Benzydamine (also known as Tantum Verde and branded in some countries as Maxtra Gargle, Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID
Nonsteroidal anti-inflammatory drug
Nonsteroidal anti-inflammatory drugs are a drug class that reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation. Side effects depend on the specific drug, but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack a…
What is benzydamine hydrochloride?
Benzydamine (also known as Tantum Verde and branded in some countries as Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.
What is benzydamine lozenges used for?
About benzydamine Benzydamine is an anti-inflammatory and painkilling medicine. It reduces pain and discomfort associated with sore throat or mouth conditions such as ulcers and sore throat. It is available as lozenges to suck, a mouthwash which you can gargle with, or as a spray which can be directed towards the sore areas of your mouth.
Is benzydamine good for sore throat?
Benzydamine is an anti-inflammatory and painkilling medicine. It reduces pain and discomfort associated with sore throat or mouth conditions such as ulcers and sore throat. It is available as a mouthwash which you can gargle with, or as a spray which can be directed towards the sore areas of your mouth.
What is benzydamine mouthwash used for?
Benzydamine is an NSAID (non-steroidal anti-inflammatory drug) that reduces pain and swelling (inflammation). It’s used for: It comes as mouthwash, mouth spray and lozenges. Benzydamine is available on prescription or to buy from a pharmacy. 2. Key facts You’ll usually use benzydamine mouthwash, mouth spray or lozenges for up to 7 days.
How does benzydamine hydrochloride work?
Benzydamine exerts an anti-inflammatory and analgesic action by stabilising the cellular membrane and inhibiting prostaglandin synthesis. The indazole analogue benzydamine has physicochemical properties and pharmacological activities which differ from those of the aspirin-like NSAIDs.
How quickly does benzydamine HCL work?
You should expect the soreness to have eased within seven days of using benzydamine. If there is no improvement after this time, you should arrange to see your doctor or dentist for further advice. Do not continue to use benzydamine for longer than seven days unless it is on the advice of a doctor or dentist.
Is benzydamine hydrochloride a drug?
Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system.
Does benzydamine help tonsillitis?
Indication. Difflam Anti-inflammatory Throat Spray can be used for the relief of pain and inflammation that may occur in conditions of the mouth and throat such as tonsillitis, sore throat and mouth ulcers.
Is benzydamine antibacterial?
Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa.
Is benzydamine an antifungal?
A very fast fungicidal activity was shown by 0.2, 50, and 30 mg/mL of benzydamine, lidocaine, and bupivacaine, respectively.
Does benzydamine hydrochloride make you drowsy?
Other side effects of benzydamine include: Cough. Drowsiness.
Is benzydamine hydrochloride addictive?
It is known that benzydamine is abused for recreational use due to its hallucinogenic effect at dosages over 500 mg. We have to reported a case of a 22 year-old male patient hospitalized because of multiple substance abuse together with benzydamine abuse in this paper.
Can you swallow benzydamine hydrochloride?
Do not swallow the solution. If a normal 15ml dose is accidentally swallowed, you need not worry as it is unlikely to cause you any problem. If a large amount is swallowed, you should contact your doctor or go to the nearest hospital. Do not use it continuously for more than 7 days.
Is benzydamine a Difflam?
Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system.
What tablets get rid of tonsillitis?
Penicillin taken by mouth for 10 days is the most common antibiotic treatment prescribed for tonsillitis caused by group A streptococcus. If your child is allergic to penicillin, your doctor will prescribe an alternative antibiotic.
What is the best gargle for tonsillitis?
Mix half a teaspoon of salt in a glass of warm water and stir until it has dissolved. Gargle with the salty water (do not swallow it), then spit it out. Repeat as often as you like.
Is benzydamine hydrochloride effective?
Benzydamine hydrochloride has been studied and found to be effective for treating oral mucositis and oral ulcers, as well as for the prevention of post-operative sore throat following endotracheal intubation [7, 8].
Does benzydamine hydrochloride numb?
Benzydamine works by stopping the production of various chemicals in the body that cause inflammation. Benzydamine reduces inflammation and pain in the area it comes into contact with. Benzydamine also acts as a local anaesthetic, causing numbness and pain relief.
How often can you use benzydamine hydrochloride?
Painful inflammatory conditions of oropharynx Rinse or gargle 15 mL every 1.5–3 hours as required usually for not more than 7 days, dilute with an equal volume of water if stinging occurs.
Can you swallow benzydamine hydrochloride?
Do not swallow the solution. If a normal 15ml dose is accidentally swallowed, you need not worry as it is unlikely to cause you any problem. If a large amount is swallowed, you should contact your doctor or go to the nearest hospital. Do not use it continuously for more than 7 days.
Is benzydamine hydrochloride an NSAID?
More... Benzydamine Hydroch loride is an indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties. Unlike other NSAIDs, benzydamine hydrochloride does not inhibit cyclooxygenases (COX) but stabilizes membranes, resulting in local anesthesia; inhibits the production of pro-inflammatory cytokines;
Is benzydamine a NSAID?
Benzydamine Hydrochloride is an indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties.
Where is Benzydamine Hydrochloride found?
Benzydamine hydrochloride is a local anti-inflammatory and analgesic active ingredient currently available as aerosol, lozenge, solution for gargling, and vaginal douche.
How can you avoid contact with Benzydamine Hydrochloride?
Avoid products that list any of the following names in the ingredients:
Additional resources and links for Benzydamine Hydrochloride
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How long can you use benzydamine?
It is available as a mouth rinse, lozenges and as a mouth spray. You can use benzydamine for up to seven days, but do not continue to use it for longer than this except on the advice of a doctor or dentist.
How often should you spray benzydamine?
If you are using benzydamine spray, use 4-8 sprays on to the sore area every 1½-3 hours. This is the dose for adults. If you are giving benzydamine to your child, check the label carefully to make sure you are using the correct number of sprays for the age of your child.
How often should you use benzydamine mouthwash?
If you are using benzydamine oral rinse (mouthwash), use 15 ml as a mouthwash every 1½-3 hours. The cap of the bottle can be used as a measure. After you have gargled with the liquid for about 20-30 seconds, spit it out - try not to swallow benzydamine. If you find the mouthwash causes some stinging, you can dilute the liquid with an equal amount ...
Does benzydamine help with sore throat?
It reduces pain and discomfort associated with sore throat or mouth conditions such as ulcers and sore throat. It is available as lozenges to suck, a mouthwash which you can gargle with, or as a spray which can be directed towards the sore areas of your mouth. Benzydamine mouthwash, lozenges and spray are available on a prescription ...
Can you take benzydamine while pregnant?
For these reasons, before you start using benzydamine it is important that your doctor, dentist or pharmacist knows: If you are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
Can benzydamine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with benzydamine oral rinse and spray. You will find a full list in the manufacturer's information leaflet supplied with the medicine.
What is Benzydamine used for?
Benzydamine (also known as Tantum Verde and branded in some countries as Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. It falls under class of chemicals known as indazole .
What is the reaction of N-benzylaniline and phosgene?
An interesting alternative synthesis of this substance starts by sequential reaction of N -benzylaniline with phosgene, and then with sodium azide to product the corresponding carbonyl azide. On heating, nitrogen is evolved and a separatable mixture of nitrene insertion product and the desired ketoindazole # results. The latter reaction appears to be a Curtius rearrangement type product to produce an N-isocyanate #, which then cyclizes. Alkylation of the enol with sodium methoxide and 3-dimethylaminopropyl chloride gives benzydamine.
Is benzydamine contraindicated?
There are no contraindications to the use of benzydamine except for known hypersensitivity .
Is benzydamine a stimulant?
Benzydamine has been used recreationally. In overdosages it acts as a deliriant and CNS stimulant. Such use, particularly among teenagers, has been reported in Poland, Brazil and Romania.
Does benzydamine work against Staphylococcus aureus?
Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa.
How does Difflam spray work?
Difflam spray contains benzydamine hydrochloride, which works by stopping the production of various chemicals in the body that cause inflammation. Benzydamine reduces inflammation and pain in the area its's applied to.
What is difflam spray?
Benzydamine: everything you need to know about difflam spray. Difflam spray is an oral spray which contains the drug benzydamine, and is often used to treat sore throats, painful gums or mouth ulcers. It is available to buy in pharmacies.
How many people are affected by difflam?
Stinging or numbness in the mouth are uncommon side effects of Difflam spray which may affect between 1 in 100 to 1 in 1000 people using it.
Where to spray difflam?
Difflam spray should be sprayed directly onto the painful area in the mouth or throat.
What to do if you are allergic to spray?
If you feel you have experienced an allergic reaction, stop using the spray and get medical advice immediately. If you think you have experienced a side effect, you can report this using the yellow card website.
Can you use difflam with other medicines?
Difflam spray and other medicines. Difflam spray is not known to affect other medicines. It is okay to use Diff lam with other medicines such as painkillers or throat lozenges to treat a sore throat.
Can you use difflam if you have asthma?
People with a history of asthma, or allergy to aspirin or other NSAIDs such as ibuprofen should only use Difflam spray after getting medical advice. ⚠️ Get medical advice from your doctor or pharmacist if the pain doesn't go away or gets worse despite using this spray.
1. What Andolex is and what it is used for
Andolex is a topical painkiller that works by stabilizing cell membranes and inhibiting the formation of prostaglandins (substances that can amplify pain signals in the body).
Other medicines and Andolex
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. This also applies to over-the-counter medicines and herbal medicines.
Pregnancy, breastfeeding, and fertility
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines
Andolex contains alcohol. Uptake into the body when rinsing the mouth is expected to be minimal, but caution is recommended when driving and using machines.
Andolex contains methyl parahydroxybenzoate, ethanol, and sodium
Andolex contains methyl parahydroxybenzoate which may cause an allergic reaction (possibly delayed
3. How to use Andolex
Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.
4. Possible side effects
Like all medicines, Andolex can cause side effects, although not everybody gets them.
