Which cell type is located outside the blood-testis barrier?
Abstract. Preleptotene spermatocytes and spermatogonia are germ cells located outside the blood-testis barrier provided by the Sertoli cells. These cells have been found to express autoantigens accessible to circulating antibodies.
Why Sertoli cells are called blood-testis barrier?
The name "blood-testis barrier" is misleading in that it is not a blood-organ barrier in a strict sense, but is formed between Sertoli cells of the seminiferous tubule and as such isolates the further developed stages of germ cells from the blood.
Why does the blood-testis barrier exist?
The presence of the blood-testis barrier allows Sertoli cells to control the environment in which germ cells (i.e., spermatocytes, spermatids, and sperm) develop. It also prevents toxins from entering the seminiferous tubules, protecting the germ cells as they develop.
What are the components of the blood-testis barrier and what is its significance?
The blood-testis barrier (BTB) is composed of highly polarized Sertoli cells and divides the seminiferous epithelium (functional unit of the testis) into a basal compartment (outer compartment, in contact with blood and lymph) and apical compartment (inner compartment, protected from blood and lymph) (Su et al., 2011).
Where are Leydig and Sertoli cells located?
In animals, Leydig cells are normally located within the connective tissue that surrounds the seminiferous tubules (where Sertoli cells reside). As such, they are also commonly referred to as interstitial cells.
Which of the following best describes the blood testes barrier?
Which of the following best describes the function of the blood-testis barrier? A) The blood-testis barrier maintains a differential fluid composition of the epididymis tubule lumen that favors maintaining high concentrations of androgens in the lumen to facilitate sperm production.
Why is the blood testes barrier important quizlet?
What is the importance of the blood-testis barrier? It prevents escape of membrane antigens of differentiating sperm through the basal lamina and into the blood, where they would activate the immune system.
What is the function of the blood-testis barrier Mcq?
11. What is the function of the blood-testis barrier? Explanation: Blood-testis barrier is a tight junction between Sertoli cells located at the capillary endothelial level of the testis. It acts as the blood-testes barrier restricting drugs to spermatocytes and spermatids.
What is the epididymis?
Listen to pronunciation. (eh-pih-DIH-dih-mis) A narrow, tightly-coiled tube that is attached to each of the testicles (the male sex glands that produce sperm). Sperm cells (male reproductive cells) move from the testicles into the epididymis, where they finish maturing and are stored.
Where are Leydig cells located?
Leydig cells can be found around seminiferous tubules forming groups of up to ten cells. They are generally described as polygonal cells with eosinophilic cytoplasm and a large round nucleus with a prominent nucleolus. Lipid content is abundant.