What is the effect of gentian violet on human health?
Gentian violet has long been reported to kill fungi that may cause the following problems in humans: Skin infections known as Gilchrist’s disease (Blastomyces) [ 10] Skin and nail infections (Fusarium oxysporum and F. moniliforme) [ 47] Ear infections (Aspergillus niger) [ 48]
Is gentian violet a direct-acting mutagen?
Z(ICR24) frameshift marker and is DNA repair proficient) indicated that gentian violet is a direct-acting mutagen causing frameshift mutations in repair-proficient bacteria. Dose levels of 75 and 100 μg/plate were toxic when S9 was omitted, but not when S9 was present in the incubation mixture.
Is gentian violet available over-the-counter?
The FDA allows the sale of over-the-counter gentian violet, which is mainly used for [ 1 ]: 1 Mouth and vaginal thrush 2 Skin infections 3 Disinfecting wounds
What is the history of gentian violet toxicity in rats?
Kinosita (1940) administered gentian violet (referred to by the author as 4:4':4''-hexamethyltriaminotriphenylmethane) to rats orally over a period of more than 300 days, and reported findings of “gastric papilloma and a slight adenomatous proliferation in the liver”.
Why is gentian violet not being used currently?
In 2019, all nonprescription products containing gentian violet for human use and veterinary products were removed from sale in Canada. Health Canada cancelled all licenses for these products after its safety review showed gentian violet could be linked to an increased risk of cancer.
How toxic is gentian violet?
Surprisingly, no acute toxic side effects were reported after administration of large amounts of gentian violet-treated blood. No studies have been done on long-term effects (chronic toxicity, carcinogenicity) of gentian violet-treated blood either in humans or in laboratory animals.
Is gentian violet banned in the US?
The use of gentian violet in animal feed or as a veterinary drug in food animals is prohibited in the US.
What cancer does gentian violet cause?
Chronic toxicity and carcinogenicity studies of gentian violet in mice. In the largest study of its kind, conducted by the US Food and Drug Administration (FDA), gentian violet was fed in large doses to rats lifelong. After 2 years, an increase in thyroid cancer was seen.
Is gentian violet cancerous?
At its November 1, 2018 meeting, the CIC by a unanimous vote found that gentian violet had been “clearly shown through scientifically valid testing according to generally accepted principles to cause cancer.” Accordingly, gentian violet (crystal violet) has been added to the Proposition 65 list of chemicals known to ...
Can I use gentian violet in my mouth?
Can you put gentian violet in your mouth? Gentian violet can be used in the mouth for thrush, but not on open ulcers or wounds, and is not to be swallowed.
Is gentian violet FDA approved?
--Gentian violet is generally recognized as safe and effective by FDA as an over-the-counter (nonprescription) drug for human use, primarily for the treatment of pinworms.
Is gentian violet safe for wounds?
Gentian violet is an antiseptic dye used to treat fungal infections of the skin (such as ringworm, athlete's foot). It also has weak antibacterial effects and may be used on minor cuts and scrapes to prevent infection.
Does CVS sell gentian violet?
Average 12 Month Prices for Gentian VioletPharmacyGentian Violet Retail PriceGentian Violet SingleCare PriceCVS Pharmacy$22.47$16.71Walmart$15.93$15.34Walgreens$21.24$9.15Rite Aid Pharmacy$25.37$15.34
Does gentian violet cure toenail fungus?
Plus: gentian violet can help improve toenail fungus, but it's a strong blue dye that can stain skin and nails.
What can I use instead of gentian violet?
During Orientation Week 2019, student leaders in the Faculty of Engineering and Applied Science used ProAiir Hybrid Face and Body FX Paint, left, as a safe alternative to gentian violet, right, used in previous years.
What is the active ingredient in gentian violet?
Drug Label InformationActive Ingredient/Active MoietyIngredient NameBasis of StrengthStrengthGENTIAN VIOLET (UNII: J4Z741D6O5) (GENTIAN VIOLET CATION - UNII:3GVJ31T6YY)GENTIAN VIOLET1 g in 100 mL
What happens if you swallow gentian violet?
Toxicity: If you ingest gentian violet, it can cause symptoms such as nausea, vomiting, diarrhea, and abdominal pain. Necrotic skin reactions: Necrotic skin, or blackened skin caused by tissue death, has also occurred when gentian violet was used in high doses.
Can I put gentian violet on my nipples?
1% Gentian Violet is a very effective anti-fungal liquid that may be used to treat an overgrowth of yeast on a mother's nipples. It may be applied ONCE A DAY or EVERY OTHER DAY to a mother's nipples, after a feeding, for up to 3 times.
Is gentian violet safe for infants?
Babies, however, do not commonly seem to be bothered by thrush. 11)Uncommonly, babies who are treated with gentian violet develop sores in the mouth which may cause them to reject the breast. If this occurs, or if the baby is irritable while nursing, stop the gentian violet immediately, and contact the clinic.
How long can you use gentian violet for thrush?
For fungus infections: Adults and children—Apply to the affected area(s) of the skin two or three times a day for three days.