Precautions
Venofer (iron sucrose) is given as an injection into the veins (intravenously or IV) by a trained healthcare provider. It can be given as a slow injection over 2 to 5 minutes or as an infusion. The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need.
How is Venofer (iron sucrose) given?
Mechanism of Action. Following intravenous administration, Venofer is dissociated into iron and sucrose and the iron is transported as a complex with transferrin to target cells including erythroid precursor cells. The iron in the precursor cells is incorporated into hemoglobin as the cells mature into red blood cells.
What is the mechanism of action of Venofer?
See why Venofer may be the right solution for your patients' iron deficiency needs. Watch the video. Venofer offers 7-day stability at controlled room temperature in both plastic syringes and IV admixtures diluted with 0.9% Sodium Chloride Injection (NaCl), avoiding potential waste.
Is Venofer the right solution for your patients' iron deficiency needs?
Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Venofer may cause clinically significant hypotension.
When should Venofer not be given?
How is Venofer given?
What is Venofer?
What other drugs will affect Venofer?
How long should you wait to be monitored for venofer injection?
What to do if you miss your Venofer appointment?
How old do you have to be to use Venofer?
What to tell your doctor before taking Venofer?
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About this website
What is the purpose of Venofer?
Venofer® (iron sucrose) injection, USP is an established and effective treatment for chronic kidney disease (CKD) patients experiencing iron deficiency anemia (IDA). Venofer provides IV iron therapy for the treatment of IDA in adult and pediatric patients 2 years and older with CKD.
What conditions require an iron infusion?
Patients with iron-deficiency anemia who are having high blood loss surgery (> 500 ml) within the next 2 months and need to replace iron quickly. (IV iron is absorbed by the body more rapidly than oral iron.) Patients with celiac disease (gluten intolerance). Cancer patients who have anemia and are taking an ESA.
Does Venofer increase hemoglobin?
At the end of treatment, 66% of patients in the Venofer group had an increase in Hb ≥2.0 g/dl compared to 47% in the oral iron group (p=0.07).
When should Venofer be administered?
Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Venofer may cause clinically significant hypotension.
What level of anemia is severe?
Mild: Hemoglobin 10.0 g/dL to lower limit of normal. Moderate: Hemoglobin 8.0 to 10.0 g/dL. Severe: Hemoglobin 6.5 to 7.9 g/dL[1] Life-threatening: Hemoglobin less than 6.5 g/dL.
What is a critically low hemoglobin level?
A severe low hemoglobin level for men is 13.5 gm/dL or lower. For women, a severe low hemoglobin level is 12 gm/dL.
How quickly does Venofer work?
It often takes 5 to 10 days after a Venofer® infusion to improve hemoglobin levels or feelings of fatigue. How many treatments will I need? Depending on the lab work results, you may need 1 to 4 Venofer® treatments. We usually schedule each treatment 5 to 14 days apart.
What happens after Venofer infusion?
Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Pain, swelling, or redness at the injection site may occur. If these effects continue or worsen, tell your doctor.
How often can Venofer be given?
Venofer® can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Total cumulative Venofer® dose = number of 100mg ampoules for Hb increase.
How long after iron infusion will I feel better?
How long after my iron infusion will I start to feel better? Your iron levels will be restored directly right after the infusion, however, it can take up to two weeks before you start to notice a difference and feel better.
How quickly does IV iron increase hemoglobin?
Iron infusions start to kick in within about a week. Hemoglobin levels should go up within 2 to 3 weeks. To compare, oral iron can take 3 to 6 months to treat IDA.
How much is Venofer infusion?
The cost for Venofer intravenous solution (20 mg/mL) is around $311 for a supply of 25 milliliters, depending on the pharmacy you visit....Intravenous Solution.QuantityPer unitPrice25 (10 x 2.5 milliliters)$12.44$310.9750 (5 x 10 milliliters)$7.94 – $12.35$397.00 – $617.61125 (25 x 5 milliliters)$12.24$1,529.77
Why do I need an iron infusion?
An iron infusion may be given if a person's blood counts are so low that taking iron supplements or increasing their daily intake of iron-containing foods would be ineffective or too slow in increasing their iron levels.
What is considered a dangerously low ferritin level symptoms?
Inflammation or soreness of your tongue. Brittle nails. Unusual cravings for non-nutritive substances, such as ice, dirt or starch. Poor appetite, especially in infants and children with iron deficiency anemia.
What symptoms does low ferritin cause?
Your doctor may order a ferritin test if you have some of the following symptoms associated with low ferritin levels: unexplained fatigue. dizziness. chronic headaches.
What ferritin level requires iron infusion?
The efficacy of intravenous iron was bound to a serum ferritin concentration ≤ 15 ng/mL.
What is the difference between Venofer (iron sucrose) and other IV forms of iron?
The major differences between the IV iron products currently available include who they're approved for, the number of injections required to finis...
Can I take Venofer (iron sucrose) at home?
No, Venofer (iron sucrose) is typically given as an IV injection at your provider's office or an infusion center.
Can I use other iron products while receiving Venofer (iron sucrose)?
No, don't take any other iron products by mouth while receiving Venofer (iron sucrose). This can put you at risk for a condition called hemochromat...
How will I know if Venofer (iron sucrose) is working?
Your provider will order certain blood tests that show how well Venofer (iron sucrose) is working for you. One of the tests measures your ferritin...
Can I receive Venofer (iron sucrose) if I'm pregnant?
Studies of females in the second or third trimester of pregnancy who received Venofer (iron sucrose) showed there wasn't any harm done to the mothe...
What is Venofer®? Why do I need Venofer®? - HRRH
www.hrh.ca Medical Day are linic Appointment Information A Patient’s Guide to Venofer® What is Venofer®? Venofer® (iron sucrose) is a liquid form of the
Venofer Side Effects: Common, Severe, Long Term - Drugs.com
Venofer Side Effects. Generic name: iron sucrose Medically reviewed by Drugs.com. Last updated on Feb 22, 2022. Consumer; Professional; Note: This document contains side effect information about iron sucrose. Some of the dosage forms listed on this page may not apply to the brand name Venofer.. Summary
Venofer Injection Dosage Guide - Drugs.com
Pediatric Patients (2 Years of Age and Older) with HDD-CKD for Iron Maintenance Treatment. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes.
Dosing & Administration Guide - Venofer
Dosing and administration for pediatric patients2 Pediatric Patients (2 years of age or older) with HDD-CKD For iron maintenance treatment, administer Venofer® (iron sucrose
Venofer (iron sucrose) dosing, indications, interactions, adverse ...
Medscape - Iron deficiency anemia dosing for Venofer (iron sucrose), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
What is the function of a carbohydrate shell in a Venofer?
The function of the carbohydrate shell is to stabilize the complex. According to the proposed mechanism, once IV iron is administered, these stable complexes are endocytosed by macrophages of the reticuloendothelial system, and the iron is transported to where it is needed.
What happens to the iron complex after IV?
According to the proposed mechanism, once IV iron is administered, these stable complexes are endocytosed by macrophages of the reticuloendothelial system, and the iron is transported to where it is needed.
Adult CKD Patients 1
The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs.
Pediatric CKD Patients 1
Venofer treatment may be repeated if necessary. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established.
What is the mechanism of action of venofer?
Mechanism of Action. Venofer is an aqueous complex of poly-nuclear iron (III)-hydroxide in sucrose. Following intravenous administration, Venofer is dissociated into iron and sucrose and the iron is transported as a complex with transferrin to target cells including erythroid precursor cells.
How is Venofer eliminated?
Following intravenous administration of Venofer, iron sucrose is dissociated into iron and sucrose. The sucrose component is eliminated mainly by urinary excretion. In a study evaluating a single intravenous dose of Venofer containing 1,510 mg of sucrose and 100 mg of iron in 12 healthy adults (9 female, 3 male: age range 32 to 52), 68.3% of the sucrose was eliminated in urine in 4 h and 75.4% in 24 h. Some iron was also eliminated in the urine. Neither transferrin nor transferrin receptor levels changed immediately after the dose administration. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500 to 700 mg of iron in 26 patients with anemia on erythropoietin therapy (23 female, 3 male; age range 16 to 60), approximately 5% of the iron was eliminated in urine in 24 h at each dose level. The effects of age and gender on the pharmacokinetics of Venofer have not been studied.
How long does Venofer take to work?
Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling ( 16.2 ).] Venofer treatment may be repeated if iron deficiency reoccurs.
How long to administer Venofer?
Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Administer on 5 different occasions over a 14 day period. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling ( 16.2 ).] Venofer treatment may be repeated if iron deficiency reoccurs.
How many patients are in the Venofer trial?
Five clinical trials involving 647 adult patients and one clinical trial involving 131 pediatric patients were conducted to assess the safety and efficacy of Venofer.
How much iron is in a venofer?
The dosage of Venofer is expressed in mg of elemental iron. Each mL contains 20 mg of element al iron.
Does Venofer cause hypotension?
Venofer may cause clinically significant hypotension. Monitor for signs and symptoms of hypotension following each administration of Venofer. Hypotension following administration of Venofer may be related to the rate of administration and/or total dose administered [see Dosage and Administration ( 2 ), Warnings and Precautions ( 5.1 ), and Adverse Reactions ( 6.2 )].
What is it called when you don't get enough iron?
This condition is called iron deficiency (iron shortage) or iron deficiency anemia. This medicine is to be given only by or under the direct supervision of a doctor.
Why is iron important for kidneys?
Iron is used to make healthy red blood cells, which carry oxygen and nutrients throughout the body. This medicine is used to treat iron deficiency anemia in people with chronic kidney disease. Compare iron supplements. Prescription Settings.
Most voted positive review
SO FAR, SO GREAT! VENOFER IS WORKING EXCELLENT! I CAN'T TAKE ORAL IRON. I TAKE 2 INFUSIONS TWICE A WEEK AS MY RED BLOOD ARE EXTREMELY!!! LOW. I HAVE NO ENERGYWHAT SO EVER, HAVE A TERRIBLE TIME BREATHING, SITTING DOWN IS OK, BUT WHEN I STAND UP I FEEL LIKE SOMEONE HAS PUT A BAG OVER MY HEAD.
Most voted negative review
This medicine was taken by my wife. First, let me tell about a powerful negative side effect. One IV treatment of 100mg/5mg solution (qty of 0300, whatever that means)cost $792. She had two treatments so combined with $700 in charges for two IV "procedures," the total cost was $2,300. An obcene amount of money when it is out of pocket.
Shared reviews and ratings
It definitely helps the low iron, ferritin goes up quick with a few treatments. Iron pills do nothing due to years of stomach damage. I get 200mg a few times a year. My first time getting treated I felt horribly dizzy and sick at the very end like I was going to pass out, so they slowed it to two hours instead and that seems to help.
How is Venofer given?
Venofer is given as an infusion into a vein. A healthcare provider will give you this injection.
What is Venofer?
Venofer injection contains iron sucrose, a form of the mineral iron. Iron is important for many functions in the body, especially for the transport of oxygen in the blood.
What other drugs will affect Venofer?
Treatment with Venofer injections can make it harder for your body to absorb iron medications you take by mouth. Tell your doctor if you are taking iron supplements or other iron-based oral medications, such as:
How long should you wait to be monitored for venofer injection?
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. You will be watched closely for at least 30 minutes to make sure you do not have an allergic reaction. You will need frequent medical tests to help your doctor determine how long to treat you with Venofer.
What to do if you miss your Venofer appointment?
Call your doctor for instructions if you miss an appointment for your Venofer injection.
How old do you have to be to use Venofer?
Venofer is for use in adults and children at least 2 years old.
What to tell your doctor before taking Venofer?
Tell your doctor if you are taking iron supplements or other iron-based oral medications. Before you receive Venofer, tell your doctor if you have low blood pressure, hepatitis, or if you have received many blood transfusions in the past.
