How effective is nefazodone?
The optimum therapeutic dosage of nefazodone appears to be between 300 and 600 mg/day. Limited long term data suggest that nefazodone is effective in preventing relapse of depression in patients treated for up to 1 year.
Is nefazodone a sedating?
Although nefazodone is mildly sedating clinically, it had no overall effect on total sleep time (or sleep efficiency) or the number of awakenings. In addition, all other aspects of sleep architecture, including the proportion of slow wave (stage 3 and 4) sleep, were unchanged after two weeks of treatment.
Does nefazodone help with anxiety?
In all 11 cases, nefazodone was efficacious and well tolerated in the treatment of both depressive and anxiety components. After nefazodone augmentation, the mean CGI score for combined depression and anxiety symptoms was (+/-sd) 1.52 (0.52) on a scale from 1 (very much better) to 7 (very much worse).
Why is nefazodone no longer commonly used?
Reason for posting: Because of concerns of hepatotoxicity, the sale of the antidepressant nefazodone hydrochloride (Serzone) will be discontinued by the manufacturer effective Nov. 27, 2003.
What drug is most similar to nefazodone?
The Food and Drug Administration (FDA) approved these atypical antidepressants to treat depression:Bupropion (Wellbutrin SR, Wellbutrin XL, others)Mirtazapine (Remeron)Nefazodone.Trazodone.Vilazodone (Viibryd)Vortioxetine (Trintellix)
Does nefazodone make you sleepy?
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking nefazodone. you should know that this medication may make you drowsy or affect your judgment, thinking, or motor skills.
Does nefazodone cause weight loss?
Results: Using 7% or greater weight change as the measure of clinical significance, 4.3% of SSRI-treated patients had lost weight at any point in the acute phase versus 1.7% of those treated with nefazodone (p = . 017).
Is nefazodone ever coming back?
Finally, an update from TEVA.com on 9/20/2021, that Nefazodone will be back on the market during last quarter of 2021.
Does Serzone cause weight gain?
duloxetine (Cymbalta), a serotonin-norepinephrine reuptake inhibitor (SNRI), may cause modest weight gain with long-term use. bupropion (Wellbutrin, Forfivo, and Aplenzin), an atypical antidepressant. nefazodone (Serzone), a serotonin antagonist and reuptake inhibitor.
What drug is similar to Serzone?
Viibryd (vilazodone) Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage. Treats depression. Viibryd (vilazodone) is a good option to treat depression, but you can cause stomach irritation including diarrhea.
How does nefazodone work in the brain?
Nefazodone works by inhibiting the uptake by nerves of serotonin and norepinephrine, two neurotransmitters, resulting in more serotonin and norepinephrine to transmit messages to other nerves.
Is nefazodone the same as trazodone?
Trazodone is a sedating antidepressant without anticholinergic properties. Nefazodone is a new antidepressant that is a structural analogue of trazodone but is less sedating.
Is trazodone the same as nefazodone?
Trazodone is a sedating antidepressant without anticholinergic properties. Nefazodone is a new antidepressant that is a structural analogue of trazodone but is less sedating.
What kind of antidepressant is Serzone?
SERZONE® (nefazodone hydrochloride) is an antidepressant for oral administration with a chemical structure unrelated to selective serotonin reuptake inhibitors, tricyclics, tetracyclics, or monoamine oxidase inhibitors (MAOI). Nefazodone hydrochloride is a synthetically derived phenylpiperazine antidepressant.
Is Serzone an SSRI or an SNRI?
Nefazodone is chemically unrelated to the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs), or the monoamine oxidase (MAO) inhibitors.
What are the side effects of Serzone?
Dizziness, drowsiness, lightheadedness, nausea, dry mouth, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
How long does it take nefazodone to work?
It might take several weeks before you start to feel the full effects of nefazodone. If it's been several weeks and you feel like your depression i...
Can I take nefazodone if I have liver disease?
No. There's a serious, life-threatening risk of liver failure with nefazodone. Don't start nefazodone if you have active liver disease. If you noti...
Can I take nefazodone with other antidepressants?
You shouldn't take nefazodone with a group of antidepressants known as monoamine oxidase inhibitors (MAOIs). Combining these antidepressants can le...
Can I drink alcohol while taking nefazodone?
No. Don’t drink alcohol if you’re taking nefazodone because it can worsen side effects like sleepiness and dizziness. Overdose, which can lead to s...
Is nefazodone safe for children?
No. Nefazodone shouldn't be used in children because it can raise their risk of suicidal thoughts and behavior. Discuss other treatment options wit...
Is nefazodone safe in pregnancy?
There haven’t been enough studies looking at nefazodone in pregnant women, so it’s not known if nefazodone is safe to use during pregnancy. Only ta...