How does metolazone work in the body?
It works by blocking salt and fluid retention by the kidneys, thereby increasing urinary output of salt and water (diuresis). Although it is not a true thiazide, metolazone is chemically related to the thiazide class of diuretics (for example, chlorthalidone [Hygroton], hydrochlorothiazide), and works in a similar manner.
What time of Day should I take metolazone?
How to use Metolazone. Therefore, it is best to take this medication at least 4 hours before your bedtime. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day as directed. It is important to continue taking this medication even if you feel well.
Does metolazone show up in blood tests?
While using metolazone, you may need frequent blood tests. Your blood and urine may both be tested if you have been vomiting or are dehydrated. Metolazone can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using metolazone.
How many mg of metolazone is in a tablet?
Metolazone Generic name: metolazone (me TOL a zone) Brand name: Zaroxolyn, Mykrox Dosage forms: oral tablet (10 mg; 2.5 mg; 5 mg)
How long do the effects of metolazone last?
The duration of action is up to 24 hours. The standard dose is 5 to 20 mg once daily for CHF or renal edema and 2.5 to 5 mg for hypertension. In combination with furosemide, metolazone may provoke a profound diuresis, with the risk of excessive volume and potassium depletion.
What happens when metolazone doesn't work?
For high blood pressure, it's used as long-term therapy. It comes with serious risks if you don't take it as prescribed. If you don't take it at all: If you don't take metolazone at all, your blood pressure or edema, or both, might not be controlled. This may lead to a heart attack, stroke, pain, or infection.
How strong is metolazone?
2.5 mg (geriatric only) 5 mg. 10 mg.
How often should metolazone be taken?
Metolazone comes as a tablet to take by mouth. It is usually taken once a day. Take metolazone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
How long do water tablets take to reduce swelling?
It treats edema and high blood pressure by removing excess fluid from your body through your kidneys. The drug starts to work within an hour after you take it. And it takes about 2 hours for half of a dose of the drug to leave your body.
Why is water pill not working?
Diuretic therapy will not be effective if it is not taken consistently. Nonadherence to the prescribed diuretic regimen is one of the most common causes of diuretic resistance. The next step is to rule out dietary indiscretion, another very common cause of diuretic resistance.
Why do you give metolazone 30 minutes before furosemide?
Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.
Which drug is the strongest diuretic?
Loop diuretics are the most potent diuretics as they increase the elimination of sodium and chloride by primarily preventing reabsorption of sodium and chloride.
Does metolazone affect heart rate?
Check with your doctor right away if you have any of the following symptoms while taking this medicine: convulsions or seizures; decreased urine; drowsiness; dry mouth; excessive thirst; muscle pains or cramps; nausea or vomiting; increased heart rate or pulse; or unusual tiredness or weakness.
What happens if I take too much metolazone?
What happens if I overdose on Metolazone (Zaroxolyn)? Overdose symptoms may include severe dizziness or drowsiness, dry mouth, thirst, muscle weakness, feeling light-headed, or fainting.
Do you need potassium with metolazone?
Which drugs or supplements interact with metolazone? Metolazone can reduce blood potassium and magnesium levels. This is especially true in patients who also are taking "loop" diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex ).
Can you give metolazone and Lasix together?
You may need dose adjustments or special tests in order to safely take both medications together. This combination may lower levels of certain minerals in your body such as potassium, magnesium, and sodium.
What Should I Discuss With My Doctor Before Taking Metolazone?
You should not use metolazone if you are allergic to it, or if you have: 1. severe liver disease; or 2. if you are unable to urinate.To make sure m...
How Should I Take Metolazone?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use t...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include severe dizziness or drowsiness, dry m...
What Should I Avoid While Taking Metolazone?
Drinking alcohol with this medicine can cause side effects.Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drink...
Metolazone Dosing Information
Usual Adult Dose for Hypertension:Initial dose: 2.5 mg orally once a day (Zaroxolyn) or0.5 mg orally once a day (Mykrox).Usual Adult Dose for Edema...
What Other Drugs Will Affect Metolazone?
Taking this medicine with other drugs that make you make you light-headed can worsen this effect. Ask your doctor before taking metolazone with a n...
How it works
Metolazone belongs to a class of drugs called diuretics. A class of drugs is a group of medications that work in a similar way. They’re often used to treat similar conditions. Diuretics work by causing you to urinate more. This helps remove excess fluid and salt from your body.
Serious side effects
Call your doctor right away if you have any of these serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency.
Antibiotics
Taking certain antibiotics with metolazone can make metolazone not work as well. These include:
Other blood pressure drugs
These drugs can lower your blood pressure too much if taken with metolazone. They include:
Blood thinners (anticoagulants)
Your dose of these drugs may need to be increased if you’re taking them with metolazone. When you take them with metolazone, they may not work as well. These drugs include:
Corticosteroids
Taking these medications with metolazone may increase your risk for hypokalemia (low sodium). These include:
Diabetes drugs
Your dose of these drugs may need to be increased if you’re taking them with metolazone. When you take them with metolazone, they may not work as well. These drugs include:
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
How to take metolazone?
How to use Metolazone. Take this medication by mouth with or without food, usually once daily, or as directed by your doctor. The dosage is based on your medical condition and response to therapy. If you take this drug too close to bedtime, you may need to wake up to urinate. Therefore, it is best to take this medication at least 4 hours ...
How long does it take for metolazone to separate from colestipol?
If you are taking either of these drugs, separate metolazone from cholestyramine by at least 4 hours and from colestipol by at least 2 hours. If your condition persists or worsens, contact your doctor or pharmacist. Side Effects. Dizziness, lightheadedness, headache, blurred vision, loss of appetite, stomach upset, diarrhea, ...
What is metolazone used for?
This drug is used to treat high blood pressure.
How to report metolazone side effects in Canada?
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions. Before taking metolazone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Can you take metolazone while pregnant?
Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness. Metolazone should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This drug passes into breast milk.
What is metolazone used for?
Expand Section. Metolazone, is used to reduce the swelling and fluid retention caused by heart failure or kidney disease. It also is used alone or with other medications to treat high blood pressure. Metolazone is in a class of medications called diuretics ('water pills').
What are the side effects of metolazone?
Metolazone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: 1 dizziness 2 weakness 3 restlessness 4 headache 5 muscle cramps 6 joint pain or swelling 7 constipation 8 diarrhea
What to do if you are allergic to metolazone?
Before taking metolazone, tell your doctor and pharmacist if you are allergic to metolazone, sulfa drugs, thiazides, any other medications, or any of the ingredients in metolazone tablets. Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, ...
Can you take metolazone more often?
Take metolazone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Your doctor will probably start you on a low dose of metolazone and gradually increase your dose, depending on your response to this medication.
Can metolazone make you dizzy?
you should know that metolazone may make you dizzy or drowsy. Do not drive a car or operate machinery until you know how this medication affects you. ask your doctor about the safe use of alcoholic beverages while you are taking metolazone. Alcohol can make the side effects from metolazone worse.
Does alcohol make metolazone worse?
Alcohol can make the side effects from metolazone worse. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Metolazone may make your skin sensitive to sunlight.
Can you take metolazone if you have kidney failure?
tell your doctor if you have kidney or liver failure. Your doctor will probably tell you not to take metolazone. tell your doctor if you have or have ever had diabetes, gout, systemic lupus erythematosus (SLE, a chronic inflammatory condition), or parathyroid, heart, kidney, or liver disease. tell your doctor if you are pregnant, plan ...
What is metolazone used for?
Metolazone is a diuretic ("water pill") used in the treatment of high blood pressure and fluid accumulation. It works by blocking salt and fluid retention by the kidneys, thereby increasing urinary output of salt and water (diuresis).
What are the side effects of metolazone?
Common side effects of metolazone are: hypomagnesemia (low blood magnesium). About 1 out of every 10 patients report dizziness, lightheadedness, and headache. Fatigue has been reported in 1 out of every 25 patients. About 1 out of every 50 patients reports: constipation.
What medications can reduce metolazone?
Steroids (for example, hydrocortisone) and nonsteroidal anti-inflammatory agents ( NSAIDs) such as ibuprofen ( Motrin ), naproxen ( Naprosyn ), and nabumetone (Relafen) can reduce the effectiveness of metolazone by interfering with the excretion of salt and water.
What drugs interact with metolazone?
This is especially true in patients who also are taking "loop" diuretics such as furosemide ( Lasix ), bumetanide (Bumex), and torsemide ( Demadex ).
Is Zaroxolyn the same as Diulo?
Zaroxolyn is the original formulation of metolazone, and Diulo is similar. The absorption of these two drugs is relatively incomplete. Mykrox has more complete absorption. Therefore, less Mykrox needs to be given to have the same effects as a larger dose of Zaroxolyn or Diulo. Metolazone was approved by the FDA in 1973.
Does metolazone cause constipation?
constipation. Thiazide diuretics, which are chemically related to metolazone, are known to increase the amount of uric acid in the blood. Precipitation of gout (which is associated with high uric acid) is rare. Metolazone can increase blood sugar in people with diabetes.
Does Metolazone cause heart problems?
Low potassium and magnesium levels can lead to heart rhythm abnormalities, especially in patients taking digoxin ( Lanoxin ). Metolazone reduces excretion of lithium ( Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity in patients receiving lithium. Steroids (for example, hydrocortisone) and nonsteroidal anti-inflammatory agents ...
How long does it take for metaxalone to peak?
Peak plasma concentrations of metaxalone occur within three hours of an oral dose. 7. Interactions. Medicines that interact with metaxalone may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with metaxalone.
How does metaxalone work?
The exact way metaxalone works has not been established; however, experts suggest it suppresses brain activity which results in sedation, reducing the sensation of pain.
What is metaxalone used for?
2. Upsides. May be used to relieve pain and stiffness associated with certain muscle conditions, sprains , or strains. Should be used in conjunction with rest and physical therapy. Available as a capsule-shaped tablet that is easy to swallow.
What medications interact with metaxalone?
Common medications that may interact with metaxalone include: anti-anxiety medications such as flunitrazepam. anticonvulsants, such as phenytoin. antidepressants, such as amitriptyline, imipramine, nortriptyline. antihistamines that cause sedation, such as diphenhydramine. botulinum-toxin-containing products.
What is the best medicine to increase serotonin?
monoamine oxidase inhibitors, such as selegiline, isocarboxazid, or phenelzine (interaction may be life-threatening) opioid analgesics such as oxycodone and morphine. other medicines that increase serotonin, such as fluoxetine, sumatriptan, and tramadol. other muscle relaxants such as methocarbamol.
Can metaxalone interact with flunitrazepam?
Speak to your doctor about how drug interactions should be managed. Common medications that may interact with metaxalone include: anti-anxiety medications such as flunitrazepam.
Can metaxalone cause diarrhea?
Some medications can interact with metaxalone and increase the risk of side effects, such as sedation, or the likelihood of serotonin syndrome (symptoms include excessive sweating, agitation, diarrhea, or confusion). Tell your doctor if you are pregnant or intending on becoming pregnant before taking metaxalone.
