Fibrate
In pharmacology, the fibrates are a class of amphipathic carboxylic acids. They are used for a range of metabolic disorders, mainly hypercholesterolemia, and are therefore hypolipidemic agents.
High-density lipoprotein
High-density lipoprotein is one of the five major groups of lipoproteins. Lipoproteins are complex particles composed of multiple proteins which transport all fat molecules around the body within the water outside cells. They are typically composed of 80–100 proteins per particle and transporting up to hundreds of fat molecules per particle.
What is another name for fibrates?
Fibric acid derivatives. Other names: Fibrates. Fibric acid derivatives or fibrates are regarded as broad-spectrum lipid lowering drugs. Their main action is to decrease triglyceride levels but they also tend to reduce low density lipoprotein (LDL) cholesterol levels and help to raise high density lipoprotein (HDL) cholesterol.
What are fibric acid derivatives?
Fibric acid derivatives. What are Fibric acid derivatives? Fibric acid derivatives or fibrates are regarded as broad-spectrum lipid lowering drugs. Their main action is to decrease triglyceride levels but they also tend to reduce low density lipoprotein (LDL) cholesterol levels and help to raise high density lipoprotein (HDL) cholesterol.
What are fibrates used to lower triglycerides?
Summary Fibrates (fibric acid derivatives) are a class of medication that lowers blood triglyceride levels. Fibrates modestly effective in increasing HDL cholesterol levels. Examples of fibrates available in the U.S. are gemfibrozil (Lopid) and fenofibrate (Tricor, Fibricor).
Is fenofibrate the same as Tricor?
fenofibrate (Tricor, Fibricor, Lofibra). Fibrates (fibric acid derivatives) are a class of medication that lowers blood triglyceride levels. Fibrates modestly effective in increasing HDL cholesterol levels. Examples of fibrates available in the U.S. are gemfibrozil ( Lopid) and fenofibrate ( Tricor, Fibricor ).
What drugs are fibric acid derivatives?
There are three agents of choice in the fibric acid drug class: fenofibric acid, fenofibrate, and gemfibrozil. All of these agents are administered orally as either tablets or capsules. Fenofibric acid and fenofibrate are both marketed under several different trade names and are available in various strengths.
Which drugs are fibrates?
Fibrates are cholesterol-lowering medicines. They work by decreasing your triglycerides, a type of fat in your blood....You may take:Clofibrate (Atromid-S®).Fenofibrate (TriCor®, Fibricor®, Lofibra®).Gemfibrozil (Lopid®).
What are examples of fibrates?
Examples of fibrates available in the U.S. include:gemfibrozil, (Lopid) and.fenofibrate (Tricor, Fibricor, Lofibra).
Which one of the following is example of fibric acid derivative?
List of Fibric acid derivatives:Drug NameAvg. RatingReviewsTriCor (Pro) Generic name: fenofibrate5.915 reviewsLopid (Pro) Generic name: gemfibrozil6.56 reviewsLipofen (Pro) Generic name: fenofibrate7.32 reviewsAntara (Pro) Generic name: fenofibrate2.01 review6 more rows
What are fibric acid agents?
Fibric acid agents are drugs used for lowering lipid levels in the body. Fibric acid agents lower triglyceride levels by suppressing the very-low-density lipoprotein (VLDL) production by the liver and rapidly eliminating triglycerides from the blood.
Which drug is considered a fibrate quizlet?
Gemfibrozil (Lopid) is a fibrate, also known as a fibric acid derivative.
Is gemfibrozil a fibrate?
Gemfibrozil is in a class of lipid-regulating medications called fibrates. It works by reducing the production of triglycerides in the liver.
Are fibrates statins?
In summary, statins and fibrates work by different mechanisms. Statins have greater benefit than fibrates in decreasing heart attacks and strokes. Fibrates, though, may be appropriate for people with elevated triglyceride levels.
What is the brand name for fenofibrate?
Fenofibrate oral tablet is available as brand-name drugs and as a generic drug. Brand names: Fenoglide, Tricor, and Triglide. Fenofibrate comes in two forms: oral tablet and oral capsule. Fenofibrate oral tablet is used to treat high cholesterol levels.
What is Bezafibrate prescribed for?
Bezafibrate is used to lower cholesterol (mainly triglycerides) levels in your blood. Bezafibrate is usually used in combination with a statin in people with high triglyceride levels or it is prescribed when statins cannot be used to lower cholesterol.
What is the drug gemfibrozil used for?
Gemfibrozil is used together with a proper diet to treat high cholesterol and triglyceride (fat) levels in the blood. This may help prevent the development of pancreatitis (inflammation or swelling of the pancreas) caused by high levels of triglycerides in the blood.
What is the classification of Crestor?
Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver.
What is fibrates in medicine?
What are fibrates? Fibric acid derivatives (fibrates) are a class of medication that lowers blood triglyceride levels. Fibrates lower blood triglyceride levels by reducing the liver 's production of VLDL (the triglyceride-carrying particle that circulates in the blood) and by speeding up the removal of triglycerides from the blood.
What are some examples of fibrates?
Examples of fibrates available in the U.S. are gemfibrozil ( Lopid) and fenofibrate ( Tricor, Fibricor ). Side effects, dosing, drug interactions, and pregnancy information should be reviewed prior to taking fibrates.
Does gemfibrozil help with heart attacks?
Fibrates also have been used alone to prevent heart attacks especially in patients with elevated blood triglycerides and low HDL cholesterol levels. In one large study, gemfibrozil decreased the risk of heart attacks but did not affect the overall survival of persons with high cholesterol levels.
Can fibrates lower LDL cholesterol?
Fibrates are not effective in lowering LDL cholesterol; however, when a high risk patient (see NCEP recommendations) also has high blood triglyceride or low HDL cholesterol levels, doctors may consider combining a fibrate, such as fenofibrate ( Tricor ), with a statin.
Is fenofibrate a statin?
However, fenofibrate does not interfere with the breakdown of statins and should be the safer fibrate to use if it is necessary to use a fibrate with a statin. Furthermore, pravastatin (Pravachol) seems to have fewer muscle toxic effects than the other statins when combined with fibrates, but the risk still exists.
Can fibrates cause diarrhea?
The side effects of fibrates include nausea, stomach upset, and sometimes diarrhea. Fibrates can irritate (inflame) the liver. The liver irritation usually is mild and reversible, but it occasionally can be severe enough to require stopping the drug. Fibrates can cause gallstones when used for several years.
Can Gemfibrozil cause muscle damage?
Fibrates can cause muscle damage particularly when taken together with statin medications. Gemfibrozil interferes with the breakdown of certain statins (for example, simvastatin [ Zocor] or lovastatin [ Mevacor, Altoprev ]), resulting in higher statin blood levels, and hence a higher likelihood of muscle toxicity from the statin.
Introduction
The drugs fenofibrate and gemfibrozil are considered fibric acid derivatives. They can reduce serum triglycerides by as much as 50% in some studies.
Adverse Reactions
Fibrates must be used with caution in patients on HMG-CoA reductase inhibitors due to potential myalgias and rhabdomyolysis. Pravastatin or fluvastatin are the safest to use in combination with fibrates due to their elimination via the CYP3A4 system.
What are the different types of fibric acid?
In the fibric acids drug class, there are three agents of choice: fenofibric acid, fenofibrate, and gemfibrozil. All of these agents are administered orally as either tablets or capsules. Fenofibric acid and fenofibrate are each marketed under several different trade names and available in various strengths.
When to use fibric acid?
Fibric acids should be used in conjunction with a restriction of cholesterol and fat intake and exercise if the response to diet and nonpharmacological interventions alone has been inadequate. The clinician should rule out secondary causes of hyperlipidemia before initiating therapy with a fibric acid.
What are the symptoms of fibric acid overdose?
Signs and symptoms of overdose may include increased CPK, abnormal liver function tests, abdominal pain, diarrhea, joint and muscle pain, nausea, and vomiting. Fibric acids are highly protein-bound, which rules out the use of hemodialysis.
What are the contraindications for fibric acid?
Contraindications for the use of fibric acids include a history of hypersensitivity to the drugs in the class, patients with active liver disease, severe renal dysfunction, and preexisting gallbladder disease.
What are the side effects of fibric acid?
Some of the most common adverse effects include headache, dizziness, back pain, diarrhea, dyspepsia, nasopharyngitis, sinusitis, and abnormal liver function tests.
What is PPAR Alpha?
Once activated, PPAR-alpha is in charge of several biological functions, including fatty acid beta-oxidation and lipid metabolism. By binding to PPAR-alpha, fibric acids reduce blood cholesterol by increasing fatty acid oxidation, eliminating triglyceride-rich particles, and the catabolism of very-low-density lipoproteins (VLDL).
Can you use fenofibric acid while pregnant?
However, fibric acids should only be considered in pregnancy if the benefit outweighs the risk of potential toxicity to the fetus; there is a lack of safety and efficacy data in the pediatric population; fenofibric acids are not recommended for use in pediatric patients with lipid disorders. [5] .
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