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which drugs are sulfonamides

by Larry Olson Published 2 years ago Updated 2 years ago
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Sulfonamides, or "sulfa drugs," are a group of medicines used to treat bacterial infections.
...
Commonly prescribed sulfonamides include:
  • Gantrisin (sulfisoxazole)
  • Bactrim or Septra (trimethoprim and sulfamethoxazole)
  • Sulfadiazine.
  • Azulfidine (sulfasalazine)
  • Zonegran (zonisamide)
Dec 1, 2015

Precautions

These include:

  • diabetes medications, such as glyburide (Glynase, Diabeta) and glimepiride (Amaryl)
  • nonsteroidal anti-inflammatory drugs (NSAIDs), such as celecoxib (Celebrex)
  • diuretics, such as hydrochlorothiazide (Microzide) and furosemide (Lasix)

What medications have sulfa drug in them?

US Brand Name

  • Azulfidine
  • Azulfidine Entabs
  • Diamox Sequels
  • Gantrisin Pediatric
  • Sulfazine
  • Sulfazine EC
  • Truxazole
  • Zonegran

What are the names of the sulfa drugs?

Types of Hallucinogens

  • LSD. LSD (lysergic acid diethylamide) is a synthetic drug that in small amounts can produce very powerful visual hallucinations and mood alterations 6.
  • Psilocybin. Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is a hallucinogenic substance that is found in more than 200 types of mushrooms 11,12.
  • Peyote. ...
  • DMT. ...

Which drugs are consider hallucinogen drugs?

Stimulants, sometimes called “uppers,” temporarily increase alertness and energy. The most commonly used street drugs that fall into this category are cocaine and amphetamines. Prescription stimulants come in tablets or capsules. When abused, they are swallowed, injected in liquid form or crushed and snorted.

What kind of drugs are considered stimulants?

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What Are Sulfonamides Used for?

Sulfonamides represent a diverse range of medicines with a diverse range of actions. Examples of some conditions that may be treated with sulfonami...

What Are The Differences Between Sulfonamides?

Sulfonamide antibiotics have an N4 amine group in their structure which is thought to contribute to their higher incidence of allergic-type reactio...

What Are The Side Effects of Sulfonamides?

Common side effects reported with sulfonamides include: 1. Gastrointestinal effects (such as diarrhea, nausea, stomach upset, vomiting) 2. Candidia...

Is Penicillin a sulfa drug?

Penicillin is not a sulfa drug. Antibiotics that are in the sulfonamide class include Bactrim and Sulfatrim pediatric solution. Sulfa drugs are us...

What drugs should be avoided while taking sulfa drugs?

Sulfonamides should not be used in combination with certain drugs. An interaction can occur with the anti-arrhythmic medication Digoxin, the blood...

What drugs are sulfa drugs?

Sulfa drugs are used for antibiotic and non-antibiotic use. Sulfonamides are used to treat infections (Bactrim), high blood pressure (Hydrochlorot...

Is ciprofloxacin a sulfonamide?

Ciprofloxacin is not a sulfonamide. Ciprofloxacin is an antibiotic in the class of medications called fluoroquinolones. A sulfonamide antibiotic c...

What are examples of sulfa antibiotics?

Two common sulfonamides used as antibiotics include Bactrim and Sulfatrim pediatric solution. The medication is composed of sulfamethoxazole and tr...

What organisms are sulfonamides used for?

Sulfonamides are medications used to treat infectious processes. They target bacteria including Gram-negative and Gram-positive bacteria. Sulfonami...

What are Sulfonamides?

What are sulfonamides? Sulfonamides are synthetic medications derived from a sulfur-based chemical. Sulfonamides assist in treating high blood pressure, a urinary tract infection, inflammatory bowel disease, and many other conditions.

Types of Sulfonamides

Sulfonamide examples include antibiotic and non-antibiotic sulfa drugs. They share the same sulfa base in their chemical structure, but target different disease processes. The different sulfa drug classes and examples are discussed more below.

Sulfonamides: Word Scramble Activity

In this activity, you'll check your knowledge regarding the definition, classification, and examples of sulfonamides.

How many permutations of sulfa have been made?

Many thousands of molecules containing the sulfanilamide structure have been created since its discovery (by one account, over 5,400 permutations by 1945), yielding improved formulations with greater effectiveness and less toxicity. Sulfa drugs are still widely used for conditions such as acne and urinary tract infections, and are receiving renewed interest for the treatment of infections caused by bacteria resistant to other antibiotics.

What are the side effects of sulfonamide?

Allergic urticaria on the skin induced by an antibiotic. Sulfonamides have the potential to cause a variety of untoward reactions, including urinary tract disorders, haemopoietic disorders, porphyria and hypersensitivity reactions.

What is the structural similarity between sulfonilamide and pABA?

Structural similarity between sulfonilamide (left) and PABA (center) is the basis for the inhibitory activity of sulfa drugs on tetrahydrofolate (right) biosynthesis. Sulfonamides are used to treat allergies and cough, as well as antifungal and antimalarial functions.

What was the first antibiotic to be used systemically?

Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine.

Which antibiotics are implicated in hypersensitivity reactions?

Two regions of the sulfonamide antibiotic chemical structure are implicated in the hypersensitivity reactions associated with the class.

How many people have adverse reactions to sulfonamide?

Approximately 3% of the general population have adverse reactions when treated with sulfonamide antimicrobials. Of note is the observation that patients with HIV have a much higher prevalence, at about 60%.

Can you take arylamine sulfonamide if you are allergic to arylamine?

Other sulfonamide drugs do not contain this arylamine group; available evidence suggests that patients who are allergic to arylamine sulfonamides do not cross-react to sulfonamides that lack the arylamine group, and may therefore safely take non-arylamine sulfonamides.

How Are Sulfonamides Used?

Sulfonamides are mainly used to treat bacterial infections and some fungal infections. As they tend to concentrate more in the urine, they are most effective against urinary tract infections.

Why do you need sulfa and trimethoprim?

Sometimes, sulfa drugs are given in combination with trimethoprim because it kills the bacteria (bactericidal). Hence, the combination of sulfonamides and trimethoprim stops the bacteria from multiplying and kills them as well.

What is the name of the drug that can cause liver problems?

Valproic acid (e.g., Depakene)—Use of sulfonamides with these medicines may increase the chance of side effects affecting the liver. Acetohydroxamic acid (e.g., Lithostat) or. Dapsone or.

What is sulfonamide used for?

Sulfonamides (sul-FON-a-mides) or sulfa medicines are used to treat infections. They will not work for colds, flu, or other virus infections.

How many grams of a sulfate can you take?

Adults and teenagers—2 to 4 grams for the first dose, then 1 to 2 grams every eight to twelve hours. Children up to 2 months of age—Use and dose must be determined by your doctor. Children 2 months of age and older—Dose is based on body weight.

How much mcg is a gram?

Adults and teenagers—500 milligrams (mg) to 1 gram every six to eight hours. Children up to 2 months of age—Use is not recommended. Children 2 months of age and older—Dose is based on body weight. The usual dose is 7.5 to 11.25 mg per kilogram (kg) (3.4 to 5.1 mg per pound) of body weight every six hours.

What to wear when you are a skeptic?

Wear protective clothing, including a hat. Also, wear sunglasses.

What is the name of the drug that is used for long term high doses?

Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or

Can sulfonamides cause bone problems?

Pregnancy— Studies have not been done in pregnant women. However, studies in mice, rats, and rabbits have shown that some sulfonamides cause birth defects, including cleft palate and bone problems. Sulfonamides are not recommended for use at the time of labor and delivery. These medicines may cause unwanted effects in the baby.

What are sulfonamides?

Sulfonamides (sulfa drugs) are drugs that are derived from sulfanilamide, a sulfur-containing chemical. Most sulfonamides are antibiotics, but some are prescribed for treating ulcerative colitis. Sulfonamide antibiotics work by disrupting the production of dihydrofolic acid, a form of folic acid that bacteria and human cells use for producing proteins.

What drugs interact with sulfonamides?

Sulfonamides can increase the blood-thinning effects of warfarin ( Coumadin ), possibly leading to abnormal bleeding.

What formulations of sulfonamides are available?

Sulfonamides are available as tablets, injections, and oral solutions.

What are some examples of sulfonamides?

Sulfonamides are a class of drugs from a sulfur-containing chemical (sulfanilamide). Examples of sulfonamides include sulfamethoxazole/trimethoprim ( Bactrim, Bactrim DS, Co-trimoxazole, Septra, Septra DS, Cotrim, SMZ-TMP, SMZ-TMP DS, Sulfatrim); sulfasalazine (Azulfidine, Sulfazine); and sulfisoxazole (Truxazole, Gantrisin). Some of these drugs are available only in generic forms. Side effects of sulfonamides may include dizziness, lethargy, diarrhea, nausea, vomiting, headache, serious skin rashes and anorexia. Sulfonamides are not recommended for women who are pregnant or breastfeeding. Side effects and drug interactions should be reviewed prior to taking this medication.

When should sulfonamides be stopped?

Sulfonamides should be stopped at the first appearance of a skin rash before the rash becomes severe.

Can you take trimethoprim while pregnant?

For this reason, sulfamethoxazole/ trimethoprim should not be used near term (late in pregnancy) among women. Sulfonamides (for example, sulfamethoxazole/trimethoprim) should not be used by nursing mothers because sulfamethoxazole is excreted in breast milk and can cause kernicterus.

Can sulfonamides be used in urine?

All sulfonamides can crystallize in the urine when the urine is acidic. Since methenamine ( Hiprex, Urex, Mandelamine) causes acidic urine, it should not be used with sulfonamides. Blood levels of digoxin may increase blood levels of digoxin ( Lanoxin) and possibly lead to serious toxic effects.

How does sulfonamide work?

Sulfonamides work by preventing the growth of bacteria in the body. They come in different formulations and may be taken as an oral, topical, vaginal, or ophthalmic (eye) medicine. The discovery of sulfonamides paved the way for the widespread use of antibiotics. The first sulfonamide, Prontosil, was tested in the 1930s.

What is sulfa medicine?

Sulfonamides, or "sulfa drugs," are a group of medicines used to treat bacterial infections.

What to tell your doctor before taking sulfonamide?

Tell your doctor about all medical conditions you have — especially kidney, liver, or blood disorders — before taking a sulfonamide.

Can sulfonamide cause allergies?

Allergies to Sulfonamides. Allergies to sulfonamides are common. Tell your doctor if you have allergies to food dyes, preservatives, or animals. Let your doctor know right away if you experience signs of a severe allergic reaction ( anaphylaxis ), which may include rash, hives, difficulty breathing, chest tightness, or swelling of the face, lips, ...

Can sulfonamides make you dizzy?

These drugs may make your skin more sensitive to the sun. Avoid unnecessary exposure to sunlight, and wear sunscreen and protective clothing while outdoors. Sulfonamides may make you dizzy. Don't drive or perform activities that require alertness until you know how your medicine affects you.

Can sulfonamide cause birth defects?

Animal studies have shown that sulfonamides may cause birth defects.

Can you give sulfonamide to an infant?

Keep all appointments with your doctor's office and laboratory. These medicines shouldn't be given to infants under 2 months old. Elderly people may be more sensitive to the side effects of sulfonamides.

What is the name of the medication that is used to treat sulfonamide?

Some nonsteroidal anti-inflammatory drugs, such as celecoxib (Celebrex) The migraine medication sumatriptan (Imitrex) Certain "water pills" (diuretics), such as furosemide (Lasix) and hydrochlorothiazide (Microzide) An allergy to sulfonamide medications is different from having an adverse reaction to wine or food that contains sulfites.

What are the chemicals that cause sulfa allergy?

Antibiotics containing chemicals called sulfonamides can trigger a reaction if you have a sulfa allergy. These antibiotics include combination drugs:

What is dapsone used for?

Dapsone, used to treat leprosy, dermatitis and certain types of pneumonia

Can sulfa be tested?

There are no diagnostic tests for sulfa allergy. However, sulfa desensitization might be an option, especially if medication containing sulfamethoxazole is needed.

Can sulfa be used for HIV?

Always tell your doctor about your sensitivities to medication. There are no diagnostic tests for sulfa allergy. However, sulfa desensitization might be an option, especially if medication containing sulfamethoxazole is needed.

Is sumatriptan a diuretic?

The migraine medication sumatriptan (Imitrex) Certain "water pills" (diuretics), such as furosemide (Lasix) and hydrochlorothiazide (Microzide) An allergy to sulfonamide medications is different from having an adverse reaction to wine or food that contains sulfites.

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Overview

This medication is used to treat bacterial eye infections (such as conjunctivitis).

Status: Discontinued

May Treat: Bacterial conjunctivitis · Chlamydial conjunctivitis · Dandruff · Seborrheic dermatitis · Trachoma

Alternate Brand Names: Bleph-10

Drug Class: Dermatological - Antiseborrheic · Ophthalmic Antibiotic - Sulfonamides

Availability: Prescription Required

Status: Discontinued

May Treat: Bacterial conjunctivitis · Chlamydial conjunctivitis · Dandruff · Seborrheic dermatitis · Trachoma

Alternate Brand Names: Bleph-10

Drug Class: Dermatological - Antiseborrheic · Ophthalmic Antibiotic - Sulfonamides

Availability: Prescription Required

Pregnancy: Consult a doctor before using

Lactation: Consult a doctor before using

Alcohol: Limit intake while taking this medication

Driving: May cause drowsiness or dizziness. Use caution

Precautions

  • Room temperature

  • Room temperature
  • Use sunscreen
  • Do not touch tip of tube
  • For cleanser products : Wet affected area before applying. Use cleanser as a soap. Rinse well after use. May sting or burn after applying. Use only recommended duration. See directions. Medication may stain clothing or bedding. Follow directions on best place to keep drug supply.
  • For cream products : Clean and dry skin, then use a thin layer on area. Use at the same time(s) daily as directed. Call Dr before increasing dose or frequency. Protect from heat, light, & moisture.
  • For drops products : Do not touch tip of open eye drop bottle.
  • For foam products : For external use only. Shake foam canister well before spraying foam. Clean skin before applying. Wash hands after applying. Avoid contact with eyes, inside of nose or mouth. Skin may be more prone to sunburn. Store at room temperature away from heat & sunlight.
  • For ointment products : Do not use if allergic to sulfa medication. Wash hands before and after using. Do not wear soft contact lenses during treatment. Prevent contamination. Wait 5 min. before other eye medications. Success is dependent on completing therapy course. May blur vision. Use caution when driving. Call doctor if you are not getting better.
  • For shampoo products : Follow directions for use of shampoo on hair. Call your doctor if you get a rash. May stain clothing. Do not use more often than recommended by Dr. Store at room temperature.

Function

History

Preparation

Side effects

Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfon…

See also

In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase (DHPS), an enzyme involved in folate synthesis. Sulfonamides are therefore bacteriostatic and inhibit growth and multiplication of bacteria, but do not kill them. Humans, in contrast to bacteria, acquire folate (vitamin B9) through the diet.

External links

Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. The first sulfonamide, trade-named Prontosil, was a prodrug. Experiments with Prontosil began in 1932 in the laboratories of Bayer AG, at that time a component of the huge German chemical trust IG Farben. The Bayer team believed that coal-tar dyes which are able to bind preferentially to bacteria and parasites might be used to …

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3.Sulfonamide (medicine) - Wikipedia

Url:https://en.wikipedia.org/wiki/Sulfonamide_(medicine)

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Url:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046889/

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Url:https://www.drugs.com/cons/sulfonamides.html

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Url:https://www.medicinenet.com/sulfonamides-oral/article.htm

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8.Sulfonamides - Side Effects & Warnings | Everyday Health

Url:https://www.everydayhealth.com/sulfonamides/

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9.Sulfa allergy: Which medications should I avoid? - Mayo …

Url:https://www.mayoclinic.org/diseases-conditions/drug-allergy/expert-answers/sulfa-allergy/faq-20057970

25 hours ago  · Sulfonamide antibiotics that can cause a reaction. Antibiotics containing chemicals called sulfonamides can trigger a reaction if you have a sulfa allergy. These …

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