What is the dosage for diphenoxylate and atropine?
In adults, the usual dose is 5 mg (2 tablets) of diphenoxylate three to four times per day initially. Thereafter, the dose may be decreased to 2.5 mg (1 tablet) two to three times a day. The dose for children (2 to 12 years old) is 0.3 to 0.4 mg/kg/day in four divided doses.
Does Lomotil (atropine/diphenoxylate) work?
Lomotil (atropine / diphenoxylate): “Other than Tincture of Opium, Lomotil is the best thing for controlling diarrhea. Because the Opium is so expensive, I often can take only lomotil, and it works at the maximum dosage (and more) to slow down my diarrhea. Without it, I would have nothing to live for, literally. It is a life-saver.”
Can you take diphenoxylate hydrochloride and atropine sulfate together?
Administration Diphenoxylate hydrochloride/atropine sulfate combination is available as the fixed-dose composition of 2.5 mg/0.025 mg. Diphenoxylate/atropine is available in both tablet and liquid preparation. Only the liquid preparation can be administered to children, and not the tablets.
When should I inform my doctor about diphenoxylate-atropine?
Inform your doctor if your condition does not improve after 2 days. Are you currently using Diphenoxylate-Atropine? This survey is being conducted by the WebMD marketing sciences department.
How long does it take for diphenoxylate to kick in?
Your diarrhea symptoms should improve within 48 hours of treatment with diphenoxylate. Your doctor may tell you to decrease your dose as your symptoms improve. If your symptoms do not improve or if they get worse within 10 days of treatment, call your doctor and stop taking diphenoxylate.
How does diphenoxylate atropine make you feel?
It works by slowing the movement of the intestines. Diphenoxylate is similar to opioid pain relievers, but it acts mainly to slow the gut. Atropine belongs to a class of drugs known as anticholinergics, which help to dry up body fluids and also slow gut movement.
How quickly does Lomotil work?
When you start using Lomotil, your doctor will prescribe two tablets four times a day. Don't take more than eight tablets (20 mg of diphenoxylate) a day. Continue this dosage until your diarrhea starts to improve (stools become firmer), which should happen within 48 hours.
How often can I take diphenoxylate atropine?
How to use Diphenoxylate-Atropine. Take this medication by mouth, usually 4 times a day or as directed by your doctor. The dosage is based on your medical condition and response to treatment.
Does Lomotil work better than Imodium?
Lomotil and Imodium are both effective drugs to treat diarrhea. Some research has shown that there is no significant difference in effectiveness between the two. However, other studies have shown that Imodium is more effective and better tolerated.
Is diphenoxylate atropine a narcotic?
Diphenoxylate is chemically related to some narcotics and may be habit-forming if taken in doses that are larger than prescribed. If higher than normal doses of the combination are taken, the atropine will cause unpleasant effects. This medicine is available only with your doctor's prescription.
What is the best medicine for chronic diarrhea?
Over-the-counter anti-diarrheal medications, such as loperamide and bismuth subsalicylate, might help reduce the number of watery bowel movements and control severe symptoms.
What is the best medicine for diarrhea?
Two types of meds relieve diarrhea in different ways: Loperamide (Imodium) slows the movement of food through your intestines, which lets your body absorb more liquid. Bismuth subsalicylate (Kaopectate, Pepto-Bismol) balances out how fluid moves through your digestive tract.
How long does Lomotil stay in your system?
How long do the effects of this medicine last? Lomotil Tablet remains active in the body for about 4 to 6 hours.
How strong is diphenoxylate?
Conversely, diphenoxylate is metabolized into difenoxin which is upwards of 250 times more potent than its parent-drug. This active metabolite readily crosses the BBB to produce depressive effects on the CNS, which in turn, produces depressive effects on the gut as well.
Can diphenoxylate give you diarrhea?
Diarrhea usually stops 2 days after treatment with this medicine. If your symptoms do not improve or if they get worse within 10 days of treatment, check with your doctor. This medicine may cause serious stomach or bowel problems (eg, toxic megacolon). This is more likely if you also have ulcerative colitis.
What are the side effects of diphenoxylate with atropine?
Common side effects may include:drowsiness, dizziness, feeling restless;headache;numbness in your hands or feet;depression, not feeling well;confusion, feelings of extreme happiness;red or swollen gums;dry mouth, nose, or throat;nausea, vomiting, upset stomach, loss of appetite; or.More items...
How does atropine affect the body?
Atropine reduces secretions in the mouth and respiratory passages, relieves the constriction and spasm of the respiratory passages, and may reduce the paralysis of respiration that results from toxic nerve agents which increase anticholinesterase activity in the central nervous system.
How strong is diphenoxylate?
Conversely, diphenoxylate is metabolized into difenoxin which is upwards of 250 times more potent than its parent-drug. This active metabolite readily crosses the BBB to produce depressive effects on the CNS, which in turn, produces depressive effects on the gut as well.
How does diphenoxylate atropine work?
Diphenoxylate helps stop diarrhea by slowing down the movements of the intestines. Diphenoxylate is chemically related to some narcotics and may be habit-forming if taken in doses that are larger than prescribed. If higher than normal doses of the combination are taken, the atropine will cause unpleasant effects.
Does atropine cause generalized excitement?
feeling restless or excited; tremors, problems with balance or muscle movement; increased thirst, hot and dry skin; tiredness; or.
What are the side effects of diphenoxylate and atropine?
The most common side effects reported in persons taking diphenoxylate include:
What drugs can reduce the effectiveness of diphenoxylate?
Such drugs include bethanechol ( Urecholine ), cisapride ( Propulsid ), metoclopramide ( Reglan ), and erythromycin. Drugs which decrease the propulsion of intestinal contents may exaggerate the effects ...
What is the difference between Lomotil and Diphenoxylate?
It is used to treat acute diarrhea ( diarrhea of limited duration). Diphenoxylate is a man-made narcotic chemically related to meperidine ( Demerol ). Like other narcotics, diphenoxylate reduces diarrhea by interfering with the propulsion of intestinal contents through ...
What is the drug for diarrhea?
Diphenoxylate and atropine (Lomotil) is a drug prescribed for the treatment of acute diarrhea. Side effects, drug interactions, dosage, and pregnancy safety should be reviewed prior to taking this medication.
Can diphenoxylate cause euphoria?
In higher doses, however, like other narcotics, diphenoxylate can cause euphoria (elevation of mood) and physical dependence. In order to prevent abuse of diphenoxylate for its mood-elevating effects, atropine is combined with diphenoxylate in small quantities. As a result, if Lomotil is taken in greater than recommended doses unpleasant side ...
How to report side effects of prescription drugs?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Does atropine cause numbness?
numbness of extremities, loss of. appetite, and. abdominal pain. Although the dose of atropine in Lomotil is too low to cause side effects when taken in the recommended doses, side effects of atropine (including dryness of the skin and mucous membranes, increased heart rate, urinary retention, and increased body temperature) have been reported, ...
What is diphenoxylate hydrochloride?
Diphenoxylate hydrochloride and atropine sulfate is recommended as adjunctive therapy for the management of diarrhea in patients 13 years of age and older. Consider the nutritional status and degree of dehydration in patients prior to initiating therapy with Diphenoxylate hydrochloride and atropine sulfate.
How much diphenoxylate is in a USP?
Each diphenoxylate hydrochloride and atropine sulfate tablet, USP contains: 2.5 mg of diphenoxylate hydrochloride USP (equivalent to 2.3 mg of diphenoxylate) and 0.025 mg of atropine sulfate USP (equivalent to 0.01 mg of atropine) Diphenoxylate hydrochloride, an antidiarrheal, is ethyl 1- (3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate ...
What is the WL on a tablet?
Tablets – white to off white, round, unscored tablets debossed with 'WL' on one side and '107' on the other side of the tablet and containing 2.5 mg of diphenoxylate hydrochloride and 0.025 mg of atropine sulfate, supplied as:
How long does it take for diarrhea to improve?
Clinical improvement of diarrhea is usually observed within 48 hours. If clinical improvement is not seen within 10 days, discontinue Diphenoxylate hydrochloride and atropine sulfate and contact their healthcare provider.
What drugs cause CNS depression?
Other Drugs that Cause CNS Depression. The concurrent use of Diphenoxylate hydrochloride and atropine sulfate with other drugs that cause CNS depression (e.g., barbiturates, benzodiazepines, opioids, buspirone, antihistamines, muscle relaxants), may potentiate the effects of Diphenoxylate hydrochloride and atropine sulfate (see WARNINGS ).
What is the best medicine for respiratory depression?
A pure narcotic antagonist (e.g., naloxone) should be used in the treatment of respiratory depression caused by Diphenoxylate hydrochloride and atropine sulfate. Refer to the prescribing information for naloxone.
Does diphenoxylate cause dizziness?
Diphenoxylate hydrochloride may potentiate the action of other drugs that cause dizziness or drowsiness, including barbiturates, benzodiazepines and other sedatives/hypnotics, anxiolytics, and tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids, and alcohol.
What is atropine used for?
Uses. This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Diphenoxylate is similar to opioid pain relievers, but it acts mainly to slow the gut. Atropine belongs to a class of drugs known as anticholinergics, ...
What drugs cause drowsiness?
Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioidpain or coughrelievers (such as codeine, hydrocodone), alcohol, marijuana(cannabis), drugs for sleepor anxiety(such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines(such as cetirizine, diphenhydramine).
What happens if you stop taking a sulfate supplement?
Consult your doctor or pharmacist for more information. If you suddenly stop using this medication, you may have withdrawal symptoms (such as stomach cramps, nausea, vomiting ).
What to do if side effects persist?
If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Can you take diphenoxylate with atropine?
Before taking diphenoxylate with atropine, tell your doctor or pharmacist if you are allergic to either drug; or to hyoscyamine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Can atropine cause diarrhea?
Atropine belongs to a class of drugs known as anticholinergics, which help to dry up body fluids and also slow gut movement.This medication should not be used to treat diarrhea caused by certain types of infection (such as C. difficile-associated diarrhea following antibiotic therapy).
Can you increase your diahria medication?
In children, the dosage is also based on weight. If you need to continue treatment once your diarrhea is controlled, your doctor may direct you to lower your dosage. Do not increase your dose, take it more often, or use it for longer than prescribed.
What to do if you miss a dose of a sulfate supplement?
Missed Dose. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Can you take IBM Micromedex more than once?
Proper Use. Drug information provided by: IBM Micromedex. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Dosage & When it is to be taken
In adults, the usual dose is 5 mg (2 tablets) three to four times per day initially. The dose for children is based on weight.
When it is not to be taken (Contraindications)
Contraindicated in patients with obstructive jaundice, pseudomembranous enterocolitis and hypersensitivity.
Why it is prescribed (Indications)
This medication is an antidiarrheal and anticholinergic combination, prescribed for diarrhea. Atropine works by reducing spasms where as Diphenoxylate decreases bowel movement.
Warnings and Precautions
Caution should be exercised in patients with history of lung disease, ulcerative colitis, or liver disease, alcohol abuse, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
Storage Conditions
Store it at room temperature (25o C), and in an airtight container, keep away from children.
