Precautions
Tinidazole is used to treat infections caused by protozoa (eg, trichomoniasis, giardiasis, and amebiasis). It is also used to treat adult women with vaginal infections (bacterial vaginosis). Tinidazole belongs to the group of medicines called antiprotozoals. These medicines are used to treat infections caused by protozoa (tiny, one-celled animals).
What is tinidazole used to treat?
Bacterial Vaginosis. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Tinidazole Tablets and other antibacterial drugs, Tinidazole Tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.
Can tinidazole be used to treat vaginal vaginosis?
Tinidazole is a synthetic antiprotozoal and antibacterial agent. It is 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole, a second-generation 2-methyl-5-nitroimidazole, which has the following chemical structure: Tinidazole Tablets pink oral tablets contain 250 mg or 500 mg of tinidazole.
What is the structure of tinidazole?
Appropriate studies have not been performed on the relationship of age to the effects of tinidazole in children 3 years of age and younger. Safety and efficacy have not been established. It is only used in children older than 3 years of age for the treatment of giardiasis and amebiasis.
Can a 3 year old take tinidazole?
Is tinidazole stronger than metronidazole?
metronidazole, respectively. The Sanz-Sanz study produced efficacy rates of 65% and 74% for tinidazole vs. metronidazole, respectively. Although a single 2g dose of tinidazole appears more effective than a single 2g dose of metronidazole, it may be slightly less effective than seven days of metronidazole.
How long do tinidazole take to work?
1. How long does tinidazole work? The effect of tinidazole varies for different medical conditions and different individuals. On average, it takes about two to seven days to render its full impact on killing the microorganisms.
What is the strength of tinidazole?
Tindamax pink oral tablets contain 250 mg or 500 mg of tinidazole.
How effective is tinidazole?
The cure rates with tinidazole ranged from 46% to 71% for tinidazole 2 g oral single dose, 74% for 2 g daily for 2 days and 91% for the 1 g daily for 5 days dose.
What bacteria does tinidazole treat?
Descriptions. Tinidazole is used to treat infections caused by protozoa (eg, trichomoniasis, giardiasis, and amebiasis). It is also used to treat adult women with vaginal infections (bacterial vaginosis). Tinidazole belongs to the group of medicines called antiprotozoals.
How many tinidazole 500mg should I take?
Tinidazole, like metronidazole, is prescribed as a single 2-g oral dose for the treatment of trichomoniasis. For bacterial vaginosis, the tinidazole dose is 2 g once daily for two days or 1 g once daily for five days, which is a less frequent and shorter regimen than metronidazole 500 mg twice daily for seven days.
Can I take 4 tablets of tinidazole at once?
As a guide, a single dose of four tablets taken at the same time is sufficient for most vaginal or dental infections in adults. For other bacterial infections, you are likely to be asked to take a course of treatment which could last up to seven days.
Can I take tinidazole on empty stomach?
How to use Tinidazole. Take this medication by mouth as directed by your doctor, usually once daily. To prevent stomach upset, take this medication with food. The dosage is based on your medical condition and response to treatment.
What is another name for tinidazole?
Tinidazole is marketed by Mission Pharmacal under the brand name Tindamax, by Pfizer under the names Fasigyn and Simplotan, and in some Asian countries as Sporinex.
When is the best time to take tinidazole?
It is usually taken with food as a single dose or once a day for 2 to 5 days. To help you remember to take tinidazole (if you are to take it for more than one day), take it around the same time every day.
Which is better Flagyl or tinidazole?
The results indicate that tinidazole is more effective and better tolerated than metronidazole when given as a short course in single daily doses for symptomatic intestinal amoebiasis and amoebic liver abscess and as a single dose in symptomatic giardiasis.
How long do you take tinidazole?
Adults—2 grams (g) once a day for 3 to 5 days. Children older than 3 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 50 milligrams (mg) per kilogram (kg) of body weight per day (up to 2 g per day) for 3 to 5 days.
Do I take all 4 tinidazole at once?
As a guide, a single dose of four tablets taken at the same time is sufficient for most vaginal or dental infections in adults. For other bacterial infections, you are likely to be asked to take a course of treatment which could last up to seven days.
How many days should I take tinidazole?
How to use Tinidazole. Take this medication by mouth as directed by your doctor, usually once daily. To prevent stomach upset, take this medication with food.
Can tinidazole treat stomach infection?
Tinidazole is used to treat trichomoniasis (a sexually transmitted disease that can affect men and women), giardiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps), and amebiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps and can spread to other ...
How long does tinidazole take to work for trichomoniasis?
How long does it take for the infection to go away? It takes 7 days for the medicine to work. For 7 days after you take the pills: ∎ It is best not to have sex at all (vaginal sex, oral sex, anal sex, or using sex toys).
What is tinidazole used for?
Uses. Tinidazole is an antibiotic that is used to treat certain types of vaginal infections ( bacterial vaginosis, trichomoniasis ). It is also used to treat certain types of parasite infections (giardiasis, amebiasis ). It works by stopping the growth of certain bacteria and parasites .This antibiotic treats only certain bacterial ...
How to report tinidazole side effects in Canada?
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking tinidazole, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as metronidazole ); or if you have any other allergies.
What to tell your dentist before surgery?
Before having surgery, tell your doctor or dentistabout all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
What happens if you take a metallic taste?
Tell your doctor if your condition lasts or gets worse. Bitter/ metallic taste in your mouth, nausea, stomach upset, diarrhea, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. This medication may cause your urine to turn darker in color.
What products interact with lopinavir?
Some products that may interact with this drug include: alcohol-containing products (such as coughand cold syrups, aftershave), products containing propylene glycol, lopinavir/ritonavirsolution, lithium.
What happens if you eat a bitter taste?
Bitter/metallic tastein your mouth, nausea, stomachupset, diarrhea, or dizzinessmay occur. If any of these effects last or get worse, tell your doctor or pharmacistpromptly.
Can you take tinidazole with disulfiram?
Some products that may interact with this drug include: alcohol-containing products (such as cough and cold syrups, aftershave), products containing propylene glycol, lopinavir/ ritonavir solution, lithium. Do not take tinidazole if you are also taking disulfiram or if you have taken disulfiram within the last 2 weeks.
How should this medicine be used?
Tinidazole comes as a suspension (liquid) prepared by the pharmacist and a tablet to take by mouth. It is usually taken with food as a single dose or once a day for 2 to 5 days. To help you remember to take tinidazole (if you are to take it for more than one day), take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tinidazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
What special dietary instructions should I follow?
Talk to your doctor about drinking grapefruit juice while taking this medication.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to tinidazole. Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking tinidazole.
Why is tinidazole prescribed?
Why is this medication prescribed? Tinidazole is used to treat trichomoniasis (a sexually transmitted disease that can affect men and women), giardiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps), and amebiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps ...
What is tinidazole used for?
Tinidazole is also used to treat bacterial vaginosis (an infection caused by an overgrowth of harmful bacteria in the vagina) in women. Tinidazole is in a class of medications called nitroimidazole antimicrobials. It works by killing the organisms that can cause infection. Antibiotics will not work for colds, flu, or other viral infections.
What to tell your doctor before taking tinidazole?
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.
How to dispose of unneeded medication?
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
How long does tinidazole last in amebiasis?
Tinidazole use in intestinal amebiasis has been documented in 26 published reports from the world literature involving over 1,400 patients. Most reports utilized tinidazole 2 g/day × 3 days. In four published, randomized, controlled studies (1 investigator single-blind, 3 open-label) of the 2 g/day × 3 days oral dose of tinidazole, reported cure rates after 3 days of therapy among a total of 220 subjects ranged from 86% (25/29) to 93% (25/27).
How effective is tinidazole in trichomoniasis?
Tinidazole (2 g single oral dose) use in trichomoniasis has been well documented in 34 published reports from the world literature involving over 2,800 patients treated with tinidazole. In four published, blinded, randomized, comparative studies of the 2 g tinidazole single oral dose where efficacy was assessed by culture at time points post-treatment ranging from one week to one month, reported cure rates ranged from 92% (37/40) to 100% (65/65) (n=172 total subjects). In four published, blinded, randomized, comparative studies where efficacy was assessed by wet mount between 7 to 14 days post-treatment, reported cure rates ranged from 80% (8/10) to 100% (16/16) (n=116 total subjects). In these studies, tinidazole was superior to placebo and comparable to other anti-trichomonal drugs. The single oral 2 g tinidazole dose was also assessed in four open-label trials in men (one comparative to metronidazole and 3 single-arm studies). Parasitological evaluation of the urine was performed both pre- and post-treatment and reported cure rates ranged from 83% (25/30) to 100% (80/80) (n=142 total subjects).
What is tinidazole used for?
Tinidazole is indicated for the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, or anaerobic vaginosis) in non-pregnant women [ see Use in Specific Populations ( 8.1) and Clinical Studies ( 14.5) ].
How old is too old to take tinidazole?
Other than for use in the treatment of giardiasis and amebiasis in pediatric patients older than three years of age, safety and effectiveness of tinidazole in pediatric patients have not been established.
How is tinidazole distributed?
Distribution: Tinidazole is distributed into virtually all tissues and body fluids and also crosses the blood-brain barrier. The apparent volume of distribution is about 50 liters. Plasma protein binding of tinidazole is 12%. Tinidazole crosses the placental barrier and is secreted in breast milk.
How long does tinidazole stay in breast milk?
Nursing Mothers. Tinidazole is excreted in breast milk in concentrations similar to those seen in serum. Tinidazole can be detected in breast milk for up to 72 hours following administration. Interruption of breast-feeding is recommended during tinidazole therapy and for 3 days following the last dose.
What is the mechanism of action of tinidazole?
Mechanism of Action: Tinidazole is an antiprotozoal, antibacterial agent. The nitro- group of tinida zole is reduced by cell extracts of Trichomonas. The free nitro- radical generated as a result of this reduction may be responsible for the antiprotozoal activity. Chemically reduced tinidazole was shown to release nitrites and cause damage to purified bacterial DNA in vitro. Additionally, the drug caused DNA base changes in bacterial cells and DNA strand breakage in mammalian cells. The mechanism by which tinidazole exhibits activity against Giardia and Entamoeba species is not known.
What is Tinidazole?
Tinidazole is an antibiotic which fights with bacteria in the body. These antibiotics are used to treat infections that are caused by bacteria such as infection of intestines and vagina. Tinidazole are also used for treating certain sexually transmitted infections.
Tinidazole Uses
Tinidazole is used for the treatment of trichomoniasis (Sexually transmitted disease), giardiasis (infection in the intestine which can cause diarrhea, stomach cramps and gas), and amebiasis. The antibiotics are also used for treating bacterial vaginosis in women. It also works in killing organisms which can cause infection.
Precautions
Before taking Tinidazole you should tell your doctor if you are taking any medications, vitamins, nutritional supplements and any other herbal products. The doctor may change the medication after monitoring your side effects.
Tinidazole Storage
Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
What is tinidazole used for?
Tinidazole is a nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis.
How is tinidazole metabolized?
Tinidazole is partly metabolized by oxidation, hydroxylation and conjugation. Tinidazole is the major drug-related constituent in plasma after human treatment, along with a small amount of the 2-hydroxymethyl metabolite.
Where is tinidazole excreted?
Tinidazole crosses the placental barrier and is secreted in breast milk. Tinidazole is excreted by the liver and the kidneys. Tinidazole is excreted in the urine mainly as unchanged drug (approximately 20-25% of the administered dose). Approximately 12% of the drug is excreted in the feces. Half-life.
What is the molecule of heredity?
DNA is the molecule of heredity, as it is responsible for the genetic propagation of most inherited traits. It is a polynucleic acid that carries genetic information on cell growth, division, and function. DNA consists of two long strands of nucleotides twisted into a double helix and held together by hydrogen bonds.
What class of compounds are nitroimidazoles?
This compound belongs to the class of organic compounds known as nitroimidazoles. These are compounds containing an imidazole ring which bears a nitro group.
How long does plasma elimination last?
The elimination half-life is 13.2±1.4 hours and the plasma half-life is 12 to 14 hours.
What is G01A in medicine?
G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
How much trichomoniasis is given per day?
The dose is usually 50 milligrams (mg) per kilogram (kg) of body weight per day (up to 2 g per day) for 3 days. Children 3 years of age and younger—Use and dose must be determined by your doctor. For trichomoniasis: Adults— 2 grams (g) given once as a single dose. Children—Use and dose must be determined by your doctor.
How much amebiasis is given to a child?
The dose is usually 50 milligrams (mg) per kilogram (kg) of body weight (up to 2 g) given as a single dose. Children 3 years of age and younger—Use and dose must be determined by your doctor. For intestinal amebiasis:
How many grams of giardiasis is given a day?
Adults— 2 grams (g) one time a day for 2 days or 1 g one time a day for 5 days. Children—Use and dose must be determined by your doctor. For giardiasis: Adults—2 grams (g) given as a single dose. Children older than 3 years of age—Dose is based on body weight and must be determined by your doctor.
How long does a liver abscess last?
For amebic liver abscess: Adults—2 grams (g) one time a day for 3 to 5 days. Children older than 3 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 50 milligrams (mg) per kilogram (kg) of body weight per day (up to 2 g per day) for 3 to 5 days.
What happens if you stop taking a med?
If you stop taking this medicine too soon, your symptoms may return. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times during the day.
How to store medicine?
Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
How long can you keep cherry syrup at room temperature?
You may store the oral liquid (crushed tablets in artificial cherry syrup) at room temperature up to 7 days.
Medical uses
Tinidazole is an antibiotic that is used to treat certain types of vaginal infections (bacterial vaginosis, trichomoniasis). It is also used to treat certain types of parasite infections (giardiasis, amebiasis).
May Treat: Giardiasis · Trichomoniasis · Acute intestinal amebiasis due to Entamoeba histolytica · Liver abscess amebiasis due to Entamoeba histolytica · Bacterial vaginosis
Brand Names: Tindamax
Drug Class: Antiprotozoal-Antibacterial 2nd Generation 2-methyl-5-nitroimidazole
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Giardiasis · Trichomoniasis · Acute intestinal amebiasis due to Entamoeba histolytica · Liver abscess amebiasis due to Entamoeba histolytica · Bacterial vaginosis
Brand Names: Tindamax
Drug Class: Antiprotozoal-Antibacterial 2nd Generation 2-methyl-5-nitroimidazole
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: This drug should not be given to breastfeeding mothers
Alcohol: Avoid intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
- Avoid alcohol during and for 3 days after therapy.
- Best to take with food to lessen stomach upset
- May make you dizzy. Use caution when driving.
- Avoid alcohol during and for 3 days after therapy.
- Best to take with food to lessen stomach upset
- May make you dizzy. Use caution when driving.
- Do not breast feed while taking this medicine
- May darken urine while taking this drug
- Review all drugs you are taking with your doctor
- Success is dependent on completing therapy course
- Sexual partner may need to be treated
Administration
Treatment
Risks
Prevention
- Tinidazole is used to treat trichomoniasis (a sexually transmitted disease that can affect men and women), giardiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps), and amebiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps and can spread to other organs such as the liver). Tinidazole is in a class of medication…
Diagnosis
- Tinidazole comes as a suspension (liquid) prepared by the pharmacist and a tablet to take by mouth. It is usually taken with food as a single dose or once a day for 3 to 5 days. To help you remember to take tinidazole (if you are to take it for more than one day), take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or …
Preparation
- Take tinidazole until you finish the prescription, even if you feel better. If you stop taking tinidazole too soon or skip doses, your infection may not be completely cured and bacteria may become resistant to antibiotics Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infecti...
Indications & Usage
- If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Dosage & Administration
- Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Protect the medication from light. Discard any remaining liquid after 7 days. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot con…
Dosage Forms & Strengths
- Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to tinidazole. Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking tinidazole.
Contraindications
- It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Tinidazole Tablets Description