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is adipic acid safe

by Michel Roberts Published 3 years ago Updated 2 years ago
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* Contact can irritate the skin and eyes. Adipic Acid is a white crystalline solid. It is used in the manufacture of nylon, plasticizers, urethanes, adhesives and food additives. * Adipic Acid is on the Hazardous Substance List because it is cited by DOT, NFPA, ACGIH and EPA.

Full Answer

Is adipic acid harmful to the skin?

By itself, however, adipic acid yields no such result. Adipic acid can be harmful to the skin, eyes, and lungs because it can irritate all of these body parts and possibly increase the risk of other diseases. The lungs are especially vulnerable to adipic acid since it can act as an asthmagen.

Is adipic acid safe to eat?

Although adipic acid has been approved for safe consumption since 1965, some people try to avoid this and other food additives altogether. In that case, it’s important to know which foods contain synthetic adipic acid.

What is adipic acid and how does it work?

Using adipic acid helps control the release of the compound over a period of time which helps someone avoid having to take the drug over shorter time intervals. Adipic acid finds use in the food industry as both a flavoring and gelling aid for things like Jello.

How much adipic acid is in the world?

Adipic acid. From an industrial perspective, it is the most important dicarboxylic acid: About 2.5 billion kilograms of this white crystalline powder are produced annually, mainly as a precursor for the production of nylon. Adipic acid otherwise rarely occurs in nature.

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Is adipic acid safe for humans?

Chronic Effects on Humans: May cause damage to the following organs: the nervous system, gastrointestinal tract. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Is adipic acid safe in food?

Although it's found naturally in a few foods, most of the adipic acid found in the food supply is synthetic. Although adipic acid has been approved for safe consumption since 1965, some people try to avoid this and other food additives altogether.

What are the side effects of adipic acid?

Eye: Causes eye irritation.Skin: May cause skin irritation. Adipic acid exerts a drying action on the skin and may cause dermatitis in humans.Ingestion: Ingestion of large amounts may cause gastrointestinal irritation.Inhalation: May cause respiratory tract irritation. ... Chronic: No information found.

Why is adipic acid used in food?

Adipic acid is a dibasic carboxylic acid that occurs naturally in beet juice. This acid is widely used in the food industry for buffering and neutralising purposes. Since it is hygroscopic, it is useful for preparing baking powder and soft drink powders.

What foods contain adipic acid?

Adipic acid is naturally found in beets and sugar cane. Adipic acid is commonly added as the main acid in bottled drinks, giving them a bubbly fizz. It is also adds a tart flavor to fruit juice and gelatin. The organic acid is used in many powdered food and drink mixes to provide a sweet flavor.

What is adipic acid used for?

Almost all adipic acid is used as a comonomer with hexamethylenediamine to produce nylon 6-6. It is also used to manufacture other polymers such as polyurethanes.

Is adipic acid vegan?

​ Oleic acid from animal fat may be used in the development of adipic acid. Trace quantities of the oleic acid are likely to remain present in adipic acid which would make it not vegan.

Does adipic acid dissolve in water?

AcetoneAdipic acid / Soluble inAcetone, is an organic compound with the formula (CH₃)₂CO. It is the simplest and smallest ketone. It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscible with water and serves as an important organic solvent in its own right, in industry, home, and laboratory. Wikipedia

Is adipic acid strong or weak?

Strong acid and bases - Weak acid and bases - Dissociation constants and pK'sCompoundkapkaAdipic acid (CH2)4(COOH)23.71 x 10-5 Step 1 3.87 x 10-5 Step 24.43 4.41Benzoic acid (C6H5COOH)6.46 x 10-54.19Carbonic acid (H2CO3)4.3 x 10-7 5.61 x 10-116.37 10.25Chloroacetic acid (ClCH2CO2H)1.4 x 10-32.8515 more rows•Nov 14, 2014

What does high adipic acid mean?

High adipic acid suggests fat processing problems. Slightly elevated adipic acid may result from excessive ingestion of gelatin or other “junk” food containing adipic acid as an additive. Elevated adipic acid may also indicate an abnormality in fatty acid metabolism.

Is adipic acid organic or inorganic?

organic compoundAdipic acid or hexanedioic acid is the organic compound with the formula (CH2)4(COOH)2. From an industrial perspective, it is the most important dicarboxylic acid: about 2.5 billion kilograms of this white crystalline powder are produced annually, mainly as a precursor for the production of nylon.

How do you make adipic acid?

Adipic acid can be synthesized in the laboratory by taking cyclohexene and exposing it to oxidation by hydrogen peroxide or potassium permanganate. On a large scale, the primary method of making adipic acid involves taking 'KA oil' (ketone-alcohol oil) and oxidizing the mixture with concentrated nitric acid.

Is Silicon Dioxide safe in food?

Silicon dioxide is a natural chemical mix of silicon and oxygen that has uses in many food products as an anticaking agent. Silicon dioxide is generally safe as a food additive, though some agencies are calling for stricter guidelines about the quality and characteristics of the silicon dioxide found in foods.

Is adipic acid organic or inorganic?

organic compoundAdipic acid or hexanedioic acid is the organic compound with the formula (CH2)4(COOH)2. From an industrial perspective, it is the most important dicarboxylic acid: about 2.5 billion kilograms of this white crystalline powder are produced annually, mainly as a precursor for the production of nylon.

Does adipic acid dissolve in water?

AcetoneAdipic acid / Soluble inAcetone, is an organic compound with the formula (CH₃)₂CO. It is the simplest and smallest ketone. It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscible with water and serves as an important organic solvent in its own right, in industry, home, and laboratory. Wikipedia

Is adipic acid vegan?

​ Oleic acid from animal fat may be used in the development of adipic acid. Trace quantities of the oleic acid are likely to remain present in adipic acid which would make it not vegan.

What is adipic acid made of?

Preparation and reactivity. Adipic acid is produced from a mixture of cyclohexanone and cyclohexanol called KA oil, the abbreviation of k etone- a lcohol oil. The KA oil is oxidized with nitric acid to give adipic acid, via a multistep pathway. Early in the reaction, the cyclohexanol is converted to the ketone, releasing nitrous acid :

What is the chemical formula for adipic acid?

Chemical compound. Adipic acid or hexanedioic acid is the organic compound with the formula (CH 2) 4 (COOH) 2. From an industrial perspective, it is the most important dicarboxylic acid: about 2.5 billion kilograms of this white crystalline powder are produced annually, mainly as a precursor for the production of nylon.

Is adipic acid a dibasic acid?

Adipic acid is a dibasic acid (it has two acidic groups). The pK a values for their successive deprotonations are 4.41 and 5.41. With the carboxylate groups separated by four methylene groups, adipic acid is suited for intramolecular condensation reactions.

Is adipic acid toxic to rats?

Adipic acid, like most carboxylic acids, is a mild skin irritant. It is mildly toxic, with a median lethal dose of 3600 mg/kg for oral ingestion by rats.

Is adipic acid a flavoring agent?

In foods. Small but significant amounts of adipic acid are used as a food ingredient as a flavorant and gelling aid. It is used in some calcium carbonate antacids to make them tart. As an acidulant in baking powders, it avoids the undesirable hygroscopic properties of tartaric acid.

Why is adipic acid used in medicine?

Using adipic acid helps control the release of the compound over a period of time which helps someone avoid having to take the drug over shorter time intervals.

How many carbons are in adipic acid?

Adipic acid is an organic acid that contains six carbon atoms, and also has two carboxylate groups (-COOH) attached to the terminal carbons in the chain. Since adipic acid contains two carboxylate groups, it is sometimes referred to as a di-acid. All of the other carbon atoms in adipic acid contain two hydrogens each, ...

Is adipic acid toxic?

In terms of ingestion, it is only mildly toxic but again, ingestion should definitely be avoided if possible (as is the case with all chemicals).

Is adipic acid a therapeutic agent?

Although adipic acid itself doesn't find use as a therapeutic agent, it has still found use in the medicinal and pharmaceutical industries . Adipic acid has been incorporated into drug tablets in order to help with the controlled release of both acidic and basic drug compounds.

What is adipic acid?

An organic compound made of carbon, hydrogen and oxygen, adipic acid is considered a dicarboxylic acid, according to The Chemical Company website. It’s used in a variety of industrial and textile applications, such as to manufacture lubricants and nylon production.

How to identify adipic acid?

The United States requires food manufacturers to clearly identify food additives used in their products. When adipic acid is used in a food product, it must be clearly identified in the ingredient list by its name or code number. According to the Food and Agricultural Organization and World Health Organization Food Standards website, ...

What percentage of adipic acid is used in food?

The Chemical Company website explains that a majority of adipic acid production is used in these industrial applications. The other 10 percent is made specifically for use in foods and beverages.

Is adipic acid a food additive?

Providing tart taste, gel-like shape, firm texture and fizzy flavors, adipic acid is a rather flexible food additive. Although it’s found naturally in a few foods, most of the adipic acid found in the food supply is synthetic. Although adipic acid has been approved for safe consumption since 1965, some people try to avoid this ...

Is adipic acid safe to eat?

Although adipic acid has been approved for safe consumption since 1965, some people try to avoid this and other food additives altogether. In that case, it’s important to know which foods contain synthetic adipic acid.

What is an adipic acid?

ADIPIC ACID is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas ( carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. Behavior in Fire: Melts and may decompose to give volatile acidic vapors of valeric acid and other substances.

Where is adipic acid excreted?

Absorbed adipic acid is primarily excreted in the urine unchanged or in the breath of carbon dioxide.

How long does adipic acid react with hydroxyl radicals?

Vapor-phase adipic acid will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.9 days. Particulate-phase adipic acid will be removed from the atmosphere by wet and dry deposition.

How is adipic acid released into the atmosphere?

Adipic acid can be released into the environment via burning of biomass and motor exhaust. Adipic acid is a chemical constituent of tobacco smoke. Adipic acid is found in beet juice and tobacco and can be formed in the ambient atmosphere via photooxidation of olefins and hydrocarbons. If released to air, a vapor pressure of 2.27X10-7 mm Hg at 25 °C indicates adipic acid will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase adipic acid will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.9 days. Particulate-phase adipic acid will be removed from the atmosphere by wet and dry deposition. If released to soil, adipic acid is expected to have very high mobility based upon an estimated Koc of 24. The pKa values of adipic acid are 4.44 and 5.44, indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.8X10-12 atm-cu m/mole. Adipic acid is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation screening tests indicate that adipic acid is readily biodegradable in soil and water. A CO2 evolution of 84% was observed after 30 days aerobic incubation in a soil flask test. If released into water, adipic acid is not expected to adsorb to suspended solids and sediments in the water column based on its estimated Koc. Adipic acid was rapidly degraded in a river die-away test with 50% and 90% degradation being achieved in 3.5 and 7 days, respectively. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to adipic acid may occur through inhalation of dust particles and dermal contact with this compound at workplaces where adipic acid is produced or used. Monitoring and use data indicate that the general population may be exposed to adipic acid via inhalation of ambient air, ingestion of foods and dermal contact with consumer products containing adipic acid. (SRC)

What is the pH of a solution of carboxylic acid?

Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.

Is adipic acid a feedstock?

Adipic acid's production and use as a feedstock in the manufacture of nylon 6,6 resins and fibers, polyester polyols, plasticizers, and lubricant additives and as a food acidulant (2) may result in its release to the environment through various waste streams (SRC).

Is adipic acid mutagenic?

Adipic acid is not mutagenic in Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538 or in Escherichia coli (WP2 (uvrA)) with or without rat microsomal activation. ECOTOXICITY STUDIES: Adipic acid is slightly to moderately toxic to fish, daphnia, and algae in acute tests.

What is the Latest Adipic Acid Price?

In order to get the latest price of Adipic Acid, please contact us and we will provide a quotation right up to your country.

Is Adipic Acid Safe?

Adipic Acid is generally considered unsafe because the chemical is mildly toxic. Contact with this chemical can have acute health effects. According to the MSDS of Adipic Acid, it is a skin irritant that can cause some skin inflammation problems. Adipic Acid should be properly stored and disposed in order to avoid any unwanted effects.

What is an adipic acid?from pubchem.ncbi.nlm.nih.gov

ADIPIC ACID is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas ( carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. Behavior in Fire: Melts and may decompose to give volatile acidic vapors of valeric acid and other substances.

What is the rate constant of adipic acid?from pubchem.ncbi.nlm.nih.gov

The rate constant for the vapor-phase reaction of adipic acid with photochemically-produced hydroxyl radicals has been estimated as 5.6X10-12 cu cm/molecule-sec at 25 °C (SRC) using a structure estimation method (1). This corresponds to an atmospheric half-life of about 2.9 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm (1). The rate constant for the reaction of hydroxyl radicals in aqueous solutions at pH 2.0-2.2 is 2.0X10+9 L/mol-sec (2); this corresponds to an aquatic half-life of 1.1 years at an aquatic concentration of 1X10-17 hydroxyl radicals per liter (3). Adipic acid is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions (4). Results of UV-assisted ozonolysis tests indicate that environmental reaction of ozone is not a significant removal pathway for adipic acid (5).

How long does adipic acid react with hydroxyl radicals?from pubchem.ncbi.nlm.nih.gov

Vapor-phase adipic acid will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.9 days. Particulate-phase adipic acid will be removed from the atmosphere by wet and dry deposition.

How is adipic acid released into the atmosphere?from pubchem.ncbi.nlm.nih.gov

Adipic acid can be released into the environment via burning of biomass and motor exhaust. Adipic acid is a chemical constituent of tobacco smoke. Adipic acid is found in beet juice and tobacco and can be formed in the ambient atmosphere via photooxidation of olefins and hydrocarbons. If released to air, a vapor pressure of 2.27X10-7 mm Hg at 25 °C indicates adipic acid will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase adipic acid will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.9 days. Particulate-phase adipic acid will be removed from the atmosphere by wet and dry deposition. If released to soil, adipic acid is expected to have very high mobility based upon an estimated Koc of 24. The pKa values of adipic acid are 4.44 and 5.44, indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.8X10-12 atm-cu m/mole. Adipic acid is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation screening tests indicate that adipic acid is readily biodegradable in soil and water. A CO2 evolution of 84% was observed after 30 days aerobic incubation in a soil flask test. If released into water, adipic acid is not expected to adsorb to suspended solids and sediments in the water column based on its estimated Koc. Adipic acid was rapidly degraded in a river die-away test with 50% and 90% degradation being achieved in 3.5 and 7 days, respectively. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to adipic acid may occur through inhalation of dust particles and dermal contact with this compound at workplaces where adipic acid is produced or used. Monitoring and use data indicate that the general population may be exposed to adipic acid via inhalation of ambient air, ingestion of foods and dermal contact with consumer products containing adipic acid. (SRC)

Where is adipic acid excreted?from pubchem.ncbi.nlm.nih.gov

Absorbed adipic acid is primarily excreted in the urine unchanged or in the breath of carbon dioxide.

Is adipic acid biodegradable?from pubchem.ncbi.nlm.nih.gov

AEROBIC: Results of biological screening tests indicate that adipic acid is readily biodegradable (1). Adipic acid, present at 100 mg/L, reached 81% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test (2). In study with 10 participating laboratories using OECD 301E (ready biodegradability test), all laboratories observed a ready biodegradability of adipic acid with a degradation of at least 86% and an average degradation of 96.6% after 19 days (1). In an aerobic modified Sturm test (CO2 evolution) according to OECD 301B guideline, adipic acid was degraded by 91% in terms of CO2 evolution after a period of 28 days (1). In a closed bottle test (OECD 301D), 83% of the adipic acid was degraded after 30 days (1). In a test according to the modified OECD screening test (OECD 301E), 96% (related to DOC) was degraded after a period of 19 days (1). In four biodegradability screening tests that were designed as models for degradability in surface water, the results ranged from 92% of theoretical BOD in 14 days to 83% in 30 days (3,4). In 5 tests designed to simulate treatment plants, results ranged from 99% DOC removal in 1 day to 92% of theoretical BOD in 14 days (3-5). In a systematic screening procedure after a 5-10 hr lag, 50-75% of theoretical BOD of adipic acid was obtained in 90-100 hr (6). Adipic acid was rapidly degraded in a river die-away test using Main River (Germany) water (5); 50% and 90% degradation being achieved in 3.5 and 7 days, respectively, at concentration levels of 700 mg/L (5). The Afnor test, which was designed to simulate degradation in polluted river water, gave a 5 day BOD of 36% of theoretical (7).

What is the pH of a solution of carboxylic acid?from pubchem.ncbi.nlm.nih.gov

Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.

Why is adipic acid used in medicine?from study.com

Using adipic acid helps control the release of the compound over a period of time which helps someone avoid having to take the drug over shorter time intervals.

How many carbons are in adipic acid?from study.com

Adipic acid is an organic acid that contains six carbon atoms, and also has two carboxylate groups (-COOH) attached to the terminal carbons in the chain. Since adipic acid contains two carboxylate groups, it is sometimes referred to as a di-acid. All of the other carbon atoms in adipic acid contain two hydrogens each, ...

Is adipic acid bad for your eyes?from naturalpedia.com

Adipic acid can be harmful to the skin, eyes, and lungs because it can irritate all of these body parts and possibly increase the risk of other diseases. The lungs are especially vulnerable to adipic acid since it can act as an asthmagen.

Is adipic acid a genetically active substance?from pubmed.ncbi.nlm.nih.gov

Adipic acid is not genetically active in a wide variety of assay systems. Adipic acid caused no developmental toxicity in mice, rats, rabbits, or hamsters when administered orally. Adipic acid is partially metabolized in humans; the balance is eliminated unchanged in the urine.

Is adipic acid toxic?from study.com

In terms of ingestion, it is only mildly toxic but again, ingestion should definitely be avoided if possible (as is the case with all chemicals).

Is adipic acid a therapeutic agent?from study.com

Although adipic acid itself doesn't find use as a therapeutic agent, it has still found use in the medicinal and pharmaceutical industries . Adipic acid has been incorporated into drug tablets in order to help with the controlled release of both acidic and basic drug compounds.

What is adipic acid?from sigmaaldrich.com

General description. Adipic acid is a straight-chain aliphatic dicarboxylic acid, commonly used in the manufacturing of nylon-6,6 and plasticizers. Conventionally it was manufactured from petrochemicals but in recent days it can be synthesized from renewable substrates by means of biological methods.

What acid can be used as a starting material in the preparation of: Aliphatic polyesters?from sigmaaldrich.com

Adipic acid can be used as a starting material in the preparation of: Aliphatic polyesters by reacting with ethyleneglycol/1,3 propyleneglycol/1,4-butanediol using inorganic acid as a catalyst. Cyclopentanone using a weak base such as Na 2 CO 3.

Is a chemical on the health and safety list?from fscimage.fishersci.com

None of the chemicals are on the Health & Safety Reporting List.

image

Overview

Safety

Adipic acid, like most carboxylic acids, is a mild skin irritant. It is mildly toxic, with a median lethal dose of 3600 mg/kg for oral ingestion by rats.

Preparation and reactivity

Adipic acid is produced from a mixture of cyclohexanone and cyclohexanol called KA oil, the abbreviation of ketone-alcohol oil. The KA oil is oxidized with nitric acid to give adipic acid, via a multistep pathway. Early in the reaction, the cyclohexanol is converted to the ketone, releasing nitrous acid:
HOC6H11 + HNO3 → OC(CH2)5 + HNO2 + H2O

Uses

About 60% of the 2.5 billion kg of adipic acid produced annually is used as monomer for the production of nylon by a polycondensation reaction with hexamethylene diamine forming nylon 66. Other major applications also involve polymers; it is a monomer for production of polyurethane and its esters are plasticizers, especially in PVC.
Adipic acid has been incorporated into controlled-release formulation matrix tablets to obtain p…

Environmental

The production of adipic acid is linked to emissions of N 2O, a potent greenhouse gas and cause of stratospheric ozone depletion. At adipic acid producers DuPont and Rhodia (now Invista and Solvay, respectively), processes have been implemented to catalytically convert the nitrous oxide to innocuous products:
2 N2O → 2 N2 + O2

Appendix

• U.S. FDA citations – GRAS (21 CFR 184.1009), Indirect additive (21 CFR 175.300, 21 CFR 175.320, 21 CFR 176.170, 21 CFR 176.180, 21 CFR 177.1200, 21 CFR 177.1390, 21 CFR 177.1500, 21 CFR 177.1630, 21 CFR 177.1680, 21 CFR 177.2420, 21 CFR 177.2600)
• European Union Citations – Decision 1999/217/EC – Flavoing Substance; Directive 95/2/EC, Annex IV – Permitted Food Additive; 2002/72/EC, Annex A – Authorized monomer for Food Contact Plastics

External links

• International Chemical Safety Card 0369
• SIDS Initial Assessment Report for Adipic acid from the Organisation for Economic Co-operation and Development (OECD)
• adipic acid on chemicalland

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