Who discovered rabies?
Louis Pasteur FRSLouis PasteurLouis Pasteur FRSAlma materÉcole Normale Supérieure University of ParisKnown forGerm theory of disease Rabies vaccine Cholera vaccine Anthrax vaccines PasteurizationSpouseMarie Laurent ( m. 1849)Children513 more rows
When was rabies first discovered and by whom?
In 1804, Georg Gottfried Zinke first transmitted rabies1 from a rabid dog to a normal one, and from dog to a rabbit and a hen, by injection of saliva. This proved that the disease was infectious. By 1826, Franz Christian Karl Krugelstein (1779–1864) wrote a full account of rabies, with a bibliography of 300 items.
When was the virus rabies Discovered?
Rabies has been known since around 2000 BC. The first written record of rabies is in the Mesopotamian Codex of Eshnunna ( c. 1930 BC), which dictates that the owner of a dog showing symptoms of rabies should take preventive measures against bites.
Who discovered the pathogen and disease of rabies?
During the mid- to late 19th century Pasteur demonstrated that microorganisms cause disease and discovered how to make vaccines from weakened, or attenuated, microbes. He developed the earliest vaccines against fowl cholera, anthrax, and rabies.
Where was rabies first discovered?
The first rabies epizootic in terrestrial wild life was documented in the USA in spotted skunks (Spilogale putorius) in 1826 (Johnson, 1971).
How did the very first animal get rabies?
In the first century A.D., the Roman scholar Celsus correctly suggested that rabies was transmitted by the saliva of the biting animal.
Who named rabies?
Rabies [ra′bēz] Democritus (460–370) described rabies, and Hippocrates is believed to refer to the disease when he said that “persons in a frenzy drink very little, are disturbed and frightened, tremble at the least noise, or are seized with convulsions.” According to Aristotle, “Dogs suffer from the madness.
What are 3 facts about rabies?
Rabies is a vaccine-preventable, zoonotic, viral disease. Once clinical symptoms appear, rabies is virtually 100% fatal. In up to 99% of cases, domestic dogs are responsible for rabies virus transmission to humans. Yet, rabies can affect both domestic and wild animals.
Who Survived rabies?
Jeanna Geise was only 15 years old when she became the world's first known survivor of Rabies without receiving any vaccination. Her miraculous survival has not only challenged a time-honored scientific fact, but has also brought about a new method of Rabies treatment, known as the Milwaukee Protocol.
What virus did Louis Pasteur discover?
Rabies and its invisible virus In 1880, Louis Pasteur's experimental method was in full swing. He decided to apply it to the study of a human disease. He chose rabies because it affected not only humans, but also animals on which he could experiment.
Who discovered virus?
Beijerinck, in 1898, was the first to call 'virus', the incitant of the tobacco mosaic. He showed that the incitant was able to migrate in an agar gel, therefore being an infectious soluble agent, or a 'contagium vivum fluidum' and definitively not a 'contagium fixum' as would be a bacteria.
What is the rabies virus called?
Rhabdoviridae, Rabies Virus Rabies virus (RABV), a member of the Lyssavirus genus belonging to the Rhabdoviridae family in the order Mononegavirales, causes a lethal neurological disease (called rabies) in humans and animals.
Who named rabies?
Rabies [ra′bēz] Democritus (460–370) described rabies, and Hippocrates is believed to refer to the disease when he said that “persons in a frenzy drink very little, are disturbed and frightened, tremble at the least noise, or are seized with convulsions.” According to Aristotle, “Dogs suffer from the madness.
Who Survived rabies?
Jeanna Geise was only 15 years old when she became the world's first known survivor of Rabies without receiving any vaccination. Her miraculous survival has not only challenged a time-honored scientific fact, but has also brought about a new method of Rabies treatment, known as the Milwaukee Protocol.
What are 3 facts about rabies?
Rabies is a vaccine-preventable, zoonotic, viral disease. Once clinical symptoms appear, rabies is virtually 100% fatal. In up to 99% of cases, domestic dogs are responsible for rabies virus transmission to humans. Yet, rabies can affect both domestic and wild animals.
Who discovered vaccine?
Edward Jenner is considered the founder of vaccinology in the West in 1796, after he inoculated a 13 year-old-boy with vaccinia virus (cowpox), and demonstrated immunity to smallpox. In 1798, the first smallpox vaccine was developed.
Epidemiology of Rabies
- The prevalence of rabies in different areas of the world varied throughout history. Some regions were thought to be free of rabies in particular time periods, although this changed with time as the disease crept back in depending on the animal population and prevalence of the disease. At the …
Prevention of Rabies Transmission
- In the 18th century, legislation was passed in countries like Germany, France and Spain for the destruction of stray dogs, in an attempt to reduce the risk that a rabid dog may come into contact and bite a human in the region. However, this was not held well by the public and was not enforced in most areas throughout the world. Other preventative methods were introduced in th…
Rabies Vaccination
- Pasteur first demonstrated the possibility of vaccinating dogs to prevent rabies infection and possible transmission to humans in 1885. However, this was not routinely practiced until the 1920s, when domestic animal vaccination was developed and became widely used. This practice helped to reduce the prevalence of rabies in animals dramatically. Provided that the majority of …
Current Management of Rabies
- Even today, once symptoms develop there is no known treatment for rabies. Instead, the current management for someone exposed to rabies is post-exposure prophylaxis (PEP). This involves administration of rabies immunoglobulin and vaccine soon after exposure to the virus, followed by a series of injections over 30 days. To date, PEP has a success rate nearing 100% when adminis…
References
Further Reading
Overview
Rabies virus, scientific name Rabies lyssavirus, is a neurotropic virus that causes rabies in humans and animals. Rabies transmission can occur through the saliva of animals and less commonly through contact with human saliva. Rabies lyssavirus, like many rhabdoviruses, has an extremely wide host range. In the wild it has been found infecting many mammalian species, while in the laborat…
Infection
In September 1931, Joseph Lennox Pawan of Trinidad found Negri bodies in the brain of a bat with unusual habits. In 1932, Pawan first discovered that infected vampire bats could transmit rabies to humans and other animals.
From the wound of entry, Rabies lyssavirus travels quickly along the neural pathways of the peripheral nervous system. The retrograde axonal transport of …
Structure
Rhabdoviruses have helical symmetry, so their infectious particles are approximately cylindrical in shape. They are characterized by an extremely broad host spectrum ranging from plants to insects and mammals; human-infecting viruses more commonly have icosahedral symmetry and take shapes approximating regular polyhedra.
Genome organization
The rhabdovirus virion is an enveloped, rod- or bullet-shaped structure containing five protein species. The nucleoprotein (N) coats the RNA at the rate of one monomer of protein to nine nucleotides, forming a nucleocapsid with helical symmetry. Associated with the nucleocapsid are copies of P (phosphoprotein) and L (large) protein. The L protein is well named, its gene taking up about half of the genome. Its large size is justified by the fact that it is a multifunctional protein. …
Life cycle
After receptor binding, Rabies lyssavirus enters its host cells through the endosomal transport pathway. Inside the endosome, the low pH value induces the membrane fusion process, thus enabling the viral genome to reach the cytosol. Both processes, receptor binding and membrane fusion, are catalyzed by the glycoprotein G which plays a critical role in pathogenesis (mutant virus without G proteins cannot propagate).
Signs and symptoms
The first symptoms of rabies may be very similar to those of the flu, including general weakness or discomfort, fever, or headache. These symptoms may last for days. There may be also discomfort or a prickling or itching sensation at the site of bite, progressing within days to symptoms of cerebral dysfunction, anxiety, confusion, agitation. As the disease progresses, the person may experience delirium, abnormal behavior, hallucinations, and insomnia. Rabies lyssav…
Antigenicity
Upon viral entry into the body and also after vaccination, the body produces virus neutralizing antibodies which bind and inactivate the virus. Specific regions of the G protein have been shown to be most antigenic in leading to the production of virus neutralizing antibodies. These antigenic sites, or epitopes, are categorized into regions I–IV and minor site a. Previous work has demonstrated that antigenic sites II and III are most commonly targeted by natural neutralizing a…
Evolution
All extant rabies viruses appear to have evolved within the last 1500 years. There are seven genotypes of Rabies lyssavirus. In Eurasia cases are due to three of these—genotype 1 (classical rabies) and to a lesser extent genotypes 5 and 6 (European bat lyssaviruses type-1 and -2). Genotype 1 evolved in Europe in the 17th century and spread to Asia, Africa and the Americas as a result of European exploration and colonization.