Which vaccines can never be frozen?
NO vaccines—refrigerated or frozen—should ever be stored in a dormitory-style unit (D). important and cannot be done by eye. 3. Varicella vaccine (A) and MMRV vaccine (C) MUST be stored in the freezer.
Which of the following vaccines should be frozen?
Most vaccines (all inactivated vaccines and live nasal spray influenza vaccine) must be stored between 2° to 8°C (36° to 46°F), which is the recommended refrigerator temperature. Live varicella (chickenpox) and Zostavax (shingles) vaccines must be stored frozen between -50° to -15°C (-58° to +5°F).
Which of these vaccines should never be placed on ice pack?
Never place freeze-sensitive vaccines in direct contact with the ice packs. Surround them with OPV/BCG/JE vaccines. Keep a thermometer in the cold box. Place two rows of conditioned ice packs above the vaccine vials.
Does MMR vaccine need to be frozen?
To maintain potency, M-M-R II must be stored between -58°F and +46°F (-50°C to +8°C). Use of dry ice may subject M-M-R II to temperatures colder than -58°F (-50°C). Before reconstitution, refrigerate the lyophilized vaccine at 36°F to 46°F (2°C to 8°C).
Can BCG be frozen?
BCG storage BCG vaccine can be also affected and damaged by heat and light, so it should be stored between +2°C and +8°C. The vaccine powder may be frozen for long-term storage, but the diluent and the reconstituted vaccine must never be frozen.
Can polio vaccine be frozen?
Abstract. PIP: Oral poliomyelitis vaccine can undergo a number of freezing-thawing cycles without necessarily losing its initial potency. Damage, if any, results from exposing the vaccine to heat.
Can pneumococcal vaccine be frozen?
Temperature. Store pneumococcal vaccines refrigerated between 2°C and 8°C (36°F and 46°F). Do not freeze vaccine or diluents, or expose to freezing temperatures.
Does Pfizer vaccine need refrigeration?
Before mixing, the vaccine may be stored in the refrigerator between 2°C and 8°C (36°F and 46°F) for up to 1 month (31 days). After 31 days, contact the manufacturer for guidance. If directed to discard any remaining vials, follow the manufacturer's and your jurisdiction's guidance for proper disposal.
How long can MMR vaccine be out of freezer?
If not administered immediately, reconstituted vaccine may be stored between 36oF to 46oF (2oC to 8oC), protected from light for up to 8 hours. Discard if not used within 8 hours.
Does Shingrix need to be refrigerated?
Shingrix Storage and Handling Shingrix (recombinant zoster vaccine) must be stored in the refrigerator. The vaccine should be administered immediately after reconstitution or stored in the refrigerator and used within 6 hours. Do not freeze Shingrix. Discard if the vaccine has been frozen.
Does tetanus toxoid need to be refrigerated?
Store diphtheria, tetanus, and pertussis vaccines refrigerated between 2°C and 8°C (36°F and 46°F). Do not freeze vaccine or expose to freezing temperatures.
What temperature should polio vaccine be stored?
It is also recommended that ice-lined refrigerators, deep freezers, and refrigerators maintain a temperature of ≥2° to ≤8° centigrade for OPV.
Is Moderna frozen?
Moderna vaccine is shipped at frozen temperatures (-25° to -15°C) pack out with frozen gel packs.
Does tetanus toxoid need to be refrigerated?
Store diphtheria, tetanus, and pertussis vaccines refrigerated between 2°C and 8°C (36°F and 46°F). Do not freeze vaccine or expose to freezing temperatures.
Does Moderna have to be refrigerated?
Refrigeration Storage: After thawing, to facilitate storage at points of administration, Moderna expects that mRNA-1273 will remain stable at standard refrigerated conditions of 2° to 8°C (36° to 46°F) for up to 30 days within the 6-month shelf life.
What temperature should polio vaccine be stored?
It is also recommended that ice-lined refrigerators, deep freezers, and refrigerators maintain a temperature of ≥2° to ≤8° centigrade for OPV.
Updates
- Most of the 2011 language was removed because this content is now codified and continually updated in the CDC’s Vaccine Storage and Handling Toolkit. This content included Storage Units, Monitoring Storage Temperature, Vaccine Inventory, and Vaccine Transport.
General Principles
- Failure to adhere to recommended specifications for storage and handling of immunobiologics can reduce or destroy their potency, resulting in inadequate or no immune response in the recipient. Recommendations in the product package inserts, including methods for reconstitution of the vaccine, should be followed carefully. Maintenance of vaccine quality is the shared respo…
Expiration Dates and Windows
- All vaccines have an expiration date determined by the manufacturer that must be observed. Providers should record the vaccine expiration dates and lot numbers on a stock or inventory record for each vaccine vial when a shipment is received. When vaccines are removed from storage, clinicians and other health-care providers should note whether an expiration window exi…
Response to out-of-range Temperature Reading
- An out-of-range temperature reading should prompt immediate action. A plan should be developed ahead of time to address various types of emergencies that might require removal of vaccine from the original storage unit. Transfer of vaccines to a predesignated alternative emergency storage site might be necessary if a temperature problem cannot be resolved immed…
References
- Kroger A, Atkinson W, Pickering L. General immunization practices. In: Plotkin S, Orenstein W, Offit P, eds. Vaccines. 6th ed. China: Elsevier Saunders; 2013:88-111.
- MMWR Morb Mortal Wkly Rep. 2003;52(42):1023-1025.