Full Answer
How do antihypertensive drugs affect lipid profile?
Some antihypertensive drugs, for example, have a neutral or beneficial effect on the lipid profile, while others have an adverse effect; such adverse effects are outweighed by the beneficial effects of blood pressure lowering on cardiovascular risk.
Do beta blockers affect serum lipids?
Beta blockers — Beta blockers are a heterogeneous class of antihypertensive medications. The effect of beta blockers on serum lipids varies with their unique pharmacologic characteristics and may be more prominent among smokers [7,10].
Do diuretics and beta-blockers affect plasma lipid and lipoprotein profiles in hypertension?
Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Archives of internal medicine.1999;159(6):551-558. van der Heijden M, Donders SH, Cleophas TJ, et al.
Do lipid-lowering drugs affect serum lipid levels?
Many drugs besides lipid-lowering drugs affect serum lipid levels in either a potentially harmful or beneficial way, and may therefore increase or decrease the risk of cardiovascular disease.
What medications affect a lipid panel?
Diuretics, beta-blocking agents, progestogens, combined oral contraceptives containing 'second generation' progestogens, danazol, immunosuppressive agents, protease inhibitors and enzyme-inducing anticonvulsants adversely affect the lipid profile.
Does beta blockers affect lipid profile?
Administration of beta blockers has been associated with alterations in the lipoprotein profile, namely an increase in triglycerides and a decrease in high-density lipoprotein (HDL) cholesterol.
Do ACE inhibitors affect lipids?
Minor differences in the blood pressure (BP)-lowering effect and metabolic response were obtained with the ACE inhibitors studied; only lisinopril improved glucose tolerance significantly; blood lipids were not changed by any drug.
Does amlodipine affect cholesterol?
amlodipine and atorvastatin can help lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).
Does amlodipine raise triglycerides?
Eight weeks of amlodipine treatment significantly reduced the levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides in the group on the hypercholesterolaemic diet (p < 0.05).
Does losartan affect cholesterol?
Conclusion: Losartan blunted the decrease in HDL cholesterol during antihypertensive treatment in the LIFE study. Higher intreatment HDL cholesterol was associated with fewer composite endpoints and may partly explain the better outcome of losartan-based treatment.
Do beta-blockers affect cholesterol levels?
Older beta blockers, such as propranolol (Inderal, Innopran XL), atenolol (Tenormin) and metoprolol (Kapspargo Sprinkle, Lopressor, Toprol-XL), can slightly increase triglycerides and decrease high-density lipoprotein (HDL) cholesterol, the "good" cholesterol.
Does lisinopril affect triglycerides?
Maximum lisinopril doses significantly and safely reduced proteinuria, serum total, LDL cholesterol, and triglycerides without substantially affecting serum HDL and renal hemodynamics.
Does hydrochlorothiazide affect cholesterol?
It's from a class of medications called diuretics, more commonly known as water pills. High doses — 50 milligrams or more — of some diuretics, including hydrochlorothiazide, can temporarily increase your low-density lipoprotein (LDL) cholesterol — the "bad" cholesterol — and triglycerides.
Does lisinopril raise cholesterol?
Maximum lisinopril doses significantly and safely reduced proteinuria, serum total, LDL cholesterol, and triglycerides without substantially affecting serum HDL and renal hemodynamics.
Why do thiazides cause hyperlipidemia?
Hyperlipidemia is prevalent in hypertension, but the cause of this association is unknown. Treatment of hypertension with thiazide diuretics accentuates the hyperlipidemia, perhaps by causing potassium or sodium depletion.
What statin is safe with amlodipine?
Change to an alternative statin ➢ Pravastatin, fluvastatin or rosuvastatin do not interact with amlodipine. ➢ Atorvastatin (20mg or 40mg daily) is an option if a more potent statin is needed. The risk of an interaction with amlodipine is much lower with atorvastatin than simvastatin.
Do statins lower blood pressure?
In general, effects of blood pressure-lowering agents on lipid levels and effects of statins on blood pressure are modest. Blood pressure lowering and lipid lowering provide independent and additive reductions in cardiovascular risk [ 3,4 ]. This topic will address the effects of antihypertensive medications on serum lipids and the effects ...
Does hypertension affect lipids?
Treatment of hypertension can affect lipid levels . Some antihypertensive drugs, for example, have a neutral or beneficial effect on the lipid profile, while others have an adverse effect; such adverse effects are outweighed by the beneficial effects of blood pressure lowering on cardiovascular risk.
What is a beta blocker?
Beta block ers are medications that are normally prescribed to treat high blood pressure. Despite the significant advantages, they offer in treating several forms of heart disease, beta blockers also have been noted to decrease HDL levels and elevate triglyceride levels. 1 Among the beta blockers that cause this effect are:
What is a protease inhibitor?
Protease inhibitors are used to treat human immunodeficiency virus (HIV). Although the mechanism by which these drugs raise cholesterol levels is not known, they appear to especially raise triglyceride levels and lower HDL cholesterol levels. 4
Does prednisone raise cholesterol?
Prednisone is a glucocorticoid used to reduce the swelling, warmth, and tenderness associated with many inflammatory conditions. Despite the relief they may give to you, they can raise triglycerides, LDL cholesterol levels, and HDL cholesterol levels. 3
Do steroids raise LDL?
These drugs are known to significantly raise LDL levels and lower HDL levels. 4 . Interestingly, the adverse effect anabolic steroids have on cholesterol are more common with oral forms of the drug rather than injectables. Beyond hypercholesterolemia, steroid abuse can lead to type 2 diabetes, hypertension, and obesity.
Can cholesterol medication raise lipid levels?
If you have high cholesterol levels and are taking a medication that could potentially raise your lipid levels further, your healthcare provider may want to monitor your blood periodically to make sure that your lipid levels are not too high. In some cases, the adverse effect on lipids may be only temporary.
Can proteases affect cholesterol?
Protease Inhibitors. Diuretics. Some of the medications you are taking for other medical conditions, such as high blood pressure or hormonal therapies, may adversely affect your lipid levels. This could inadvertently increase your triglycerides and "bad" LDL cholesterol while lowering your "good" HDL cholesterol .
Do beta blockers lower blood pressure?
Beyond their role in lowering blood pressure, beta-blockers are instrumental in prolonging the survival of people with congestive heart failure or a previous heart attack. Even if a slight alteration of your lipids is observed, it is important that beta-blockers are not discontinued. 2 . The Use of Beta Blockers.
How do beta blockers work?
Beta-blockers work by inhibiting the catecholamines from binding to the Beta 1,2, and 3 receptors. Beta-1 receptors are found primarily in the heart muscle, beta-2 receptors are located in the bronchial and peripheral vascular smooth muscles, and beta-3 receptors appear in adipose tissue of the heart.
What is the target BP for kidney disease?
In patients with chronic kidney disease, the target BP is 130/80. For patients with type 2 diabetes mellitus (T2DM), it is recommended to start on antihypertensive medications if BP is more than 130/80 with a goal of BP lower than 130/80.
What are the side effects of thiazide?
Thiazide and thiazide-like diuretics are associated with multiple side effects. Most of these side effects are directly related to the diuretic dose; hypokalemia and hyponatremia are the most common metabolic effects, followed by hyperuricemia, hypomagnesemia, hyperlipidemia, and increased glucose levels. [42][29] .
Which is better, chlorthalidone or doxazosin mesylate?
Chlorthalidone, when compared with doxazosin mesylate, was better in preventing cardiovascular disease, when compared with lisinopril was found to be better in preventing cardiovascular disease, including strokes and heart failure incidence, and when compared with amlodipine was better in preventing heart failure.
Does hydrochlorothiazide lower blood pressure?
Switching to chlorthalidone from hydrochlorothiazide decreases systolic blood pressure by 7 to 8 mm Hg.
Is chlorthalidone better than hydrochlorothiazide?
They are better at decreasing the risk of cardiovascular disease comparing to hydrochlorothiazide. [4][5] Chlorthalidone is the drug of choice to start as monotherapy for hypertension. Studies show it to be the best diuretic to control blood pressure and to prevent mortality and morbidity.
Can non-dihydropyridine cause constipation?
Non-dihydropyridines are associated with bra dycardia and can cause constipation in 25% of patients. CCBs inhibit platelet aggregation and are associated with an increased risk of gastrointestinal bleed; caution is necessary when prescribing these agents to older patients and patients with a high risk of GI bleed.
Various Drugs Affect the Lipid Profile
There are many factors, including drug therapy, that can affect serum lipid levels both positively or negatively, and, therefore, these drugs may decrease or increase the risk of cardiovascular morbidity or mortality.
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Medical uses
- Beta blockers are medications that are normally prescribed to treat high blood pressure. Despite the significant advantages, they offer in treating several forms of heart disease, beta blockers also have been noted to decrease HDL levels and elevate triglyceride levels. Beyond their role in lowering blood pressure, beta blockers are instrumental in prolonging the survival of people with…
Overview
- Estrogen is a female sex hormone found in female hormonal birth control and in other forms of hormone replacement therapy. For many years, estrogen had been considered \"cardioprotective,\" thus promoting a healthy heart. This is primarily due to the drug's ability to raise HDL levels. The news led many post-menopausal women to starting taking hormone repla…
Interactions
- However, recent studies have found that estrogen does not protect against heart disease after menopause. Additionally, estrogens may increase triglyceride levels. By contrast, progestin, a form of progesterone, is often combined with estrogen for us in oral contraceptives and hormone replacement therapies. Higher levels of progestin are associated with lower HDL levels. When u…
Uses
- Prednisone is a glucocorticoid used to reduce the swelling, warmth, and tenderness associated with many inflammatory conditions. Despite the relief they may give to you, they can raise triglycerides, LDL cholesterol levels, and HDL cholesterol levels.
Side effects
- Amiodarone is a drug used to treat a variety of heart arrhythmias and is associated with a wide range of side effects. One of the smaller side effects is related to high cholesterol. Amiodarone mainly raises LDL cholesterol levels but does not appear to have an effect on HDL cholesterol or triglyceride levels.
Treatment
- If you have high cholesterol levels and are taking a medication that could potentially raise your lipid levels further, your healthcare provider may want to monitor your blood periodically to make sure that your lipid levels are not too high. In some cases, the adverse effect on lipids may be only temporary. However, if they persist to be high after treatment starts, your healthcare provider m…