WinRho SDF contains approximately 5 mcg/ml of IgA, Rhophylac has less than 5 mcg/ml of IgA, and RhoGAM and MICRhoGAM typically contain less than 15 mcg per dose. The benefits of Rh0 [D] immune globulin must be carefully weighed against the potential risk of severe hypersensitivity reactions.
Full Answer
What is the difference between Rh0[D] immune globulin and Rhophylac?
WinRho SDF contains approximately 5 mcg/ml of IgA, Rhophylac has less than 5 mcg/ml of IgA, and RhoGAM and MICRhoGAM typically contain less than 15 mcg per dose. The benefits of Rh0 [D] immune globulin must be carefully weighed against the potential risk of severe hypersensitivity reactions.
What are the uses of Rhophylac?
Rhophylac may also be used in the treatment of immune thrombocytopenic purpura (ITP). Rhophylac may also be used for purposes not listed in this medication guide. You should not receive Rhophylac if you have immune globulin A (IgA) deficiency with antibody to IgA, or if you have hemolytic anemia (a lack of red blood cells).
What are the contraindications for the use of Rhophylac?
Rhophylac is contraindicated in individuals with known anaphylactic or severe systemic reaction to human immune globulin products, and in IgA-deficient patients with antibodies to IgA and a history of hypersensitivity to Rhophylac or any of its components.
Do you give RhoGAM IV or WinRho?
I especially like the IV part after once issuing 5 vials of Rhogam for a large fetal maternal bleed. I felt bad for that brand new mom and all the injections she was about to get. We also have an agreement with the pharmacy for ITP patients. We give the first dose using Rhophylac and they order in WinRho for future dosing.
Why did Ortho switch to Rhophylac?
Is rhophylac cheaper than rhogam?
How much less is CSL than Rhogam?
Do doctors order name brand drugs?
What is rhophylac injection used for?
Rhophylac is indicated to raise platelet counts in Rh (D)-positive, non-splenectomized adult patients with chronic immune thrombocytopenic purpura (ITP). For the treatment of ITP, Rhophylac must be administered IV.
What is another name for RhoGAM injection?
RhoGAM (rhod immune globulin human) is a sterilized solution made from human blood used to prevent an immune response to Rh positive blood in people with an Rh negative blood type.
What is the generic name of RhoGAM?
Rho(D) Immune Globulin is available under the following different brand names: RhoGAM, Gamulin Rh, HypRho D, MicRhoGAM, Rhesonativ, HyperRHO, Rhophylac, WinRho SDF.
Is RhoGAM the same as Rho D immune globulin?
A single dose of RhoGAM (rhod immune globulin human) contains sufficient anti-D (approximately 300 μg or 1500 IU)* to suppress the immune response to 15 mL (or less) of Rh-positive red blood cells.
How many times do you get the RhoGAM shot?
For a first pregnancy, RhoGAM is typically injected at about 28 weeks and then again within 72 hours post-delivery. For any subsequent pregnancies, RhoGAM is administered regularly during the second half of the pregnancy.
How many doses of RhoGAM is needed by the mother?
Your doctor will administer at least one dose of RhoGAM Ultra-Filtered PLUS between 26 and 28 weeks of pregnancy. If your baby is found to be Rh-positive at birth, you will receive an additional dose within 72 hours after delivery. Your doctor will determine the appropriate dose of RhoGAM after delivery.
What blood type are you if you need RhoGAM shot?
You should get a RhoGAM shot within 72 hours of the possible exposure to Rh-positive blood for the shot to work best. How safe is RhoGAM? RhoGAM is very safe. It is recommended for all pregnant women with Rh-negative blood type and has been used for about 50 years.
Do all Rh-negative moms get RhoGAM?
Key takeaways: People who are Rh-negative should have a RhoGAM shot during their pregnancy. RhoGAM is effective in preventing Rh isoimmunization, a reaction that can cause harm to an unborn baby.
How long does a shot of RhoGAM last?
RhoGAM is effective for about 13 weeks.
Why is Rho D immune globulin given?
Rho(D) immune globulin is used to treat immune thrombocytopenic purpura (ITP) in patients with Rh-positive blood. ITP is a type of blood disorder where the person has a very low number of platelets.
What is Rho D immune globulin used for in pregnancy?
Rho(D) immune globulin is also used to prevent antibodies from forming after a person with Rh-negative blood receives a transfusion with Rh-positive blood, or during pregnancy when a mother has Rh-negative blood and the baby is Rh-positive. It belongs to a group of medicines called immunizing agents.
When should Rh immune globulin be given?
When is RhIG given? RhIG is given when: you're 26 to 28 weeks pregnant, and when you deliver if your baby is Rh positive. you have certain tests, treatments, or procedures (such as amniocentesis or chorionic villous sampling) during your pregnancy.
What type of vaccine is RhoGAM?
What exactly is the RhoGAM shot? RhoGAM is a brand of Rh immune globulin that's given as an injection. Like all immunoglobulins, RhoGAM is an antibody. And like all immunoglobulins, RhoGAM works by neutralizing something that can cause harm to our bodies, in this case, anti-D antibodies.
Which injection is given Rh-negative mother?
Special immune globulins, called RhoGAM, are now used to prevent RH incompatibility in mothers who are Rh-negative. If the father of the infant is Rh-positive or if his blood type is not known, the mother is given an injection of RhoGAM during the second trimester.
What type of injection is RhoGAM?
RhoGAM is a sterilized solution made from human blood that contains a very small amount of Rh-positive proteins. These proteins keep your immune system from making permanent antibodies to Rh-positive blood. They do not hurt your baby. RhoGAM is given as an injection (shot).
What is another name for the Rh factor?
Rh factor, also called Rhesus factor, is a type of protein found on the outside of red blood cells. The protein is genetically inherited (passed down from your parents). If you have the protein, you are Rh-positive. If you did not inherit the protein, you are Rh-negative.
Rhophylac vs. Rhogam - Page 2 - Transfusion Services - PathLabTalk
One word of caution with the IV administration of Rhophylac. I think I read on this site that there have been some problems with the multiple doses of Rhophylac given too quickly and too close together by the IV route causing some "transfusion reaction like" problems and that the product insert had to be modified to address the problem and slow the administration rates down.
Rhophylac vs WinRho SDF Comparison - Drugs.com
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 12 Oct 2022), Cerner Multum™ (updated 21 Sep 2022), ASHP (updated 12 Oct 2022 ...
What is a RhoGAM Shot and Why Is It Given During Pregnancy?
Did your initial round of prenatal bloodwork reveal that you’re Rh negative? That could mean that you and your baby are Rh incompatible. In that case, your doctor may suggest a shot of Rh immunoglobulin — commonly known in the U.S. by the brand name RhoGAM — during pregnancy and after delivery if you have an Rh positive baby.
Rhophylac | FDA - U.S. Food and Drug Administration
Routine antepartum and postpartum prevention of Rho(D) immunization in Rho(D)-negative women, for Rhesus prophylaxis in case of obstetric complications, for Rhesus prophylaxis in case of invasive ...
RhoGAM Uses, Side Effects & Warnings - Drugs.com
RhoGAM side effects. Get emergency medical help if you have any of these signs of an allergic reaction: rash or hives; feeling light-headed, chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat.. RhoGAM may cause serious side effects. Call your doctor at once if you have:
What is Rhophylac?
Rhophylac contains RHo (D) immune globulin. RHo (D) immune globulin is a sterilized solution made from human blood. Rh is a substance that most people have in their blood (Rh positive) but some people don't (Rh negative). A person who is Rh negative can be exposed to Rh positive blood through a mismatched blood transfusion or during pregnancy when the baby has the opposite blood type. When this exposure happens, the Rh negative blood will respond by making antibodies that will try to destroy the Rh positive blood cells. This can cause medical problems such as anemia (low red blood cells), kidney failure, or shock.
How is Rhophylac given?
Rhophylac is injected into a muscle or a vein. You will receive this injection in a clinic or hospital setting.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What other drugs will affect Rhophylac?
Other drugs may interact with Rhophylac, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
How to know if you have a kidney infection?
Call your doctor at once if you have: 1 fever, chills, shaking, back pain, unusual weakness, red or pink urine; 2 pale or yellowed skin, dark colored urine; 3 rapid breathing, rapid heart rate, confusion, feeling short of breath; 4 signs of kidney failure--little or no urinating, swelling, rapid weight gain; or 5 signs of a blood clot--sudden numbness or weakness, slurred speech, problems with vision or balance, chest pain, coughing up blood, swelling with redness and warmth in one or both legs.
When to give rhophylac?
For treatment of a mismatched blood transfusion, Rhophylac is given when symptoms of an immune response appear (when the body starts making Rh antibodies). To be sure this medicine is helping your condition, you may need frequent blood tests.
How to know if you are allergic to rhophylac?
Get emergency medical help if you have any of these signs of an allergic reaction to Rhophylac: rash or hives; feeling light-headed, chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat.
What is rhophylac used for?
About Rhophylac. Rhophylac is indicated for suppression of rhesus (Rh) isoimmunization in: Pre gnancy and obstetric conditions in non-sensitized, Rh o (D)-negative women with an Rh-incompatible pregnancy, including routine antepartum and postpartum Rh prophylaxis and Rh prophylaxis in cases of obstetric complications, ...
What are the side effects of Rhophylac?
Suppression of Rh Isoimmunization: The most common adverse reactions in the suppression of Rh isoimmunization with Rhophylac (≥0.5% of patients) are nausea, dizziness, headache, injection-site pain, and malaise.
How is rhophylac administered?
Rhophylac can be administered by intravenous (IV) or intramuscular (IM) injection. For treatment of ITP, Rhophylac must be administered intravenously. Rhophylac is made from human plasma collected from US donors using a patented manufacturing process called ChromaPlus ® .
Is rhophylac contraindicated?
Rhophylac is contraindicated in individuals with known anaphylactic or severe systemic reaction to human immune globulin products, and in IgA -deficient patients with anti bodies to IgA and a history of hypersensitivity to Rhophylac or any of its components. Do not administer Rhophylac to the newborn infant of a mother who received Rhophylac postpartum.
Does rhophylac raise platelet count?
Rhophylac is indicated to raise platelet counts in Rh (D)-positive, non-splenectomized adult patients with chronic immune thrombocytopenic purpura (ITP). For the treatment of ITP, Rhophylac must be administered IV.
Is Rhophylac a sterile solution?
Incompatible transfusions in Rh o (D)-negative individuals transfused with blood components containing Rh o (D)-positive red blood cells. Rhophylac is a sterile solution of anti-D, also known as Rh o (D) Immune Globulin or Rh factor, which protects against Rh-sensitization or alloimmunization. Rhophylac can be administered by intravenous (IV) ...
Is rhophylac derived from human plasma?
Rhophylac is derived from human plasma. The risk of transmission of infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent, cannot be completely eliminated.
How long to give anti-Rh0?
300 mcg (1500 international units) IM or IV within 72 hours of the event. Repeat this dose at 12 week intervals during the pregnancy to maintain sufficient levels of passively acquired anti-Rh0 [D] antibodies. A 120 mcg (600 international units) IM or IV dose should be given as soon as possible and preferably within 72 hours of delivery of a confirmed Rh0 [D]-positive infant. If Rh status of the infant is unknown at 72 hours or > 72 hours have passed, do not withhold the dose.
How much mcg for transplacental bleeding?
If excess transplacental bleeding is measured, give 20 mcg (100 international units) IV or IM for every ml of fetal red blood cells. If testing for the number of fetal red blood cells in the maternal circulation is not feasible and an excessive fetomaternal hemorrhage cannot be excluded, give an additional 300 mcg (1500 international units) IV or IM, which will suppress the immunizing potential of 15 ml of Rh0 [D] positive packed red blood cells. The total calculated dose should be administered as soon as possible and within 72 hours of the exposure.
What is rh0D?
Rh0 [D] immune globulin is is a immune globulin (IgG) rich in IgG antibodies. IgG is a normal component of breastmilk. Rh0 [D] immune globulin is frequently used in nursing mothers and no adverse effects have been reported in a breast-feeding infant. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. If a breast-feeding infant experiences an adverse effect related to a maternally administered drug, healthcare providers are encouraged to report the adverse effect to the FDA.
How long after delivery can you give Rh0?
300 mcg (1500 international units) IM at 28 weeks gestation. Repeat the 300 mcg (1500 international units) IM dose within 72 hours of delivery of a confirmed Rh0 [D]-positive infant. If Rh status of the infant is unknown at 72 hours or > 72 hours have passed, do not withhold the dose. A dose of Rh0 [D] immune globulin after delivery is not needed if delivery is within 3 weeks of the last dose and no fetomaternal hemorrhage of greater than 15 ml of RBC has occurred.
How soon can you give 120 mcg?
120 mcg (600 international units) IM or IV as soon as possible and within 72 hours of the event. A 120 mcg (600 international units) IM or IV dose should be given as soon as possible and preferably within 72 hours of delivery or a confirmed Rh0 [D]-positive infant. If Rh status of the infant is unknown at 72 hours or > 72 hours have passed, do not withhold the dose.
What color should rhophylac be?
The Rhophylac solution should be clear or slightly opalescent and colorless to pale yellow; do not use if the solution is cloudy, has deposits, or has been frozen. [52598]
How long does it take to give 50 mcg of a sulfate solution?
Give the dose within 3 hours of the spontaneous or surgical removal of aborted tissues, if possible, and within 72 hours of the exposure.
Why did Ortho switch to Rhophylac?
We switched to Rhophylac just recently. Our major reason was cost reduction . Ortho raised their prices , changed their pricing scheme and bowed out of all the purchasing groups which had the net effect of raising the cost even more. Oddly enough, our Pharmacy brought up the idea of a switch to reduce confusion and get the 30mcg dose out of the Pharmacy and into the blood bank (out of their hair). We have seen no real difference in the products other than what has already been mentioned.
Is rhophylac cheaper than rhogam?
We also use Rhophylac exclusively. It is much cheaper. The Ortho rep has told me that it is not as high quality as Rhogam, but as shelleyk482 says above, we haven't seen any clinical difference.
How much less is CSL than Rhogam?
CSL quoted me $1.25 less than Rhogam! The only advantage is IM or IV.
Do doctors order name brand drugs?
It could depend on what's on your hospital's formulary. Docs order name brand products/drugs all the time and the pharmacies routinely supply an equivalent drug/product based on the formulary list.