Precautions
Usual Adult Dose for:
- Deep Vein Thrombosis - Prophylaxis
- Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery
- Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery
- Prevention of Thromboembolism in Atrial Fibrillation
- Thromboembolic Stroke Prophylaxis
- Deep Vein Thrombosis
- Pulmonary Embolism
What is the drug apixaban used for?
Apixaban oral tablet is a prescription drug used to treat and prevent blood clots such as deep vein thrombosis (DVT) and pulmonary embolism (PE). It also helps decrease risk of stroke in atrial ...
What is apixaban prescribed for?
hot www.drugs.com. Along with its needed effects, apixaban (the active ingredient contained in Eliquis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. ... Insomnia, depression. Uncommon (0.1% to 1%): Anxiety . Dermatologic.
Does apixaban cause insomnia?
- Bluish color of the skin of the fingers or toes
- chills
- clay-colored stools
- continuing loss of appetite
- continuing or severe abdominal or stomach pain
- continuing or severe nausea and vomiting
- dark urine
- difficulty with moving
- fever
- hoarseness
What are the worst side effects of metoprolol?
What is apixaban?
How should I take apixaban?
What other drugs will affect apixaban?
What happens if you stop taking Apixaban?
Does Apixaban cause hives?
Can you take Apixaban if you are allergic to it?
Can you give Apixaban through a tube?
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About this website
Apixaban Side Effects: Common, Severe, Long Term - Drugs.com
Warning. Oral route (Tablet) Premature discontinuation of apixaban or any oral anticoagulant increases the risk of thrombotic events. Consider an alternative anticoagulant if apixaban treatment is discontinued for any reason other than pathological bleeding or treatment completion.
apixaban oral: Uses, Side Effects, Interactions, Pictures ... - WebMD
Find patient medical information for apixaban oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Apixaban: Side Effects, Dosage, Uses, and More - Healthline
Apixaban oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with apixaban include:
Common and Rare Side Effects for apixaban oral - WebMD
INFREQUENT side effects If experienced, these tend to have a Severe expression i ; anemia ; blood coming from anus ; coughing up of blood ; If experienced, these tend to have a Less Severe ...
When was Apixaban approved?
Apixaban was approved for medical use in the European Union in May 2011, and in the United States in December 2012. In 2018, it was the 66th most commonly prescribed medication in the United States with more than 12 million prescriptions. In December 2019, generic versions were approved in the United States.
What is Andexanet Alfa?
Andexanet alfa is a Food and Drug Administration (FDA) approved antidote for apixaban in people with uncontrolled and life-threatening bleeding events.
What is the name of the medication that is used to treat a clot in the hip?
Apixaban, sold under the brand name Eliquis among others, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation. Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots.
Is Apixaban being used in the NHS?
The NHS is currently trialling the use of apixaban in treating post-recovery COVID-19 patients.
Does Apixaban inhibit thrombin?
Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. Apixaban has no direct effect on platelet aggregation, but by inhibiting factor Xa, it indirectly decreases clot formation induced by thrombin.
Is Apixaban the same as Warfarin?
Apixaban and other anticoagulants ( dabigatran, edoxaban and rivaroxaban) appear equally effective as warfarin in preventing non-hemorrhagic stroke in people with atrial fibrillation and are associated with lower risk of intracranial bleeding.
Why is Apixaban prescribed?
Apixaban is used help prevent strokes or blood clots in people who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body and possibly causing strokes) that is not caused by heart valve disease.
What to do if you are allergic to Apixaban?
tell your doctor and pharmacist if you are allergic to apixaban, any other medications, or any of the ingredients in apixaban tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients .
Can you get pregnant while taking Apixaban?
If you become pregnant while taking apixaban, call your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking apixaban. Your doctor may tell you to stop taking apixaban before the surgery or procedure.
Can you take apixaban with an epidural?
If you have epidural or spinal anesthesia or a spinal puncture while taking a 'blood thinner' such as apixaban, you are at risk of having a blood clot form in or around your spine that could cause you to become paralyzed. Tell your doctor if you have an epidural catheter that is left in your body or have or have ever had repeated epidural or spinal punctures, spinal deformity, or spinal surgery. Tell your doctor and pharmacist if you are taking any of the following: anagrelide (Agrylin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin, Tivorbex), ketoprofen, and naproxen (Aleve, Anaprox, others); cilostazol (Pletal); clopidogrel (Plavix); dipyridamole (Persantine); eptifibatide (Integrilin); heparin; prasugrel (Effient); ticagrelor (Brilinta); ticlopidine; tirofiban (Aggrastat), and warfarin (Coumadin, Jantoven). If you experience any of the following symptoms, call your doctor immediately: muscle weakness (especially in your legs and feet), numbness or tingling (especially in your legs), or loss of control of your bowels or bladder.
Can you swallow Apixaban?
If you are unable to swallow the tablets, you can crush them and mix with water, apple juice, or applesauce. Swallow the mixture right after you prepare it. Apixaban can also be given in certain types of feeding tubes. Ask your doctor if you should take this medication in your feeding tube.
Can you take Apixaban without talking to your doctor?
If you have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) and are taking apixaban to help prevent strokes or serious blood clots, you are at a higher risk of having a stroke after you stop taking this medication. Do not stop taking apixaban without talking to your doctor. Continue to take apixaban even if you feel well. Be sure to refill your prescription before you run out of medication so that you will not miss any doses of apixaban. If you need to stop taking apixaban, your doctor may prescribe another anticoagulant ('blood thinner') to help prevent a blood clot from forming and causing you to have a stroke.
Is Apixaban a blood thinner?
Apixaban is best broadly described as a blood thinner. This is a misnomer, however. This is because blood thinners don't actually thin out or dilute your blood. Blood thinners make your blood less likely to clot, that's all.
Does Apixaban help with thrombosis?
For example, apixaban can help reduce the risk of something known as deep vein thrombosis. This is where blood clots form in the deep veins of the legs. The danger lies in that a piece of such a blood clot can break off and travel to the lungs, whereupon it can lead to difficulty breathing and, potentially, death.
What is Apixaban used for?
Also used to protect against the development of deep vein thrombosis (DVT) (blood clots in the deep veins) following hip or knee replacement surgery. Apixaban is also used in the treatment of DVT and pulmonary embolism (PE) (where blood clots lodge in the lungs), and to lower the risk of recurrent DVT and PE.
Why is Apixaban given?
Apixaban may be given to reduce the risk of blood clot formation.
How long does it take for Apixaban to peak?
Peak concentrations of apixaban appear within 3 to 4 hours of an oral dose. Absorption is not affected by food or by crushing the tablets but the rate of absorption is reduced at higher dosages.
How many strengths does Apixaban have?
Apixaban is available as an oral tablet in two strengths (2.5mg and 5mg).
What medications interact with Apixaban?
Common medications that may interact with apixaban include: amiodarone. antibiotics, such as erythromycin, anticonvulsants such as carbamazepine, phenobarbital, phenytoin or valproic acid. antimicrobial agents, such as ciprofloxacin, clarithromycin, erythromycin, metronidazole. antivirals, such as boceprevir, or delavirdine.
Why should I avoid apixaban?
Guidelines suggest avoiding the use of apixaban in people who are obese (BMI >40kg/m2 or weight of 120kg or more) because there is a lack of research investigating the use of the drug in this population.
What to do if you miss Apixaban?
If you miss a dose, take the dose as soon as you remember but if it is almost time for your next dose, do not double up the dose to make up for the missed dose. Just go back to your usual twice-daily dosage schedule. Tell all healthcare providers that you are taking Apixaban.
What is Apixaban used for?
Apixaban tablets are indicated for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery.
Why is Apixaban prescribed?
Apixaban tablets are indicated to reduce the risk of recurrent DVT and PE following initial therapy.
How long does Apixaban stay in water?
Crushed Apixaban tablets are stable in water, D5W, apple juice, and applesauce for up to 4 hours.
How long does it take to take Apixaban?
After 7 days, the recommended dose is 5 mg taken orally twice daily. Reduction in the Risk of Recurrence of DVT and PE. The recommended dose of Apixaban tablets is 2.5 mg taken orally twice daily after at least 6 months of treatment for DVT or PE [see Clinical Studies ( 14.3 )].
How many patients were randomized to Apixaban?
A total of 11,659 patients were randomized in 3 double-blind, multi-national studies. Included in this total were 1866 patients age 75 or older, 1161 patients with low body weight (≤60 kg), 2528 patients with Body Mass Index ≥33 kg/m 2, and 625 patients with severe or moderate renal impairment.
Does Apixaban cause bleeding?
Bleeding. Apixaban tablets increases the risk of bleeding and can cause serious, potentially fatal, bleeding [see Dosage and Administration ( 2.1) and Adverse Reactions ( 6.1 )]. Concomitant use of drugs affecting hemostasis increases the risk of bleeding.
Can you switch from anticoagulant to apixaban?
Switching from anticoagulants other than warfarin (oral or parenteral) to apixaban: Discontinue the anticoagulant other than warfarin and begin taking Apixaban at the usual time of the next dose of the anticoagulant other than warfarin.
Does Xa inhibitor affect platelet aggregation?
Acts as a selective, reversible site inhibitor of factor Xa, inhibiting both free and bound factor. Does not affect platelet aggregation directly, but does inhibit thrombin-induced platelet aggregation. Decreases thrombin generation and thrombus development.
Can you take Apixaban twice daily?
Instruct patient to take apixaban as directed. Take missed doses as soon as remembered on the same day and resume twice daily administration; do not double doses. Do not discontinue without consulting health care professional; may increase risk of having a stroke, DVT, or PE. If temporarily discontinued, restart as soon as possible. Store apixaban at room temperature. Advise patient to read Medication Guide before beginning therapy and with each Rx refill in case of changes.
Does apixaban affect INR?
When converting from apixaban to warfarin , apixaban affects INR, so INR measurements may not be useful for determining appropriate dose of warfarin. If continuous anticoagulation is necessary, discontinue apixaban and begin both a parenteral anticoagulant and warfarin at time of next dose of apixaban, discontinue parenteral anticoagulant when INR reaches acceptable range.
What is the metabolite of Apixaban?
Apixaban is mainly metabolized by CYP3A4/5 with conjugation via SULT1A1, but several other CYP and SULT isozymes are also involved. No apixaban metabolites were found to have pharmacological activity and there were no unique human metabolites.
Where is apixaban metabolized?
Approximately 25% of an orally administered apixaban dose is recovered in urine and feces as metabolites. Apixaban is metabolized mainly via CYP3A4 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2. O-demethylation and hydroxylation at the 3-oxopiperidinyl moiety are the major sites of biotransformation.
What is the effect of apixaban on thrombin?
Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and preventing formation of cross-linked fibrin clots.
What is Eliquis used for?
Eliquis (apixaban) is indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. /Included in US product label/
What is the NCIt apixaban?
NCI Thesaurus (NCIt) Apixaban is a pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c]pyridine-3-carboxamide substituted at position 1 by a 4-methoxyphenyl group and at position 6 by a 4- (2-oxopiperidin-1-yl)phenyl group. It is used for the prevention and treatment of thromboembolic diseases.
Is Apixaban a factor XA inhibitor?
Apixaban is a Factor Xa Inhibitor. The mechanism of action of apixaban is as a Factor Xa Inhibitor.
Does apixaban excrete in milk?
It is unknown whether apixaban or its metabolites are excreted in human milk. Rats excrete apixaban in milk (12% of the maternal dose). Women should be instructed either to discontinue breastfeeding or to discontinue Eliquis therapy, taking into account the importance of the drug to the mother.
What is apixaban?
Apixaban is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation.
How should I take apixaban?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
What other drugs will affect apixaban?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
What happens if you stop taking Apixaban?
If you stop taking apixaban for any reason, your doctor may prescribe another medicine to prevent blood clots.
Does Apixaban cause hives?
Apixaban side effects. Get emergency medical help if you have signs of an allergic reaction: hives; chest pain, wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.
Can you take Apixaban if you are allergic to it?
You should not take apixaban if you are allergic to it, or if you have active bleeding from a surgery, injury, or other cause. Apixaban may cause you to bleed more easily, especially if you have a bleeding disorder that is inherited or caused by disease.
Can you give Apixaban through a tube?
A crushed tablet mixture may also be given through a nasogastric (NG) feeding tube. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Apixaban can make it easier for you to bleed, even from a minor injury.
Overview
Apixaban is used to prevent serious blood clots from forming due to a certain irregular heartbeat (atrial fibrillation) or after hip/knee replacement surgery.
May Treat: Pulmonary thromboembolism · Deep venous thrombosis · Hip surgery deep vein thrombosis · Knee replacement deep vein thrombosis · Prevent thromboembolism in chronic atrial fibrillation and more
Brand Names: Eliquis · Eliquis DVT-PE Treat 30D Start
Drug Class: Direct Factor Xa Inhibitors
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Pulmonary thromboembolism · Deep venous thrombosis · Hip surgery deep vein thrombosis · Knee replacement deep vein thrombosis · Prevent thromboembolism in chronic atrial fibrillation and more
Brand Names: Eliquis · Eliquis DVT-PE Treat 30D Start
Drug Class: Direct Factor Xa Inhibitors
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: This drug should not be given to breastfeeding mothers
Alcohol: Limit intake while taking this medication
- Important to read patient package insert& med guide
- Call MD NOW if persistent or severe bleeding occurs
- Not recommended when breast feeding
- Important to read patient package insert& med guide
- Call MD NOW if persistent or severe bleeding occurs
- Not recommended when breast feeding
- Do not increase dose or frequency or prolong use.
- No alcohol/aspirin-like meds. Ask MD re. aspirin.
- Tell doctor & dentist you are using this medicine
- Review all drugs you are taking with your doctor
- Lab tests may be ordered to monitor therapy
Medical uses
Side effects
Mechanism of action
History
Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. It is used as an alternative to warfarin and does not requir…
Research
Apixaban is indicated for the following:
• To lower the risk of stroke and embolism in people with nonvalvular atrial fibrillation.
• Deep vein thrombosis (DVT) prevention. DVTs may lead to pulmonary embolism (PE) in knee or hip replacement surgery patients.
External links
Apixaban can increase the risk of bleeding which may be serious and potentially fatal. Concurrent use with other medications that affect blood clotting can further increase this risk. This includes medications such as other anticoagulants, heparin, aspirin, antiplatelet medications, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and nonsteroidal anti-inflammatory drugs (NSAIDs).
Medical uses
Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. Apixaban has no direct effect on platelet aggregation, but by inhibiting factor Xa, it indirectly decreases clot formation induced by thrombin.
Administration
Apixaban was approved for medical use in the European Union in May 2011.
A new drug application (NDA) for the approval of apixaban was submitted to the U.S. Food and Drug Administration (FDA) by Bristol-Myers Squibb (BMS) and Pfizer jointly after conclusion of the ARISTOTLE clinical trial in 2011. Apixaban was approved for the prevention of stroke in people with atrial fibrillation on 28 December 2012. On 13 March 2014, it was approved for the addition…
Preparation
The UK National Health Service (NHS) is testing the use of apixaban in treating post-recovery COVID-19.
Prognosis
• "Apixaban". Drug Information Portal. U.S. National Library of Medicine.
Diet
- Apixaban is used help prevent strokes or blood clots in people who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body and possibly causing strokes) that is not caused by heart valve disease. Apixaban is also used to prevent deep vein thrombosis (DVT; a blood clot, usually i...
Risks
- Apixaban comes as a tablet to take by mouth. It is usually taken with or without food twice a day. When apixaban is taken to prevent DVT and PE after hip or knee replacement surgery, the first dose should be taken at least 12 to 24 hours after surgery. Apixaban is usually taken for 35 days after a hip replacement surgery and for 12 days after knee replacement surgery. Take apixaban …
Prevention
- If you are unable to swallow the tablets, you can crush them and mix with water, apple juice, or applesauce. Swallow the mixture right after you prepare it. Apixaban can also be given in certain types of feeding tubes. Ask your doctor if you should take this medication in your feeding tube. Follow your doctor's directions carefully.
How It Works
- Continue to take apixaban even if you feel well. Do not stop taking apixaban without talking to your doctor. If you stop taking apixaban, your risk of a blood clot may increase.
Upsides
- Unless your doctor tells you otherwise, continue your normal diet. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Downsides
- Apixaban prevents blood from clotting normally, so it may take longer than usual for you to stop bleeding if you are cut or injured. This medication may also cause you to bruise or bleed more easily. Call your doctor right away if bleeding or bruising is unusual, severe, or cannot be controlled. Apixaban may cause other side effects. Call your doctor if you have any unusual prob…
Bottom Line
- Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom). Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toi…
Tips
- Apixaban may be given to reduce the risk of blood clot formation.
- Apixaban works by selectively inhibiting (blocking) the effects of factor Xa (FXa), an enzyme that plays a key role in the formation of substances that cause blood clotting. Through its action on F...
- Apixaban belongs to the class of drugs known as factor Xa inhibitors. It may also be called a…
- Apixaban may be given to reduce the risk of blood clot formation.
- Apixaban works by selectively inhibiting (blocking) the effects of factor Xa (FXa), an enzyme that plays a key role in the formation of substances that cause blood clotting. Through its action on F...
- Apixaban belongs to the class of drugs known as factor Xa inhibitors. It may also be called an anticoagulant.
Response and Effectiveness
- Used to reduce the risk of stroke and blood clot formation in people with nonvalvular Atrial Fibrillation (AF).
- Also used to protect against the development of deep vein thrombosis (DVT) (blood clots in the deep veins) following hip or knee replacement surgery.
- Apixaban is also used in the treatment of DVT and pulmonary embolism (PE) (where blood cl…
- Used to reduce the risk of stroke and blood clot formation in people with nonvalvular Atrial Fibrillation (AF).
- Also used to protect against the development of deep vein thrombosis (DVT) (blood clots in the deep veins) following hip or knee replacement surgery.
- Apixaban is also used in the treatment of DVT and pulmonary embolism (PE) (where blood clots lodge in the lungs), and to lower the risk of recurrent DVT and PE.
- Does not require regular blood tests.
Interactions
- If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: 1. Minor bleeding, nausea, anemia, and hemorrhage are the most common side effects. Gastrointestinal side effects such as constipation, vomiting, diarrhea, or abdominal pain may also occur. 2. Severe bleeding is uncom…
Further Information
- Apixaban reduces the clotting ability of the blood and is used in the treatment and prevention of several medical conditions associated with blood clots. It does not require monitoring; and an antidote, called andexanet alfa, is available if severe bleeding occurs.