Precautions
DESCRIPTION. AMRIX is a skeletal muscle relaxant which relieves muscle spasm of local origin without interfering with muscle function. The active ingredient in AMRIX extendedrelease capsules is cyclobenzaprine hydrochloride, USP. Cyclobenzaprine hydrochloride (HCl) is a white, crystalline tricyclic amine salt with the empirical formula C 20 H 21...
What is the chemical name of amrix?
AMRIX ® (Cyclobenzaprine Hydrochloride Extended-Release Capsules) is a skeletal muscle relaxant which relieves muscle spasm of local origin without interfering with muscle function. The active ingredient in AMRIX extended-release capsules is cyclobenzaprine hydrochloride, USP.
What is amrix ® (cyclobenzaprine hydrochloride extended-release capsules)?
It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Amrix is used together with rest and physical therapy to relieve muscle spasms caused by painful conditions such as an injury. Amrix may also be used for purposes not listed in this medication guide.
How does amrix work to treat muscle spasms?
Muscle relaxers, or muscle relaxants, are medications used to treat muscle spasms or muscle spasticity. Muscle spasms or cramps are sudden, involuntary contractions of a muscle or group of muscles.
What are muscle relaxers?
What does Amrix do?
Amrix (cyclobenzaprine hcl) is a muscle relaxant used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Amrix is available in generic form.
Which tablet is best for muscle relaxant?
Antispasmodics: Centrally Acting Skeletal Muscle RelaxersCarisoprodol (Soma) Carisoprodol is a centrally acting muscle relaxant. ... Chlorzoxazone (Lorzone, Parafon Forte DSC, Remular-S) ... Cyclobenzaprine (Amrix) ... Metaxalone (Skelaxin) ... Methocarbamol (Robaxin) ... Orphenadrine (Norflex) ... Baclofen (Ozobax) ... Tizanidine (Zaniflex)More items...
What is the most common muscle relaxer?
Common Muscle RelaxantsBaclofen. Muscle tightness and muscle spasms, including those related to spine injuries, may be eased with baclofen. ... Benzodiazepines. In addition to treating anxiety, alcohol withdrawal, and seizure disorders, such as epilepsy, benzodiazepines can also treat muscle spasms and skeletal pain.
Is Amrix a benzo?
A list of common benzodiazepines include diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), temazepam (Restoril), and clonazepam (Klonopin). Brand names for cyclobenzaprine include Flexeril and Amrix.
What are the top 5 muscle relaxers?
Common Muscle RelaxersCarisoprodol. Carisoprodol helps alleviate musculoskeletal pain. ... Cyclobenzaprine. A medication used since the late 1970s, cyclobenzaprine helps treat muscle spasms that suddenly arise. ... Diazepam. ... Metaxalone. ... Methocarbamol. ... Back Pain Treatments. ... Caudal Steroid Injection. ... Celiac Plexus Block.More items...
What is the safest muscle relaxer?
Taken as 800 mg tablets 3 to 4 times a day, metaxalone (Skelaxin) has the fewest reported side effects and lowest sedation potential of the muscle relaxants based on clinical studies. Simply put, it is the best-tolerated of the muscle relaxants.
Is tramadol a muscle relaxant?
Official answer. No, Tramadol is not an anti-inflammatory drug or muscle relaxer. It's a synthetic opioid that relieves pain. Because it's not an anti-inflammatory drug, it likely won't reduce any swelling you have when taken alone.
What's best for muscle pain relief?
Rest and elevate the painful area. Alternate between ice packs to reduce inflammation and heat to improve blood flow. Soak in a warm bath with Epsom salts or take a warm shower. Take over-the-counter pain relievers (aspirin, acetaminophen, ibuprofen, naproxen).
What are relaxants list five examples of relaxants?
List of Skeletal muscle relaxants:Drug NameAvg. RatingReviewsFlexeril (Pro) Generic name: cyclobenzaprine6.2222 reviewsSoma (Pro) Generic name: carisoprodol8.9194 reviewsZanaflex (Pro) Generic name: tizanidine7.6110 reviewsSkelaxin (Pro) Generic name: metaxalone7.185 reviews32 more rows•Mar 20, 2018
Is Amrix and Flexeril the same?
Amrix and Flexeril are both brand-name medications that contain the active drug cyclobenzaprine. Flexeril has been discontinued and is no longer available. Amrix is a long-acting form of cyclobenzaprine. Amrix and its generic form come as extended-release (ER) capsules that are taken by mouth once a day.
Can Klonopin be used as a muscle relaxer?
Baclofen and Klonopin (clonazepam) are muscle relaxants used for treating muscle spasms.
Are muscle relaxers Benzos?
Benzodiazepines such as diazepam may also be used short-term as a muscle relaxant. These are generally used to relieve acute painful skeletal muscle spasms, such as what might occur with acute lower back muscle spasm.
How do I relax my muscles?
Rest. Perhaps the best and most natural way to relax your muscles is to rest. Make sure to get lots of sleep, drink plenty of fluids, and try not to overwork the affected muscle. Using heat pads or ice packs on the muscle can provide immediate relief.
Which medicine is used for muscle pain?
If you get sore muscles once in a while, you can take acetaminophen or a nonsteroidal anti-inflammatory drug (NSAID) like aspirin, ibuprofen, or naproxen to help ease the discomfort. Just be cautious about using NSAIDs regularly.
What is the best pain reliever for muscle pain?
Ibuprofen (trade names are Advil, Motrin, Midol) "targets inflammation, so it is particularly helpful for muscle pain, joint pain and sports injuries.
What's best for muscle pain relief?
Rest and elevate the painful area. Alternate between ice packs to reduce inflammation and heat to improve blood flow. Soak in a warm bath with Epsom salts or take a warm shower. Take over-the-counter pain relievers (aspirin, acetaminophen, ibuprofen, naproxen).
Before Taking This Medicine
Do not use Amrix if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarbox...
How Should I Take Amrix?
Amrix is usually taken once daily for only 2 or 3 weeks. Follow all directions on your prescription label. Do not take this medicine in larger or s...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Amrix can be fatal.
What Should I Avoid While Taking Cyclobenzaprine?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.Avoid drinking alcohol....
What Other Drugs Will Affect Amrix?
Taking Amrix with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor bef...
How effective is Amrix?
Amrix was effective for treating muscle spasms caused by acute painful musculoskeletal conditions in two clinical studies. In these studies, adults took either Amrix or a placebo for 2 weeks. (A placebo is a treatment with no active drug.)
What is the purpose of Amrix?
Amrix works to relieve muscle pain, tenderness, and stiffness. It belongs to a class of drugs called muscle relaxants. A drug class is a group of medications that act in a similar way.
How long does Amrix last?
And Amrix should only be taken for up to 2 to 3 weeks.
Why is it important to dispose of Amrix?
If you no longer need to take Amrix and have leftover medication, it’s important to dispose of it safely. This helps prevent others, including children and pets, from taking the drug by accident. It also helps keep the drug from harming the environment.
How often should I take Flexeril?
Flexeril was a short-acting form of cyclobenzaprine that was typically taken three times a day. Flexeril and its generic forms are immediate-release (IR) tablets that are typically taken three times a day. IR drugs release their active drug into your body all at once.
How long should I take amrix?
If this dosage doesn’t work well enough for you, your doctor may increase it to 30 mg, once a day. Amrix should be taken at the same time each day. And it shouldn’t be taken for longer than 2 to 3 weeks.
What is the FDA approved drug for muscle spasms?
The Food and Drug Administration (FDA) has approved Amrix, Flexeril, and the generic forms of Flexeril to treat certain muscle spasms in adults. Muscle spasms are sudden, involuntary muscle movements. All of these drugs are muscle relaxants, which help relax the muscles without affecting your ability to control and use them.
What Is Amrix?
Amrix (cyclobenzaprine) is a prescription medication used to treat pain and tenderness caused by muscle spasms.
What Is Amrix Used For?
The Food and Drug Administration (FDA) approved Amrix to treat muscle spasms caused by acute musculoskeletal conditions, including low back pain and neck pain. 1
What Are the Side Effects of Amrix?
This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 800-FDA-1088.
Dosage: How Much Amrix Should I Take?
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Overdose: What Happens If I Take Too Much Amrix?
Taking more than your recommended dose of Amrix can be dangerous. Overdosing on Amrix can cause serious symptoms, including death. If you or someone else has overdosed on Amrix, it is important to seek medical care immediately since symptoms can progress quickly.
Precautions
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
What Other Medications Interact With Amrix?
Many drugs may interact with Amrix, including over-the-counter (OTC) nonprescription products. Keep an updated list of all the medicines you take. Share this information with your healthcare providers and pharmacist any time there are changes.
What is AMRIX used for?
AMRIX® (cyclobenzaprine hydrochloride extended-release capsules) is indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, and limitation of motion.
What are the side effects of Amrix?
What are the possible side effects of Amrix? Amrix may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, fast or irregular heartbeats, chest pain or pressure, pain spreading to your jaw or shoulder,
How long does cyclobenzaprine stay in plasma?
Although there were no notable differences in Cmax or Tmax, cyclobenzaprine plasma AUC is increased by 40% and the plasma half-life of cyclobenzaprine is prolonged in elderly subjects greater than 65 years of age (50 hours) after dosing with AMRIX compared to younger subjects 18 to 45 years of age (32 hours).
How many AMRIX capsules should I take daily?
Some patients may require up to 30 mg/day, given as one (1) AMRIX 30 mg capsule taken once daily or as two (2) AMRIX 15 mg capsules taken once daily. It is recommended that doses be taken at approximately the same time each day. Use of AMRIX for periods longer than two or three weeks is not recommended.
What is the color of AMRIX capsules?
30 mg: Capsules are blue/orange and are embossed in white ink with “30 mg” on the body, and Cephalon “C” logo, “ Cephalon,” and a dashed band on the cap. AMRIX extended-release capsules are available in 15 and 30 mg strengths, packaged in bottles of 60 capsules.
How long can you use AMRIX?
AMRIX should be used only for short periods (up to two or three weeks) because adequate evidence of effectiveness for more prolonged use is not available and because muscle spasm associated with acute, painful musculoskeletal conditions is generally of short duration and specific therapy for longer periods is seldom warranted.
Does AMRIX cause nausea?
Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise. These are not indicative of addiction.
What is AMRIX HCl?
AMRIX ® (Cyclobenzaprine Hydrochloride Extended-Release Capsules) is a skeletal muscle relaxant which relieves muscle spasm of local origin without interfering with muscle function. The active ingredient in AMRIX extended-release capsules is cyclobenzaprine hydrochloride, USP. Cyclobenzaprine hydrochloride (HCl) is a white, crystalline tricyclic amine salt with the empirical formula C 20 H 21 N•HCl and a molecular weight of 311.9. It has a melting point of 217°C, and a pK a of 8.47 at 25°C. It is freely soluble in water and alcohol, sparingly soluble in isopropanol, and insoluble in hydrocarbon solvents. If aqueous solutions are made alkaline, the free base separates. Cyclobenzaprine HCl is designated chemically as 3- ( 5H -dibenzo [ a,d] cyclohepten-5-ylidene)- N,N -dimethyl-1-propanamine hydrochloride, and has the following structural formula:
How many AMRIX capsules should I take daily?
Some patients may require up to 30 mg/day, given as one (1) AMRIX 30 mg capsule taken once daily or as two (2) AMRIX 15 mg capsules taken once daily.
How long does cyclobenzaprine affect the liver?
In rats treated with cyclobenzaprine for up to 67 weeks at doses of approximately 5 to 40 times the maximum recommended human dose, pale, sometimes enlarged, livers were noted and there was a dose-related hepatocyte vacuolation with lipidosis. In the higher dose groups, this microscopic change was seen after 26 weeks and even earlier in rats that died prior to 26 weeks; at lower doses, the change was not seen until after 26 weeks. Cyclobenzaprine did not affect the onset, incidence, or distribution of neoplasia in an 81-week study in the mouse or in a 105-week study in the rat. At oral doses of up to 10 times the human dose, cyclobenzaprine did not adversely affect the reproductive performance or fertility of male or female rats. Cyclobenzaprine did not demonstrate mutagenic activity in the male mouse at dose levels of up to 20 times the human dose.
Can you use AMRIX in the elderly?
Accordingly, AMRIX should not be used in the elderly.
Can aMRIX be excreted in milk?
It is not known whether this drug is excreted in human milk. Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when AMRIX is administered to a nursing woman.
Is AMRIX a tricyclic?
AMRIX is closely related to the tricyclic antidepressants, e.g., amitriptyline and imipramine. In short term studies for indications other than muscle spasm associated with acute musculoskeletal conditions, and usually at doses somewhat greater than those recommended for skeletal muscle spasm, some of the more serious central nervous system reactions noted with the tricyclic antidepressants have occurred (see WARNINGS, below, and ADVERSE REACTIONS ).
Does cyclobenzaprine help with muscle spasms?
Cyclobenzaprine relieves skeletal muscle spasm of local origin without interfering with muscle function. Cyclobenzaprine has not been shown to be effective in muscle spasm due to central nervous system disease. In animal models, cyclobenzaprine reduced or abolished skeletal muscle hyperactivity. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Such studies show that cyclobenzaprine acts primarily within the central nervous system at the brain stem as opposed to the spinal cord level, although an overlapping action on the latter may contribute to its overall skeletal muscle relaxant activity. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. Pharmacological studies in animals demonstrated a similarity between the effects of cyclobenzaprine and the structurally related tricyclic antidepressants, including reserpine antagonism, norepinephrine potentiation, potent peripheral and central anticholinergic effects, and sedation. Cyclobenzaprine caused slight to moderate increase in heart rate in animals.
How long does cyclobenzaprine last?
Cyclobenzaprine is usually taken taken for up to 2 or 3 weeks. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Follow your doctor's dosing instructions very carefully.
What is cyclobenzaprine used for?
Cyclobenzaprine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
What are the side effects of Cyclobenzaprine?
Cyclobenzaprine side effects. Get emergency medical help if you have signs of an allergic reaction to cyclobenzaprine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. sudden numbness or weakness (especially on one side of the body), slurred speech, balance problems.
Can you take cyclobenzaprine if you have a heart attack?
You should not use cyclobenzaprine if you have an allergy to the medication, a certain type of thyroid disorder (hyperthyroidism), heart block, congestive heart failure, a heart rhythm disorder, or you have recently had a heart attack.
Can cyclobenzaprine make you drowsy?
Using cyclobenzaprine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. MAO inhibitors, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine;
What are muscle relaxers used for?
Increase mobility of the affected muscles. See Medications for Back Pain and Neck Pain. Muscle relaxers are used in addition to rest, physical therapy, and other measures to relieve discomfort. They are typically prescribed for short-term use to treat acute, painful musculoskeletal conditions.
What is the best medication for skeletal pain?
Benzodiazepines. In addition to treating anxiety, alcohol withdrawal, and seizure disorders, such as epilepsy, benzodiazepines can also treat muscle spasms and skeletal pain. Benzodiazepines, such as diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril), are typically only intended for short-term use.
Is muscle relaxer a class of drugs?
Muscle relaxers are not a class of drugs—meaning they do not all have the same chemical structure or work the same way in the brain. Rather, the term muscle relaxer is used to describe a group of drugs that act as central nervous system depressants and have sedative and musculoskeletal relaxant properties.
Can you take a tablet of a syringe for multiple sclerosis?
The medication may be helpful in treating multiple sclerosis and stabbing nerve pain. It is available as a tablet and can be taken by children as young as 12 years old. Some common side effects could include nausea and vomiting, confusion, drowsiness, headache, or muscle weakness.
Can muscle relaxers help with back pain?
Muscle relaxers may be prescribed to treat back pain: Early in the course of back pain, on a short -term basis, to relieve pain associated with muscle spasms. Muscle relaxers are also prescribed for other conditions such as fibromyalgia, multiple sclerosis, and seizure disorders.
What is a muscle relaxer?
Muscle relaxers, or muscle relaxants, are medications used to treat muscle spasms or muscle spasticity. Muscle spasms or cramps are sudden, involuntary contractions of a muscle or group of muscles. They can be caused by too much muscle strain and lead to pain. They’re associated with conditions such as lower back pain, neck pain, and fibromyalgia.
How to treat muscle spasms?
Your muscle spasms or spasticity are likely treatable with rest, physical therapy, medications , or all of the above. Work with your doctor to put together a care plan that can ease your pain and get you moving comfortably again.
What is the term for a muscle spasm that causes stiffness, rigidity, and tightness?
Muscle spasticity , on the other hand, is a continuous muscle spasm that causes stiffness, rigidity, or tightness that can interfere with normal walking, talking, or movement. Muscle spasticity is caused by injury to parts of the brain or spinal cord involved with movement.
What are the side effects of Valium?
Side effects can include drowsiness, dizziness, lightheadedness, and fatigue. Diazepam: Diazepam (Valium) is used to relieve muscle spasms caused by inflammation, trauma, or muscle spasticity. It works by increasing the activity of a certain neurotransmitter to decrease the occurrence of muscle spasms.
What are the side effects of centrally acting SMRs?
The more common side effects of centrally acting SMRs include: drowsiness. dizziness. headache. nervousness. reddish-purple or orange urine. lowered blood pressure upon standing. You should talk to your doctor about the benefits and risks of these medications for the treatment of your muscle spasms.
Does dantrium cause muscle spasms?
It’s not fully understood how it works, but it seems to block nerve signals from the spinal cord that cause muscles to spasm. Side effects can include drowsiness, dizziness, weakness, and fatigue. Dantrolene: Dantrolene (Dantrium) is used to treat muscle spasms caused by spinal cord injury, stroke, cerebral palsy, or MS.
Do antispasmodics work better than acetaminophen?
While antispasmodics can be used to treat muscle spasms, they have not been shown to work better than nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen. In addition, they have more side effects than NSAIDs or acetaminophen. The more common side effects of centrally acting SMRs include: drowsiness. dizziness.
