Does amlodipine cause constipation?
It is one of the most widely prescribed anti-hypertensive agents. The reported chronic gastrointestinal side effects from amlodipine include constipation, dyspepsia, dysphagia, diarrhea, flatulence and pancreatitis.
Does amlodipine cause stomach issues?
Serious side effects after taking amlodipine are rare and happen in less than 1 in 10,000 people. Call a doctor or contact 111 straight away if: you have stomach problems – severe pain in your stomach, with or without diarrhoea (whether it has blood in it or not), feeling sick and being sick (nausea and vomiting) – these can be signs of pancreatitis
Does amlodipine cause stomach pain?
Summary: Abdominal pain is found among people who take Amlodipine, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. The phase IV clinical study analyzes which people take Amlodipine and have Abdominal pain. It is created by eHealthMe based on reports of 252,343 people who have side effects when taking Amlodipine from the FDA, and is updated regularly.
Does amlodipine cause excessive sleepiness?
Amlodipine oral tablet may cause extreme sleepiness. It can also cause other side effects. More common side effects. The more common side effects that can occur with amlodipine include:
Can amlodipine affect bowel movements?
You may have constipation while you're taking amlodipine oral tablets. But this wasn't a common side effect in studies of the drug. Constipation can cause symptoms such as: having fewer bowel movements than usual.
How common is constipation with amlodipine?
The relative risk (RR) of developing constipation was 4.00 with 95% CI 0.8930 to 17.917 in amlodipine alone group.
What is the most common side effect of amlodipine?
Amlodipine (Norvasc) is a medication used to treat high blood pressure and coronary artery disease. Swelling, fatigue, palpitations, and flushing are the most common side effects.
Can you take a stool softener with amlodipine?
Interactions between your drugs No interactions were found between amlodipine and Dulcolax Stool Softener.
Which blood pressure meds cause constipation?
Blood pressure medications There are two types of blood pressure medications that cause constipation: calcium channel blockers and beta blockers.
Do blood pressure tablets make you constipated?
Calcium Channel Blockers (CCBs) These high blood pressure medications keep calcium from entering heart muscle and blood vessel cells. Blood vessels can then relax. CCBs may cause these side effects: Constipation.
What should you avoid when taking amlodipine?
Some medicines can affect the way amlodipine works....Cautions with other medicinesantibiotics such as clarithromycin, erythromycin or rifampicin.calcium channel blockers like diltiazem or verapamil.itraconazole or ketoconazole, antifungal medicines.medicines to treat HIV or HCV (hepatitis C virus)More items...
Can blood pressure medicine cause bowel problems?
A type of blood pressure lowering medication, called a calcium-channel blocker, may be linked with increased risk of bowel condition diverticulosis. This condition causes small bulges or pouches to appear in the lining of the intestine.
Why should amlodipine be taken at night?
Overnight blood pressure control is important in order to lower your risk. If your medication wears off before your next dose is due, your blood pressure may be elevated for several hours while you sleep. You may also wake with high blood pressure. Taking your medication at bedtime may help prevent this issue.
What is the best thing to take for constipation?
In general, bulk-forming laxatives, also referred to as fiber supplements, are the gentlest on your body and safest to use long term. Metamucil and Citrucel fall into this category.
What gets rid of constipation?
Here are 13 natural home remedies to relieve constipation.Drink more water. ... Eat more fiber, especially soluble, non-fermentable fiber. ... Exercise more. ... Drink coffee, especially caffeinated coffee. ... Take Senna, an herbal laxative. ... Eat probiotic foods or take probiotic supplements. ... Over-the-counter or prescription laxatives.More items...
How do you poop when your constipated?
Take these steps:Drink two to four extra glasses of water a day, unless your doctor told you to limit fluids for another reason.Try warm liquids, especially in the morning.Add fruits and vegetables to your diet.Eat prunes and bran cereal.Exercise most days of the week. ... Don't ignore the urge to poop.
Do all calcium channel blockers cause constipation?
Background: Constipation is not an infrequent side effect complained of by patients taking calcium channel blockers. This effect may reduce patients' compliance and yield potentially serious consequences. However, the underlying mechanisms for constipation caused by such compounds are not known.
How do you poop when constipated on medication?
Stimulant laxatives are a commonly used and effective option for constipation caused by medications. Osmotic laxatives, like Miralax, can take a bit longer to work but tend to have fewer side effects. Stool softeners (emollient laxatives) are also available, but they may not work as well on their own.
What can I use instead of amlodipine?
Top 5 amlodipine alternativesOther calcium channel blockers (such as nifedipine, diltiazem, or verapamil) ... ACE Inhibitors (such as lisinopril, ramipril, or benazepril) ... ARBs (such as losartan, telmisartan, or candesartan) ... Beta-blockers (such as carvedilol, metoprolol, or bisoprolol)More items...•
Can blood pressure medicine cause bowel problems?
A type of blood pressure lowering medication, called a calcium-channel blocker, may be linked with increased risk of bowel condition diverticulosis. This condition causes small bulges or pouches to appear in the lining of the intestine.
What is Amlodipine?
Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 240,514 Amlodipine users for its effectiveness, alternative drugs and more.
What is phase IV of Amlodipine?
The phase IV clinical study analyzes which people take Amlodipine and have Constipation. It is created by eHealthMe based on reports of 235,390 people who have side effects when taking Amlodipine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
What is Constipation?
Constipation is found to be associated with 4,069 drugs and 3,692 conditions by eHealthMe.
Can you stop a medication without a doctor?
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
Is amlodipine based on generic drugs?
It is based on amlodipine besylate (the active ingredients of Amlodipine) and Amlodipine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
What are the side effects of amlodipine?
Commonly reported side effects of amlodipine include: edema. Other side effects include: fatigue, palpitations, and flushing. See below for a comprehensive list of adverse effects.
How many female patients have edema from a 10 mg med?
Edema occurred in 14.6% of female patients given this drug compared to 5.6% of male patients, and was more likely to occur in patients given the 10 mg dose (compared to the 5 and 2.5 mg doses). [ Ref]
Does amlodipine need immediate medical attention?
Side effects not requiring immediate medical attention. Some side effects of amlodipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Does amlodipine cause swelling?
Along with its needed effects, amlodipine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking amlodipine: More common. Swelling of the ankles or feet.
What are the side effects of amlodipine?from drugs.com
Commonly reported side effects of amlodipine include: edema. Other side effects include: fatigue, palpitations, and flushing. See below for a comprehensive list of adverse effects.
How many people take amlodipine daily?from peoplespharmacy.com
Amlodipine is perceived by many health professionals as a highly effective, low-risk medication. We estimate that nearly 14 million Americans swallow a pill containing amlodipine every day.
How many female patients have edema from a 10 mg med?from drugs.com
Edema occurred in 14.6% of female patients given this drug compared to 5.6% of male patients, and was more likely to occur in patients given the 10 mg dose (compared to the 5 and 2.5 mg doses). [ Ref]
Does amlodipine clear up rash?from peoplespharmacy.com
“My husband has been taking amlodipine 10 mg and he has had a rash for 2 years. It never clears up. His nurse told him her uncle was on amlodipine and he developed a rash which never went away. I will make sure his primary changes it to something else.”
How to report side effects of prescription drugs?from medicinenet.com
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
What is the most common adverse event in Camelot?from medicinenet.com
In the CAMELOT and PREVENT studies, the adverse event profile was similar to that reported previously (see above), with the most common adverse event being peripheral edema.
Does Norvasc cause heart palpitations?from medicinenet.com
palpitations. Serious side effects of Norvasc include: increased frequency and severity of angina, heart attacks, and. congestive heart failure. Drug interactions of Norvas c include sildenafil and similar drugs used to treat erectile dysfunction, which when combined may lead to excessive lowering of blood pressure with complications.
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
How the study uses the data?
The study is based on amlodipine besylate (the active ingredients of Amlodipine besylate). Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature.
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
What are the interactions of Amlodipine Besylate 5 MG Tablet ?from lybrate.com
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
How does amlodipine besylate 5 mg work?from lybrate.com
Amlodipine Besylate 5 MG Tablet works by inhibiting the entry of calcium into the cardiac and vascular smooth muscles and prevents the contraction of the muscles and thereby reduces the blood pressure .
What are the side effects of Norvasc 5 mg?from healthfully.com
The most common side effect with the 5 mg dose is dizziness. You may feel dizzy or faint upon standing up quickly after sitting or lying down. According to the Norvasc prescribing information as revised in January 2013, about 3 percent of people taking this dose report dizziness . Equally common with the 5 mg dose is swelling, called edema, due to excess collection of fluid. Edema usually is peripheral, or most noticeable in the legs and ankles.
How many female patients have edema from a 10 mg med?from drugs.com
Edema occurred in 14.6% of female patients given this drug compared to 5.6% of male patients, and was more likely to occur in patients given the 10 mg dose (compared to the 5 and 2.5 mg doses). [ Ref]
Does amlodipine cause sleepiness?from healthfully.com
Fatigue and sleepiness are common side effects of amlodipine besylate regardless of the dose taken 3. In general, gastrointestinal and other side effects are well tolerated, and most of them are mild or moderate in severity.
Is amlodipine besylate bad for you?from lybrate.com
Dosage should be low for elderly people and for those with liver problems. If you have heart problems then intake of Amlodipine Besylate 5 MG Tablet may increase your health problems. Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person.
Can amlodipine be used in elderly?from mayoclinic.org
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amlodipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.
How long does amlodipine stay in your system?
1 Following oral administration, the absolute bioavailability is estimated to be anywhere between 64 and 90% with peak concentrations occurring 6–12 h after administration and steady state 7–8 days after consecutive daily dosing. 2 Amlodipine has a high degree of protein binding (93–98%), is extensively hepatically metabolized with a slow biphasic elimination half-life of approximately 30–50 h, and has a large volume of distribution (21 l/kg). 3 In the elderly and patients with hepatic impairment, elimination is significantly prolonged (48 vs. 35 h, respectively; P < 0.025) and bioavailability is increased. 3
Can amlodipine cause intestinal obstruction?
In conclusion, severe acute intestinal obstruction should be included to the list of gastrointestinal side effects from amlodipine. Aggressive treatment of the accompanying cardiovascular shock and supportive care in an intensive care unit setting is likely to lead into the resolution of this potentially fatal complication.
Does amlodipine cause diarrhea?
It is one of the most widely prescribed anti-hypertensive agents. The reported chronic gastrointestinal side effects from amlodipine include constipation, dyspepsia, dysphagia, diarrhea, flatulence and pancreatitis.
Is amlodipine toxic to the body?
Our patient inadvertently took a high dose of amlodipine, which led to toxic side effects. Although constipation is a well-known side effect of amlodipine , to the best of our knowledge severe acute intestinal obstruction as a side effect has not been reported previously. Continuous oral administration of supra-therapeutic dose of amlodipine in the setting of constipation will likely increase the oral bioavailability of the drug. A vicious cycle may thus start ending in complete intestinal obstruction/ileus. This was the likely underlying mechanism in our patient.
Is verapamil safe for elderly?
Verapamil is not recommended in the elderly on account of high incidences of trouble some cons tipation. Amlodipine has become very popular with the cardiologists and general physicians. Survey of literature has not yielded any citation where the troublesome effect of amlodipine on the gastrointestinal tract has been reported.
Does amlodipine affect bowel habit?
The effect of amlodipine alone and in combination with atenolol on bowel habit in patients with hypertension: an observation. The prevalence of hypertension increases with advancing age. The management of hypertension especially in the elderly has its own limitations.
Is Verapamil recommended for elderly?
The prevalence of hypertension increases with advancing age. The management of hypertension especially in the elderly has its own limitations. Verapamil is not recommended in the elderly on account of high incidences of troublesome constipation. Amlodipine has become very popular ...
Summary
For The Consumer
- Applies to amlodipine: oral capsules, oral tablets Side effects include: Edema, dizziness, flushing, palpitations, fatigue, nausea, abdominal pain, somnolence. Edema, flushing, palpitations, and somnolence may be more common in women than men. Edema may be less frequent with concomitant ACE inhibitor or angiotensin II receptor antagonist therapy.
Frequently Asked Questions
Further Information
- Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some side effects may not be reported. You may report them to the FDA. Medical Disclaimer