How does zafirlukast work to treat asthma?
These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms. Zafirlukast is used for chronic treatment of asthma, and to prevent asthma attacks in adults and children as young as 5 years old.
What is zafirlukast (Accolate)?
Zafirlukast (Accolate) is a leukotriene receptor antagonist. It helps by stopping inflammatory cells, called leukotrienes, from constricting (closing) your airways and from producing mucus in your lungs. What is zafirlukast (Accolate) used for?
Can you take zafirlukast with fluconazole?
Additionally, taking aspirin, fluconazole, theophylline, or erythromycin can alter the effects of zafirlukast. What are the side effects of zafirlukast? The most common side effects include headaches, infections, nausea, diarrhea, and insomnia.
What is the half-life of zafirlukast?
In the pivotal bioequivalence study, the mean terminal half-life of Zafirlukast is approximately 10 hours in both normal adult subjects and patients with asthma. In other studies, the mean plasma half-life of Zafirlukast ranged from approximately 8 to 16 hours in both normal subjects and patients with asthma.
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What are side effects of zafirlukast?
Common side effects may include:nausea, diarrhea, stomach pain;headache; or.cold symptoms such as stuffy nose, sneezing, sore throat.
Is zafirlukast the same as Singulair?
#5: Accolate (Zafirlukast) Accolate is an alternative to Singulair for asthma and allergies. Like Singulair, it's a prescription-only LTRA except that the active ingredient is different (zafirlukast rather than montelukast). Estimated Cost (Without Insurance): Accolate tends to be cheaper than Singulair.
Is zafirlukast an inhaler?
Zafirlukast (Accolate) is used to help control the symptoms of asthma and improve lung function. It doesn't replace your rescue inhaler (albuterol (ProAir, Ventolin, Proventil)) when you're having an asthma attack, and you need to take it regularly twice a day.
Is zafirlukast a control or rescue medication?
How does Accolate (zafirlukast) work? Accolate is a preventive drug. It is not a rescue medication and does not provide immediate relief of acute symptoms.
Which is better montelukast or zafirlukast?
Singulair (montelukast) Although it's less effective than inhaled steroid medications for controlling asthma, Accolate (zafirlukast) has less side effects. Makes it easier to breathe. Singulair (montelukast) has fewer side effects but doesn't work as well as some inhaled medications for asthma and allergies.
When was zafirlukast discontinued?
The manufacturer of zafirlukast (Accolate®) has discontinued this product with effect from the end of March 2018. No further supplies are being made and it is predicted that minimal supplies will be available within the supply chain.
What is the generic name for zafirlukast?
Accolate is a prescription medicine used to treat the symptoms of Asthma. Accolate may be used alone or with other medications. Accolate belongs to a class of drugs called Leukotriene Receptor Antagonists.
Is zafirlukast discontinued in the US?
Zafirlukast is an oral prescription tablet used for the long-term management of asthma. Accolate, the brand version of zafirlukast, is no longer available in the United States.
Is zafirlukast good for allergies?
Zafirlukast is also sometimes used to treat allergic rhinitis (hay fever; runny nose, watery eyes, and other symptoms caused by an allergic reaction to pollen or other substances in the air). Zafirlukast is also sometimes used to prevent breathing difficulties during exercise in people who have asthma.
How long does it take for zafirlukast to work?
It may take 1 to 2 weeks before you feel the full benefit of this medication. Inform your doctor if your condition (e.g., asthma symptoms, number of times you use your rescue inhaler) persists or worsens.
Can you take Benadryl with zafirlukast?
Interactions between your drugs No interactions were found between Benadryl and zafirlukast.
What are the contraindications of zafirlukast?
Common side effects of zafirlukast may include: nausea, diarrhea, stomach pain; headache; or. cold symptoms such as stuffy nose, sneezing, sore throat.
Before Taking This Medicine
You should not use this medicine if you are allergic to zafirlukast, or if you have liver disease (including cirrhosis).To make sure zafirlukast is...
How Should I Take Zafirlukast?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.Zafirlukast...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Zafirlukast Dosing Information
Usual Adult Dose for Asthma -- Maintenance:-20 mg orally twice a day, 1 hour before or 2 hours after mealsComments:-A dose of 20 mg twice daily was...
What Other Drugs Will Affect Zafirlukast?
Other drugs may interact with zafirlukast, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your...
What is Zafirlukast used for?
Uses. Zafirlukast is used to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma. Controlling symptoms of asthma helps you maintain your normal activities and cuts down on time lost from work or school.This medication must be used regularly to be effective.
How to report side effects of Zafirlukast?
You may report side effects to Health Canada at 1-866-234-2345. Before taking zafirlukast, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Can Zafirlukast cause allergies?
Before taking zafirlukast, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Does Zafirlukast slow down the removal of other medications?
Other medications can affect the removal of zafirlukast from your body, which may affect how zafirlukast works. An example is erythromycin, among others. This medication can slow down the removal of other medications from your body, which may affect how they work. An example is warfarin, among others.
What Is Zafirlukast?
Zafirlukast is an oral prescription tablet used for the long-term management of asthma .
What Is Zafirlukast Used For?
The Food and Drug Administration approved zafirlukast for long-term prevention of asthma symptoms in adults and children aged 5 years and older. 2
What Are the Side Effects of Zafirlukast?
This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Dosage: How Much Zafirlukast Should I Take?
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Precautions
It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
What Other Medications Interact With Zafirlukast?
Zafirlukast has several medication interactions. If you take a medication that interacts with zafirlukast, your healthcare provider might adjust the doses or monitor for side effects.
What Medications Are Similar?
There are many medications prescribed for the treatment of asthma with a variety of different mechanisms. 1 Some medications are prescribed as part of combination therapy.
What are the side effects of Zafirlukast?
The most common side effects of Zafirlukast in people 12 years and older include: · headache. · infection. · nausea. · diarrhea.
How long does Zafirlukast last?
In other studies, the mean plasma half-life of Zafirlukast ranged from approximately 8 to 16 hours in both normal subjects and patients with asthma.
Does Zafirlukast cause liver failure?
right upper quadrant abdominal pain, nausea, fatigue, lethargy, pruritus, jaundice, flu-like symptoms, and anorexia). Liver failure resulting in liver transplantation and death has occurred in patients taking Zafirlukast (see WARNINGS, Hepatotoxicity and ADVERSE REACTIONS).
Does Zafirlukast increase prothrombin time?
Coadministration of Zafirlukast with warfarin results in a clinically significant increase in prothrombin time (PT). Patients on oral warfarin anticoagulant therapy and Zafirlukast should have their prothrombin times monitored closely and anticoagulant dose adjusted accordingly (see PRECAUTIONS, Drug Interactions).
Does Zafirlukast have a gender?
Gender:The pharmacokinetics of Zafirlukast are similar in males and females. Weight-adjusted apparent oral clearance does not differ due to gender. Race: No differences in the pharmacokinetics of Zafirlukast due to race have been observed. Elderly: The apparent oral clearance of Zafirlukast decreases with age.
Does Zafirlukast inhibit CYP3A4?
Additional in vitro studies utilizing human liver microsomes show that Zafirlukast inhibits the cytochrome P450 CYP3A4 and CYP2C9 isoenzymes at concentrations close to the clinically achieved total plasma concentrations (see Drug Interactions).
Is Zafirlukast a plasma protein?
Zafirlukast is more than 99% bound to plasma proteins, predominantly albumin. The degree of binding was independent of concentration in the clinically relevant range. The apparent steady-state volume of distribution (Vss/F) is approximately 70 L, suggesting moderate distribution into tissues.
What is Zafirlukast used for?
Expand Section. Zafirlukast is used to prevent asthma symptoms. Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of certain natural substances that cause swelling and tightening of the airways.
What are the side effects of Zafirlukast?
yellowing of the skin or eyes. flu-like symptoms. rash. swelling of the eyes, face, lips, tongue, or throat. difficulty breathing or swallowing . hoarseness. pain, burning, numbness, or tingling in the hands or feet. Zafirlukast may cause other side effects.
What to tell your doctor before taking Zafirlukast?
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
How often should I take Zafirlukast?
Zafirlukast comes as a tablet to take by mouth. It is usually taken two times a day, 1 hour before or 2 hours after meals. Try to take zafirlukast at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Does Zafirlukast help with asthma?
Zafirlukast may help control asthma symptoms, but it does not cure asthma. Continue to take zafirlukast even if you feel well. Do not stop taking zafirlukast without talking to your doctor.
Can you take Zafirlukast more often?
Take zafirlukast exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Do not use zafirlukast to treat a sudden attack of asthma symptoms. Your doctor will prescribe a short-acting inhaler to use during attacks. Talk to your doctor about how to treat symptoms of a sudden asthma attack.
Can you get pregnant while taking Zafirlukast?
Your doctor may need to change the doses of your medications or monitor you more carefully for side effects. tell your doctor if you have or have ever had liver disease. tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking zafirlukast, call your doctor.
What is Zafirlukast used for?
It helps by stopping inflammatory cells, called leukotrienes, from constricting (closing) your airways and from producing mucus in your lungs.
Can elderly people take Zafirlukast?
Appropriate studies performed to date have not demonstrated geriatric- specific problems that would limit the usefulness of zafir lukast in the elderly . However, elderly patients are more likely to have lower respiratory tract infections and unwanted side effects, which may require caution and an adjustment in the dose for elderly patients receiving zafirlukast.
Does Zafirlukast interact with other medications?
Zafirlukast (Accolate) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Can Zafirlukast cause liver failure?
LIVER DAMAGE. Some people taking zafirlukast (Accolate) have had liver failure, which can be dangerous. If you have abdominal pain, nausea, tiredness, yellowing of your skin or whites of the eyes, dark stool, flu-like symptoms, or loss of appetite, talk to your healthcare provider right away.
Is Zafirlukast safe for children?
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of zafirlukast in children. However, safety and efficacy have not been established in children younger than 5 years of age.
Does Zafirlukast cause insomnia?
Insomnia or trouble sleeping is not a common side effect. Usually, zafirlukast (Accolate) is well tolerated. However, some people have reported insomnia while taking zafirlukast (Accolate). If you have any issues with sleep or any changes in your mood while on this medication, let you provider know as soon as possible.
Can Zafirlukast be used for asthma?
Zafirlukast is used to help control the symptoms of asthma and improve lung function. However, this medicine should not be used to relieve an asthma attack that has already started.
What is Zafirlukast used for?
Zafirlukast is an oral leukotriene receptor antagonist used for treating asthma. Leukotrienes are a group of chemicals manufactured in the body from arachidonic acid. Release of leukotrienes within the body, for example, by allergic reactions, promotes inflammation in many diseases such as asthma, a disease in which inflammation occurs in the lungs.
How long does Zafirlukast work?
For the treatment of asthma, it starts working only after 3 to 14 days of therapy.
Is Zafirlukast a hay fever medicine?
Zafirlukast (Accolate) is a drug prescribed for the treatment of chronic asthma, preventing exercise-induced asthma, and the symptoms of allergic rhinitis (hay fever). It is not prescribed for acute asthma attacks.
Does Zafirlukast interact with warfarin?
Thus far, data in humans are very limited. In one small study, zafirlukast was shown to interact with warfarin ( Coumadin, Jantoven ), resulting in increased "thinning" of blood and a decreased ability of blood to clot. This can increase the risk of bleeding.
Does Zafirlukast block leukotriene?
Zafirlukast blocks the binding of leukotriene types D4 (LTD4), and E4 (LTE4) and the promotion of inflammation. Accolate is the brand name for zafirlukast. Zafirlukast is available in generic form. You need a prescription for zafirlukast.
What is Zafirlukast accolate?
What is zafirlukast (Accolate)? Zafirlukast is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.
How much phenylalanine is in Zafirlukast?
The chewable tablet form of this medication may contain up to 0.842 milligrams of phenylalanine. Talk to your doctor before using this form of zafirlukast if you have phenylketonuria (PKU). Zafirlukast is not expected to harm an unborn baby.
How long after a meal can I take Zafirlukast?
Take zafirlukast on an empty stomach, at least 1 hour before or 2 hours after a meal. Your dose needs may change if you have surgery, are ill, are under stress, or have recently had an asthma attack. Do not change your medication dose or schedule without your doctor's advice.
What is Multum's drug information?
Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
Is Zafirlukast safe for you?
To make sure zafirlukast is safe for you, tell your doctor if you have: a history of liver disease; if you also take erythromycin or theophylline; or. if you also take a blood thinner ( warfarin, Coumadin, Jantoven ). The chewable tablet form of this medication may contain up to 0.842 milligrams of phenylalanine.
Can you take Zafirlukast with liver disease?
You should not use this medicine if you have liver disease (including cirrhosis ). Zafirlukast will not work fast enough to treat an asthma attack. Use only a fast acting inhalation medicine for an asthma attack. Tell your doctor if it seems like your asthma medications don't work as well.
Does Multum cover all medical issues?
Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
warnings
You should not use zafirlukast if you are allergic to it, or if you have liver disease (including cirrhosis).
Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives, blisters, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat.
Pregnancy & Breastfeeding
It is not known if zafirlukast will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Dosage Guidelines & Tips
Use Zafirlukast (Accolate) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Zafirlukast Description
Zafirlukast - Clinical Pharmacology
- Mechanism of Action: Zafirlukast is a selective and competitive receptor antagonist of leukotriene D4 and E4 (LTD4 and LTE4), components of slow-reacting substance of anaphylaxis (SRSA). Cysteinyl leukotriene production and receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle constriction, and altered ce…
Indications and Usage For Zafirlukast
- Zafirlukast is indicated for the prophylaxis and chronic treatment of asthma in adults and children 5 years of age and older.
Contraindications
- Zafirlukast is contraindicated in patients who are hypersensitive to Zafirlukast or any of its inactive ingredients. Zafirlukast is contraindicated in patients with hepatic impairment including hepatic cirrhosis. Hepatotoxicity: Cases of life-threatening hepatic failure have been reported in patients treated with Zafirlukast. Cases of liver injury without other attributable cause have bee…
Precautions
- Information for Patients
Patients should be told that a rare side effect of Zafirlukast is hepatic dysfunction, and to contact their physician immediately if they experience symptoms of hepatic dysfunction (eg. right upper quadrant abdominal pain, nausea, fatigue, lethargy, pruritus, jaundice, flu-like symptoms, and an… - Eosinophilic Conditions:
In rare cases, patients with asthma on Zafirlukast may present with systemic eosinophilia, eosinophilic pneumonia, or clinical features of vasculitis consistent with Churg-Strauss syndrome, a condition which is often treated with systemic steroid therapy. Physicians should be alert to e…
Adverse Reactions
- Adults and Children 12 years of age and older The safety database for Zafirlukast consists of more than 4000 healthy volunteers and patients who received Zafirlukast, of which 1723 were asthmatics enrolled in trials of 13 weeks duration or longer. A total of 671 patients received Zafirlukast for 1 year or longer. The majority of the patients were 18 years of age or older; howev…
Overdosage
- No deaths occurred at oral Zafirlukast doses of 2000 mg/kg in mice (approximately 210 times the maximum recommended daily oral dose in adults and children on a mg/m2 basis), 2000 mg/kg in rats (approximately 420 times the maximum recommended daily oral dose in adults and children on a mg/m2 basis), and 500 mg/kg in dogs (approximately 350 times the maximum recommend…
Zafirlukast Dosage and Administration
- Because food can reduce the bioavailability of Zafirlukast, Zafirlukast should be taken at least 1 hour before or 2 hours after meals. Adults and Children 12 years of age and older The recommended dose of Zafirlukast in adults and children 12 years and older is 20 mg twice daily. Pediatric Patients 5 through 11 years of age The recommended dose of Zafirlukast in children 5 …
How Is Zafirlukast Supplied
- Zafirlukast 20 mg Tablets,white, round, biconvex, film-coated tablets debossed with “P” on one side and “20” on the other, are supplied as follows: Carton of 30 tablets (10 tablets each blister pack x 3) NDC 0904-6646-04 Store at controlled room temperature, 20-25°C (68-77°F) [see USP]. Protect from light and moisture. Dispense in the original air-tight container.
Patient Information
- Zafirlukast Tablets Read the Patient Information leaflet before you start taking Zafirlukast and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. What is Zafirlukast? Zafirlukast is a prescription medicine used to help prevent asthma attacks and for t…
Medical uses
- Zafirlukast is used to prevent asthma symptoms. Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of certain natural substances that cause swelling and tightening of the airways.
Usage
- Zafirlukast comes as a tablet to take by mouth. It is usually taken two times a day, 1 hour before or 2 hours after meals. Try to take zafirlukast at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take zafirlukast exactly as directed. Do not take more or less of it o…
Treatment
- Do not use zafirlukast to treat a sudden attack of asthma symptoms. Your doctor will prescribe a short-acting inhaler to use during attacks. Talk to your doctor about how to treat symptoms of a sudden asthma attack.
Management
- Zafirlukast may help control asthma symptoms, but it does not cure asthma. Continue to take zafirlukast even if you feel well. Do not stop taking zafirlukast without talking to your doctor.
Diet
- Unless your doctor tells you otherwise, continue your normal diet. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Risks
- Zafirlukast may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
Prevention
- Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom) . It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resista…
Diagnosis
- Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to zafirlukast.
Preparation
- It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.