Precautions
Why was mexiletine discontinued?
However, mexiletine treatment had to be discontinued permanently in 8 of 92 patients (9%) because of intolerable side effects. We conclude that the added efficacy and possible improved arrhythmia-free survival associated with combining mexiletine with a class Ia agent should be further investigated.
What does mexiletine do for the heart?
Mexiletine is used to treat certain types of ventricular arrhythmias (abnormal heart rhythms). Mexiletine is in a class of medications called antiarrhythmics. It works by blocking certain electrical signals in the heart to stabilize the heart rhythm.
What is the side effects of mexiletine?
Nausea, vomiting, heartburn, dizziness, lightheadedness, vision problems (such as blurred vision), headache, shaking, nervousness, or problems with muscle control (coordination difficulties) may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
How long does it take mexiletine to be out of the body?
In normal subjects, the plasma elimination half-life of Mexiletine is approximately 10 to 12 hours.
Can mexiletine cause heart failure?
The haemodynamic response to an oral loading dose of mexiletine (400 mg) was assessed in 20 patients with severe chronic heart failure. Mexiletine caused marked haemodynamic deterioration, with stroke work index decreasing in 18 of the patients.
How long can you take mexiletine?
Sixty-one patients (57%) have continued on mexiletine therapy for an average of 32.2 months (1 to 70 months). Outcome during long-term therapy was not related to drug dose, blood level, or presenting arrhythmia.
What is the alternative to mexiletine?
Tocainide (Tonocard - Astra) is a new antiarrhythmic agent. Like mexiletine, it is chemically related to lignocaine and is active by mouth.
What happens if you take too much mexiletine?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, drowsiness, confusion, feeling lightheaded, seizures, loss of consciousness, and a worsening irregular heartbeat.
Is mexiletine still on the market?
MEXITIL (mexiletine hydrochloride) capsules, 150 mg, 200 mg, and 250 mg, are currently listed in the “Discontinued Drug Product List” section of the Orange Book.
Does Mexitil affect blood pressure?
Does mexiletine affect blood pressure? Mexiletine can cause both higher and lower blood pressure, though rarely. If you already have low blood pressure issues, it's important to be careful when starting this medication, since it can make the pressure go even lower.
Does mexiletine slow heart rate?
Mexiletine belongs to the group of medicines known as antiarrhythmics. It is used to correct irregular heartbeats to a normal rhythm. Mexiletine produces its helpful effects by slowing nerve impulses in the heart and making the heart tissue less sensitive.
Can mexiletine cause tremors?
Oral mexiletine doses utilized in NeuP studies ranged between 225 and 1200 mg/day. Mexiletine may cause heartburn and nausea and vomiting, with at least one of these occurring in up to 40% of patients. Among common side effects are coordination problems (10%) as well as dizziness and tremor (25% of patients).
What does the medication mexiletine do?
Mexiletine belongs to the group of medicines known as antiarrhythmics. It is used to correct irregular heartbeats to a normal rhythm. Mexiletine produces its helpful effects by slowing nerve impulses in the heart and making the heart tissue less sensitive. Mexiletine is available only with your doctor's prescription.
How long does it take for mexiletine to start working?
Mexiletine typically starts to work 2 or 3 hours after you take a dose. If you are in the hospital, you might get you a higher "loading dose" so that the medication kicks in faster.
Does Mexitil affect blood pressure?
Low blood pressure: Mexiletine may cause or worsen low blood pressure. Tell your doctor if you experience symptoms of severely decreased blood pressure, such as weakness or dizziness, particularly when rising suddenly from a sitting or lying position.
When do you hold mexiletine?
You should not use mexiletine if you have a serious heart condition such as "AV block" (unless you have a pacemaker). Mexiletine may cause you to have abnormal liver function tests, especially if you also have congestive heart failure, or blood circulation problems.