Which B12 is better cyano or methyl?
Unlike adenosyl B12, methyl B12 donates a valuable methyl group that further enhances your health (unlike cyano, which steals one). This is especially important for pernicious anemia patients or anyone suffering from high homocysteine levels.
When to take methylcobalamin?
- 0-6 months: 0.4 mcg
- 7-12 months: 0.5 mcg
- 1-3 years: 0.9 mcg
- 4-8 years: 1.2 mcg
- 9-13 years: 1.8 mcg
- Over 14 years: 2.4 mcg
- Teen girls and women who could become pregnant or who are breastfeeding should consume at least 2.8 mcg of vitamin B12 a day.
How much B12 methylcobalamin should I take daily?
How much B12 methylcobalamin should I take daily? There are dangers and side effects. It is generally considered safe to take vitamins B-12 and B-21. The recommended daily amount of B-12 for adults is less than 2 micrograms. Your body doesn’t absorb as much as it needs, and any excess is passed through your urine. Can I take methylcobalamin daily?
Which B12 is better?
“There is no advantage to using the light-sensitive forms of cobalamin, such as methyl B12…, instead of the stable cyano…forms, which are readily converted in the body” into the type you need, where you need it. The one major exception may be kidney failure, though. Methylcobalamin may be better for those with impaired kidney function.
What is the best form of vitamin B12 to take?
For prevention and treatment of vitamin B12 deficiency, cyanocobalamin in chewable, sublingual, or liquid forms (rather than in a multivitamin) is best under most circumstances.
What is the safest form of B12?
Cyanocobalamin B12 contains a cyanide molecule that gives it stability in products and the body. Cyanide is a poison, of course, but in the minuscule quantities found in Cyanocobalamin, this is of no consequence – it's perfectly safe to take!
What is the difference between cobalamin and cyanocobalamin?
Vitamin B12 is produced by fermentation and is available commercially as cyanocobalamin. Vitamin B12, also known as cobalamin, is an important water-soluble vitamin involved in red blood cell production, brain health, and DNA synthesis. Vitamin B-12 plays an essential role in a our health.
How much B12 methylcobalamin should I take daily?
The recommended daily amount of vitamin B-12 for adults is 2.4 micrograms.
What is wrong with cyanocobalamin?
Cyanocobalamin may cause low potassium levels in the blood (hypokalemia). Tell your doctor if you have unlikely but serious side effects of Cyanocobalamin including: muscle cramps, or. irregular heartbeat.
What are side effects of cyanocobalamin?
Side EffectsAbdominal or stomach pain.bleeding from the gums or nose.blue lips and fingernails.chest pain.coughing that sometimes produces a pink frothy sputum.decreased urine output.difficult, fast, noisy breathing, sometimes with wheezing.difficulty with swallowing.More items...•
Can you take both methylcobalamin and cyanocobalamin?
No interactions were found between cyanocobalamin / methylcobalamin and Vitamin B12.
Can I take methylcobalamin daily?
Dosage. For the best bioavailability and absorption, the recommended dose is 500 mcg three times daily or 1500 mcg daily of methylcobalamin or 5-adenosylcobalamin.
Can vitamin B12 cause heart problems?
Macrocytosis associated with vitamin B12 deficiency is also associated with fatal and non-fatal coronary disease, myocardial infarction, stroke, and other circulatory health problems.
How long can I take methylcobalamin?
How long does it take for methylcobalamin to work? With brisk development of new red blood cells, a response is typically seen within 48 to 72 hours. When B12 supplies have reached normal levels, vitamin B12 injections will be required every one to three months to avoid the return of symptoms.
What medications should not be taken with vitamin B12?
Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers ...
When should I take B12 morning or night?
the morningAs a general rule of thumb, take your B vitamins in the morning or with a meal. Vitamin B12, for example, should definitely be taken in the morning. This is because it is important for energy metabolism, which may interrupt your sleep if taken at night.
What should you not take with B12?
Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers ...
Is liquid B12 better than tablets?
This route of administration is particularly useful in patients who find it difficult to take B12 in liquid and tablet forms. In terms of effectiveness, research suggests that compared to tablet forms, sprays have a faster onset of action as they do not need to wait for dissolution.
Is liquid B12 better than sublingual?
Comparing the sublingual method to vitamin B12 injections, research found that taking B12 under the tongue had a higher absorption rate, making it a better option (Bensky, 2019). Taking vitamin B12 sublingually may also be a good option for people with a condition called pernicious anemia.
Is cyanocobalamin safe to take?
Most adults and children aged 2 years and over can take cyanocobalamin. It's not suitable for everyone. To make sure it's safe for you, tell your doctor before starting cyanocobalamin if you: have ever had an allergic reaction to cyanocobalamin or any other medicine.
What are Cyanocobalamin and Methylcobalamin?
In some cases, deficiency in vitamin B12 requires dietary adjustments. Some people may need to take medications such as Cyanocobalamin and Methylcobalamin. Let’s introduce these drugs first.
Which is better, B12 or cyanocobalamin?
Even though as a natural form of vitamin B12 Methylcobalamin is considered superior, in some aspects, Cyanocobalamin may perform better. In other words, both versions have their strengths and weaknesses.
How common is vitamin B12 deficiency?
In the United States and the United Kingdom, about 6% of adults younger than 60 are deficient in vitamin B12. Additionally, 20% of people older than 60 have vitamin B12 deficiency.
How is vitamin B12 deficiency treated?
When left unmanaged properly, vitamin B12 deficiency can be sneaky and harmful. The treatment of this condition depends on its severity. For the mildest forms, simple diet adjustments are enough. Moderate deficiency requires the intake of standard multivitamins to bring vitamin B12 levels to be normal.
Why is B12 deficiency in hypothyroidism?
While more research is necessary on this subject, vitamin B12 deficiency in hypothyroid persons could be due to anemia. Hypothyroidism is strongly associated with anemia, a condition where the body doesn’t have enough healthy red blood cells that would carry oxygen to the tissues. There are different types of anemia , including pernicious anemia , which affects the absorption of vitamin B12 and thereby contributes to deficiency.
What is a cyanobalamin?
Cyanocobalamin is a synthetic form of vitamin B12 available in prescription or over-the-counter (OTC) form to prevent or treat low vitamin B12 levels. It also prevents or aids the management of anemia caused by vitamin B12. Cyanocobalamin was first manufactured in the 1940s, and it is used as a nasal spray, by mouth, and by injection.
Why do we need B12?
We also need vitamin B12 for the production of red blood cells, the synthesis of DNA, and other functions. Deficiency in vitamin B12 is possible, especially in persons with thyroid problems. In this post, we discuss Cyanocobalamin and Methylcobalamin or which version could be better for the thyroid.
What is the difference between cyanocobalamin and methylcobalamin?
The difference between cyanocobalamin and methylcobalamin is actually very simple. Both of these products are considered B12 so they don't differ in that aspect. Where they differ is in what is attached to the B12. You can think of this as a carrier product that simply holds onto the B12 portion.
How does Hydroxycobalamin Compare?
We've talked about both cyanocobalamin and methylcobalamin but there are other forms of B12 that you should know about.
What is the preactivated form of B12?
Hydroxycobalamin is another pre-activated form of B12 found in animal protein such as beef (4). In fact, animal protein contains a number of pre-activated B12 versions including methylcobalamin, hydroxycobalamin, and adenosylcobalamin. You can compare this to cyanocobalamin which does not naturally occur in nature.
What is the B12 form?
We've talked about both cyanocobalamin and methylcobalamin but there are other forms of B12 that you should know about. One such version is known as hydroxycobalamin and this form of B12 occurs in nature much like methylcobalamin.
What is the role of methylcobalamin in the body?
That's where methylcobalamin steps in. Methylcobalamin is attached to a methyl group and your body is very accustomed to using methylation intracellularly. Methylcobalamin also comes pre-activated ...
Why do I have low B12 levels?
One of the most common causes of B12 deficiency is inflammation in the stomach. It's estimated that a huge portion of the population (2) (up to 50%) suffer from subclinical gastritis (inflammation in the stomach) from a bacteria known as H. pylori. This low grade gastritis, found in up to 50% of people, is enough to slowly cause problems ...
Can you take B12 with cyanocobalamin?
B12 deficiency is incredibly common and even though many people supplement with B12 they may not be getting the beneficial effects due to problems with absorption and utilization by the body. Whenever possible, avoid B12 supplements that contain cyanocobalamin and opt for supplements that contain methylcobalamin.
Which is more stable, cyanocobalamin or adenyl B12?
The bottom line is that so-called coenzyme forms of B12, like methyl B12 and adenyl B12 (also known as adenosyl b12), “are not likely to be superior to cyanocobalamin,” which is more stable. Cyanocobalamin “appears to be best suited for oral supplementation,” which is why I specify its use in my recommendations.
Why do people use cyanocobalamin?
Another reason to use the cyanocobalamin as opposed to the more expensive kinds is that it has a track record of safety and efficacy , whereas for example, in one study even up to 2,000 micrograms a day of methylcobalamin wasn’t enough to correct vitamin B12 deficiency in one of three vegans they tested it on.
Why chew a B12 supplement?
Why chewable or sublingual? Absorption is boosted when the B12 mixes with saliva, since you secrete a B12 binding protein from your salivary glands that helps transport B12 safely through the digestive tract. Having people chew a tablet of B12 and their B12 levels go up ten times more than just simply swallowing the exact same pill. Check it out. Vegans boosted out of deficiency chewing a B12 supplement, but nothing in those who just swallowed it whole. Maybe they had some sort of absorption problem or something? No, because then if you tell them to start chewing it instead of swallowing it whole, their levels shoot right up as well.
What is the best vitamin B12?
The Best Type of Vitamin B12: Cyanocobalamin or Methylcobalamin? 4.52 (90.35%) 143 votes. For prevention and treatment of vitamin B12 deficiency, cyanocobalamin in chewable, sublingual, or liquid forms (rather than in a multivitamin) is best under most circumstances.
Is there a vitamin B12 deficiency in vegan babies?
And this isn’t just in theory. There was a tragic case of severe vitamin B12 deficiency in an infant born to a vegan mother who thought she was doing everything right taking a multivitamin that contained B12, though it may have also just been inadequate dosing.
Is adenyl B12 a coenzyme?
The bottom line is that so-called coenzyme forms of B12, like methyl B12 and adenyl B12 (also known as adenosyl b12), “are not likely to be superior to cyanocobalamin,” which is more stable. Cyanocobalamin “appears to be best suited for oral supplementation,” which is why I specify its use in my recommendations.
Can you take B12 injections?
Your doctor might want you to get vitamin B12 injections, but oral B12, even for those who can’t absorb it well, has long been considered one of medicine’s best kept secrets. It is now considered well-known that orally administered B12 supplements are “as effective in overcoming deficiency states as intramuscular” injections when you get up to taking 1,000 micrograms a day. How long do you have to take 1,000 a day for? It depends how low your levels start out.
Which is more effective, methylcobalamin or hydroxocobalamin?
Methylcobalamin, for injection, is less stable, harder to source, more expensive and no more effective than hydroxocobalamin.
Which cobalamin is the worst?
Cyanocobalamin is the worst possible cobalamin that works at all for some humans. Methylcobalamin and Adenosylcobalamin are both human usable B12 forms that do different things in the body and both are needed, along with l-methylfolate and l-carnitine (fumarate often) are all mutually deadlocking when any one is deficient.
What happens when B12 is added to a cell?
When B12 gets into the cell the first thing that happens in that the top ligand (the methyl, adenosyl, cyano or hydroxo) gets removed to form cob (II)alamin. This is then passed on to where it's needed, where it is converted to methylcobalamin or adenosylcobalamin, whichever is appropriate.
What is the name of the ligand that removes B12 from the cell?
As soon as any form of B12 enters the cell the top ligand (methyl, adenosyl, hydroxo, or cyano) is removed to form cob (II)alamin. From that point on all forms are identical. Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency
What is the ligand of B12?
All forms of B12, when they first enter the cell, have their upper ligand (methyl, cyano, hydroxo, adenosyl) to form cob (II)alamin. That means that methylcobalamin are, from that point onwards, identical.
Does MTHFR affect cyanocobalamin?
MTHFR mutations do not hinder the conversion of cyanocobalamin to methylcobalamin. They hinder the
Is methylcobalamin the same as cyanocobalamin?
Both containing a cobalt ion, methylcobalamin and cyanocobalamin show similarities in structure. However, their attached molecules differ, making a difference in how the body absorbs them. Cyanocobalamin is more common in supplements because it is slightly more stable and less expensive than other forms of it. The body may also absorb cyanocobalamin better tha
How long does it take for cyano B12 to convert to methyl B12?
It takes more than 48 hours for cyano B12 to convert to usable methyl B12. Even then, only a small amount is converted. And remember, when it does convert, it requires the interaction (possibly the depletion) of glutathione and other agents.
Where is methylcobalamin stored?
You’ll find methyl B12 in the blood plasma, cytosol cells, and certain fluids (like cerebral spinal fluid), and adenosyl B12 in cellular tissues where it is stored in the mitochondria.
What are the two forms of B12?
Two other forms you may find are hydroxocobalamin and adenosylcobalamin. All these forms of vitamin B12 are present to some degree in the foods you eat, with the predominant ones being adenosyl B12 and hydroxo B12. Another B12 form found in foods is sulphitocobalamin.
How long does methyl B12 help with sperm count?
In one study, methyl B12 at daily doses of 6,000mcg for four months improved sperm count by 37.5%. In another one, at doses of 1,500mcg a day for 4-24 weeks, it increased sperm concentrations in 38% of cases, total sperm count in 54% of cases, and sperm motility in 50% of cases. This is incredible.
What is the donor of cobalamin?
The molecule that is attached to the cobalamin is called a donor . The two most common donors in supplements are cyanide (making the type of B12 known as cyanocobalamin, or cyano B12) and methyl (making methylcobalamin, or methyl B12). Two other forms you may find are hydroxocobalamin and adenosylcobalamin. All these forms of vitamin B12 are present ...
What is the largest and most complex vitamin?
Vitamin B12 (cobalamin) is the largest and most complex vitamin out there. It is unique, because it is the only vitamin that contains a metal ion, cobalt (hence its name). B12 is a co-factor for two enzymes in mammals (and you are a mammal). One is methionine synthase, the other methylmalonyl-CoA mutase.
Where is B12 stored?
Actuallly, our body stores most of our B12 reserves in the liver as adenosyl B12, and converts it to methyl B12 whenever needed.