Precautions
Some of the dosage forms listed on this page may not apply to the brand name Sensipar. Common side effects of Sensipar include: decreased plasma testosterone, diarrhea, dizziness, myalgia, nausea, vomiting, and hypoparathyroidism. Other side effects include: dialysis access infection, asthenia, chest pain, hypertension, hypotension, and anorexia.
What are the side effects of Sensipar?
Using both medications together may increase the risk of side effects (especially low calcium levels). Does Sensipar interact with other drugs you are taking? If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
Does Sensipar interact with other medications or foods?
Sensipar (or placebo) was initiated at a dose of 30 mg once daily and titrated every 3 or 4 weeks to a maximum dose of 180 mg once daily to achieve an iPTH of ≤ 250 pg/mL. The dose was not increased if a patient had any of the following: iPTH ≤ 200 pg/mL,...
What is the maximum dose of Sensipar that can be taken?
The calcium-sensing receptor on the surface of the chief cell of the parathyroid gland is the principal regulator of PTH synthesis and secretion. Cinacalcet, the active ingredient in Sensipar, directly lowers PTH levels by increasing the sensitivity of the calcium-sensing receptor to extracellular calcium.
How does Sensipar work in the parathyroid?
Does cinacalcet cause weight gain?
Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia.
What are side effects of Sensipar?
Common side effects of Sensipar include:nausea,vomiting,diarrhea,loss of appetite,muscle pain,mild chest pain,dizziness, or.weakness.
Does Sensipar affect blood pressure?
Low blood pressure: Blood pressure may occasionally drop when taking cinacalcet. Be alert for any lightheadedness, dizziness, or a faster-than-normal heart rate.
What are the main side effects of cinacalcet?
Cinacalcet may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:upset stomach.vomiting.diarrhea.dizziness.weakness.chest pain.
How long does it take Sensipar to work?
In phase I-II studies, the maximum effect of cinacalcet was achieved within 2–6 hours after administration, with a terminal half-life of 30–40 hours (30, 31).
What is the difference between Sensipar and cinacalcet?
Sensipar is the trade name, the generic name for this drug is "Cinacalcet". Sensipar comes as a small pill in three strengths (30mg, 60mg, and 90mg). This drug was designed for the treatment of SECONDARY hyperparathyroidism.
Can you drink alcohol with cinacalcet?
There is 1 alcohol/food/lifestyle interaction with cinacalcet....Drug Interaction Classification.MajorHighly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.UnknownNo interaction information available.2 more rows
Can you stop Sensipar?
Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: thioridazine. If your doctor tells you to switch from using this medication to etelcalcetide, this medication should be stopped at least 7 days before starting etelcalcetide.
Does Sensipar lower calcium?
Low calcium levels: Sensipar® lowers calcium and can lead to low calcium levels in your blood. Tell your healthcare provider if you have spasms, twitches, or cramps in your muscles; numbness or tingling in your fingers, toes, or around your mouth; or seizures.
When is the best time to take cinacalcet?
It is best to take this medicine with food or shortly after a meal. Swallow the tablet whole. Do not crush, break, or chew it.
What are the benefits of cinacalcet?
Some randomized controlled trials (RCTs) found that cinacalcet significantly reduced the likelihood of parathyroidectomy, fracture, and cardiovascular hospitalization; improved physical function; and diminished pain. However, the effect on all-cause and cardiovascular mortality was not demonstrated [9, 10].
How long can you live with hyperparathyroidism?
Parathyroid disease (hyperparathyroidism) causes symptoms in most people, but it will decrease the life expectancy in all patients by about 5-6 years if the parathyroid tumor is not removed … Most people with hyperparathyroidism don't feel well.
Before Taking This Medicine
You should not use Sensipar if you are allergic to cinacalcet, or if you have: 1. low levels of calcium in your blood (hypocalcemia).To make sure S...
How Should I Take Sensipar?
Take Sensipar exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose...
Sensipar Dosing Information
Usual Adult Dose for Secondary Hyperparathyroidism:Initial dose: 30 mg orally once a day (cinacalcet should be titrated no more frequently than eve...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Other Drugs Will Affect Sensipar?
Many drugs can interact with cinacalcet. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible...
What are the symptoms of a syringe?
cough or hoarseness. fever or chills. loss of bladder control. lower back or side pain. muscle spasm or jerking of all extremities. painful or difficult urination. sudden loss of consciousness. Incidence not known. Abdominal or stomach cramps.
What are the side effects of cinacalcet?
Check with your doctor immediately if any of the following side effects occur while taking cinacalcet: More common. Blurred vision.
Does Sensipar cause dizziness?
Common side effects of Sensipar include: decreased plasma testosterone, diarrhea, dizziness, myalgia, nausea, vomiting, and hypoparathyroidism. Other side effects include: dialysis access infection, asthenia, chest pain, hypertension, hypotension, and anorexia. See below for a comprehensive list of adverse effects.
What is Sensipar used for?
What Is Sensipar? Sensipar ( cinacalcet) is a calcimimetic agent that decreases levels of parathyroid hormone (PTH), calcium, and phosphorous in the body used to treat hyperparathyroidism (overactive parathyroid glands) in people who are on long-term dialysis for kidney disease.
What are the side effects of a syringe?
Common side effects may include: nausea, vomiting; or. diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How many patients have seizures with cinacalcet?
Seizures were observed in 0.7% (1/140) of cinacalcet -treated patients and 0.0% (0/46) of placebo-treated patients in all clinical studies.
Can you take Sensipar while pregnant?
During pregnancy, Sensipar should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.
Does Sensipar cause low calcium levels?
Common side effects of Sensipar include: weakness. Sensipar can cause low calcium blood levels. Tell your doctor if you have symptoms of low calcium levels including numb or tingling skin, severe muscle spasms, seizures, unusual tiredness, or fast/irregular/pounding heartbeat.
Is Sensipar an adverse reaction?
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Can adverse reaction rates be directly compared with rates in the clinical trials of another drug?
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
What does Sensipar do to the body?
Sensipar (cinacalcet) decreases levels of parathyroid hormone (PTH), calcium, and phosphorous in the body.
How should I take Sensipar?
Take Sensipar exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
What other drugs will affect Sensipar?
Many drugs can interact with cinacalcet. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Sensipar. Give a list of all your medicines to any healthcare provider who treats you.
How long after taking Sensipar can you test your blood?
Do not crush or break a tablet. Swallow the pill whole. To be sure your calcium and phosphorous levels do not get too low, your blood will need to be tested 1 week after you start taking Sensipar or whenever your dose is changed. You may also need blood tests on a regular basis during treatment.
What are the symptoms of Sensipar?
Get emergency medical help if you have signs of an allergic reaction to Sensipar : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
What are the side effects of a syringe?
nausea, vomiting; headache, fatigue; diarrhea. low blood pressure; decreased appetite; or; tingling in the arms, hands, legs or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Does Sensipar harm babies?
It is not known whether Sensipar will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
How many mg of Sensipar are in a tablet?
Sensipar tablets are formulated as light-green, film-coated, oval-shaped tablets for oral administration in strengths of 30 mg, 60 mg, and 90 mg of cinacalcet as the free base equivalent (33 mg, 66 mg, and 99 mg as the hydrochloride salt, respectively).
What is Sensipar 30 mg?
Sensipar 30 mg tablets are formulated as light-green, film-coated, oval-shaped tablets marked with “AMG” on one side and “30” on the opposite side, packaged in bottles of 30 tablets. ( NDC 55513-073-30)
How long does it take to get Cmax after taking cinacalcet?
After oral administration of cinacalcet, Cmax is achieved in approximately 2 to 6 hours. Cinacalcet Cmax and AUC (0-infinite) were increased by 82% and 68%, respectively, following administration with a high-fat meal compared with fasting in healthy volunteers. The Cmax and AUC (0-infinite) of cinacalcet were increased by 65% and 50%, respectively, when cinacalcet was administered with a low-fat meal compared with fasting.
What is Sensipar a calcimimetic agent?
DESCRIPTION. Sensipar (cinacalcet) is a calcimimetic agent that increases the sensitivity of the calcium-sensing receptor to activation by extracellular calcium. Sensipar tablets contain the hydrochloride salt of cinacalcet.
What is the serum calcium level of Sensipar?
If serum calcium falls below 7.5 mg/dL, or if symptoms of hypocalcemia persist and the dose of vitamin D cannot be increased, withhold administration of Sensipar until serum calcium levels reach 8.0 mg/dL and/or symptoms of hypocalcemia have resolved.
How many people are over 65 in Sensipar?
Of the total number of subjects (n = 1136) in clinical studies of Sensipar, 26 percent were 65 and over, and 9 percent were 75 and over. No overall differences in the safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger subjects, but greater sensitivity of some older individuals cannot be ruled out [see Clinical Studies and CLINICAL PHARMACOLOGY ].
How to report side effects of prescription drugs?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
How to take Sensipar?
How to use Sensipar. Take this medication by mouth with food or shortly after a meal, as directed by your doctor. The manufacturer directs not to split the tablet before taking it. However, many similar drugs (immediate-release tablets) can be split/crushed. Follow your doctor's directions on how to take this medication.
What are the side effects of a syringe?
Side Effects. Nausea, vomiting, or unusual tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
Can cinacalcet cause low calcium levels?
Cinacalcet can cause low calcium blood levels. Your doctor will check your calcium blood levels while you are taking this medication. Tell your doctor right away if you have any of the following symptoms of low calcium levels: numb/tingling skin, severe muscle spasms, seizures, fast/irregular/pounding heartbeat.
Where to report side effects?
You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions.
Can cinacalcet cause allergies?
Before taking cinacalcet, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Are you currently using Sensipar?
This survey is being conducted by the WebMD marketing sciences department.
What are the symptoms of a syringe?
cough or hoarseness. fever or chills. loss of bladder control. lower back or side pain. muscle spasm or jerking of all extremities. painful or difficult urination. sudden loss of consciousness. Incidence not known. Abdominal or stomach cramps.
Does cinacalcet cause dizziness?
Commonly reported side effects of cinacalcet include : decreased plasma testosterone, diarrhea, dizziness, myalgia, nausea, vomiting, and hypoparathyroidism. Other side effects include: dialysis access infection, asthenia, chest pain, hypertension, hypotension, and anorexia. See below for a comprehensive list of adverse effects.
Anatomy of the parathyroid glands
The parathyroid glands are tiny glands located at the back of the thyroid gland in the neck. They produce parathyroid hormone (PTH) in response to blood calcium levels, increasing output when blood levels of calcium are low and decreasing output when levels return to normal.
What causes hyperparathyroidism?
Primary hyperparathyroidism is a disorder of the parathyroids, four tiny pea-sized glands located behind the thyroid gland in the neck. Rarely, a parathyroid will be located elsewhere in the neck or upper chest region, and it's possible, though not common, to have more than four glands.
Decision factors for surgery in asymptomatic primary hyperparathyroidism
1.0 milligrams per deciliter (mg/dL) or more above the upper limit of normal*
How is hyperparathyroidism diagnosed?
Some experts consider the term "asymptomatic" something of a misnomer because of the many nonspecific complaints associated with the disease. However, these aren't clear heralds of hyperparathyroidism, and people often discount them and don't seek medical attention for them.
What about surgery?
When it causes kidney or bone disease or severe symptoms, primary hyperparathyroidism almost always calls for parathyroidectomy — removal of the enlarged parathyroid gland (or glands). In experienced hands, this operation has few complications, and it cures the condition 95% to 98% of the time.
What is sestamibi scanning?
Sestamibi scanning is a painless technique often used before surgery to locate abnormal parathyroid glands and determine whether minimally invasive surgery is appropriate. A radiolabeled compound (technetium sestamibi) is injected into a vein and is taken up preferentially by the abnormal parathyroids.
Surgery: What's involved?
The standard surgery, called bilateral neck exploration, entails making a two- to five-inch incision across the front of the neck, examining all four parathyroid glands, and removing the enlarged ones. It's usually performed under general anesthesia, although local anesthesia is sometimes an option.