How do you factor 2A 10?
Factor the expression by grouping. First, the expression needs to be rewritten as 2a^{2}+pa+qa-18. To find p and q, set up a system to be solved.
How do you factor 2A plus 8B?
The factorization fom of (4a 2 - 4ab + b 2 +16a - 8b +15) is (2a - b) 2 +(16a - 8b +15). ... How do you factor x cubed plus 14x squared plus 85x. asked Feb 22, ...
What is 2A plus 2B in factored form?
With form 2B, both parties (the GST department personnel) & the assessee themselves can tally the in/outputs of ITC of forms 1, 2A & 3B. With the auto-population facility, both monthly & quarterly based filing will ensue from the start of the next calendar & financial year, respectively.
How to simplify 2A?
2a = a + a 2. Now, let's add the two terms: 6a +2a = a + a + a +a +a +a 6 +a +a 2 8
What is factor 2a called?
Thrombin (EC 3.4. 21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
Is Factor 2 deficiency rare?
Factor II deficiency is a rare, inherited or acquired bleeding disorder with an estimated incidence of one case per 2 million population. Accordingly, they usually have either little normal prothrombin or a near-normal output of dysfunctional prothrombin.
How common is factor 2 mutation?
A change in the prothrombin gene is present in 2-4% (or 1 in 50 to 1 in 25) of Caucasians, and is more common in individuals of European ancestry. In the United States, approximately 0.4% (about 1 in 250) of African Americans also have the mutation. Prothrombin G20210A mutation is rare in other groups.
Does Factor 2 cause blood clots?
Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE).
Is factor 2 a bleeding disorder?
Factor II (2) or prothrombin deficiency is an inherited bleeding disorder caused when a person's body does not produce as much of a protein in the blood (factor II) that helps blood clot as it needs to or the factor II doesn't work properly.
What causes factor 2 blood disorder?
Prothrombin deficiency is a disorder caused by a lack of a protein in the blood called prothrombin. It leads to problems with blood clotting (coagulation). Prothrombin is also known as factor II (factor two). Blood clotting normally occurs when there is damage to a blood vessel.
How many people in the world have factor 2?
The incidence is estimated at 1 in 2 million in the general population.
What is worse Factor 2 or Factor 5?
The Factor V variant known as Factor V Leiden (or rs6025) is associated with an approximately 300% increased risk in heterozygotes and an up to 8000% increased risk in homozygotes. The Factor II rs1799963 polymorphism (or G20210A) may also independently increase the risk by approximately 200%.
How is factor 2 diagnosed?
Diagnosis of factor II deficiency is based on your medical history, any family history of bleeding problems, and lab tests. Lab tests for bleeding disorders include: Factor assays: These tests check the performance of specific factors to identify missing or poorly performing factors.
What Is factor II activity?
Definition. The factor II assay is a blood test to measure the activity of factor II. Factor II is also known as prothrombin. This is one of the proteins in the body that helps the blood clot.
What is factor 2 in coagulation pathway?
Factor IIa (thrombin) goes on to activate fibrinogen into fibrin. Thrombin also goes on to activate other factors in the intrinsic pathway (factor XI) as well as cofactors V and VIII and factor XIII. Fibrin subunits come together to form fibrin strands, and factor XIII acts on fibrin strands to form a fibrin mesh.
How serious is prothrombin gene mutation?
Having the prothrombin mutation increases the risk of developing a DVT (a blood clot in the deep veins, typically the legs) and/or PE (blood clot that travels to the lungs). DVTs are dangerous because they can damage the veins, leading to pain and swelling, and sometimes to disability.
History
After the description of fibrinogen and fibrin, Alexander Schmidt hypothesised the existence of an enzyme that converts fibrinogen into fibrin in 1872.
Physiology
Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex.
Structure
Anchoring of bovine prothrombin to the membrane through its Gla domain.
Gene
The thrombin (prothrombin) gene is located on the eleventh chromosome (11p11-q12).
Role in disease
Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin have been described (e.g., hypoprothrombinemia ). Anti-prothrombin antibodies in autoimmune disease may be a factor in the formation of the lupus anticoagulant (also known as antiphospholipid syndrome ).
Applications
Due to its high proteolytic specificity, thrombin is a valuable biochemical tool. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is commonly included in linker regions of recombinant fusion protein constructs.
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human Thrombin.
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