What is the chemical equation for the synthesis of aspirin?
What Is the Chemical Equation for the Synthesis of Aspirin? The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. The byproduct is acetic acid.
What chemicals are found in aspirin?
- The inactive ingredients in Aspirin are carnauba wax, corn starch and hypromellose.
- hypromellose or Hydroxypropyl methylcellulose is a polymer.
- Corn starch is actually many different compounds. 25% amylase and 75% amylopectin
What are some chemical properties of aspirin?
Chemical properties. Aspirin decomposes rapidly in solutions of ammonium acetate or the acetates, carbonates, citrates, or hydroxides of the alkali metals. It is stable in dry air, but gradually hydrolyses in contact with moisture to acetic and salicylic acids. In solution with alkalis, the hydrolysis proceeds rapidly and the clear solutions ...
What is the structural formula of aspirin?
Structural-formula meaning A chemical formula that shows how the atoms making up a compound are arranged within the molecule. For example, the structural formula of aspirin is CH3 COOC6 H4 COOH, indicating that it consists of an acetyl group (CH3 COO) attached to the carboxylic acid (COOH) of a phenyl group (C6 H4 ).
What is aspirin official name?
What is aspirin? Aspirin (acetylsalicylic acid) is a pharmaceutical drug used to reduce pain1,2 or inflammation. 3 It is classified as a non-steroidal anti-inflammatory drug (NSAID).
What is the chemical name of aspirin What is it used for?
Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects.
Which of the following is chemical form of aspirin?
Acetylsalicylic AcidThe chemical name of Aspirin is Acetylsalicylic Acid (ASA).
What class of drug is aspirin?
Aspirin, an acetylated salicylate (acetylsalicylic acid), is classified among the nonsteroidal antiinflammatory drugs (NSAIDs).
What is the difference between aspirin and acetylsalicylic acid?
Acetylsalicylic acid (ASA), also known as aspirin, acts by irreversibly inhibiting the platelet cyclooxygenase (COX) enzyme, resulting in inhibition of platelet thromboxane A2 (TXA-2) synthesis.
What ingredients are in aspirin?
Carnauba Wax, Corn Starch, D&C Yellow #10 Aluminum Lake, FD&C Yellow #6 Aluminum Lake, Ferric Oxide, Hypromellose, Methacrylic Acid And Ethyl Acrylate Copolymer, Polysorbate 80, Potassium Hydroxide, Powdered Cellulose, Propylene Glycol, Shellac, Sodium Lauryl Sulfate, Triacetin, Triethyl Citrate.
Is aspirin an acid or base?
acidicAspirin itself is an acidic medicine and causes gastric irritation and regurgitation which can lead to low oral pH levels [7].
Does aspirin work ASA blood thinner?
It can help prevent a heart attack or clot-related stroke by interfering with how the blood clots. But the same properties that make aspirin work as a blood thinner to stop it from clotting may also cause unwanted side effects, including bleeding into the brain or stomach.
Who should not take aspirin?
have ever had an allergy to aspirin or similar painkillers such as ibuprofen. have ever had a stomach ulcer. have recently had a stroke (although depending on the kind of stroke you've had, your doctor may recommend that you take low-dose aspirin to prevent another one)
Is aspirin the same as ibuprofen?
Aspirin and ibuprofen contain different active ingredients — whereas aspirin is made with salicylic acid, ibuprofen is made with propionic acid. However, both aspirin and ibuprofen can be used to treat pain caused by inflammation or injury, headaches, fevers, arthritis, and menstrual cramps.
Is aspirin a blood thinner Yes or no?
A: Aspirin is a type of blood thinner called an antiplatelet. Antiplatelets reduce your blood cells' ability to clump together to form a clot. If you have heart disease, you're probably familiar with taking a low dose of aspirin to help prevent heart attack.
Q.1. What is the chemical formula for Aspirin?
Ans: The chemical formula of Aspirin is C9H8O4 It is a non-steroidal anti-inflammatory drug and is non-addictive used to relieve pain and fever.
Q.2. Are Ecosprin –75 and Aspirin the same?
Ans: Yes, Ecosprin –75 and Aspirin are the same as Ecosprin –75 contains Aspirin as an active ingredient. Each tablet of Ecosprin –75 contains 75 m...
Q.3. What is the other name of Aspirin?
Ans: Another common name of Aspirin is Acetylsalicylic acid. Its IUPAC name is 2– Acetoxybenzoic acid.
Q.4. Why is Aspirin banned?
Ans: In many countries, Aspirin is banned due to its severe side effects. In children and adolescents, Aspirin may cause Reye’s syndrome – a condit...
Q.5. Is the synthesis of Aspirin reversible?
Ans: Yes, the synthesis of Aspirin is reversible because it is stable in dry air but gets hydrolysed to acetic acid and salicylic acid on coming in...
Q.6. What is Aspirin used for?
Ans: Aspirin is a Non-Steroidal Anti-Inflammatory Drug (NSAID). This drug has many uses like It helps relieve pain and swelling and treat various c...
What is the formula for aspirin?
It belongs to a group of drugs known as ‘salicylates’. Aspirin is chemically known as acetylsalicylic acid, which reduces pain, fever, or inflammation. The chemical formula of Aspirin is C 9 H 8 O 4.
When was aspirin first discovered?
The discovery of Aspirin may be traced back over 3500 years when willow tree bark was utilised to treat pain and as an antipyretic. In 1897, Felix Hoffman, a German scientist working for Bayer, developed Aspirin by accident when he accidentally acetylated salicylic acid to produce acetylsalicylic acid. Aspirin is one of the most widely used medications on the planet. Its significance in preventing cardiovascular and cerebrovascular illness has resulted in one of the most significant therapeutic breakthroughs in the previous century.
How is aspirin synthesised?
As we know that Aspirin is also known as Acetylsalicylic acid, this compound can be synthesised by the action of salicylic acid on acetic anhydride through an esterification reaction. In this chemical reaction, when salicylic acid reacts with acetic anhydride (an acid derivative), the hydroxyl group of salicylic acid turns into an ester group.
What is the effect of aspirin on protaglandin production?
Aspirin or Acetylsalicylic Acid is a well-known anti-inflammatory drug as it causes suppression of Prostaglandin production by inhibiting the action of the enzyme cyclooxygenase.
What does aspirin smell like?
As a result, it smells like vinegar . Aspirin emerged as a beneficial drug in the medical field as it gets absorbed quickly in the bloodstream and provides rapid relief from pain and inflammation. It may be used as a primary treatment for heart attack. Though Aspirin is very useful, it has many serious side effects such as hallucinations, nausea, long-lasting pain, stomach aches, and if taken in higher doses for the long term, it may affect the liver and nervous system. Due to so many adverse side effects, it was widely replaced by other drugs like Paracetamol, Ibuprofen, etc.
What was the first non-steroidal anti-inflammatory drug?
Aspirin is the first Non-Steroidal Anti-Inflammatory Drug (NSAID) that was discovered. This drug has many uses listed below:
Is aspirin a carboxylic acid?
Aspirin has both ester and carboxylic acid functional groups. It is an acetyl derivative of salicylic acid. Hence, commonly known as Acetylsalicylic acid. The chemical structure of Aspirin is given below:
When was aspirin invented?
In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world.
How much aspirin is in a bottle?
The usage guidance label on a bottle of aspirin indicates that the dosage is "325 mg (5 gr)". Adult aspirin tablets are produced in standardised sizes, which vary slightly from country to country, for example 300 mg in Britain and 325 mg (or 5 grains) in the United States.
Why does aspirin smell like vinegar?
Formulations containing high concentrations of aspirin often smell like vinegar because aspirin can decompose through hydrolysis in moist conditions, yielding salicylic and acetic acids.
How is aspirin absorbed?
Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionized. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.
How long does aspirin last?
Aspirin is a first-line treatment for the fever and joint-pain symptoms of acute rheumatic fever. The therapy often lasts for one to two weeks, and is rarely indicated for longer periods. After fever and pain have subsided, the aspirin is no longer necessary, since it does not decrease the incidence of heart complications and residual rheumatic heart disease. Naproxen has been shown to be as effective as aspirin and less toxic, but due to the limited clinical experience, naproxen is recommended only as a second-line treatment.
How long does it take for aspirin to work?
For pain or fever, effects typically begin within 30 minutes. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and works similarly to other NSAIDs but also suppresses the normal functioning of platelets.
What is the melting point of aspirin?
Physical properties. Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 136 °C (277 °F), and a boiling point of 140 °C (284 °F). Its acid dissociation constant ( p Ka) is 3.5 at 25 °C (77 °F).
How is aspirin made?
Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder. Aspirin is an oral non-steroidal anti-inflammatory drug (NSAID) that is rapidly absorbed from the stomach and ...
How long does it take for aspirin to excrete?
It takes about 48 hours to excrete an aspirin completely. The half-life of aspirin in the blood stream is 13-19 minutes and the half-life of its metabolite salicylate is around 3.5-4.5 hours. Aspirin’s inhibition of COX-1 results in reduced platelet aggregation for the 7-10-day average lifespan of platelets 1.
Does aspirin help with myocardial infarction?
In this way aspirin can help lower the risk of future myocardial infarction ( MI) or stroke 1,3. Aspirin, therefore, has an analgesic (reduces pain), anti-inflammatory (reduces redness and swelling), anti-platelet (reduces blood clots) and antipyretic (temperature reduction) effects 1,2,3. In cancer, aspirin is believed to impact a number ...
Does aspirin help with thrombus formation?
This aspirin effect is mediated via COX-1 inhibition within platelets and helps stop the platelets from sticking to each other or to plaques within the artery therefore reducing the risk of blood clot (thrombus) formation within the blood stream. In this way aspirin can help lower the risk of future myocardial infarction (MI) or stroke 1,3.
Does aspirin cause inflammation?
This in turn mediates aspirin’s effect of reduced inflammation and pain in affected tissues.
Does aspirin affect cancer?
In cancer, aspirin is believed to impact a number of cancer signalling pathways and may induce or upregulate cancer suppressor genes 3.
Can children take aspirin?
Aspirin should not be used in children as it can produce a rare but dangerous Reye’s syndrome resulting in coma and liver damage that can prove fatal 1,3.
When was aspirin first used?
It is a very popular medicine and is available all over the world in large quantities. In the year of 1897 , Bayer laboratory gave Acetylsalicylic Acid the name of Aspirin. Ever since the naming, the commercialization of it began. This medicine is most commonly used as an anti-inflammatory and antipyretic.
What does aspirin smell like?
Answer – The correct answer is option A. Aspirin smells like Vinegar.
How to synthesize acetylsalicylic acid?
One can easily synthesize Acetylsalicylic Acid through the esterification of salicylic acid by the acetic anhydride. Therefore, the ester group replaces the hydroxyl group which is present in the salicylic acid. Similarly, one can catalyze the reaction by sulfuric acid.
Why does aspirin smell like vinegar?
It has a smell similar to that of vinegar. This smell is because of the hydrolysis yielding salicylic and acetic acid of Acetylsalicylic Acid. The taste of Aspirin is bitter. Similarly, the density of it is 1.40 g mL-1. The melting point of Acetylsalicylic Acid is 135 ºC. Thus, if kept in higher temperatures, it will decompose.
What is the name of the drug that is used to treat inflammatory diseases?
Aspirin Formula. Aspirin is essentially a medication that people use broadly all over the world. The chemical name of Aspirin is Acetylsalicylic Acid (ASA). It remains to be one of the oldest and most used forms of the drug that has common usage as an anti-inflammatory and antipyretic medication. We will further discuss about ...
Why is acetylsalicylic acid used as an anti-inflammatory?
Acetylsalicylic Acid is generally known by the ability of it being an anti-inflammatory drug. The mechanism of action is because it inhibits enzyme cyclooxygenase. Therefore, it causes suppression of Prostaglandin production (prostaglandins are molecules that are present in the process of inflammation).
What is the melting point of acetylsalicylic acid?
The melting point of Acetylsalicylic Acid is 135 ºC. Thus, if kept in higher temperatures, it will decompose. Acetylsalicylic Acid is also soluble in water, ethyl ether, ethanol, and chloroform.
What is the main component of aspirin?
The major component of aspirin is acetylsalicylic acid which gives it all these properties. This is the reason aspirin is also known as acetylsalicylic acid. Its molecular formula is C9H8O4.
What is the summary of aspirin?
Aspirin: Summary in Tabular Form. Acetylsalicylic acid, aspirin, acetylsalicylate. By the reaction of salicylic acid and acetic anhydride in the presence of sulfuric acid/ phosphoric acid as catalyst. Causes side effects like nausea, muscle cramps, bloating. This ends our coverage on the topic “Acetylsalicylic acid”.
What happens when salicylic acid reacts with acetic anhydride?
In this reaction, when salicylic acid reacts with acetic anhydride, the hydroxyl group of salicylic acid converts into an ester group. This results into aspirin and acetic acid. Sulfuric acid or phosphoric acid act as catalysts. Reaction is given below.
What is acetylsalicylic acid used for?
Acetylsalicylic acid is mainly used in the medical field. Few of its medical uses are listed below –. It is an analgesic and used to get relief from acute pain. It is highly effective against muscle pain, bloating, skin irritation, gastric distension. It is also used for the treatment of migraine.
How much aspirin dissolves in water?
It's soluble in water. 3g of aspirin can dissolve in 1 liter of water.
Who made acetylsalicylic acid?
Acetylsalicylic acid was first produced by Alsatian Chemist Charles Frederic Gerhardt in 1853 from sodium salicylate and acetyl chloride. Soon the drug became famous and Bayer (a drug and dye firm) started producing it at large scale. Bayer named it Aspirin. It was Bayer’s brand name for the drug.
Is aspirin a NSAID?
Aspirin is NSAID ( Nonsteroidal anti-inflammatory drug) but it suppresses the normal functioning of platelets. It is not recommended during pregnancy and to children with infections. It has various side effects as well such as high dose may result in the ringing of ears, Reye syndrome, nausea, upset stomach, headache etc.
Overview
Adverse effects
In October 2020, the US Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid. They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy. One exception to the recommendation is the use of low-dose 81 mg aspirin at any point in pregnancy under the direction of a health care professional.
Brand vs. generic name
In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world.
Aspirin's popularity grew over the first half of the 20th century, leading to competition between many brands and formulations. The word Aspirin was Bayer's brand name; however, their rights t…
Chemical properties
Aspirin decomposes rapidly in solutions of ammonium acetate or the acetates, carbonates, citrates, or hydroxides of the alkali metals. It is stable in dry air, but gradually hydrolyses in contact with moisture to acetic and salicylic acids. In solution with alkalis, the hydrolysis proceeds rapidly and the clear solutions formed may consist entirely of acetate and salicylate.
Physical properties
Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 136 °C (277 °F), and a boiling point of 140 °C (284 °F). Its acid dissociation constant (pKa) is 3.5 at 25 °C (77 °F).
Polymorphism, or the ability of a substance to form more than one crystal structure, is important in the development of pharmaceutical ingredients. Many drugs receive regulatory approval for o…
Mechanism of action
In 1971, British pharmacologist John Robert Vane, then employed by the Royal College of Surgeons in London, showed aspirin suppressed the production of prostaglandins and thromboxanes. For this discovery he was awarded the 1982 Nobel Prize in Physiology or Medicine, jointly with Sune Bergström and Bengt Ingemar Samuelsson.
Aspirin's ability to suppress the production of prostaglandins and thromboxanes is due to its irre…
Pharmacokinetics
Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionized. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations …
History
Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. Hippocrates referred to the use of salicylic tea to reduce fevers around 400 BC, and willow bark preparations were part of the pharmacopoeia of Western medicine in classical antiquity and the Middle Ages. Willow bark extract becam…