A comparison of timolol maleate and levobunolol. Length of use per 5-ml bottle There is a markedly greater length of use of the 5-ml bottle of timolol compared with the 5-ml bottle of levobunolol. The difference is believed to be due to the configuration of the levobunolol's bottle tip and the vehicle used to deliver the drug.
Is timolol maleate the same as betimol?
The study is based on timolol maleate and timolol (the active ingredients of Timolol maleate and Betimol, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
What is timolol maleate ophthalmic solution?
Dorzolamide hydrochloride and timolol maleate ophthalmic solution is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open -angle glaucoma or ocular hypertension who are insufficiently responsive to bet a-blockers (failed to achieve target IOP determined after multiple measurements over time).
Can timolol maleate and dorzolamide hydrochloride be given together?
If more than one topical ophthalmic drug is being used, the drugs should be administered at least five minutes apart. Advise patients that dorzolamide hydrochloride and timolol maleate ophthalmic solution contains benzalkonium chloride which may be absorbed by soft contact lenses.
How much timolol maleate do you give a patient?
Both the 0.25% and 0.5% concentrations were evaluated against similar concentrations of timolol maleate. Dosing was twice daily. An open-label, nine-month study followed the masked portion of the protocol, in which all patients received either 0.25% or 0.5% timolol hemihydrate.
What is another name for timolol maleate?
Timolol is available under the following different brand names: Blocadren and Timol.
What is timolol maleate used for?
Timolol eye drops is used alone or together with other medicines to treat increased pressure in the eye that is caused by open-angle glaucoma or a condition called ocular (eye) hypertension. This medicine is a beta-blocker.
What is timolol maleate generic for?
Timoptic and Xalatan are both brand-name drugs. There are currently generic forms of both medications. The generic form of Timoptic is called timolol. The generic form of Xalatan is called latanoprost.
Is timolol maleate still available?
The company discontinued timolol ophthalmic gel forming solution in September 2020.
What is the safest eye drop for glaucoma?
Next came apraclonidine, brand name Iopidine, marketed by Alcon. I did much of the clinical work on apraclonidine, a relatively selective alpha-2 agonist. It is probably the safest drug we have seen so far in the therapy of glaucoma.
Is timolol maleate safe?
It was concluded that switching from timolol maleate to timolol hemihydrate is safe and effective in maintaining control of the intraocular pressure.
Which glaucoma eye drops have the least side effects?
CARBONIC ANHYDRASE INHIBITORS Topical CAIs have largely replaced oral CAIs in glaucoma treatment, resulting in far fewer systemic side effects. The two most popular topical CAIs are dorzolamide and brinzolamide.
Does timolol maleate affect blood pressure?
It works by blocking the action of certain natural chemicals in your body such as epinephrine on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart. This medication is also used to prevent migraine headaches.
What are side effects of timolol maleate?
Temporary blurred vision, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, or headache may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.
Why is there a shortage of timolol maleate?
Reason for the Shortage Sandoz has dorzolamide and timolol ophthalmic solution available. Bausch Health had dorzolamide and timolol ophthalmic solution on shortage due to manufacturing delays.
How long should you use timolol eye drops?
Timolol eye drops are usuallyinstilled once or twice a day, at evenly spaced intervals, until pressure in the eye is controlled (about 4 weeks).
When is the best time to take timolol eye drops?
Hold the dropper directly over your eye and place one drop into the pouch as directed by your doctor, usually once in the morning or twice daily. Look downward, gently close your eyes, and place one finger at the corner of your eye (near the nose). Apply gentle pressure for 1 to 2 minutes before opening your eyes.
What are the side effects of timolol eye drops?
Temporary blurred vision, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, or headache may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.
What are side effects of timolol maleate?
Temporary blurred vision, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, or headache may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.
Does timolol maleate lower blood pressure?
Timolol is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used after a heart attack to help prevent another heart attack from occurring.
How long does it take for timolol eye drops to work?
The onset of reduction in intra-ocular pressure can be detected within one-half hour after a single dose. The maximum effect occurs in one or two hours; significant lowering of IOP can be maintained for as long as 24 hours with a single dose.
How long does timolol hemihydrate last?
This study suggests that timolol hemihydrate had an ocular hypotensive efficacy and safety profile statistically equivalent to that of timolol maleate for up to three months of therapy. Timolol hemihydrate showed efficacy and safety similar to that observed within the first three months, for up to o ….
Is timolol maleate a hypotensive?
This study suggests that timolol hemihydrate had an ocular hypotensive efficacy and safety profile statistically equivalent to that of timolol maleate for up to three months of therapy.
What is Timolol maleate?
Timolol maleate has active ingredients of timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,869 Timolol maleate users for its effectiveness, alternative drugs and more.
What is Betimol?
Betimol has active ingredients of timolol. It is often used in glaucoma. eHealthMe is studying from 535 Betimol users for its effectiveness, alternative drugs and more.
What are the side effects of timolol?
blurred vision; watery eyes; or. redness, burning, stinging, or itching in your eyes. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Dorzolamide/timolol ophthalmic side effects (more detail)
What is dorzolamide and timolol ophthalmic?
Dorzolamide and timolol ophthalmic (for the eyes) is a combination medicine used to treat certain types of glaucoma and other causes of high pressure inside the eye.
How to know if dorzolamide is absorbed into your bloodstream?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Certain symptoms may occur if dorzolamide and timolol ophthalmic is absorbed into your bloodstream. This includes dizziness, muscle pain or weakness, numbness or tingling, trouble breathing, slow heartbeats, or fluttering in your chest.
Can you use dorzolamide with soft contact lenses?
Use the medicine exactly as directed. Do not use while wearing soft contact lenses. A preservative in dorzolamide and timolol ophthalmic could permanently stain the lenses. Use the medicine at least 15 minutes before inserting your contact lenses.
Can dorzolamide cause shortness of breath?
dorzolamide and timolol ophthalmic can cause serious breathing problems or heart failure. Get medical help if you have shortness of breath, pounding heartbeats, swelling in your lower legs, or rapid weight gain.
Can you take timolol and dorzolamide at the same time?
Many drugs can interact with dorzolamide and timolol, and using certain other drugs at the same time is not recommended. Tell your doctor about all your other medicines including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Can you take timolol if you are allergic to dorzolamide?
Before taking this medicine. You should not use this medicine if you are allergic to dorzolamide or timolol, or if you have: heart muscle damage (such as from a heart attack ). a genetic disposition for allergic reactions, or if you've had a severe allergic (anaphylactic) reaction; if you plan to have surgery.
What is dorzolamide hydrochloride and timolol maleate ophthalmic solution?
Dorzolamide hydrochloride and timolol maleate ophthalmic solution is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time). The IOP-lowering of dorzolamide hydrochloride and timolol maleate ophthalmic solution administered twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol administered twice a day and 2% dorzolamide administered three times a day [see Clinical Studies (14) ].
How many drops of dorzolamide hydrochloride and timolol maleate ophthal?
The dose is one drop of dorzolamide hydrochloride and timolol maleate ophthalmic solution in the affected eye (s) two times daily.#N#If more than one topical ophthalmic drug is being used, the drugs should be administered at least five minutes apart [see Drug Interactions (7.3) ].
How to open a dorzolamide tamper evident ring?
Step 1. To open the dorzolamide hydrochloride and timolol maleate ophthalmic solution bottle, unscrew the cap by turning counter clockwise. Step 2.
What is dorzolamide hydrochloride?
Dorzolamide hydrochloride and timolol maleate ophthalmic solution is a prescription eye drop solution that contains two medicines, dorzolamide hydrochloride called an ophthalmic carbonic anhydrase inhibitor and timolol maleate called a beta-blocker.
How long after dorzolamide hydrochloride can you put contact lenses back in?
The lenses can be placed back into your eyes 15 minutes after using dorzolamide hydrochloride and timolol maleate ophthalmic solution.
What is dorzolamide maleate?
Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. The higher the level of intraocular pressure, the greater the likelihood of glaucomatous field loss and optic nerve damage.#N#Dorzolamide hydrochloride is an inhibitor of human carbonic anhydrase II. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol maleate is a beta 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. The combined effect of these two agents administered as dorzolamide hydrochloride and timolol maleate twice daily results in additional intraocular pressure reduction compared to either component administered alone, but the reduction is not as much as when dorzolamide administered three times daily and timolol twice daily are administered concomitantly. [See Clinical Studies (14) .]
How long to wait before using dorzolamide?
If you are using dorzolamide hydrochloride and timolol maleate ophthalmic solution with another eyedrop, wait at least 5 minutes before or after using dorzolamide hydrochloride and timolol maleate ophthalmic solution.
What is timolol maleate?
Timolol maleate 0.5% solution or gel forming solution is a topical nonselective β-blocker that was first reported in 2010 for use in the treatment of small superficial hemangiomas.50,51 A randomized controlled study, using one drop of the 0.5% gel forming solution, demonstrated efficacy for small nonulcerated and nonmucosal hemangiomas in term infants, between the ages of 5 and 24 weeks. 52 In a large multicenter study of 731 infants treated with topical timolol 0.5% solution or gel forming solution for infantile hemangioma, significant improvement was more likely to occur when treating superficial hemangiomas less than 1 mm in initial thickness, with the most significant improvement being noted in the color of the hemangioma. 53 Timolol can often be quite beneficial when started early in the course of the hemangioma and may sometimes prevent the need for oral treatment. It can be used as monotherapy, until the hemangioma is significantly resolved, or as a bridge to oral propranolol in very young infants, with contraindications to propranolol early in life.
When was timolol maleate released?
The latanoprost/timolol maleate FC (Xalacom™, Pfizer, Inc., New York, NY, USA) was commercially released in Europe in 2001. The regulatory trials by Pfeiffer and associates41 and Higginbotham and coworkers 42 reported the morning dosing of this FC to further reduce the IOP compared to both latanoprost dosed once daily (1.1 to 1.2 mmHg), or timolol dosed twice daily (1.9 to 2.9 mmHg, respectively). Unfortunately, the extent of IOP reduction with the morning dosing of the latanoprost/timolol FC compared to latanoprost alone was less than anticipated during development. The reason for the relative lack of efficacy has not been explained. Preclinical data suggest that the combination of the two drugs in one formulation did not adversely affect the absorption of either drug. 42 The bioavailability of latanoprost and timolol in the aqueous with this FC was at least as good as for the two drugs administered separately. One reason why there is less efficacy than anticipated may be because the FC was administered in the morning in both regulatory trials, whereas latanoprost alone was dosed in the evening in the Higginbotham study. 42 Previously, Alm and associates 43 as well as Konstas and coworkers 44–46 have consistently shown that the evening dosing of latanoprost provides lower daytime pressures than the morning dosing.
Does timolol lower IOP?
Timolol reduces IOP in normal and glaucomatous eyes without changing visual acuity, accommodation, or pupil size. 11,38,39 On average , timolol lowers IOP by about 5 mmHg over a 6–12 month period. 43 While timolol (and the other β-blockers) do a reasonable job of flattening the diurnal curve, the β-blockers are less effective during the night-time hours, possibly because the secretion of aqueous is lowest during the night. 44 The only effect of timolol on the pupil is a clinically insignificant decrease in the amplitude of redilation as detected by pupillography. 45 Timolol binds to melanin and is not metabolized by ocular tissues. 23,46 Timolol is excreted in the urine in the form of unknown metabolites. The ocular hypotensive effect of timolol is greater in human eyes than in animal eyes; in animals, the effect can often only be demonstrated in experimental ocular hypertensive conditions such as water loading. This is a good example of the importance of species differences in the ocular response to adrenergic drugs.
What is the secondary purpose of latanoprost?
The secondary purpose is to assess the effects of both latanoprost and timolol maleate on the fluorophotometric outflow facility (Cflu), and episcleral venous pressure (Pev) and on all parameters over time.
Does latanoprost increase uveoscleral drainage?
The primary purpose of this study is to show, through a controlled masked clinical study of OHT patients, that latanoprost increases the low uveoscleral drainage of aqueous humor (Fu) back to normal levels, and timolol maleate reduces the formation of aqueous humor (Fa) below normal. Both of these mechanisms will effectively reduce IOP.