how do you take ondansetron odt 4mg

Precautions

Take the ondansetron regular tablet with a full glass of water. Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole.

How do I take ondansetron?

Ondansetron AN ODT 4 mg (AUST R 196807) Contains 4 mg Ondansetron White to off white, round tablets debossed with ‘5’ on one side and ‘E’ on one side with an embossed circular edge. Available in blister packs of 4, 11, or 20 tablets. Ondansetron AN ODT 8 mg (AUST R 196805)

What is ondansetron an ODT 4 mg?

Four and eight hours after the first dose, your child can take another 4 mg. For 1–2 days after chemotherapy, your child can take 4 mg, three times per day. It has not been confirmed that ondansetron is safe and effective for use in children younger than 4 years.

How often can a child take ondansetron 4 mg?

Phenylketonuric patients should be informed that ondansetron orally disintegrating tablets contain phenylalanine (a component of aspartame). Each 4 mg and 8 mg orally disintegrating tablet contains 0.51 mg and 1.01 mg phenylalanine, respectively.

What should be included in patient education about ondansetron oral disintegrating tablets?

Should ondansetron be taken under the tongue?

For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film.

When should ondansetron be taken before or after meals?

To prevent nausea after surgery, take ondansetron by mouth 1 hour before the start of surgery. This medication may be taken with or without food. However, your doctor may tell you not to eat before chemotherapy, radiation, or surgery.

Can you take ondansetron ODT on an empty stomach?

Ondansetron can be taken with or without food. However, it works faster on an empty stomach, an hour before food, or 2 hours after meals. The first dose of Ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment.

Do you swallow ondansetron 4mg?

These tablets are made to dissolve in the mouth. Do not try to push the tablet through the foil backing. With dry hands, peel away the foil backing and gently remove the tablet. Place the tablet in the mouth and allow it to dissolve, then swallow.

Can I take ondansetron after eating?

General. You can take ondansetron with or without food. Take this drug at the time(s) recommended by your doctor. Do not cut or crush the orally disintegrating tablets.

How long does it take for ondansetron to kick in?

You can take ondansetron with or without food. Ondansetron should start to work within 30 minutes to an hour. Ondansetron tablets are available in two different forms – tablets or oral disintegrating tablets (also called ODT). Tablets: swallow the tablets with a glass of water.

How do I use ODT on my tablet?

How should I take Zofran ODT?Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. ... Use dry hands to remove the tablet and place it in your mouth.Do not swallow the tablet whole. ... Swallow several times as the tablet dissolves.

Can you just swallow dissolvable tablets?

Most ODTs disintegrate within a matter of seconds when placed on the tongue. However, some may take up to one minute to disintegrate. > Alternatively, ODTs may be swallowed whole.

What does ODT mean?

Orally disintegrating tablet (or orally dissolving tablet), a pill that "melts" on contact with saliva.

What happens if you swallow a sublingual pill?

by Drugs.com Subutex is readily absorbed into your bloodstream through the gastrointestinal and mucosal membranes. But because of what scientists call “first-pass metabolism,” if you swallow Subutex instead of letting it dissolve under your tongue, only a very small amount of the medicine will be absorbed.

How long does it take for a pill to digest on an empty stomach?

In general, it typically takes approximately 30 minutes for most medications to dissolve.

Can you take ondansetron with water?

Ondansetron can be taken with or without food. The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully. Take the ondansetron regular tablet with a full glass of water.

How do you take ondansetron?

The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Additional doses are sometimes taken one to three times a day during chemotherapy or radiation therapy and for 1 to 2 days after the end of treatment.

Can I take Ondem after food?

Ondem 4 Tablet can be taken with or without food and can be used alone or in combination with other medications. Depending on the reason you're taking it, your doctor will recommend an appropriate dose. The first dose is typically administered prior to the start of surgery, chemotherapy, or radiotherapy.

Does ondansetron stop stomach pain?

Descriptions. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.

Can we eat Ondem after food?

Product introduction. Ondem -MD 4 Tablet may be used alone or with other medications and can be taken with or without food. Your doctor will suggest the appropriate dose depending on what you are taking it for. The first dose is normally taken before the start of surgery, chemotherapy, or radiotherapy.

Before Taking Ondansetron

You should not use ondansetron if: 1. you are also using apomorphine (Apokyn); or 2. you are allergic to ondansetron or similar medicines (dolasetr...

How Should I Take Ondansetron?

Take ondansetron exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or sma...

What Happens If I Miss A Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include sudden loss of vision, severe constip...

What Should I Avoid While Taking Ondansetron?

Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Ondansetron Dosing Information

Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Chemotherapy Induced:Oral:Highly Emetogenic Cancer Chemotherapy (HEC):-Recommended dose: 24...

What Other Drugs Will Affect Ondansetron?

Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, he...

How to take Ondansetron?

Take the ondansetron regular tablet with a full glass of water. To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.

What are the symptoms of Ondansetron?

Get emergency medical help if you have signs of an allergic reaction to ondansetron: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe constipation, stomach pain, or bloating;

How much IV nausea is recommended for a 12 year old?

Parenteral:#N#1 month to 12 years:#N#Less than 40 kg:#N#-Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#40 kg and greater:#N#-Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#Use:#N#-Prevention of postoperative nausea and vomiting

How much cisplatin should I take for chemo?

Oral:#N#Highly Emetogenic Cancer Chemotherapy (HEC):#N#-Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater )#N#Moderately Emetogenic Cancer Chemotherapy (MEC):#N#-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy#N#Parenteral:#N#-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.#N#-Maximum dose: 16 mg per dose#N#Comments:#N#-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied.#N#-The injection formulation should be diluted prior to IV administration.#N#Uses:#N#-Prevention of nausea and vomiting associated with HEC or MEC#N#-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy

How long does it take to take chemo?

Oral: 4 to 11 years: -Recommended dose: 4 mg orally 3 times a day, with the first dose administered 30 minutes before the start of chemotherapy, and subsequent doses 4 and 8 hours after the first dose; then 4 mg orally 3 times a day (every 8 hours) for 1 to 2 days after the completion of chemotherapy.

What are the side effects of Ondansetron?

Common ondansetron side effects may include: diarrhea or constipation; headache; drowsiness; or. tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Can Ondansetron cause heart problems?

Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS.

How it works

Ondansetron belongs to a class of drugs called antiemetics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Antiemetics are drugs that reduce nausea and vomiting.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Drugs you should not use with ondansetron

Do not take these drugs with ondansetron. Doing so can cause dangerous effects in your body. Examples of these drugs include:

Interactions that increase your risk of side effects from ondansetron

Taking ondansetron with certain medications raises your risk of side effects from ondansetron. This is because the amount of ondansetron in your body may be increased. Examples of these drugs include:

Interactions that can make ondansetron less effective

Taking these drugs with ondansetron can make ondansetron less effective. This is because the amount of ondansetron in your body may be decreased. Examples of these drugs include:

Allergy warning

Ondansetron can cause a severe allergic reaction. Symptoms can include:

Warnings for people with certain health conditions

For people with risk factors for heart arrhythmias: If you have conditions such as heart failure or congenital long QT syndrome, this drug may increase your risk of arrhythmias. Ask your doctor if you have risk factors for arrhythmias.

What is the USP for Ondansetron?

Ondansetron Orally Disintegrating Tablets USP, 4 mg are white to off-white, round tablets debossed with ‘5’ on one side and ‘E’ on the other side with an embossed circular edge.

What is the primary pathway of ondansetron?

The primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation. In vitro metabolism studies have shown that ondansetron is a substrate for human hepatic cytochrome P-450 enzymes, including CYP1A2, CYP2D6, and CYP3A4.

What is Ondansetron used for?

Ondansetron orally disintegrating tablets are indicated for the prevention of nausea and vomiting associated with: highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m 2. initial and repeat courses of moderately emetogenic cancer chemotherapy. radiotherapy in patients receiving either total body irradiation, ...

What are the side effects of Ondansetron?

Hypotension (and faintness) occurred in a patient that took 48 mg of ondansetron tablets. Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed. In all instances, the adverse reactions resolved completely.#N#Pediatric cases consistent with serotonin syndrome have been reported after inadvertent oral overdoses of ondansetron (exceeding estimated ingestion of 5 mg per kg) in young children. Reported symptoms included somnolence, agitation, tachycardia, tachypnea, hypertension, flushing, mydriasis, diaphoresis, myoclonic movements, horizontal nystagmus, hyperreflexia, and seizure. Patients required supportive care, including intubation in some cases, with complete recovery without sequelae within 1 to 2 days.

Is Ondansetron 8 mg twice daily?

Dosage regimens of ondansetron 8 mg twice daily and 32 mg once daily are not recommended for the prevention of nausea and vomiting associated with highly emetogenic chemotherapy [see Dosage and Administration (2.1)].

Is Ondansetron a dopamine receptor antagonist?

While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. Serotonin receptors of the 5-HT 3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. It is not certain whether ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. In humans, urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion increases after cisplatin administration in parallel with the onset of emesis. The released serotonin may stimulate the vagal afferents through the 5-HT 3 receptors and initiate the vomiting reflex.

Is Ondansetron safe for pregnancy?

Published epidemiological studies on the association between ondansetron use and major birth defects have reported inconsistent findings and have important methodological limitations that preclude conclusions about the safety of ondansetron use in pregnancy (see Data). Available postmarketing data have not identified a drug-associated risk of miscarriage or adverse maternal outcomes. Reproductive studies in rats and rabbits did not show evidence of harm to the fetus when ondansetron was administered during organogenesis at approximately 6 and 24 times the maximum recommended human oral dose of 24 mg/day, based on body surface area, respectively (see Data).

How to use oral disintegrating tablet?

To use the oral disintegrating tablet: Make sure your hands are dry. Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. Immediately place the tablet on top of the tongue.

How long does it take to take a 4 mg med?

The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days.

What to do if you miss a dose of a sulfate supplement?

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible.

Can you take IBM Micromedex more than once?

Drug information provided by: IBM Micromedex. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To use the oral disintegrating tablet: Make sure your hands are dry.

What to know before taking Ondansetron?

Before using ondansetron, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems ( QT prolongation in the EKG, sudden cardiac death).

Where to report side effects?

You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions.

Can Ondansetron make you dizzy?

Talk to your doctor about using ondansetron safely. This drug may make you dizzy or drowsy. Alcohol or marijuana ( cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages.

Can Ondansetron cause allergic reactions?

Precautions. Before taking ondansetron, tell your doctor or pharmacist if you are allergic to it; or to other anti- nausea serotonin blockers (e.g., granisetron ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Can Ondansetron cause heart problems?

Ondansetron may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

What Is Zofran ODT?

Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain.

What Is Zofran ODT Used For?

The Food and Drug Administration (FDA) has approved Zofran ODT to prevent: 1

What Are the Side Effects of Zofran ODT?

This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Dosage: How Much Zofran ODT Should I Take?

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

Overdose: What Happens If I Take Too Much Zofran ODT?

Cases of accidental Zofran overdose in children have been reported. Their symptoms were consistent with serotonin syndrome.

Precautions

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

What Other Medications Interact With Zofran ODT?

When taken with Zofran ODT, several medications may increase your risk of developing serotonin syndrome. Along with Zofran ODT, if you are taking a medicine that increases serotonin levels in the body, your doctor may need to choose a different treatment or monitor you more closely.

1. Indications and Usage Section

Ondansetron orally disintegrating tablets are indicated for the prevention of nausea and vomiting associated with:

2. Dosage and Administration Section

The recommended dosage regimens for adult and pediatric patients are described in Table 1 and Table 2, respectively. Corresponding doses of ondansetron tablets, ondansetron orally disintegrating tablets and ondansetron oral solution may be used interchangeably.

3. Dosage Forms and Strengths

Ondansetron Orally Disintegrating Tablets USP, 4 mg are white to off-white, round tablets debossed with ‘5’ on one side and ‘E’ on the other side with an embossed circular edge.

4. Contraindications

Ondansetron orally disintegrating tablets are contraindicated in patients:

7. Drug Interactions

Serotonin syndrome (including altered mental status, autonomic instability, and neuromuscular symptoms) has been described following the concomitant use of 5-HT3 receptor antagonists and other serotonergic drugs, including SSRIs and SNRIs. Monitor for the emergence of serotonin syndrome.

8. Use in Specific Populations

Published epidemiological studies on the association between ondansetron use and major birth defects have reported inconsistent findings and have important methodological limitations that preclude conclusions about the safety of ondansetron use in pregnancy (see Data).

9. Drug Abuse and Dependence

Animal studies have shown that ondansetron is not discriminated as a benzodiazepine nor does it substitute for benzodiazepines in direct addiction studies.

What are the conditions that need to be diagnosed before taking Ondansetron?

They need to know if you have any of these conditions: heart disease. history of irregular heartbeat. liver disease. low levels of magnesium or potassium in the blood. an unusual or allergic reaction to ondansetron, granisetron, other medicines, foods, dyes, or preservatives. pregnant or trying to get pregnant.

How to dissolve a tablet in your mouth?

These tablets are made to dissolve in the mouth. Do not try to push the tablet through the foi l backing. With dry hands, peel away the foil backing and gently remove the tablet. Place the tablet in the mouth and allow it to dissolve, then swallow.

What is the name of the drug that is used to treat nausea and vomiting after surgery?

ONDANSETRON (on DAN se tron) is used to treat nausea and vomiting caused by chemotherapy. It is also used to prevent or treat nausea and vomiting after surgery. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME (S): Zofran ODT.

What are the adverse events of Ondansetron?

Cardiovascular adverse events (bradycardia and hypotension) occurred in approximately 4% in both placebo and ondansetron groups; gastrointestinal adverse events (constipation, nausea/ vomiting, flatulence and abdominal pain) occurred in approximately 7% of patients both receiving placebo and IV ondansetron.

Can you breastfeed with Ondansetron?

It is therefore recommended that mothers receiving ondansetron should not breastfeed their babies. Carcinogenicity. No evidence for carcinogenic activity was found in two year studies at ondansetron doses up to 10 mg/kg/day by gavage in rats or up to 30 mg/kg/day via drinking water in mice. Genotoxicity.

Does Ondansetron block blood vessels?

In certain illnesses and treatments where Ondansetron AN ODT has been used, blood vessel blockage has occurred. However, it is important to note that blood vessel blockage has also occurred in these illnesses and treatments when Ondansetron AN ODT has NOT been used.

Can you take Ondansetron more than once?

DO NOT take more Ondansetron AN ODT than your doctor or pharmacist tells you. DO NOT take Ondansetron AN ODT MORE OFTEN than your doctor or pharmacist tells you. If you vomit within one hour of taking your first Ondansetron AN ODT of each course prescribed for you, you should take the same dose again.

Is Ondansetron addictive?

Ask your doctor if you have any questions about why Ondansetron AN ODT has been prescribed for you. Ondansetron AN ODT is not addictive.

Does Ondansetron contain all the information?

It does not contain all of the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Ondansetron AN ODT against the benefits they expect it will have for you.

Is Ondansetron safe for pregnancy?

The safety of ondansetron for use in human pregnancy has not been established. Evaluation of experimental animal studies does not indicate direct or indirect harmful effects with respect to the development of the embryo, or foetus, the course of gestation and perinatal and postnatal development.