penicillin and a carbapenem?

In terms of structure, the carbapenems are very similar to the penicillins (penams), but the sulfur atom in position 1 of the structure has been replaced with a carbon atom, and an unsaturation has been introduced—hence the name of the group, the carbapenems.

Is aztreonam a beta lactamase inhibitor?

Aztreonam was extremely stable as to the typical class C cephalosporinase of Citrobacter freundii, and acted as a competitive and progressive inhibitor for the beta-lactamase.

Is meropenem a carbapenem?

Meropenem is a broad-spectrum carbapenem antibiotic that possesses excellent activity against both aerobic Gram-positive and aerobic Gram-negative bacteria, and also covers common anaerobes.

Aztreonam Dosage Guide + Max Dose, Adjustments - Drugs.com

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 12 Oct 2022), Cerner Multum™ (updated 21 Sep 2022), ASHP (updated 12 Oct 2022 ...

Aztreonam injection Uses, Side Effects & Warnings - Drugs.com

Aztreonam side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).. Aztreonam may cause serious side effects. Call your doctor at once if you have:

GUIDANCE ON THE USE OF AZTREONAM in ADULTS

Prescribe antibiotics as per Hospital Antibiotic Adult (penicillin allergy options given) Prescribe Gentamicin as per guidance Use online calculator also available on

Aztreonam in the treatment of urinary tract infection - PubMed

The possible advantages of the monobactam antibiotic aztreonam in the treatment of hospital-acquired urinary tract infection were assessed in a study comparing aztreonam (0.5 to 1 g twice daily or three times daily) to cefamandole (1 g three times daily) in 159 patients. Initial pathogens were eradi …

What is aztreonam used for?

Medical uses. Nebulized forms of aztreonam are used to treat infections that are complications of cystic fibrosis and are approved for such use in Europe and the US; they are also used off-label for non-CF bronchiectasis, ventilator-associated pneumonia, chronic obstructive pulmonary disease, mycobacterial disease, ...

How does azoteonam work?

Mechanism of action. Aztreonam is similar in action to penicillin. It inhibits synthesis of the bacterial cell wall, by blocking peptidoglycan crosslinking. It has a very high affinity for penicillin-binding protein -3 and mild affinity for penicillin-binding protein-1a.

What is the purpose of azoteonam?

Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis. It is given by intravenous or intramuscular injection or by inhalation.

When was Aztreonam approved?

Aztreonam was approved for medical use in the United States in 1986. It was removed from the World Health Organization's List of Essential Medicines in 2019. It is available as a generic medication. It is a manufactured version of a chemical from the bacterium Chromobacterium violaceum.

What are the side effects of a syringe?

It is given by intravenous or intramuscular injection or by inhalation. Common side effects when given by injection include pain at the site of injection, vomiting, and rash. Common side effects when inhaled include wheezing, cough, and vomiting. Serious side effects include Clostridium difficile infection and allergic reactions including ...

Is aztreonam a nebulizer?

Aztreonam is poorly absorbed when given orally, so it must be administered as an intravenous or intramuscular injection (trade name Azactam ), or inhaled (trade name Cayston) using an ultrasonic nebulizer. In the United States, the Food and Drug Administration (FDA) approved the inhalation form on 22 February 2010, for the suppression of P. aeruginosa infections in patients with cystic fibrosis. It received conditional approval for administration in Canada and the European Union in September 2009, and has been fully approved in Australia.

Which organisms are susceptible to Aztreonam?

Acinetobacter anitratus, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis are generally susceptible to aztreonam, while some staphylococci, Staphylococcus aureus, Staphylococcus haemolyticus and Xanthomonas maltophilia are resistant to it. Furthermore, Aeromonas hydrophila, Citrobacter diversus, Enterobacter agglomerans, Haemophilus spp. and Streptococcus pyogenes have developed resistance to aztreonam to varying degrees.

What is the name of the first class of beta-lactam antibiotics?

Aztre onam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics, the monobactams.

Is aztreonam an aerobic antibiotic?

Azt reonam is selectively active against Gram-negative aerobic bacteria and inactive against Gram-positive bacteria. Thus, in vitro, aztreonam is inhibitory at low concentrations (MIC90 l …. Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics, the monobactams. Aztreonam is selectively active ...

Is Aztreonam safe for a gram negative infection?

Therapeutic trials have shown aztreon am to be effective in Gram-negative infections including complicated infections of the urinary tract, in lower respiratory tract infections and in gynaecological and obstetric, intra-abdominal, joint and bone, skin and soft tissue infections, uncomplicated gonorrhoea and septicaemia.

What should I avoid while using aztreonam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What other drugs will affect aztreonam?

Other drugs may affect aztreonam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

How cold should aztreonam be stored?

If possible, keep the freezer set at 4 degrees below 0 Fahrenheit or colder.

How long can you keep aztreonam at room temperature?

Store unmixed aztreonam at room temperature away from moisture and heat. You may store mixed medicine for up to 48 hours at room temperature, or up to 7 days in a refrigerator. Aztreonam is sometimes mixed with other antibiotics in the same solution. You may need to store this type of mixture differently.

What is the name of the antibiotic that fights bacteria?

Aztreonam is an antibiotic that fights bacteria.

How old do you have to be to take Aztreonam?

Aztreonam is not approved for use by anyone younger than 9 months old.

Where is aztreonam injected?

Aztreonam is injected into a muscle, or as an infusion into a vein. A healthcare provider may teach you how to properly use the medication by yourself.

How long does aztreonam last?

In elderly patients and in patients with impaired renal function, the mean serum half-life of aztreonam increased (4.7 to 6 hours and 2.1 hours , respectively). Clearance.

What is the mechanism of action of Aztreonam?

The bactericidal action of aztreonam results from the inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3). By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis.

How long does it take for aztreonam to be excreted?

Urinary excretion of a single parenteral dose was essentially complete by 12 hours after injection.

What is a monocyclic beta-lactam antibiotic?

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.

Which acid decreases the excretion rate of acetylsalicylic acid?

Acetylsalicylic acid may decrease the excretion rate of Aztreonam which could result in a higher serum level. Aclidinium. Aztreonam may decrease the excretion rate of Aclidinium which could result in a higher serum level. Acrivastine.

What class of compounds are monobactams?

This compound belongs to the class of organic compounds known as monobactams. These are compounds comprising beta-lactam ring is alone and not fused to another ring.

What are Gram negative infections?

For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections.

How should I use aztreonam?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

What should I avoid while using aztreonam?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect aztreonam?

If you use other inhaled medications, you may need to use them in a certain order while using aztreonam inhalation. Ask your doctor for specific instructions about when to use your other medications in relation to your aztreonam inhalation doses.

Why is azoteonam used for lung infection?

Aztreonam inhalation is used to improve breathing symptoms in people with cystic fibrosis and a lung infection caused by bacteria called Pseudomonas aeruginosa.

How to store diluent?

Store the medicine and diluent in the refrigerator. Do not freeze. Do not use past the expiration date on the label.

Do you need a bronchodilator before aztreonam?

You may need to use a bronchodilator medicine before each dose of aztreonam. Use only the bronchodilator your doctor has prescribed and carefully follow all instructions about timing the doses in relation to your aztreonam dose.

What are the side effects of a bronchospasm?

Call your doctor at once if you have a serious side effect such as: bronchospas m (wheezing, chest tightness, trouble breathing) right after using the medicine; or. any new or worsening symptoms. Less serious side effects may include: mild stomach discomfort, vomiting; cough, sore throat; stuffy nose; or. low fever.

How to prepare aztreonam for nebulizer?

Prepare aztreonam in the nebulizer only when you are ready to give yourself a dose. Swirl the mixture gently until the powder has dissolved, then pour the mixture into the handset of the nebulizer. Use the medicine right away after placing it in the nebulizer. Do not save it for later use.

Do you need a bronchodilator before aztreonam?

You may need to use a bronchodilator medication before each dose of aztreonam inhalation. Follow your doctor's instructions about the type of bronchodilator to use and when to use it.

What does it mean when you have a bronchospasm?

bronchospasm (wheezing, chest tightness, trouble breathing) right after using the medicine; or

What are the signs of an allergic reaction?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

What are the side effects of a syringe?

Call your doctor at once if you have a serious side effect such as: 1 bronchospasm (wheezing, chest tightness, trouble breathing) right after using the medicine; or 2 any new or worsening symptoms.

Can you use Aztreonam in larger amounts?

Use Aztreonam (Azactam) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Can you freeze diluent powder?

Store the powder and diluent in the refrigerator, do not freeze.

How long does it take for aztreonam to be in your system?

Serum concentrations of Aztreonam in healthy subjects following completion of single intramuscular injections of 500 mg and 1 g doses are depicted in Figure 1; maximum serum concentrations occur at about 1 hour. After identical single intravenous or intramuscular doses of Aztreonam for injection, the serum concentrations of Aztreonam are comparable at 1 hour (1.5 hours from start of intravenous infusion) with similar slopes of serum concentrations thereafter.

What is USP aztreonam?

Aztreonam for Injection, USP contains the active ingredient Aztreonam, a monobactam. It was originally isolated from Chromobacterium violaceum. It is a synthetic bactericidal antibiotic.

What is aztreonam used for?

Aztreonam for injection is indicated for adjunctive therapy to surgery in the management of infections caused by susceptible organisms, including abscesses, infections complicating hollow viscus perforations, cutaneous infections and infections of serous surfaces.

How long does it take for a Pseudomonas aeruginosa to produce?

For Pseudomonas aeruginosa, a single 2 g intravenous dose produces serum levels that exceed the MIC 90 for approximately 4 to 6 hours. All of the above doses of Aztreonam for injection result in average urine levels of Aztreonam that exceed the MIC 90 for the same pathogens for up to 12 hours.

What to do if you are allergic to Aztreonam?

If an allergic reaction to Aztreonam occurs, discontinue the drug and institute supportive treatment as appropriate (e.g., maintenance of ventilation, pressor amines, antihistamines, corticosteroids). Serious hypersensitivity reactions may require epinephrine and other emergency measures (see ADVERSE REACTIONS ).

How much arginine is in a 2 gram vial of aquous solution?

Each 1 gram vial contains 1 gram Aztreonam with approximately 780 mg arginine. Each 2 gram vial contains 2 grams Aztreonam with approximately 1.56 grams arginine.

How much arginine is in a gram of azoteonam?

Aztreonam for injection is a sterile, nonpyrogenic, sodium-free lyophilized, off-white to slightly yellow solid containing approximately 780 mg arginine per gram of Aztreonam. Following constitution, the product is for intramuscular or intravenous use.

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Mechanism of action

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