What is the use of eugenol oil in dentistry?
Suggested as a solution in order to use with cement-retained implant restorations. Extra pure eugenol oil is used for the relief of insignificant dental pain and also to form sedative dentinal dressing with zinc oxide.
Is eugenol a sedative?
It has sedative and anodyne effects 5 as well as antibacterial properties. 6 Eugenol is found as a major ingredient in a variety of dental materials such as impression materials, filling materials, dental cements, endodontic sealers, periodontal dressing materials and dry socket dressings.
What is eugenol paste used for?
The potent inhibitor can also be used to treat oral diseases with its antibiotic properties. Eugenol paste is also used in dentistry to keep pain at bay, relax the pulp and treat damaged gums. The smoky compound is also used with zinc oxide to use as fillings and dental prosthetics.
Is eugenol an antifungal?
In vitro, eugenol has been shown to have antibacterial, antifungal, antioxidant and antineoplastic activity. Clove oils including eugenol have been claimed to have gentle local anesthetic and antiseptic activities and previously were commonly used in dentistry.
What is eugenol used for?
Eugenol, also called clove oil, is an aromatic oil extracted from cloves that is used widely as a flavoring for foods and teas and as an herbal oil used topically to treat toothache and more rarely to be taken orally to treat gastrointestinal and respiratory complaints.
Is eugenol still used in dentistry?
Eugenol is used as a dental filling or dental cement in dentistry. It is regularly used in dentistry if your decay is pretty deep or not far from the nerve or pulp chamber.
Is eugenol good for toothache?
Clove oil contains the active ingredient eugenol, which is a natural anesthetic. It helps numb and reduce pain to ease a toothache. Eugenol also has natural anti-inflammatory properties. It may reduce swelling and irritation in the affected area.
Can eugenol be used on gums?
Clove oil has long been applied directly to the gums to ease toothache. There is evidence that the eugenol in clove oil is effective at fighting several known oral bacteria. Medicines containing eugenol are widely used in dentistry.
Is eugenol toxic?
Eugenol is listed by the FDA as GRAS when consumed orally, in unburned form. It is nontoxic in food but toxic upon inhalation. High doses of eugenol may cause damage to the liver (Thompson et al., 1998).
How does eugenol reduce pain?
The analgesic effect of eugenol has been attributed to its capability for inhibiting the prostaglandins and other inflammatory mediators such as leukotrienes (Raghavenra et al., 2006 ▶).
What do dentists use to fill dry socket?
Your dentist or oral surgeon may pack the socket with medicated gel or paste and medicated dressings. These can provide relatively fast pain relief. The severity of your pain and other symptoms will determine whether you need dressing changes and how often or if you need other treatment.
How often can you use eugenol?
Apply the dose not more than four times daily or as directed by a dentist or physician. Children 2 to 12 years of age: should be supervised in the use of this product. Children under 2 years of age: use only under the advice of a dentist or physician.
Will dry socket heal itself?
Will a dry socket heal on its own? Yes, in most cases a dry socket will heal on its own. However, because most people experience moderate to severe dry socket pain, seeing your dentist for prompt treatment can help ease discomfort sooner.
How long does eugenol take to work?
The numbing effect is usually fully felt within five to 10 minutes. You can reapply the clove oil every two to three hours as needed. If you have more than one area of mouth pain after a dental procedure, you can add a few drops of clove oil to a teaspoon of coconut oil and swirl it in your mouth to coat it.
Is it safe to put clove oil on gums?
According to Medline Plus, clove oil is generally considered safe for adults. However, they do note that when applied to the gums, clove oil can cause damage to the gums and tooth pulp. They do not recommend using clove oil on children or infants.
What does cloves do to teeth?
Cloves contain a strong anaesthetic known as eugenol which similarly works as an antiseptic to fight bacteria that may cause infections. That is why cloves are so effective at fighting cavities and are often added to oral products such as toothpaste and mouthwash.
What is the paste they use for dry socket?
DESCRIPTION. Dry Socket Paste is formulated relieve the symptoms of alveolar osteitis ("dry socket syndrome"). Dry Socket Paste contains 4% guaicol and 4% eugenol in a petrolatum base.
Is zinc oxide eugenol safe?
It is considered non-carcinogenic and non-mutagenic and is generally recognised as safe by the Food and Drug Administration.
How do I use eugenol for toothache?
Moisten a cotton pellet with 1 or 2 drops of medication and using the tweezer, place in the cavity for approximately 1 minute. Avoid touching tissues other than the tooth cavity . Apply the dose not more than four times daily or as directed by a dentist or physician.
Does Cavit contain eugenol?
Cavit is a self-curing temporary restorative material. Itdoes not contain eugenol and is used for temporary restorations, as it can be easily removed in one go. Being Eugenol-free, it does not prevent the polymerisation of other resin-based dental materials or resin-modified glass ionomers.
What is the chemical name for eugenol?
It has a corrosive chemical structure and has a wide range of medicinal properties to treat diseases. The scientific name of the chemical compound is 4-allyl-2-methoxyphenyl.
Why is Eugenol used in perfumes?
The spectrum of properties of the Eugenol also helps to tackle lifestyle-related diseases. Due to the spicy scent, the compound is used in perfumes. A few mosquito repellent creams use this ingredient to repel insects, whereas several researchers use this compound to attract insects for their research studies.
What is the chemical compound in clove oil?
The chemical compound is a pale-yellow liquid and exhibits the antiseptic and antioxidant properties. In no small measure, the reduced phenylpropanoids is a significant ingredient in the clove oil. Eugenol compound is a homologous series which is found in sweet basil, lemon balm, nutmeg and cinnamon.
What is the refractive index of eugenol?
The refractive index of the compound is nD20 1.538~1.542, and as soon as it gets in contact with the air, it tends to darken. Eugenol must be stored under 25 degrees Celsius and must not have any contact with light. The chemical compound has the chemical properties to turn the red litmus paper into the blue.
What is the melting point of eugenol?
It can also be dissolved in ether, chloroform and alcohol. The melting point of Eugenol is -9.2 degrees Celsius , and the boiling point is 225 degrees Celsius.
Is eugenol a chemical?
Thus, the substance is well-known as aromatic photochemical. The phenolic compound is a very weak acid and is represented as C10H12O2. The chemical compound is a pale-yellow liquid and exhibits the antiseptic and antioxidant properties. In no small measure, the reduced phenylpropanoids is a significant ingredient in the clove oil. Eugenol compound is a homologous series which is found in sweet basil, lemon balm, nutmeg and cinnamon.
Is eugenol a polar compound?
The chemical compound is water-soluble and has a massive polar surface area. Eugenol has three rotatable chemical bond counts and acts as per rule of five. It belongs to the kingdom of organic compounds, and its class is phenols.
What is eugenol used for?
It was first introduced in the 1890s. The use of eugenol can help to reduce burning sensation in patients when it is placed inside their teeth. The placement of a zinc oxide eugenol for several days prior to the placement of the final filling can help to sedate the pulp. It is quite popular as a dental cement due to several advantages, such as an intermediate restorative material and has anesthetic & antibacterial agents. It is also used as a temporary firing in dental caries treatment.
What is zinc oxide eugenol?
Zinc oxide eugenol (ZOE) is one of the most popular materials used in dentistry. Based on a study, it is a material created by the combination of zinc oxide, white rosin, zinc acetate, zinc stearate, and liquid matter, which is a mix of eugenol & olive oil.
Why use dental liners?
Dental liners and bases are used as an improvement in dental caries treatment along with other restorative dental procedures. The increasing number of these procedures cause a high need for new dental liners or bases material. According to PR Newswire, the high demand for dental liners or bases materials with a focus on antibacterial properties has occurred over the years. Zinc oxide eugenol has been used for years to manufacture dental liners and bases, as it is able to lock the microorganisms inside the decayed tooth. The use of zinc oxide eugenol for dental liners or bases has dominated the global market during 2016. However, it is still popular and is expected to continue the trend in the future.
What does a positive patch test for Eugenol mean?
In the cases reported here, the history of the lesions, their clinical relationship to eugenol containing dental material, coupled with the evidence of a positive patch test result would indicate that a genuine hypersensitivity reaction to eugenol was involved in the aetiology of the oral lesions.
How long does it take for eugenol to react?
In Case 1 the patient was exposed to eugenol and on two separate occasions showed a reaction that took 2–3 days to appear and resolved only after removal of the eugenol containing material. The reaction was typical in its presentation of a localised reaction confined to a small area, analogous to allergic contact dermatitis.
What is the best oil for toothache?
Oil of cloves (eugenol in its unrefined form) has been a popular remedy for toothache for over a century. Chisholm 4 in 1873 described its mixture with zinc oxide to form a plastic mass and its therapeutic uses. It has sedative and anodyne effects 5 as well as antibacterial properties. 6 Eugenol is found as a major ingredient in a variety of dental materials such as impression materials, filling materials, dental cements, endodontic sealers, periodontal dressing materials and dry socket dressings.
Is eugenol a biofriendly material?
Eugenol is a material commonly used in dentistry with few reported side effects. It is not however, a bio-friendly material when in contact with oral soft tissues. It can produce both local irritative and cytotoxic effects, as well as hypersensitivity reactions. Here we report on two cases of adverse local reaction to eugenol, ...
Is Eugenol cytotoxic or irritant?
Case 2 probably displays a mixture of eugenol's allergic, irritant, and cytotoxic effects. Eugenol in high enough concentrations to be cytotoxic may explain the direct tissue damage and necrosis (as evident circumferentialy around the gingival col). The more widespread inflammation of the lip may have been allergic in nature.
Is Eugenol a contact allergen?
In the 1960s eugenol was a common constituent of dressings used after periodontal surgery. As eugenol was a well known contact allergen in dermatology, investigation soon centred on its ability to sensitise patients after dental use.
Can Eugenol cause an allergic reaction?
Rarely, eugenol when placed in the mouth, can cause a more significant generalised allergic response. 12 One particularly sensitive patient is reported to have developed anaphylactic-like shock subsequent to a pulpotomy in which zinc-oxide and eugenol cement was used. 22.
What is Eugenol oil?
It is a colorless to pale yellow, aromatic oily liquid extracted from certain essential oils especially from clove oil, nutmeg, cinnamon, basil and bay leaf. It is present in concentrations of 80–90% in clove bud oil and at 82–88% in clove leaf oil. Eugenol has a pleasant, spicy, clove -like scent.
How is eugenol made?
The biosynthesis of eugenol begins with the amino acid tyrosine. L -tyrosine is converted to p -coumaric acid by the enzyme tyrosine ammonia lyase (TAL). From here, p -coumaric acid is converted to caffeic acid by p -coumarate 3-hydroxylase using oxygen and NADPH. S -Adenosyl methionine (SAM) is then used to methylate caffeic acid, forming ferulic acid, which is in turn converted to feruloyl- CoA by the enzyme 4-hydroxycinnamoyl-CoA ligase (4CL). Next, feruloyl-CoA is reduced to coniferaldehyde by cinnamoyl-CoA reductase (CCR). Coniferaldeyhyde is then further reduced to coniferyl alcohol by cinnamyl-alcohol dehydrogenase (CAD) or sinapyl-alcohol dehydrogenase (SAD). Coniferyl alcohol is then converted to an ester in the presence of the substrate CH 3 COSCoA, forming coniferyl acetate. Finally, coniferyl acetate is converted to eugenol via the enzyme eugenol synthase 1 and the use of NADPH.
How is coniferyl alcohol converted to eugenol?
Finally, coniferyl acetate is converted to eugenol via the enzyme eugenol synthase 1 and the use of NADPH. Biosynthesis of eugenol.
How long does it take for eugenol to be excreted?
In humans, complete excretion occurs within 24 hour and metabolites are mostly conjugates of eugenol.
What is the biosynthesis of eugenol?
Biosynthesis. The biosynthesis of eugenol begins with the amino acid tyrosine. L -tyrosine is converted to p -coumaric acid by the enzyme tyrosine ammonia lyase (TAL). From here, p -coumaric acid is converted to caffeic acid by p -coumarate 3-hydroxylase using oxygen and NADPH.
What is Eugenol Zinc Oxide paste used for?
Eugenol-zinc oxide paste is also used for root canal sealing. It is one of many compounds that is attractive to males of various species of orchid bees, which apparently gather the chemical to synthesize pheromones; it is commonly used as bait to attract and collect these bees for study.
Is Eugenol a balsam?
Eugenol is a component of balsam of Peru, to which some people are allergic. When eugenol is used in dental preparations such as surgical pastes, dental packing, and dental cement, it may cause contact stomatitis and allergic cheilitis. The allergy can be discovered via a patch test.
What is eugenol used for?
Eugenol (ue gen’ ol) is the major constituent [70% to 90%] in the aromatic oil extract from cloves (Syzygium aromaticum), a spice widely used as a flavoring for meats, stews, cakes and teas. Eugenol is also found in lower concentrations in cinnamon and other aromatic spices. The clove is native to the Moluccas, a chain of small islands that are now part of Indonesia and were formerly known as the Spice Islands. Cloves are now grown in several tropical regions and the spice sold as intact flower buds or as a ground powder. Eugenol is the most abundant ingredient in clove oil and is thought to be responsible for its aromatic as well as both beneficial and harmful effects. In vitro, eugenol has been shown to have antibacterial, antifungal, antioxidant and antineoplastic activity. Clove oils including eugenol have been claimed to have gentle local anesthetic and antiseptic activities and previously were commonly used in dentistry. Eugenol and clove extracts have also been purposed to be beneficial for gastrointestinal complaints such as nausea, diarrhea, abdominal pain and for cough, phlegm and chest congestion (as an expectorant). However, there are no convincing data to support the efficacy for any of these conditions, and neither eugenol or other clove extracts have been approved for use in any medical condition in the United States. Nevertheless, clove extracts are found in many topical creams, lotions and bath oils and occasionally in toothpaste for its possible effect in alleviating toothache or painful gums and in electronic cigarette refills. Vials of clove oil are available in health food and ethnic grocery stores and on the internet. Clove oil is advertised as having powerful antioxidant benefits and being useful for toothache, cleaning teeth and freshening of the breath. Clove cigarettes consisting of 60% to 70% tobacco and 30% to 40% cloves were imported from Indonesia and became popular in the United States in the early 1980’s when they were ultimately linked to a dozen cases of severe lung injury and banned from sale in many states. In addition, eugenol in higher doses has been used as an “organic” insecticide in households and gardens. Thus, eugenol used in low doses appears to have few side effects other than local irritation, rare allergic reactions and contact dermatitis, while exposure or ingestion of a large amounts, as in overdose, can result in tissue injury and a syndrome of acute onset of seizures, coma and damage to the liver and kidneys.
Is Eugenol a cytotoxic insecticide?
In high concentrations, eugenol has cytotoxic activity both in vitro and in vivo, characteristics [along with its aromatic qualities] that support its use as an insecticide. Thus, liver injury from eugenol is likely direct hepatotoxicity.
Is eugenol good for liver?
Eugenol in therapeutic doses has not been implicated in causing serum enzyme elevations or clinically apparent liver injury, but ingestions of high doses, as with an overdose, can cause severe liver injury.
Does eugenol cause liver damage?
The acute liver injury of eugenol overdose presents clinically with acute hepatic necrosis, a pattern similar to that of acetaminophen hepatotoxicity. For these reasons, N-acetyl cysteamine has been used to treat patients with eugenol or clove oil overdose. While not proven to be effective for eugenol overdose in humans, it has been shown to be effective in preventing hepatic injury in animal models. Also important in management is careful attention to details of medical management including prevention of hypoglycemia and maintenance of electrolyte balance and respiratory support. If patients present early, use of activated charcoal or emetics may be useful.
