Per the NIH, zosyn and vanco are variably compatible. If I were sending a patient home on q 6hr zosyn and q 12 hr vanco, we would be recommending a double lumen PICC because we typically put q 6hr zosyn on a continuous pump.
What diluents are compatible with vancomycin?
When 0.9% sodium chloride was used as the diluents, Y-site compatibility was found with vancomycin 2 and 5 mg/mL and all tested concentrations of piperacillin-tazobactam. Vancomycin 10 mg/mL was incompatible with piperacillin-tazobactam 40, 80, and 100 mg/mL.
How do you administer Zosyn and vancomycin together?
vancomycin and zosyn through the same lumen concurrently if possible (i.e. administer vancomycin and zosyn infusion through separate lumens or try administering vancomycin prior to the zosyn 4-hour infusion).
What is the difference between Zosyn and vancomycin?
Zosyn and vancomycin are different types of antibiotics. Zosyn is a combination a penicillin antibiotic and a beta-lactamase inhibitor and vancomycin is a glycopeptide. A brand name of vancomycin is Vancocin. Side effects of Zosyn and vancomycin that are similar include itching.
How do you test Y-site compatibility between vancomycin and piperacillin?
Methods: Vancomycin and piperacillin-tazobactam were tested using simulated and actual Y-site infusion methodologies. Simulated Y-site compatibility was performed using previously published methods via visual inspection, turbidity evaluation, and pH evaluation.
Is ZOSYN and Vanc compatible?
Our results demonstrated that piperacillin sodium–tazobactam and vancomycin are physically compatible at concentrations typically used for prolonged infusions.
What is ZOSYN not compatible with?
ZOSYN is not compatible with tobramycin for simultaneous co-administration via Y-site infusion. Compatibility of ZOSYN with other aminoglycosides has not been established.
Why are vancomycin and ZOSYN given together?
The rationale for combination therapy includes prevention of resistance to a single agent, treatment of polymicrobial infection, empiric therapy for immunocompromised and critically ill patients, and using synergistic antibiotics to treat a serious, hard to treat infection due to relatively resistant organisms, such as ...
What is vancomycin IV compatible with?
The Y-site compatibility of vancomycin and piperacillin-tazobactam showed greater compatibility with 0.9% sodium chloride than with 5% dextrose. At the lowest tested concentration, vancomycin was compatible with all tested piperacillin-tazobactam in both diluents.
What IV fluids is Zosyn compatible with?
ZOSYN containing EDTA is compatible for co-administration via a Y-site intravenous tube with Lactated Ringer's injection, USP.
How do you know IV compatibility?
You can also check the IV compatibility of a single drug. Enter one drug and click “View compatibility.” The default compatibility result will display the solution compatibilities for the IV Drug searched. You can also view different drugs and solutions that are compatible by clicking the drop-down arrows.
Can you give vancomycin and piperacillin together?
Vancomycin and piperacillin-tazobactam are 2 of the most commonly prescribed antibiotics in hospitals. Recent data from multiple meta-analyses suggest that the combination increases the risk for vancomycin-induced kidney injury when compared to alternative viable options.
Is Zosyn the same as vancomycin?
Zosyn and vancomycin are different types of antibiotics. Zosyn is a combination a penicillin antibiotic and a beta-lactamase inhibitor and vancomycin is a glycopeptide. A brand name of vancomycin is Vancocin. Side effects of Zosyn and vancomycin that are similar include itching.
Does Zosyn cover VRE?
Comparison of the 3 broadest spectrum beta-lactams: Cefepime, Zosyn, and Carbapenems (non-Ertapenem) have activity against both Gram positive (MSSA, Strep) and Gram negative including Pseudomonas. They do NOT cover: MRSA, VRE, Atypicals, among others.
What is not compatible with vancomycin?
26 For example, vancomycin is incompatible with many β-lactam antibiotics (flucloxacillin, piperacillin/tazobactam, cefotaxime, ceftazidime and imipenem).
Can you piggyback vancomycin?
Vancomycin is used to treat serious bacterial infections. It is an antibiotic that works by stopping the growth of bacteria. This medication is usually given by injection into a vein.
What does Y site incompatibility mean?
Y-site Compatibility - A single drug that is administered simultaneously at a Y-site connection with another drug in a solution. Solution Compatibility - A single drug in a solution. Admixture Compatibility - Two drugs in a solution.
Are Zosyn and potassium compatible?
Interactions between your drugs No interactions were found between piperacillin / tazobactam and Potassium Chloride in Sodium Chloride.
Are Zosyn and magnesium compatible?
Interactions between your drugs No interactions were found between piperacillin / tazobactam and Sulfamag.
Are Zosyn and LR compatible?
In addition, the label of Zosyn instructed that lactated Ringer's injection solution (LRS) was not compatible with Zosyn and hence could not be used as a reconstitution or admixture diluent.
Are albumin and Zosyn compatible?
ZOSYN should not be mixed with other drugs in a syringe or infusion bottle since compatibility has not been established. ZOSYN is not chemically stable in solutions that contain only sodium bicarbonate and solutions that significantly alter the pH. ZOSYN should not be added to blood products or albumin hydrolysates.
What are the interactions between Zosyn and Vancomycin?
Drug interactions are reported among people who take Vancomycin hcl and Zosyn. Common interactions include blood creatinine increased among females and pyrexia among males.
What is Zosyn?
Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in infection. eHealthMe is studying from 9,030 Zosyn users for its effectiveness, alternative drugs and more.
What is Vancomycin hcl?
Vancomycin hcl has active ingredients of vancomycin hydrochloride. It is often used in infection. eHealthMe is studying from 6,089 Vancomycin hcl users for its effectiveness, alternative drugs and more.
What are the side effects of vancomycin?
Vancomycin may cause serious side effects, including: 1 serious allergic reactions (anaphylactoid reactions), 2 including low blood pressure, 3 wheezing, 4 indigestion, 5 hives, or 6 itching. 7 Rapid infusion of Vancomycin may also cause flushing of the upper body (called "red neck" or "red man syndrome"), 8 dizziness, 9 low blood pressure, or 10 pain and muscle spasm of the chest and back.
What is the brand name of vancomycin?
A brand name of vancomycin is Vancocin.
What Is Vancomycin?
Vancomycin is an antibiotic indicated for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci . Vancomycin is indicated for penicillin-allergic patients, for patients who cannot receive or who have failed to respond to other drugs, including the penicillins or cephalosporins, and for infections caused by Vancomycin susceptible organisms that are resistant to other antimicrobial drugs.
What is Zosyn used for?
Zosyn (piperacillin and tazobactam for injection) is a combination of two antibiotics used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia. Zosyn is available in generic form.
Does Zosyn interact with Vancomycin?
Both Zosyn and vancomycin may interact with other antibiotics. Zosyn may also interact with probenecid, blood thinners, or any other medication used to prevent blood clots. Vancomycin may also interact with anesthetic agents, or other potentially neurotoxic and/or nephrotoxic drugs (such as amphotericin B, aminoglycosides, colistin, viomycin, ...
Does Zosyn cause bruising?
Tell your doctor if you have serious side effects of Zosyn including muscle cramps or spasms, swelling of the arms /legs/hands/ feet, easy bruising or bleeding, chest pain, confusion, new signs of infection (such as fever, persistent sore throat ), severe abdominal or stomach pain, slow/fast/irregular heartbeat, persistent nausea or vomiting, seizures, extreme tiredness, dark or cloudy urine, change in the amount of urine, yellowing eyes or skin, or serious skin reactions (rash, peeling, sores, or blisters).
Does vancomycin interact with cidofovir?
Vancomycin hydrochloride may interact with cidofovir, drugs that may harm the kidneys (amphotericin B, cisplatin, polymyxin, colistin, aminoglycosides such as gentamicin, tobramycin ), other antibiotics, and live bacterial vaccines.
Severe Interactions
These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
Serious Interactions
These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
Moderate Interactions
These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
