Does NexGard treat mange?
Two consecutive monthly treatments of NexGard or NexGard SPECTRA are recommended for sarcoptic mange. Demodex treatment with NexGard or NexGard SPECTRA should be continued monthly until your vet confirms the absence of mites on two consecutive monthly skin scrapings.
How fast does NexGard work on mange?
How fast does NexGard work on mange? A third EU field study involved 38 dogs with sarcoptic mange which were treated monthly for two months with NexGard. NexGard reduced the number of live mites by 96% 28 days after starting treatment and by 100% 56 days after starting treatment. Click to see full answer.
Does NexGard protect against ticks?
NexGard kills fleas and ticks fast, all month long, and is the only chew that’s FDA-approved to prevent the infections that cause Lyme disease by killing black-legged ticks. NexGard is a bite-sized dose that’s safe for dogs and puppies as young as 8 weeks, weighing just 4 pounds, through adulthood.
Does simparica kill Demodex?
SIMPARICA® (oral tablet) provides immediate and persistent protection from parasites in one convenient monthly dose. The only oral product licensed to treat Demodex canis, Otodectes cynotis and Sarcoptes scabei Kills fleas and ticks for at least 35 days minimising any protection gaps1
How long does it take to cure demodicosis in dogs?
As recently as 2013, the leading veterinary dermatology textbook, Small Animal Dermatology, stated that, despite a good prognosis with appropriate treatment, cure “may take nearly a year”. The need to titrate ivermectin, avoid its use in susceptible breeds, deal with occasional but alarming adverse effects, and repeat scrapings over many months, has made generalized demodicosis a particular challenge for shelters, and created a significant barrier to management and adoption.
Which is better, Afoxolaner or Moxidectin?
Afoxolaner performed significantly better than imidacloprid/moxidectin in one study (both were given at days 0, 14, 28, 56)
How much does ivermectin cost?
A 50mL bottle of Ivomec® (ivermectin) cost $37.95, This bottle would be enough, diluted, to dose almost 70,000 kg of dog. For a shelter treating multiple dogs, ivermectin is much, much cheaper, but there would be no cost advantage for an individual private client if they had to buy a whole bottle.
Can demodicosis be cured?
There are limitations to the “magic cure”. Many dogs with generalized demodicosis have seconda ry bacteria l and yeast infections, and need additional systemic and/or topical treatment to manage infections and complications. In dogs with adult-onset, generalized demodicosis, an underlying immune-deficiency may be present and recurrences should be assumed to be possible regardless of the product used.
Is Advantage Multi approved for demodicosis?
Studies have compared isoxazolines with imidacloprid + moxidectin (Advantage Multi®, which is currently approved as “an aid in treatment and control ” of canine demodicosis.
Can isoxazolines be used in Canada?
Isoxazolines are currently not labelled for treatment of demodicosis in Canada. These products have several potential side effects (including vomiting, diarrhea and seizures) and should only be used in suitable patients and under veterinary supervision.
Why was Nexgard removed from my dog?
One dog from the Nexgard® group was removed at the owner’s request because of an aggressive behavior that jeopardized the appropriate follow-up of the dog, and another dog from the same group previously diagnosed with cancer and chronic heart problems died from heart failure.
What are the criteria for a dog to be treated for Demodex?
Criteria for inclusion were the presence of clinical signs of generalised demodicosis (i.e. erythema, hair loss, follicular casts and crust, and/or pyoderma) on 5 or more areas, or pododemodicosis on 2 or more paws and at least 5 live Demodex spp. mites (i.e. at least 1 alive mite/alopecic area). All dogs were subjected to a physical examination before treatment to be considered suitable for inclusion into the study. Clinical history and ongoing medications were recorded at inclusion.
How often is Nexgard Spectra given to dogs?
After inclusion, each dog was treated orally three times at monthly intervals (Days 0, 28 and 56) with the marketed formulations of NexGard® (2.7 mg/kg afoxolaner) or NexGard Spectra® (2.5 mg/kg afoxolaner and 0.5 mg/kg milbemycin oxime) according the European label instructions. The veterinarian could choose NexGard® or NexGard Spectra® based on the needs of the client, i.e. anthelmintic activity of milbemycin oxime. At least 30% of the dogs were required to be treated with NexGard Spectra®. Dogs were weighed before each treatment for appropriate dose determination.
What is the best treatment for demodicosis in dogs?
Many treatment protocols in the field include off label use of macrocyclic lactone , providing variable efficacy with potential for toxicity, especially in dogs carrying MDR-1 gene mutations [ 3, 9, 10 ]. Recently, a new class of insecticides/acaricides, the isoxazolines, demonstrated very good efficacy against many ectoparasites of dogs and cats: fleas and ticks, but also mites, including Otodectes cynotis, Sarcoptes scabiei, Lynxacarus radovskyi and Demodex canis [ 11, 12, 13, 14, 15, 16, 17, 18 ]. Among the isoxazolines, the efficacy of afoxolaner against D. canis has been demonstrated in one laboratory study involving naturally infested animals conducted in South Africa. In this study, afoxolaner was administered at fortnighly interval for one month then at a monthly interval for two additional months and demonstrated > 99% reduction in mite counts [ 11 ]. The purpose of the present field study was to assess the efficacy of monthly oral administration of afoxolaner in two different formulations, alone (NexGard®) and in combination with milbemycin oxime (NexGard Spectra®) against generalised canine demodicosis in the European pet dog population.
What is demodicosis in dogs?
Demodicosis is one of the most frequent skin conditions in dogs. It is a parasitic disease caused by mites of the genus Demodex [ 1, 2 ]. A small number of mites are usually considered as a normal component of the dog’s skin microbiota, but their proliferation leads to a potentially serious condition [ 3, 4 ]. Puppies acquire mites from their mother in the first days of their life through direct skin contact [ 2 ]. The evolution from asymptomatic carriage to skin disease may be related to a particular cellular immunodeficiency allowing the multiplication of the mites, although the pathogenesis is not yet elucidated [ 3, 4, 5 ]. Canine demodicosis is classically divided into two main clinical manifestations, i.e. localised and generalised demodicosis. The localised form appears as patches of alopecia and mild erythema in limited areas of the body, usually in young dogs, although it may also affect older ones. It can regress spontaneously without treatment [ 2 ]. Generalised demodicosis is more severe and can even be fatal if a secondary bacterial infection develops [ 2 ]. It may evolve from the localised condition or occur spontaneously especially in older animals with underlying diseases [ 5, 6 ]. Recently, it has been proposed that localised demodicosis is characterised as no more than four lesions with a diameter of up to 2.5 cm, while canine generalised demodicosis is characterised by five or more affected areas, or by lesions covering an entire region of the body, and/or demodectic podal dermatitis involving two or more paws [ 3, 4, 6, 7 ]. In the case of generalised demodicosis, the affected areas are frequently erythematous, with comedones, hair loss, follicular papules to pustules, and scales. Secondary severe bacterial infections are frequent. Suspicion of demodicosis based on clinical signs has to be confirmed by the detection of mites in deep skin scrapings. Alternatively, skin biopsy or hair plucks may also be performed [ 3, 4, 6 ].
What is Nexgard Spectra?
A multi-centre field trial was conducted to evaluate the effica cy of afoxolaner based chewables (NexGard® or NexGard Spectra®) for the treatment of generalised demodicosis caused by Demodex canis in dogs under field conditions in France, Italy and Poland.
Does afoxolaner help with Demodex mites?
This multi-center clinical field study demonstrated that monthly oral administrations of afoxolaner, both alone or in combination with milbemycin oxime, provided a rapid and significant reduction of the number of Demodex mites and of clinical signs of demodicosis in privately-owned dogs in Europe. The results obtained are consistent with the findings reported previously with afoxolaner [ 11] or other isoxazolines [ 14, 15, 21, 22, 23 ].
What is demodectic mange?
Demodectic mange is caused by microscopic Demodex mites that live in the dog’s hair follicles. Demodex mites are a normal inhabitant of a dog’s skin, however, they can cause skin disease if the immune system cannot control the mite population (e.g. young or malnourished dogs).
What is sarcoptic mange?
Sarcoptic mange is an extremely itchy skin disease. The dog variety of the mite can also infest humans and cause temporary dermatitis with intensely itchy skin lesions that can last for several weeks.
